Estudo termoanalítico de furanocumarinas de Brosimum gaudichaudii Trécul

• Autor(a) principal: Rocha, Thaíza Carvalho da
• Data de Publicação: 2012
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• dARK ID: ark:/38995/0013000004qnb
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/3296
• topic: Vitiligo; Furocoumarins; TG/DSC; QUIMICA::QUIMICA ANALITICA

Thermal analysis techniques have been very useful to study the pre-formulations since it consists in techniques that can provide quick and reliable results. This study evaluated the thermoanalytical profiles of psoralen and bergapten, compounds used in the treatment of vitiligo, and their interactions with excipients. We also evaluated the thermal profile of the plant extract Brosimum gaudichaudii Trécul (Moraceae) and a medicine containing the same extract. The results showed that psoralen and bergapten are substances with decomposition and have only one melting step at 162 ° C and 190 respectively. The compounds psoralen and bergapten interact with each other, but the results by XRD clearly show that the crystal structures of the compounds are not affected by these interactions. Furthermore, the results of thermal analysis showed that there was no interaction with the excipients of these compounds under study. All results were confirmed by FT-IR, used as a complementary technique. The plant extract showed an endothermic event which can be attributed to the fusion of these assets. The DSC curve profile of the drug trade allowed the detection of lactose in their composition, whose presence is not included in the package leaflet.