Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia

Detalhes bibliográficos
Autor(a) principal: Silva Júnior, George Martins Ney da
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/001300000051k
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/6587
Resumo: Background: this study aimed to contribute to the knowledge of the interrelation of two morbid conditions that affect the autonomy and independence of the elderly: Bipolar disorder (BD) and the dementias. Methods: the medical records were reviewed to meet criteria at the same time for BD and dementia, resulting in a database of 130 cases (n = 130). Their demographics characteristics were described, as well as the frequencies of the diagnoses of dementia subtypes, their correlations with the age of dementia, the age of initiation of BD, its clinical forms and psychopathologic presentation. It was also studied the impact when the DSM4-TR diagnostic criteria was shifted to the Akiskal criteria for BD. Results: in the sample, the predominant dementia age range was senile dementia (senile: 85.71%; presenile: 14.29%) and the most common dementia subtypes were Corticobasal degeneration (CBD: 24.62%) and the Fronto-Temporal Lobar Degeneration (FTLD: 19.23%). The age of initiation of BD starting 35 years old or over amounted to 74.78% (between 10 and 34 years: 25.22%; between 35 and 59 years: 36.52%; and ≥ 60 years: 38.26%), with the following clinical forms of BD present in the sample: BD1: 71.54%, BD2: 20.77%; and Cyclothymia: 7.69%. The psychopathologic clinical presentation of BD prevalent in the sample was Mixed Episodes (38.46%), followed by Mania (33.07%), Hypomania with major depression (20.77%) and Hypomania without major depression (7.7%). When applied diagnostic criteria of Akiskal, the clinical form of BD prevalent in the sample remained the BD1 (46.92%), followed by the BD6 (34.62%) and the BD2 (18.46%). Conclusions: the results showed that the CBD and FTLD were the most common dementia in comorbidity with BD. And that the BD, in such cases, was predominantly late (≥ 35 years) or very late (≥ 60 years) and in its most severe form (BD1), with the most common psychopathologic syndrome of Mixed State or Mania, suggesting that the CBD and FTLD should be actively searched in the follow-up of these cases. DCB and DLFT in comorbidity to BD offer a privileged field of research for the pathophysiology of dementia and TB itself.
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spelling Caixeta, Leonardo Ferreirahttp://lattes.cnpq.br/9536747113677509Caixeta, Leonardo Ferreirahttp://lattes.cnpq.br/9536747113677509Teixeira Júnior, Antonio LúcioAzevedo, Paulo Verlaine Borges ehttp://lattes.cnpq.br/1499301175428864Silva Júnior, George Martins Ney da2016-12-13T19:31:57Z2015-08-04SILVA JUNIOR, G. M. N. Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia. 2015. 86 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2015.http://repositorio.bc.ufg.br/tede/handle/tede/6587ark:/38995/001300000051kBackground: this study aimed to contribute to the knowledge of the interrelation of two morbid conditions that affect the autonomy and independence of the elderly: Bipolar disorder (BD) and the dementias. Methods: the medical records were reviewed to meet criteria at the same time for BD and dementia, resulting in a database of 130 cases (n = 130). Their demographics characteristics were described, as well as the frequencies of the diagnoses of dementia subtypes, their correlations with the age of dementia, the age of initiation of BD, its clinical forms and psychopathologic presentation. It was also studied the impact when the DSM4-TR diagnostic criteria was shifted to the Akiskal criteria for BD. Results: in the sample, the predominant dementia age range was senile dementia (senile: 85.71%; presenile: 14.29%) and the most common dementia subtypes were Corticobasal degeneration (CBD: 24.62%) and the Fronto-Temporal Lobar Degeneration (FTLD: 19.23%). The age of initiation of BD starting 35 years old or over amounted to 74.78% (between 10 and 34 years: 25.22%; between 35 and 59 years: 36.52%; and ≥ 60 years: 38.26%), with the following clinical forms of BD present in the sample: BD1: 71.54%, BD2: 20.77%; and Cyclothymia: 7.69%. The psychopathologic clinical presentation of BD prevalent in the sample was Mixed Episodes (38.46%), followed by Mania (33.07%), Hypomania with major depression (20.77%) and Hypomania without major depression (7.7%). When applied diagnostic criteria of Akiskal, the clinical form of BD prevalent in the sample remained the BD1 (46.92%), followed by the BD6 (34.62%) and the BD2 (18.46%). Conclusions: the results showed that the CBD and FTLD were the most common dementia in comorbidity with BD. And that the BD, in such cases, was predominantly late (≥ 35 years) or very late (≥ 60 years) and in its