Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/5177 |
Resumo: | Introduction: Leprosy Type 1 ( T1R) and type 2 reactions ( T2R) are considered the major complicators in the clinical management of leprosy patients. Leprosy reactions can occur before, during or after multidrug therapy (MDT). T1R is associated with exacerbated Th1 type cell mediated immunity (CMI) whereas T2R is associated with Th2 type immunity characterized by strong antibody production and in some cases transitory CMI to M. leprae antigens. Objective: Assess the serological reactivity to LID-1 fusion protein and to PGL-I M. leprae antigens among multibacillary (MB), paucibacillary (PB) leprosy patients that developed reaction at diagnosis or during MDT compared to reaction free MB and PB patients. Material and Methods: Paired serum samples from 73 leprosy patients were tested by ELISA to detect IgG antibodies to LID-1 and IgM responses to PGL-I. Leprosy patients included MB that developed T1R or T2R at diagnosis or during MDT and PB patients that developed T1R at diagnosis or during MDT compared to reaction free MB and PB patients. For T1R and T2R patients, samples collected during reactions and in the absence of reactions were tested and for reaction free patients samples collected at diagnosis and after MDT were tested. Results: The decline of anti LID-1 and anti PGL-I antibodies levels was significant among MB patients with T1R at diagnosis (p <0,05). Among MB patients with T2R at diagnosis and non reactional MB leprosy patients, the decline of antibodies was significant only to LID-1 (p <0,05). Higher levels of anti LID-1 antibodies were observed in MB patients who developed T2R at diagnosis compared with unreactional patients (p = 0.020) and patients who developed T1R at diagnosis (p = 0.008). Moreover, different antibody levels were seen in patients who developed T2R during MDT compared with unreactional MB patients after MDT (p = 0.020). Conclusions: Our data suggest that high anti LID-1 antibody levels may be associated with higher risk of T2R in MB patients. |
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Stefani, Mariane Martins de Araújohttp://lattes.cnpq.br/5581414958714905Stefani, Mariane Martins de AraújoBuhrer, SamiraCastilho, Mirian Lane de Oliveira Rodrigueshttp://lattes.cnpq.br/5540830886708480Mizoguti, Danielle de Freitas2016-02-01T08:37:28Z2014-02-21MIZOGUTI, D. F. Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais. 2013. 90 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2014.http://repositorio.bc.ufg.br/tede/handle/tede/5177Introduction: Leprosy Type 1 ( T1R) and type 2 reactions ( T2R) are considered the major complicators in the clinical management of leprosy patients. Leprosy reactions can occur before, during or after multidrug therapy (MDT). T1R is associated with exacerbated Th1 type cell mediated immunity (CMI) whereas T2R is associated with Th2 type immunity characterized by strong antibody production and in some cases transitory CMI to M. leprae antigens. Objective: Assess the serological reactivity to LID-1 fusion protein and to PGL-I M. leprae antigens among multibacillary (MB), paucibacillary (PB) leprosy patients that developed reaction at diagnosis or during MDT compared to reaction free MB and PB patients. Material and Methods: Paired serum samples from 73 leprosy patients were tested by ELISA to detect IgG antibodies to LID-1 and IgM responses to PGL-I. Leprosy patients included MB that developed T1R or T2R at diagnosis or during MDT and PB patients that developed T1R at diagnosis or during MDT compared to reaction free MB and PB patients. For T1R and T2R patients, samples collected during reactions and in the absence of reactions were tested and for reaction free patients samples collected at diagnosis and after MDT were tested. Results: The decline of anti LID-1 and anti PGL-I antibodies levels was significant among MB patients with T1R at diagnosis (p <0,05). Among MB patients with T2R at diagnosis and non reactional MB leprosy patients, the decline of antibodies was significant only to LID-1 (p <0,05). Higher levels of anti LID-1 antibodies were observed in MB patients who developed T2R at diagnosis compared with unreactional patients (p = 0.020) and patients who developed T1R at diagnosis (p = 0.008). Moreover, different antibody levels were seen in patients who developed T2R during MDT compared with unreactional MB patients after MDT (p = 0.020). Conclusions: Our data suggest that high anti LID-1 antibody levels may be associated with higher risk of T2R in MB patients.Introdução: As reações hansênicas (tipo 1/RT1 e tipo 2/RT2) são as principais complicações no manejo clínico de pacientes com hanseníase e podem ocorrer antes, durante e após multidrogaterapia (MDT). A RT1 está associada a exacerbação da imunidade mediada por células (CMI) do tipo Th1 para antígenos do Mycobacterium leprae. Já a RT2 está associada com a resposta imunitária do tipo Th2, caracterizada por forte produção de anticorpos e em alguns casos ativação transitória da CMI. Objetivo: Avaliar a reatividade sorológica a proteína de fusão LID-1 e ao PGL-I do M. leprae em pacientes com hanseníase multibacilares (MB) e paucibacilares (PB) com reação hansênica e em pacientes MB e PB que não desenvolveram reação. Materiais e Métodos: Foram testadas amostras um total de 73 pacientes com hanseníase MB que desenvolveram RT1 ou RT2 ao diagnóstico ou durante MDT e em pacientes PB que desenvolveram RT1 ao diagnóstico ou durante MDT comparados com pacientes MB e PB que não desenvolveram reação hansênica ao diagnóstico nem durante MDT. A presença de IgG anti LID-1 e IgM anti PGL-I foi testada por ELISA. Resultados: O declínio dos níveis de anticorpos anti LID-1 e anti PGL-I foi significativo dentre os pacientes MB que estavam em RT1 ao diagnóstico (p< 0.05). Dentre os pacientes MB que estavam em RT2 ao diagnóstico e pacientes MB não reacionais, o declínio dos anticorpos foi significante apenas para LID-1 (p< 0.05). Níveis mais altos de anticorpos anti LID-1 foram observados nos pacientes MB que desenvolveram RT2 ao diagnóstico quando comparados com pacientes MB que desenvolveram RT1 ao diagnóstico (p=0.008) ou pacientes MB não reacionais (p=0.020). Pacientes MB que desenvolveram RT2 durante a MDT também apresentaram níveis mais altos de anticorpos anti LID-1 comparados com pacientes MB não reacionais após MDT (p=0.020). Conclusões: Nossos resultados sugerem que altos níveis de anticorpos anti LID-1 podem estar associados ao maior risco de desenvolvimento de RT2 em pacientes MB.