Investigação do perfil soroepidemiológico da infecção pelo vírus da hepatite C em pacientes com diabetes mellitus tipo 2 em Goiânia- Goiás

• Autor(a) principal: Santos, lorena Santana de Mendonça
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• dARK ID: ark:/38995/001300000bpwd
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/8088
• topic: Hepatite C; Diabetes mellitus tipo 2; Epidemiologia; Hepatitis C; Diabetes mellitus type 2; Epidemiology; CIENCIAS BIOLOGICAS::MICROBIOLOGIA

Hepatitis C (HCV) virus is one of the major cause of chronic liver disease worldwide and 350,000 to 500,000 deaths occur each year related to the virus. Epidemiological studies suggest that chronic HCV infection may have implications in the genesis of some extra-hepatic diseases, among them diabetes mellitius type 2 (DM2). This study aimed to describe the epidemiological profile of HCV infection in DM 2 patients. All patients with DM2 that were followed up at the Hospital das Clinicas da Universidade Federal de Goias and Unidades de Atenção Básica Saúde da Familia in Goiania-GO were invited to take part in the research. 622 patients with DM 2 were recruited, of whom 17 refused to participate. Therefore, the population was composed of 605 individuals, being the casuistry enough to the design of the study according to the sample calculation. Individuals were interviewed and a blood sample was collected. Sera were tested for the detection of anti - HCV by third-generation enzyme-linked immunosorbent assay. Positive samples for this marker were submitted for detection of viral RNA by Polymerase Chain Reaction post Reverse Transition (RT-PCR) and RNAHCV positive samples were genotyped by Line Probe Essay method (LIPA). The average age of the studied population was 62.1 years (SD = 11.3), female predominance and 78.4% have up to 9 years of study. Nine samples were positive for anti-HCV, resulting in a prevalence of 14.9% (95% CI: 0.73-2,9) for HCV infection in patients with DM2. Viral RNA was detected in four anti-HCV positive specimens and genotypes 1 (2/4) and 3 (2/4) were identified. In the multivariate analysis, blood transfusion before 1994 and the use of illicit drugs were associated with HCV infection. Male remained marginally associated (p = 0.06). Despite the global prevalence for HCV in patients with DM 2 in Goiania-GO have been similar to the one found in the population in general, more studies are needed to clarify the epidemiology of HCV infection in individuals with DM 2 and provide information which can support prevention measures and control of infection in this group of the population.