most severe form (BD1), with the most common psychopathologic syndrome of Mixed State or Mania, suggesting that the CBD and FTLD should be actively searched in the follow-up of these cases. DCB and DLFT in comorbidity to BD offer a privileged field of research for the pathophysiology of dementia and TB itself.Introdução: O presente estudo teve como objetivo contribuir para o conhecimento da inter-relação de duas condições mórbidas que afetam a autonomia e a independência dos idosos: o Transtorno Bipolar (TB) e as demências. Métodos: Foram revistos os prontuários que preenchiam critérios concomitantemente para TB e demência, resultando num banco de dados de 130 casos. Foram descritas as suas caraterísticas sociodemográficas, as frequências dos diagnósticos dos subtipos de demência e suas correlações com: a faixa etária da demência; a faixa etária de início do TB, suas formas clínicas e apresentação psicopatológica. Foi também estudado se a mudança de critérios diagnósticos do DSM4-TR para os de Akiskal impactaria nos resultados. Resultados: Na amostra (n=130), a faixa etária predominante da demência foi a senil (senil: 85,71%; pré-senil:14,29%) e os tipos de demência mais frequentes foram a Degeneração Corticobasal (DCB: 24,62%) e a Degeneração Lobar Fronto-Temporal (DLFT: 19,23%). A faixa etária de início do TB acima dos 35 anos ocorreu em 74,78% (entre 10 e 34 anos: 25,22%; entre 35 e 59 anos: 36,52%; e≥60 anos: 38,26%), com as seguintes formas clínicas de TB presentes na amostra: TB1: 71,54%, TB2: 20,77% e Ciclotimia: 7,69%. A configuração psicopatológica de apresentação clínica do TB predominante na amostra foi a de Episódios Mistos (38,46%), seguida por Mania (33,07%), Hipomania com Depressão Maior (20,77%) e Hipomania sem Depressão Maior (7,7%). Quando aplicados os critérios diagnósticos de Akiskal, a forma clínica de TB predominante na amostra permaneceu o TB1 (46,92%), seguido pelo TB6 (34,62%) e o TB2 (18,46%). Conclusões: Os resultados mostraram que a DCB e a DLFT foram as demências mais frequentes em comorbidade com o TB. E que o TB, nesses casos, foi predominantemente de início tardio (≥35 anos) ou muito tardio (≥60 anos) e em sua forma mais grave (TB1), tendo como síndrome psicopatológica mais frequente o Episódio Misto ou a Mania, sugerindo que a DCB e a DLFT sejam pesquisadas ativamente ao longo de seu seguimento. DCB e DLFT comórbidas ao TB oferecem um campo privilegiado de pesquisas para a fisiopatologia das demências e do próprio TB.Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2016-12-12T17:52:54Z No. of bitstreams: 2 Dissertação - George Martins Ney da Silva Júnior - 2015.pdf: 2151149 bytes, checksum: 266f50dd135504e70740809576b490bf (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2016-12-13T19:31:57Z (GMT) No. of bitstreams: 2 Dissertação - George Martins Ney da Silva Júnior - 2015.pdf: 2151149 bytes, checksum: 266f50dd135504e70740809576b490bf (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2016-12-13T19:31:57Z (GMT). No. of bitstreams: 2 Dissertação - George Martins Ney da Silva Júnior - 2015.pdf: 2151149 bytes, checksum: 266f50dd135504e70740809576b490bf (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2015-08-04application/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências da Saúde (FM)UFGBrasilFaculdade de Medicina - FM (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessTranstorno bipolarDemênciaDegeneração corticobasalPrevalênciaFisiopatologiaBipolar disorderDementiaCorticobasal degenerationPrevalencePathophysiologyCIENCIAS DA SAUDETranstorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologiaBipolar disorder associated with dementia: typology, clinical correlations and pathophysiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-100686431261774531060060060015457724759504863388765449414823306929reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia
dc.title.alternative.eng.fl_str_mv Bipolar disorder associated with dementia: typology, clinical correlations and pathophysiology
title Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia
spellingShingle Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia
Silva Júnior, George Martins Ney da
Transtorno bipolar
Demência
Degeneração corticobasal
Prevalência
Fisiopatologia
Bipolar disorder
Dementia
Corticobasal degeneration
Prevalence
Pathophysiology
CIENCIAS DA SAUDE
title_short Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia
title_full Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia
title_fullStr Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia
title_full_unstemmed Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia
title_sort Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia
author Silva Júnior, George Martins Ney da
author_facet Silva Júnior, George Martins Ney da
author_role author
dc.contributor.advisor1.fl_str_mv Caixeta, Leonardo Ferreira
