Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/6825 |
Resumo: | Glyphosate-based herbicides are the most commonly used worldwide due to their effectiveness and they are relatively non-toxic to non-target species. Unlimited and uncontrolled use of such pesticides can lead to serious consequences in terms of human health and ecological balance. We evaluated the acute toxicity of active ingredient glyphosate (GLI) and two glyphosate-based formulations, Roundup Original (RUP) and Glyphosate AKB 480 (AKB) on different organisms: seeds of cucumber (Cucumis sativus), lettuce (Lactuca sativa) and tomato (Lycopersicon esculentum), microcrustacean Artemia salina and zebrafish (Danio rerio) early life stages. For germination endpoint, L. esculentum presented sensitivity (EC50 = 702.10 mg/L) for AKB and L. sativa for GLI exposure (EC50 = 612.30 mg/l) whereas the three substances induced significant toxic effect on root elongation of all tested species. GLI, RUP and AKB induced significant toxicity to A. salina and were classified as Category III according to Globally Harmonized Classification System (GHS) criteria. However, RUP (LC50-48h of 39.4 mg/L) was more toxic than GLI (LC50-48h of 65.24 mg/L) and AKB (LC50-48h of 104.20 mg/L). For embryo-larval toxicity test, RUP proved be more toxic than AKB for mortality endpoint (LC50-96h of 28.23 and 75.33 mg/L, respectively) and GLI (LC50 > 100 mg/L) while for hatching parameter, AKB (EC50-48h of 6.23 mg/L) was more toxic than RUP (EC50-48h of 8.29 mg/L) and GLI exposure did not affect the hatching process. We concluded that active ingredient (GLI), AKB and RUP glyphosate-based formulations are phytotoxic and induce toxic effects in non-target organisms like A. salina and zebrafish early life stage. In addition, our results shows the evaluation necessity of glyphosate-based formulations, once they present different toxic potentials on different organisms. |
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Oliveira, Gisele Augusto Rodrigues dehttp://lattes.cnpq.br/6221735418479539Valadares, Marize Camposhttp://lattes.cnpq.br/6157755243167018Oliveira, Gisele Augusto Rodrigues deGrisolia, Cesar KoppeOliveira, Danielle Palma dehttp://lattes.cnpq.br/0266761443016631Rodrigues, Laís de Brito2017-02-06T14:01:33Z2016-03-23RODRIGUES, L. B. Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos. 2016. 71 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2016.http://repositorio.bc.ufg.br/tede/handle/tede/6825Glyphosate-based herbicides are the most commonly used worldwide due to their effectiveness and they are relatively non-toxic to non-target species. Unlimited and uncontrolled use of such pesticides can lead to serious consequences in terms of human health and ecological balance. We evaluated the acute toxicity of active ingredient glyphosate (GLI) and two glyphosate-based formulations, Roundup Original (RUP) and Glyphosate AKB 480 (AKB) on different organisms: seeds of cucumber (Cucumis sativus), lettuce (Lactuca sativa) and tomato (Lycopersicon esculentum), microcrustacean Artemia salina and zebrafish (Danio rerio) early life stages. For germination endpoint, L. esculentum presented sensitivity (EC50 = 702.10 mg/L) for AKB and L. sativa for GLI exposure (EC50 = 612.30 mg/l) whereas the three substances induced significant toxic effect on root elongation of all tested species. GLI, RUP and AKB induced significant toxicity to A. salina and were classified as Category III according to Globally Harmonized Classification System (GHS) criteria. However, RUP (LC50-48h of 39.4 mg/L) was more toxic than GLI (LC50-48h of 65.24 mg/L) and AKB (LC50-48h of 104.20 mg/L). For embryo-larval toxicity test, RUP proved be more toxic than AKB for mortality endpoint (LC50-96h of 28.23 and 75.33 mg/L, respectively) and GLI (LC50 > 100 mg/L) while for hatching parameter, AKB (EC50-48h of 6.23 mg/L) was more toxic than RUP (EC50-48h of 8.29 mg/L) and GLI exposure did not affect the hatching process. We concluded that active ingredient (GLI), AKB and RUP glyphosate-based formulations are phytotoxic and induce toxic effects in non-target organisms like A. salina and zebrafish early life stage. In addition, our results shows the evaluation necessity of glyphosate-based formulations, once they present different toxic potentials on different organisms.Herbicidas à base de glifosato são amplamente utilizados em todo o mundo devido à sua eficácia e pelo fato de serem relativamente