Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/8005 |
Resumo: | The central nervous system (CNS) plays an important role in maintaining the regulation of homeostatic mechanisms that control the osmolarity and volume of body fluids. The amygdala is a limbic structure of the brain circuit involved in the sodium and water intake control. Its structure is composed of several subnuclei: the basal , the medial , the lateral and the central . The importance of angiotensin receptors in the central nucleus of the amygdala (CeA) in regulating thirst and sodium appetite is poorly understood. Here we have evaluated the participation of angiotensina II (ANGII) receptors AT1 and AT2 in the CeA on water and sodium intake induced by sodium depletion. Wistar male rats (250-280g) were submitted to extracellular dehydration by subcutaneous injections of furosemide (10 mg/kg) and captopril (5mg/kg) (FURO+CAP). In rats treated with FURO+CAP, central microinjections (0,1 μl ) of either ANGII (48 pM), Compound 21 (AT2 receptor selective agonist - C21; 0.1 μM) or PD123319 (AT2 receptor antagonist, 40 mM) forty-five minutes after FURO+CAP treatment did not significantly change water intake (ANGII:3.3±1.2 vs. Control:2.5±0.9 ml/120 min; C21:4.7±1.3 vs. Control:4.6±0.9 ml/120 min; PD123319:6.1±1.7 vs. Control:6.2±1.3 ml/120 min). However, losartan (AT1 receptor antagonist, 217 mM) to potentiate water intake (losartan: 4.8±0.6 vs. Control:3.1±1.1 ml/120 min, p<0.05 between treatments). Sodium intake was not different following ANGII (48 pM), losartan (217 mM), C21 (0,1 μM) or PD123319 (40 mM) treatments. We also tested AT2 receptors activation or blockade in the CeA before the establishment of ANGII mechanisms caused by extracellular dehydration. Right after FURO+CAP treatment, we microinjected C21 or PD123319 and saw an impaired in sodium intake caused by selective activation of AT2 receptors (C21:3.5±0.9 vs Control:5.8±2.0 ml/120 min, p<0.05 between treatments) and a reduction on water intake after AT2 receptors blockade (PD123319:3.5±1.0 vs Control:5.6±1.5 ml/120 min, p<0.05 between treatments). Thus, our results suggest that the AT1 and AT2 receptor in CeA could be part of a integrate circuitry to regulate water and sodium intake caused by extracellular dehydration. |
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Oliveira, André Henrique Freiria dehttp://lattes.cnpq.br/0152151142555605Oliveira, André Henrique Freiria deBlanch, Graziela TorresPedrino, Gustavo Rodrigueshttp://lattes.cnpq.br/0549742136529928Oliveira, Ludmila Corrêa Guimarães de2017-11-30T12:52:29Z2017-10-27OLIVEIRA, Ludmila Corrêa Guimarães de. Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio. 2017. 38 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2017.http://repositorio.bc.ufg.br/tede/handle/tede/8005The central nervous system (CNS) plays an important role in maintaining the regulation of homeostatic mechanisms that control the osmolarity and volume of body fluids. The amygdala is a limbic structure of the brain circuit involved in the sodium and water intake control. Its structure is composed of several subnuclei: the basal , the medial , the lateral and the central . The importance of angiotensin receptors in the central nucleus of the amygdala (CeA) in regulating thirst and sodium appetite is poorly understood. Here we have evaluated the participation of angiotensina II (ANGII) receptors AT1 and AT2 in the CeA on water and sodium intake induced by sodium depletion. Wistar male rats (250-280g) were submitted to extracellular dehydration by subcutaneous injections of furosemide (10 mg/kg) and captopril (5mg/kg) (FURO+CAP). In rats treated with FURO+CAP, central microinjections (0,1 μl ) of either ANGII (48 pM), Compound 21 (AT2 receptor selective agonist - C21; 0.1 μM) or PD123319 (AT2 receptor antagonist, 40 mM) forty-five minutes after FURO+CAP treatment did not significantly change water intake (ANGII:3.3±1.2 vs. Control:2.5±0.9 ml/120 min; C21:4.7±1.3 vs. Control:4.6±0.9 ml/120 min; PD123319:6.1±1.7 vs. Control:6.2±1.3 ml/120 min). However, losartan (AT1 receptor antagonist, 217 mM) to potentiate water intake (losartan: 4.8±0.6 vs. Control:3.1±1.1 ml/120 min, p<0.05 between treatments). Sodium intake was not different following ANGII (48 pM), losartan (217 mM), C21 (0,1 μM) or PD123319 (40 mM) treatments. We also tested AT2 receptors activation or blockade in the CeA before the establishment of ANGII mechanisms caused by extracellular dehydration. Right after FURO+CAP treatment, we microinjected C21 or PD123319 and saw an impaired in sodium intake caused by selective activation of AT2 receptors (C21:3.5±0.9 vs Control:5.8±2.0 ml/120 min, p<0.05 between treatments) and a reduction