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/9536747113677509
dc.contributor.referee1.fl_str_mv Caixeta, Leonardo Ferreira
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/9536747113677509
dc.contributor.referee2.fl_str_mv Teixeira Júnior, Antonio Lúcio
dc.contributor.referee3.fl_str_mv Azevedo, Paulo Verlaine Borges e
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1499301175428864
dc.contributor.author.fl_str_mv Silva Júnior, George Martins Ney da
contributor_str_mv Caixeta, Leonardo Ferreira
Caixeta, Leonardo Ferreira
Teixeira Júnior, Antonio Lúcio
Azevedo, Paulo Verlaine Borges e
dc.subject.por.fl_str_mv Transtorno bipolar
Demência
Degeneração corticobasal
Prevalência
Fisiopatologia
topic Transtorno bipolar
Demência
Degeneração corticobasal
Prevalência
Fisiopatologia
Bipolar disorder
Dementia
Corticobasal degeneration
Prevalence
Pathophysiology
CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv Bipolar disorder
Dementia
Corticobasal degeneration
Prevalence
Pathophysiology
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
description Background: this study aimed to contribute to the knowledge of the interrelation of two morbid conditions that affect the autonomy and independence of the elderly: Bipolar disorder (BD) and the dementias. Methods: the medical records were reviewed to meet criteria at the same time for BD and dementia, resulting in a database of 130 cases (n = 130). Their demographics characteristics were described, as well as the frequencies of the diagnoses of dementia subtypes, their correlations with the age of dementia, the age of initiation of BD, its clinical forms and psychopathologic presentation. It was also studied the impact when the DSM4-TR diagnostic criteria was shifted to the Akiskal criteria for BD. Results: in the sample, the predominant dementia age range was senile dementia (senile: 85.71%; presenile: 14.29%) and the most common dementia subtypes were Corticobasal degeneration (CBD: 24.62%) and the Fronto-Temporal Lobar Degeneration (FTLD: 19.23%). The age of initiation of BD starting 35 years old or over amounted to 74.78% (between 10 and 34 years: 25.22%; between 35 and 59 years: 36.52%; and ≥ 60 years: 38.26%), with the following clinical forms of BD present in the sample: BD1: 71.54%, BD2: 20.77%; and Cyclothymia: 7.69%. The psychopathologic clinical presentation of BD prevalent in the sample was Mixed Episodes (38.46%), followed by Mania (33.07%), Hypomania with major depression (20.77%) and Hypomania without major depression (7.7%). When applied diagnostic criteria of Akiskal, the clinical form of BD prevalent in the sample remained the BD1 (46.92%), followed by the BD6 (34.62%) and the BD2 (18.46%). Conclusions: the results showed that the CBD and FTLD were the most common dementia in comorbidity with BD. And that the BD, in such cases, was predominantly late (≥ 35 years) or very late (≥ 60 years) and in its most severe form (BD1), with the most common psychopathologic syndrome of Mixed State or Mania, suggesting that the CBD and FTLD should be actively searched in the follow-up of these cases. DCB and DLFT in comorbidity to BD offer a privileged field of research for the pathophysiology of dementia and TB itself.
publishDate 2015
dc.date.issued.fl_str_mv 2015-08-04
dc.date.accessioned.fl_str_mv 2016-12-13T19:31:57Z
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA JUNIOR, G. M. N. Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia. 2015. 86 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2015.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/6587
dc.identifier.dark.fl_str_mv ark:/38995/001300000051k
identifier_str_mv SILVA JUNIOR, G. M. N. Transtorno bipolar associado à demência: tipologia, correlações clínicas e fisiopatologia. 2015. 86 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2015.
ark:/38995/001300000051k
url http://repositorio.bc.ufg.br/tede/handle/tede/6587
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language por
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dc.relation.confidence.fl_str_mv 600
600
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dc.relation.department.fl_str_mv 1545772475950486338
dc.relation.cnpq.fl_str_mv 8765449414823306929
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dc.publisher.none.fl_str_mv Universidade Federal de Goiás
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dc.publisher.initials.fl_str_mv UFG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Faculdade de Medicina - FM (RG)
publisher.none.fl_str_mv Universidade Federal de Goiás
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repository.name.fl_str_mv Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)
repository.mail.fl_str_mv tasesdissertacoes.bc@ufg.br
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