não-tóxicos para espécies não-alvo. O uso indiscriminado desses praguicidas podem levar a consequências graves em termos de saúde humana e desequilíbrio de ecossistemas. O presente trabalho avaliou a toxicidade aguda do ingrediente ativo (GLI) e duas formulações à base de glifosato, Roundup Original (RUP) e Glifosato de AKB 480 (AKB), em diferentes organismos: sementes de pepino (Cucumis sativus), alface (Lactuca sativa) e tomate (Lycopersicon esculentum), microcrustáceo Artemia salina e fases iniciais de desenvolvimento de zebrafish (Danio rerio). Para o endpoint de germinação, L. esculentum mostrou-se sensível a exposição ao AKB com CE50 de 702,10 mg/L e L. sativa para a exposição ao GLI com CE50 de 612,30 mg/L. No entanto, as três substâncias induziram efeito tóxico significativo no alongamento da raiz de todas as espécies testadas. GLI, RUP e AKB induziram toxicidade significativa para A. salina e foram classificados na Categoria III de acordo com critérios do Sistema Globalmente Harmonizado de Classificação (GHS). No entanto, o RUP (CL50-48h de 39,4 mg/L) foi mais tóxico do que GLI (CL50-48h de 65,24 mg/L) e AKB (CL50-48h de 104,20 mg/L). Para o teste de toxicidade com as fases iniciais de zebrafish, RUP (CL50-96h de 28,23 mg/L) provou ser mais tóxico para o parâmetro de mortalidade do que AKB (CL50-96h de 75,33 mg/L) e GLI (CL50 > 100 mg/L), enquanto que para o endpoint de eclosão, AKB (CE50-48h de 6,23 mg/L) mostrou-se mais tóxico do que o RUP (CE50-48h de 8,29 mg/L) e a exposição GLI não afetou a eclosão das larvas. Concluiu-se que, tanto o ingrediente ativo glifosato, quanto as formulações AKB e RUP foram fitotóxicos para as três espécies de sementes e induziram efeitos tóxicos em organismos não-alvo como A. salina e zebrafish. Além disso, nossos dados apontam para a necessidade de avaliação das diversas formulações a base de glifosato, uma vez que as mesmas apresentam diferentes potenciais tóxicos para diferentes organismos.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-02-06T14:01:10Z No. of bitstreams: 2 Dissertação - Laís de Brito Rodrigues - 2016.pdf: 1513682 bytes, checksum: f083fb3e5a8cc62aa1d67ed3d78fbfe1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-02-06T14:01:33Z (GMT) No. of bitstreams: 2 Dissertação - Laís de Brito Rodrigues - 2016.pdf: 1513682 bytes, checksum: f083fb3e5a8cc62aa1d67ed3d78fbfe1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-02-06T14:01:33Z (GMT). No. of bitstreams: 2 Dissertação - Laís de Brito Rodrigues - 2016.pdf: 1513682 bytes, checksum: f083fb3e5a8cc62aa1d67ed3d78fbfe1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-03-23Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências Farmacêuticas (FF)UFGBrasilFaculdade Farmácia - FF (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessGlifosatoRoundup®Glifosato AKB 480Toxicidade agudaFitotoxicidadeGlyphosateRoundup®Glyphosate AKB 480Acute toxicityPhytotoxicityFARMACOLOGIA::TOXICOLOGIAEfeitos ecotoxicológicos do glifosato e formulações em diferentes organismosEcotoxicological effects of glyphosate and formulations on different organismsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8249369881961524126006006006006010281161524209375-45635194137514547662075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGORIGINALDissertação - Laís de Brito Rodrigues - 2016.pdfDissertação - Laís de Brito Rodrigues - 2016.pdfapplication/pdf1513682http://repositorio.bc.ufg.br/tede/bitstreams/a7d11704-ddf5-4c1b-bd25-a12c96bc8cc2/downloadf083fb3e5a8cc62aa1d67ed3d78fbfe1MD55LICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos |
dc.title.alternative.eng.fl_str_mv |
Ecotoxicological effects of glyphosate and formulations on different organisms |
title |
Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos |
spellingShingle |
Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos Rodrigues, Laís de Brito Glifosato Roundup® Glifosato AKB 480 Toxicidade aguda Fitotoxicidade Glyphosate Roundup® Glyphosate AKB 480 Acute toxicity Phytotoxicity FARMACOLOGIA::TOXICOLOGIA |
title_short |
Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos |
title_full |
Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos |
title_fullStr |
Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos |
title_full_unstemmed |
Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos |
title_sort |
Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos |
author |
Rodrigues, Laís de Brito |
author_facet |
