Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona

Detalhes bibliográficos
Autor(a) principal: Castro, Rosane de Paula
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/001300000687c
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/5122
Resumo: In this work will be done initially, a review of the fundamentals of crystallography, besides the description of Direct Methods, commonly used in structural determination of small molecules, and the process of refinement of the obtained structure. The techniques for crystal growth will be presented and also a discussion about the process of data collection in the CAD4 diffractometer. Next, the process of obtaining single crystals and the crystallographic analysis of five novel compounds, which were synthesized by the Laborat´orio de Avaliac¸ ˜ao e S´ıntese de Substˆancias Bioativas (LASSBio) of Universidade Federal do Rio de Janeiro (UFRJ), are presented. These compounds are analogues of drugs, derivatives of N-phenylpiperazine and N-acylhydrazones, fragments that have important biological activities. The crystallographic structures of the following derivatives of N-phenylpiperazine were elucidated : LASSBio-1597, very active as anti-inflammatory, and an inclusion complex of the antipsychotic prototype, LASSBio-579, a dopamine receptor agonist, in β- cyclodextrin. The other compounds elucidated by X-ray crystallography are the N-acylhydrazones derivatives LASSBio-1606 analogue of Piroxicam, and compounds LASSBio-1586 polymorph I and LASSBio-1586 polymorph II , combretastatin-A4 analogue having potent anti-cancer activity, whose crystallographic analysis aimed to verify the existence of polymorphism suggested by DSC analysis (Differential scanning calorimetry).
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spelling Sabino, José RicardoSabino, José RicardoAparício, RicardoMarques, Ivo de AlmeidaCastro, Rosane de Paula2016-01-18T09:12:08Z2012-03-26CASTRO, Rosane de Paula. Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona. 2012. 78 f. Dissertação (Mestrado em Física) - Universidade Federal de Goiás, Goiânia, 2012.http://repositorio.bc.ufg.br/tede/handle/tede/5122ark:/38995/001300000687cIn this work will be done initially, a review of the fundamentals of crystallography, besides the description of Direct Methods, commonly used in structural determination of small molecules, and the process of refinement of the obtained structure. The techniques for crystal growth will be presented and also a discussion about the process of data collection in the CAD4 diffractometer. Next, the process of obtaining single crystals and the crystallographic analysis of five novel compounds, which were synthesized by the Laborat´orio de Avaliac¸ ˜ao e S´ıntese de Substˆancias Bioativas (LASSBio) of Universidade Federal do Rio de Janeiro (UFRJ), are presented. These compounds are analogues of drugs, derivatives of N-phenylpiperazine and N-acylhydrazones, fragments that have important biological activities. The crystallographic structures of the following derivatives of N-phenylpiperazine were elucidated : LASSBio-1597, very active as anti-inflammatory, and an inclusion complex of the antipsychotic prototype, LASSBio-579, a dopamine receptor agonist, in β- cyclodextrin. The other compounds elucidated by X-ray crystallography are the N-acylhydrazones derivatives LASSBio-1606 analogue of Piroxicam, and compounds LASSBio-1586 polymorph I and LASSBio-1586 polymorph II , combretastatin-A4 analogue having potent anti-cancer activity, whose crystallographic analysis aimed to verify the existence of polymorphism suggested by DSC analysis (Differential scanning calorimetry).Neste trabalho será feita, inicialmente, uma revisão dos fundamentos de cristalografia, além da descrição dos Métodos Diretos, correntemente utilizados na determinação estrutural de pequenas moléculas, e do processo de refinamento da estrutura obtida. Serão apresentadas técnicas de crescimento de cristais e, também, uma discussão sobre o processo de coleta de dados no Difratômetro CAD4. Posteriormente, serão apresentados o processo de obtenção dos monocristais e as análises cristalográficas de cinco compostos inéditos, que foram sintetizados pelo Laboratório de Avaliação e Síıntese de Substâncias Bioativas (LASSBio) da Universidade Federal do Rio de Janeiro (UFRJ). Estes compostos são análogos de fármacos, derivados de N-fenilpiperazina e de N-acilidrazona, fragmentos que apresentam importantes atividades biológicas. Foram elucidadas as estruturas cristalográficas dos seguintes derivados de N-fenilpiperazina: LASSBio-1597, bastante ativo como antiinflamatório, e o complexo de inclusão do protótipo antipsicótico, LASSBio-579, um agonista do receptor de dopamina, em β-ciclodextrina. Os outros compostos elucidados por cristalografia de raios X foram os derivados de N-acilidrazona LASSBio-1606, análogo do medicamento Piroxicam, e os compostos LASSBio-1586 polimorfo I e LASSBio-1586 polimorfo II, análogos da Combretastatina - A4 com potente atividade citotóxica tendo aplicações no tratamento de câncer, cuja análise cristalográfica teve como objetivo verificar a existência do polimorfismo sugerido pela análise de DSC (Differential scanning calorimetry).Submitted by Cláudia Bueno (claudiamoura18@gmail.com) on 2016-01-15T17:06:54Z No. of bitstreams: 2 