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-02-01T08:34:02Z No. of bitstreams: 2 Dissertação - Danielle de Freitas Mizoguti - 2013.pdf: 1318732 bytes, checksum: 8084d20c2bec9e4264a71581ca4d04b2 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-02-01T08:37:28Z (GMT) No. of bitstreams: 2 Dissertação - Danielle de Freitas Mizoguti - 2013.pdf: 1318732 bytes, checksum: 8084d20c2bec9e4264a71581ca4d04b2 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2016-02-01T08:37:28Z (GMT). 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dc.title.por.fl_str_mv |
Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais |
dc.title.alternative.eng.fl_str_mv |
Leprosy: serologic reactivity to LID-1 and PGL-i antigens in patients with type I , type II reactions and unreactional patients |
title |
Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais |
spellingShingle |
Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais Mizoguti, Danielle de Freitas Reação hansênica Sorologia LID-1 PGL-I Leprosy reaction Serology LID-1 PGL-I CIENCIAS DA SAUDE::MEDICINA |
title_short |
Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais |
title_full |
Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais |
title_fullStr |
Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais |
title_full_unstemmed |
Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais |
title_sort |
Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais |
author |
Mizoguti, Danielle de Freitas |
author_facet |
Mizoguti, Danielle de Freitas |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Stefani, Mariane Martins de Araújo |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5581414958714905 |
dc.contributor.referee1.fl_str_mv |
Stefani, Mariane Martins de Araújo |
dc.contributor.referee2.fl_str_mv |
Buhrer, Samira |
dc.contributor.referee3.fl_str_mv |
Castilho, Mirian Lane de Oliveira Rodrigues |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5540830886708480 |
dc.contributor.author.fl_str_mv |
Mizoguti, Danielle de Freitas |
contributor_str_mv |
Stefani, Mariane Martins de Araújo Stefani, Mariane Martins de Araújo Buhrer, Samira Castilho, Mirian Lane de Oliveira Rodrigues |
dc.subject.por.fl_str_mv |
Reação hansênica Sorologia LID-1 PGL-I |
topic |
Reação hansênica Sorologia LID-1 PGL-I Leprosy reaction Serology LID-1 PGL-I CIENCIAS DA SAUDE::MEDICINA |
dc.subject.eng.fl_str_mv |
Leprosy reaction Serology LID-1 PGL-I |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
Introduction: Leprosy Type 1 ( T1R) and type 2 reactions ( T2R) are considered the major complicators in the clinical management of leprosy patients. Leprosy reactions can occur before, during or after multidrug therapy (MDT). T1R is associated with exacerbated Th1 type cell mediated immunity (CMI) whereas T2R is associated with Th2 type immunity characterized by strong antibody production and in some cases transitory CMI to M. leprae antigens. Objective: Assess the serological reactivity to LID-1 fusion protein and to PGL-I M. leprae antigens among multibacillary (MB), paucibacillary (PB) leprosy patients that developed reaction at diagnosis or during MDT compared to reaction free MB and PB patients. Material and Methods: Paired serum samples from 73 leprosy patients were tested by ELISA to detect IgG antibodies to LID-1 and IgM responses to PGL-I. Leprosy patients included MB that developed T1R or T2R at diagnosis or during MDT and PB patients that developed T1R at diagnosis or during MDT compared to reaction free MB and PB patients. For T1R and T2R patients, samples collected during reactions and in the absence of reactions were tested and for reaction free patients samples collected at diagnosis and after MDT were tested. Results: The decline of anti LID-1 and anti PGL-I antibodies levels was significant among MB patients with T1R at diagnosis (p <0,05). Among MB patients with T2R at diagnosis and non reactional MB leprosy patients, the decline of antibodies was significant only to LID-1 (p <0,05). Higher levels of anti LID-1 antibodies were observed in MB patients who developed T2R at diagnosis compared with unreactional patients (p = 0.020) and patients who developed T1R at diagnosis (p = 0.008). Moreover, different antibody levels were seen in patients who developed T2R during MDT compared with unreactional MB patients after MDT (p = 0.020). Conclusions: Our data suggest that high anti LID-1 antibody levels may be associated with higher risk of T2R in MB patients. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-02-21 |
dc.date.accessioned.fl_str_mv |
2016-02-01T08:37:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MIZOGUTI, D. F. Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais. 2013. 90 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/5177 |
identifier_str_mv |
MIZOGUTI, D. F. Perfil sorológico à LID-1 e PGL-I em pacientes com reação hansênica tipo I e tipo II e em pacientes não reacionais. 2013. 90 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2014. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/5177 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6085308344741430434 |
dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
-7769011444564556288 |
dc.relation.cnpq.fl_str_mv |
-969369452308786627 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
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UFG |
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UFG |
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bitstream.checksum.fl_str_mv |
8084d20c2bec9e4264a71581ca4d04b2 bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f ef48816a10f2d45f2e2fee2f478e2faf 9da0b6dfac957114c6a7714714b86306 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044394817847296 |