Rodrigues, Laís de Brito |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Oliveira, Gisele Augusto Rodrigues de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6221735418479539 |
dc.contributor.advisor-co1.fl_str_mv |
Valadares, Marize Campos |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/6157755243167018 |
dc.contributor.referee1.fl_str_mv |
Oliveira, Gisele Augusto Rodrigues de |
dc.contributor.referee2.fl_str_mv |
Grisolia, Cesar Koppe |
dc.contributor.referee3.fl_str_mv |
Oliveira, Danielle Palma de |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0266761443016631 |
dc.contributor.author.fl_str_mv |
Rodrigues, Laís de Brito |
contributor_str_mv |
Oliveira, Gisele Augusto Rodrigues de Valadares, Marize Campos Oliveira, Gisele Augusto Rodrigues de Grisolia, Cesar Koppe Oliveira, Danielle Palma de |
dc.subject.por.fl_str_mv |
Glifosato Roundup® Glifosato AKB 480 Toxicidade aguda Fitotoxicidade |
topic |
Glifosato Roundup® Glifosato AKB 480 Toxicidade aguda Fitotoxicidade Glyphosate Roundup® Glyphosate AKB 480 Acute toxicity Phytotoxicity FARMACOLOGIA::TOXICOLOGIA |
dc.subject.eng.fl_str_mv |
Glyphosate Roundup® Glyphosate AKB 480 Acute toxicity Phytotoxicity |
dc.subject.cnpq.fl_str_mv |
FARMACOLOGIA::TOXICOLOGIA |
description |
Glyphosate-based herbicides are the most commonly used worldwide due to their effectiveness and they are relatively non-toxic to non-target species. Unlimited and uncontrolled use of such pesticides can lead to serious consequences in terms of human health and ecological balance. We evaluated the acute toxicity of active ingredient glyphosate (GLI) and two glyphosate-based formulations, Roundup Original (RUP) and Glyphosate AKB 480 (AKB) on different organisms: seeds of cucumber (Cucumis sativus), lettuce (Lactuca sativa) and tomato (Lycopersicon esculentum), microcrustacean Artemia salina and zebrafish (Danio rerio) early life stages. For germination endpoint, L. esculentum presented sensitivity (EC50 = 702.10 mg/L) for AKB and L. sativa for GLI exposure (EC50 = 612.30 mg/l) whereas the three substances induced significant toxic effect on root elongation of all tested species. GLI, RUP and AKB induced significant toxicity to A. salina and were classified as Category III according to Globally Harmonized Classification System (GHS) criteria. However, RUP (LC50-48h of 39.4 mg/L) was more toxic than GLI (LC50-48h of 65.24 mg/L) and AKB (LC50-48h of 104.20 mg/L). For embryo-larval toxicity test, RUP proved be more toxic than AKB for mortality endpoint (LC50-96h of 28.23 and 75.33 mg/L, respectively) and GLI (LC50 > 100 mg/L) while for hatching parameter, AKB (EC50-48h of 6.23 mg/L) was more toxic than RUP (EC50-48h of 8.29 mg/L) and GLI exposure did not affect the hatching process. We concluded that active ingredient (GLI), AKB and RUP glyphosate-based formulations are phytotoxic and induce toxic effects in non-target organisms like A. salina and zebrafish early life stage. In addition, our results shows the evaluation necessity of glyphosate-based formulations, once they present different toxic potentials on different organisms. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-03-23 |
dc.date.accessioned.fl_str_mv |
2017-02-06T14:01:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
RODRIGUES, L. B. Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos. 2016. 71 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/6825 |
identifier_str_mv |
RODRIGUES, L. B. Efeitos ecotoxicológicos do glifosato e formulações em diferentes organismos. 2016. 71 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2016. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/6825 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
824936988196152412 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
6010281161524209375 |
dc.relation.cnpq.fl_str_mv |
-4563519413751454766 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Ciências Farmacêuticas (FF) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Faculdade Farmácia - FF (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
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UFG |
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UFG |
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Repositório Institucional da UFG |
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bitstream.checksum.fl_str_mv |
f083fb3e5a8cc62aa1d67ed3d78fbfe1 bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044330800185344 |