on water intake after AT2 receptors blockade (PD123319:3.5±1.0 vs Control:5.6±1.5 ml/120 min, p<0.05 between treatments). Thus, our results suggest that the AT1 and AT2 receptor in CeA could be part of a integrate circuitry to regulate water and sodium intake caused by extracellular dehydration.O sistema nervoso central (SNC) desempenha um papel importante na manutenção da regulação dos mecanismos homeostáticos que controlam a osmolaridade e o volume dos líquidos corporais. A amígdala é uma estrutura límbica do circuito cerebral envolvida no controle da ingestão de sódio e água. Sua estrutura é composta por diversos subnúcleos: o basal, o medial, o lateral e o central. A importância dos receptores de angiotensina no núcleo central da amígdala (CeA) na regulação da sede e do apetite de sódio é pouco conhecida. Neste trabalho, avaliamos a participação dos receptores de angiotensina II (ANGII) AT1 e AT2 no CeA na ingestão de água e sódio induzida pela depleção de sódio. Ratos Wistar (250-280g) foram submetidos à desidratação extracelular por injeções subcutâneas de furosemida (10 mg / kg) e captopril (5 mg / kg) (FURO + CAP). Em ratos tratados com FURO + CAP, as microinjeções centrais (0,1 μl)? de ANGII (48 pM), Composto 21 (agonista de receptores AT2 - C21; 0,1 μM) ou PD123319 (antagonista dos receptores AT2, 40 mM) quarenta e cinco minutos após o tratamento com FURO + CAP não alteraram significativamente a ingestão de água (ANGII: 3,3 ± 1,2 vs. Controle: 2,5 ± 0,9 ml / 120 min; C21: 4,7 ± 1,3 vs. Controle: 4,6 ± 0,9 ml / 120 min; PD123319: 6,1 ± 1,7 vs. Controle: 6,2 ± 1,3 ml / 120 min). No entanto, o losartan (antagonista de receptores AT1, 217 mM) potencializou a ingestão de água quando comparado com o controle (losartan: 4,8 ± 0,6 vs. Controle: 3,1 ± 1,1 ml / 120 min, p <0,05 entre os tratamentos). A ingestão de NaCl 0,3 M não foi diferente após os tratamentos com ANGII (48 pM), losartan (217 mM), C21 (0,1 μM) ou PD123319 (40 mM). Também testamos a ativação ou o bloqueio dos receptores AT2 no CeA antes que os mecanismos dependentes da ANGII causados pela desidratação estivessem estabelecidos. Logo após o tratamento com FURO + CAP, microinjetamos C21 ou PD123319 e vimos uma diminuição na ingestão de NaCl 0,3 M causada pela ativação seletiva de receptores AT2 (C21: 3,5 ± 0,9 vs Controle: 5,8 ± 2,0 ml / 120 min, p <0,05 entre tratamentos) e uma diminuição na ingestão de água após o bloqueio dos receptores AT2 (PD123319: 3,5 ± 1,0 vs. Controle: 5,6 ± 1,5 ml / 120 min, p <0,05 entre os tratamentos). Assim, nossos resultados sugerem que os receptores AT1 e AT2 no CeA fazem parte de um circuito integrador que regula a ingestão de água e sódio causados por desidratação extracelular.Submitted by Franciele Moreira (francielemoreyra@gmail.com) on 2017-11-30T11:54:27Z No. of bitstreams: 2 Dissertação - Ludmila Corrêa Guimarães de Oliveira - 2017.pdf: 1800128 bytes, checksum: 54cb8a55b9534c5187510046f3a4c8b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-11-30T12:52:29Z (GMT) No. of bitstreams: 2 Dissertação - Ludmila Corrêa Guimarães de Oliveira - 2017.pdf: 1800128 bytes, checksum: 54cb8a55b9534c5187510046f3a4c8b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-11-30T12:52:29Z (GMT). No. of bitstreams: 2 Dissertação - Ludmila Corrêa Guimarães de Oliveira - 2017.pdf: 1800128 bytes, checksum: 54cb8a55b9534c5187510046f3a4c8b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-10-27Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Biologia (ICB)UFGBrasilInstituto de Ciências Biológicas - ICB (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessMecanismos angiotensinégicosSedeApetite ao sódioDesidratação extracelularAngiotensin mechanismsThirstSodium appetiteExtracellular dehydrationCIENCIAS BIOLOGICAS::FISIOLOGIAParticipação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódioThe angiotensin II AT1 and AT2 receptors participation in the central nucleus of the amigdala on sodium ingestioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis6883982777473437920600600600600-387277211782737340477377082474190182232075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.eng.fl_str_mv |
Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio |
dc.title.alternative.eng.fl_str_mv |
The angiotensin II AT1 and AT2 receptors participation in the central nucleus of the amigdala on sodium ingestion |
title |
Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio |
spellingShingle |
Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio Oliveira, Ludmila Corrêa Guimarães de Mecanismos angiotensinégicos Sede Apetite ao sódio Desidratação extracelular Angiotensin mechanisms Thirst Sodium appetite Extracellular dehydration CIENCIAS BIOLOGICAS::FISIOLOGIA |