Dissertação - Rosane de Paula Castro - 2012.pdf: 7116126 bytes, checksum: d96286a63399d5f5187348a56b34a414 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-01-18T09:12:08Z (GMT) No. of bitstreams: 2 Dissertação - Rosane de Paula Castro - 2012.pdf: 7116126 bytes, checksum: d96286a63399d5f5187348a56b34a414 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2016-01-18T09:12:08Z (GMT). No. of bitstreams: 2 Dissertação - Rosane de Paula Castro - 2012.pdf: 7116126 bytes, checksum: d96286a63399d5f5187348a56b34a414 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2012-03-26Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfhttp://repositorio.bc.ufg.br/tede/retrieve/25192/Disserta%c3%a7%c3%a3o%20-%20Rosane%20de%20Paula%20Castro%20-%202012.pdf.jpgporUniversidade Federal de GoiásPrograma de Pós-graduação em Fisica (IF)UFGBrasilInstituto de Física - IF (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessDifração de raios XMonocristalN-fenilpiperazinaN-acilidrazonaX-ray diffractionSingle crystalN-phenylpiperazineN-acylhydrazonesBIOFISICA::BIOFISICA MOLECULARAnálise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazonaCrystal structure analysis of pharmaceutical prototypes of N-phenylpiperazine and N-acylhydrazone derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis3162138865744262028600600600600-4029658853652049306-69559936639900141892075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona
dc.title.alternative.eng.fl_str_mv Crystal structure analysis of pharmaceutical prototypes of N-phenylpiperazine and N-acylhydrazone derivatives
title Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona
spellingShingle Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona
Castro, Rosane de Paula
Difração de raios X
Monocristal
N-fenilpiperazina
N-acilidrazona
X-ray diffraction
Single crystal
N-phenylpiperazine
N-acylhydrazones
BIOFISICA::BIOFISICA MOLECULAR
title_short Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona
title_full Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona
title_fullStr Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona
title_full_unstemmed Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona
title_sort Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona
author Castro, Rosane de Paula
author_facet Castro, Rosane de Paula
author_role author
dc.contributor.advisor1.fl_str_mv Sabino, José Ricardo
dc.contributor.referee1.fl_str_mv Sabino, José Ricardo
dc.contributor.referee2.fl_str_mv Aparício, Ricardo
dc.contributor.referee3.fl_str_mv Marques, Ivo de Almeida
dc.contributor.author.fl_str_mv Castro, Rosane de Paula
contributor_str_mv Sabino, José Ricardo
Sabino, José Ricardo
Aparício, Ricardo
Marques, Ivo de Almeida
dc.subject.por.fl_str_mv Difração de raios X
Monocristal
N-fenilpiperazina
N-acilidrazona
topic Difração de raios X
Monocristal
N-fenilpiperazina
N-acilidrazona
X-ray diffraction
Single crystal
N-phenylpiperazine
N-acylhydrazones
BIOFISICA::BIOFISICA MOLECULAR
dc.subject.eng.fl_str_mv X-ray diffraction
Single crystal
N-phenylpiperazine
N-acylhydrazones
dc.subject.cnpq.fl_str_mv BIOFISICA::BIOFISICA MOLECULAR
description In this work will be done initially, a review of the fundamentals of crystallography, besides the description of Direct Methods, commonly used in structural determination of small molecules, and the process of refinement of the obtained structure. The techniques for crystal growth will be presented and also a discussion about the process of data collection in the CAD4 diffractometer. Next, the process of obtaining single crystals and the crystallographic analysis of five novel compounds, which were synthesized by the Laborat´orio de Avaliac¸ ˜ao e S´ıntese de Substˆancias Bioativas (LASSBio) of Universidade Federal do Rio de Janeiro (UFRJ), are presented. These compounds are analogues of drugs, derivatives of N-phenylpiperazine and N-acylhydrazones, fragments that have important biological activities. The crystallographic structures of the following derivatives of N-phenylpiperazine were elucidated : LASSBio-1597, very active as anti-inflammatory, and an inclusion complex of the antipsychotic prototype, LASSBio-579, a dopamine receptor agonist, in β- cyclodextrin. The other compounds elucidated by X-ray crystallography are the N-acylhydrazones derivatives LASSBio-1606 analogue of Piroxicam, and compounds LASSBio-1586 polymorph I and LASSBio-1586 polymorph II , combretastatin-A4 analogue having potent anti-cancer activity, whose crystallographic analysis aimed to verify the existence of polymorphism suggested by DSC analysis (Differential scanning calorimetry).
publishDate 2012
dc.date.issued.fl_str_mv 2012-03-26
dc.date.accessioned.fl_str_mv 2016-01-18T09:12:08Z
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dc.identifier.citation.fl_str_mv CASTRO, Rosane de Paula. Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona. 2012. 78 f. Dissertação (Mestrado em Física) - Universidade Federal de Goiás, Goiânia, 2012.
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identifier_str_mv CASTRO, Rosane de Paula. Análise estrutural cristalográfica de protótipos de fármacos derivados de N-fenilpiperazina e de N-acilidrazona. 2012. 78 f. Dissertação (Mestrado em Física) - Universidade Federal de Goiás, Goiânia, 2012.
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