Estudo fitoquímico de espécies de clusia presentes no cerrado com potencial atividade biológica

• Autor(a) principal: Novais, Celice Souza
• Data de Publicação: 2016
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/5964
• topic: Benzofenona; Clusia; Benzophenone; CIENCIAS EXATAS E DA TERRA::QUIMICA

The investigation of the chemical composition of the fruits and floral resin extract of Clusia rosea acclimatized in the Brazilian Savana (Cerrado) by classical chromatographic techniques led to identification of 14 compounds, such as the known hyperibona, nemorosona, plukenetionas and five new compounds. The composition of the volatiles oil of flower bud is significantly different from that observed in essence Clusia rosea grown on Atlantic Rainforest. The evaluation of the cytotoxic activity of the extract of the fruit and floral resin of Clusia rosea showed that these materials are significantly active against the lineage leukemic HL-60 and the floral resin extract was more active than the fruit extract. The selectivity is significant in Lucena resistant strain and the IC50 values are about 20 times larger than the HL-60 in the incubation time 24 hours. In the floral resin extract of Clusia gardnerii was found triterpenoids and benzophenones and no significant differences were observed the majority composition of male and female floral resin extracts. The fruits extract of this species have a large amount of eufol triterpeno. This study also includes the first report of the crystallography structure of propolona A roseafenona A and 1,2-bis (3,5-di-tert-butyl-4-hydroxyphenyl)ethane.