Caracterização clinico-patológico e densidade de mastócitos em pacientes com câncer gástrico avançado

• Autor(a) principal: Taveira, Eliseu José Fleury
• Data de Publicação: 2014
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/10324
• topic: Câncer gástrico; Perfil clínico; Perfil patológico; Epidemiologia; Mastócitos; Gastric câncer; Clinical profile; Pathological profile; Epidemiology; Mast cells; CIENCIAS DA SAUDE

Gastric cancer is the second most common cause of cancer-related mortality worldwide, mainly due to chronic infection by the bacteria Helicobacter pylori. Epidemiological, clinical, pathological and molecular investigations seeking a better understanding of these tumors may help establish a better prognosis for the disease and the development of better therapeutic possibilities. In particular the tumor microenvironment has been studied to better understand the ways of interacting with the immune system and neoplasms. Within this context, the aim of this study was a retrospective survey of the epidemiology and pathology of patients with gastric cancer in a hospital in Goiânia and evaluate pathological, clinical aspects as well as the density of mast cells in some selected cases. To do so, we reviewed medical records of 220 patients with advanced gastric cancer in the period 2005-2009 of Araújo Jorge Hospital according to established inclusion criteria. Data were collected as gender, age, histological type, grade of differentiation, site of cancer incidence according to the topography of the stomach and palliative surgeries performed to determine the clinical-pathological profile of patients. Blocks were selected with the biopsy some cases (29 cases) for cutting and staining of slides for immunohistochemistry and hematoxylin-eosin to evaluate the density of mast cells present in the samples. The results showed that most patients (62.96%) were males, with the majority of cases of gastric cancer has been found in elderly over 60 years (62%). Tumors were located preferably in the antrum of the stomach (32%) or the antrum / body region (28%). Regarding the degree of differentiation, the majority (46%) of the tumors are grade 3 (poorly differentiated) and, with respect to the histological subtype, the intestinal type was more prevalent totaling 49.38% of cases. It was also observed that 52.38% of patients underwent gastrectomy as palliative surgery. In studies of marking the mast cell carcinomas showed a significantly lower density of mast cells when compared to the control - the free margin of the disease (p = 0.01). However, no difference was observed in the density of mast cells for different ages, gender, histological type. Differences in topography and degree of differentiation. These studies demonstrated the necessity and the importance of investigating the role of mast cells in tumor regions.