Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
dARK ID: | ark:/38995/0013000000fgb |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/12828 |
Resumo: | Cross-sectional study conducted at the Center of Reference in Ophthalmology UFG in conjunction with Oregon Health and Science University and the Brazilian Center for Eye Surgery (CBCO). To evaluate the genotype of patients with Usher syndrome of Reference Center for Ophthalmology, Federal University of Goias (UFG-CEROF). Patients clinically diagnosed with SU underwent complete ophthalmic examination, Goldmann manual kinetic perimetry, audiometry and subsequent collection of peripheral blood chromosomal microarray for sequencing. We examined 19 patients with clinical suspicion of SU with a mean age at first visit was 42.5 years (± 12.2) and a slight predominance of males (52.63%). The most prevalent subtype in clinical diagnosis of type I disease (68.4%). The visual acuity measured on the day of the exam for eye examination was 20/92 on the Snellen chart. Examinations audiometry showed hearing loss in all patients ranging from moderate in 12.5% of patients, deep (56.25%) and severe (31.25%). In 36.8% of patients analyzed, we found at least two mutations in the same gene, and of these, 21% were heterozygous mutations, and 15.8% homozygous. The homozygous mutations, which were of the type no sense, occurred in the gene CLRN1 whose patients had a previous diagnosis of USH 2. Met 26.31% of the sample analyzed in heterozygous. Of these, two patients showed mutations in the MYO7A gene (40%), both with clinical suspicion of USH 1. For the proposed methodology, we found no disease-causing mutations in 79% of the sample analyzed. Following the proposed methodology, the authors were able to determine the mutation in seven patients of nineteen patients inclued in this study. Of these, three patients were diagnosed with homozygous mutations in gene CLRN1, and had previous clinical diagnosis of type 2. Two patients had heterozygous mutations in gene MYO7A, both with previous clinical diagnosis of type 1. |
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Ávila, Marcos Pereira dehttp://lattes.cnpq.br/3335187297522447Ávila, Marcos Pereira deRassi, Alan RicardoLima, Francisco Eduardo Lopes deSilva, Leopoldo Magacho dos Santoshttp://lattes.cnpq.br/3835239829040839Cruvinel Filho, Ricardo Campos2023-05-11T12:05:19Z2023-05-11T12:05:19Z2014-12-16CRUVINEL FILHO, R. C. Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás. 2014. 86 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2014.http://repositorio.bc.ufg.br/tede/handle/tede/12828ark:/38995/0013000000fgbCross-sectional study conducted at the Center of Reference in Ophthalmology UFG in conjunction with Oregon Health and Science University and the Brazilian Center for Eye Surgery (CBCO). To evaluate the genotype of patients with Usher syndrome of Reference Center for Ophthalmology, Federal University of Goias (UFG-CEROF). Patients clinically diagnosed with SU underwent complete ophthalmic examination, Goldmann manual kinetic perimetry, audiometry and subsequent collection of peripheral blood chromosomal microarray for sequencing. We examined 19 patients with clinical suspicion of SU with a mean age at first visit was 42.5 years (± 12.2) and a slight predominance of males (52.63%). The most prevalent subtype in clinical diagnosis of type I disease (68.4%). The visual acuity measured on the day of the exam for eye examination was 20/92 on the Snellen chart. Examinations audiometry showed hearing loss in all patients ranging from moderate in 12.5% of patients, deep (56.25%) and severe (31.25%). In 36.8% of patients analyzed, we found at least two mutations in the same gene, and of these, 21% were heterozygous mutations, and 15.8% homozygous. The homozygous mutations, which were of the type no sense, occurred in the gene CLRN1 whose patients had a previous diagnosis of USH 2. Met 26.31% of the sample analyzed in heterozygous. Of these, two patients showed mutations in the MYO7A gene (40%), both with clinical suspicion of USH 1. For the proposed methodology, we found no disease-causing mutations in 79% of the sample analyzed. Following the proposed methodology, the authors were able to determine the