title_short |
Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio |
title_full |
Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio |
title_fullStr |
Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio |
title_full_unstemmed |
Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio |
title_sort |
Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio |
author |
Oliveira, Ludmila Corrêa Guimarães de |
author_facet |
Oliveira, Ludmila Corrêa Guimarães de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Oliveira, André Henrique Freiria de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0152151142555605 |
dc.contributor.referee1.fl_str_mv |
Oliveira, André Henrique Freiria de |
dc.contributor.referee2.fl_str_mv |
Blanch, Graziela Torres |
dc.contributor.referee3.fl_str_mv |
Pedrino, Gustavo Rodrigues |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0549742136529928 |
dc.contributor.author.fl_str_mv |
Oliveira, Ludmila Corrêa Guimarães de |
contributor_str_mv |
Oliveira, André Henrique Freiria de Oliveira, André Henrique Freiria de Blanch, Graziela Torres Pedrino, Gustavo Rodrigues |
dc.subject.por.fl_str_mv |
Mecanismos angiotensinégicos Sede Apetite ao sódio Desidratação extracelular |
topic |
Mecanismos angiotensinégicos Sede Apetite ao sódio Desidratação extracelular Angiotensin mechanisms Thirst Sodium appetite Extracellular dehydration CIENCIAS BIOLOGICAS::FISIOLOGIA |
dc.subject.eng.fl_str_mv |
Angiotensin mechanisms Thirst Sodium appetite Extracellular dehydration |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::FISIOLOGIA |
description |
The central nervous system (CNS) plays an important role in maintaining the regulation of homeostatic mechanisms that control the osmolarity and volume of body fluids. The amygdala is a limbic structure of the brain circuit involved in the sodium and water intake control. Its structure is composed of several subnuclei: the basal , the medial , the lateral and the central . The importance of angiotensin receptors in the central nucleus of the amygdala (CeA) in regulating thirst and sodium appetite is poorly understood. Here we have evaluated the participation of angiotensina II (ANGII) receptors AT1 and AT2 in the CeA on water and sodium intake induced by sodium depletion. Wistar male rats (250-280g) were submitted to extracellular dehydration by subcutaneous injections of furosemide (10 mg/kg) and captopril (5mg/kg) (FURO+CAP). In rats treated with FURO+CAP, central microinjections (0,1 μl ) of either ANGII (48 pM), Compound 21 (AT2 receptor selective agonist - C21; 0.1 μM) or PD123319 (AT2 receptor antagonist, 40 mM) forty-five minutes after FURO+CAP treatment did not significantly change water intake (ANGII:3.3±1.2 vs. Control:2.5±0.9 ml/120 min; C21:4.7±1.3 vs. Control:4.6±0.9 ml/120 min; PD123319:6.1±1.7 vs. Control:6.2±1.3 ml/120 min). However, losartan (AT1 receptor antagonist, 217 mM) to potentiate water intake (losartan: 4.8±0.6 vs. Control:3.1±1.1 ml/120 min, p<0.05 between treatments). Sodium intake was not different following ANGII (48 pM), losartan (217 mM), C21 (0,1 μM) or PD123319 (40 mM) treatments. We also tested AT2 receptors activation or blockade in the CeA before the establishment of ANGII mechanisms caused by extracellular dehydration. Right after FURO+CAP treatment, we microinjected C21 or PD123319 and saw an impaired in sodium intake caused by selective activation of AT2 receptors (C21:3.5±0.9 vs Control:5.8±2.0 ml/120 min, p<0.05 between treatments) and a reduction on water intake after AT2 receptors blockade (PD123319:3.5±1.0 vs Control:5.6±1.5 ml/120 min, p<0.05 between treatments). Thus, our results suggest that the AT1 and AT2 receptor in CeA could be part of a integrate circuitry to regulate water and sodium intake caused by extracellular dehydration. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-11-30T12:52:29Z |
dc.date.issued.fl_str_mv |
2017-10-27 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Ludmila Corrêa Guimarães de. Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio. 2017. 38 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2017. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/8005 |
identifier_str_mv |
OLIVEIRA, Ludmila Corrêa Guimarães de. Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio. 2017. 38 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2017. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/8005 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6883982777473437920 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-3872772117827373404 |
dc.relation.cnpq.fl_str_mv |
7737708247419018223 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
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