Efeitos do uso de drogas ilícitas na resposta inflamatória

• Autor(a) principal: Ribeiro, Camila Bastos
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/5875
• topic: Drogas ilícitas; Resposta inflamatória; Citocinas inflamatórias; Illicit drugs; Inflamatory response; Inflamatory cytokines; CIENCIAS BIOLOGICAS::FARMACOLOGIA

Studies have reported that illicit drugs can alter immune system function and further suggest a greater commitment related to the use of these drugs, such as increased susceptibility to infection and progression to disease. Considering these effects in the body, we conducted a study to investigate the effect of drug use on the inflammatory response in subjects grouped according to the drug used: marijuana, cocaine and crack users and individuals from more than one drug. Thus, the study groups were: 1. non drug users (control); 2. marijuana users; 3. Cocaine/crack users; 4.cocaine/crack/marijuana users (multiuser). The profile of proinflammatory and anti-inflammatory cytokines and C-reactive protein (CRP) in the plasma of study subjects was investigated. There were also measured the levels of soluble CD14 (sCD14) and lipopolysaccharide (LPS) circulating in the plasma of individuals that are indicative of microbial translocation. We obtained high levels of sCD14, LPS, CRP, IL-6 and IL-8 in multi-user group and decreased levels of IL-6 and TNF- in cannabis user group compared to the control group. This set of findings suggests that illicit drugs may be causing a change in the integrity of the intestinal mucosa multiuser individuals due to the increased presence of LPS and sCD14 was detected in the circulation and changes in the inflammatory response with increased production and / or decreased biomarkers relevant inflammation.