mutation in seven patients of nineteen patients inclued in this study. Of these, three patients were diagnosed with homozygous mutations in gene CLRN1, and had previous clinical diagnosis of type 2. Two patients had heterozygous mutations in gene MYO7A, both with previous clinical diagnosis of type 1.Estudo transversal, desenvolvido no Centro de Referência em Oftalmologia da UFG em conjunto com a Oregon Health and Science University e Centro Brasileiro de Cirurgia de Olhos (CBCO), que teve como objetivo avaliar o genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goias (CEROF-UFG). Pacientes clinicamente diagnosticados com SU foram submetidos a exame oftalmológico completo, perimetria cinética manual de Goldmann, audiometria e posterior coleta de sangue periférico para sequenciamento cromossômico por microarray. Foram examinados 19 pacientes com diagnostico clínico de SU com média de idade na primeira consulta de 42,5 anos (± 12,2) e pequena predominância do sexo masculino (52,63%). O subtipo mais prevalente no diagnóstico clínico foi do tipo I da doença (68,4%). A acuidade visual média medida no dia do exame por olho examinado foi de 20/92 na escala de Snellen. Os exames audiométricos mostraram perda de audição em todos pacientes variando de moderada em 12,5% dos pacientes, profunda (56,25%) e severa (31,25%). Em 36,8% dos pacientes analisados, encontraram-se ao menos duas mutações em um mesmo gene, sendo que destes, 21% eram mutações heterozigotas e, 15,8% homozigotas. As mutações homozigotas, as quais eram do tipo sem senso, ocorreram no gene CLRN1, cujos pacientes tinham o diagnóstico clínico prévio de USH 2. Encontrou-se 26,31% da amostra analisada em heterozigose. Desses, dois pacientes mostraram mutações para o gene MYO7A (40%), ambos com suspeita clínica de USH 1. Pela metodologia proposta, não foram encontradas mutações causadoras de doença em 79% da amostra analisada. Dos 19 pacientes incluídos no presente estudo os autores conseguiram determinar a mutação de sete deles segundo a metodologia proposta. Desses, três pacientes foram diagnosticados com mutações homozigoticas todas no gene CLRN1 e possuíam diagnostico clinico prévio de SU tipo 2. Dois pacientes apresentaram mutações heterozigóticas para o gene MYO7A, ambos com diagnostico clinico prévio de SU tipo 1 e um paciente apresentou mutação heterozigótica para o gene ALMS1 que apresentava diagnostico clinico de SU tipo 1Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2023-05-10T20:31:33Z No. of bitstreams: 3 Dissertação - Ricardo Campos Cruvinel Filho - 2014.pdf: 8522041 bytes, checksum: 659668f14255c2cc2bc672ca7e68b69d (MD5) Dissertação - Ricardo Campos Cruvinel Filho - 2014 - Teca Desembargo.pdf: 147697 bytes, checksum: 001015a3b708d5ed1ba4b77170883da8 (MD5) license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2023-05-11T12:05:19Z (GMT) No. of bitstreams: 3 Dissertação - Ricardo Campos Cruvinel Filho - 2014.pdf: 8522041 bytes, checksum: 659668f14255c2cc2bc672ca7e68b69d (MD5) Dissertação - Ricardo Campos Cruvinel Filho - 2014 - Teca Desembargo.pdf: 147697 bytes, checksum: 001015a3b708d5ed1ba4b77170883da8 (MD5) license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5)Made available in DSpace on 2023-05-11T12:05:19Z (GMT). No. of bitstreams: 3 Dissertação - Ricardo Campos Cruvinel Filho - 2014.pdf: 8522041 bytes, checksum: 659668f14255c2cc2bc672ca7e68b69d (MD5) Dissertação - Ricardo Campos Cruvinel Filho - 2014 - Teca Desembargo.pdf: 147697 bytes, checksum: 001015a3b708d5ed1ba4b77170883da8 (MD5) license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5) Previous issue date: 2014-12-16OutroporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências da Saúde (FM)UFGBrasilFaculdade de Medicina - FM (RMG)Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessRetinose pigmentar/diagnósticoRetinose pigmentar/genéticaPerda auditiva neurosensorial/genéticaSíndrome de Usher/diagnóstico molecularRetinitis pigmentosa/ diagnosisRetinitis pigmentosa/ geneticsSensorineural hearing loss / geneticsUsher / molecular diagnostic syndromeCIENCIAS DA SAUDEAvaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de GoiásEvaluation of patients with genotype Reference Center Ophthalmology, Federal University of Goiás Usher syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis25500500500500191825reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.pt_BR.fl_str_mv |
Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás |
dc.title.alternative.eng.fl_str_mv |
Evaluation of patients with genotype Reference Center Ophthalmology, Federal University of Goiás Usher syndrome |
title |
Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás |
spellingShingle |
Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás Cruvinel Filho, Ricardo Campos Retinose pigmentar/diagnóstico Retinose pigmentar/genética Perda auditiva neurosensorial/genética Síndrome de Usher/diagnóstico molecular Retinitis pigmentosa/ diagnosis Retinitis pigmentosa/ genetics Sensorineural hearing loss / genetics Usher / molecular diagnostic syndrome CIENCIAS DA SAUDE |
title_short |
Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás |
title_full |
Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás |
title_fullStr |
Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás |
title_full_unstemmed |
Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás |
title_sort |
Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás |
author |
Cruvinel Filho, Ricardo Campos |
author_facet |
Cruvinel Filho, Ricardo Campos |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Ávila, Marcos Pereira de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3335187297522447 |
dc.contributor.referee1.fl_str_mv |
Ávila, Marcos Pereira de |
dc.contributor.referee2.fl_str_mv |
Rassi, Alan Ricardo |
dc.contributor.referee3.fl_str_mv |
Lima, Francisco Eduardo Lopes de |
dc.contributor.referee4.fl_str_mv |
Silva, Leopoldo Magacho dos Santos |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3835239829040839 |
dc.contributor.author.fl_str_mv |
Cruvinel Filho, Ricardo Campos |
contributor_str_mv |
Ávila, Marcos Pereira de Ávila, Marcos Pereira de Rassi, Alan Ricardo Lima, Francisco Eduardo Lopes de Silva, Leopoldo Magacho dos Santos |
dc.subject.por.fl_str_mv |
Retinose pigmentar/diagnóstico Retinose pigmentar/genética Perda auditiva neurosensorial/genética Síndrome de Usher/diagnóstico molecular |
topic |
Retinose pigmentar/diagnóstico Retinose pigmentar/genética Perda auditiva neurosensorial/genética Síndrome de Usher/diagnóstico molecular Retinitis pigmentosa/ diagnosis Retinitis pigmentosa/ genetics Sensorineural hearing loss / genetics Usher / molecular diagnostic syndrome CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Retinitis pigmentosa/ diagnosis Retinitis pigmentosa/ genetics Sensorineural hearing loss / genetics Usher / molecular diagnostic syndrome |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Cross-sectional study conducted at the Center of Reference in Ophthalmology UFG in conjunction with Oregon Health and Science University and the Brazilian Center for Eye Surgery (CBCO). To evaluate the genotype of patients with Usher syndrome of Reference Center for Ophthalmology, Federal University of Goias (UFG-CEROF). Patients clinically diagnosed with SU underwent complete ophthalmic examination, Goldmann manual kinetic perimetry, audiometry and subsequent collection of peripheral blood chromosomal microarray for sequencing. We examined 19 patients with clinical suspicion of SU with a mean age at first visit was 42.5 years (± 12.2) and a slight predominance of males (52.63%). The most prevalent subtype in clinical diagnosis of type I disease (68.4%). The visual acuity measured on the day of the exam for eye examination was 20/92 on the Snellen chart. Examinations audiometry showed hearing loss in all patients ranging from moderate in 12.5% of patients, deep (56.25%) and severe (31.25%). In 36.8% of patients analyzed, we found at least two mutations in the same gene, and of these, 21% were heterozygous mutations, and 15.8% homozygous. The homozygous mutations, which were of the type no sense, occurred in the gene CLRN1 whose patients had a previous diagnosis of USH 2. Met 26.31% of the sample analyzed in heterozygous. Of these, two patients showed mutations in the MYO7A gene (40%), both with clinical suspicion of USH 1. For the proposed methodology, we found no disease-causing mutations in 79% of the sample analyzed. Following the proposed methodology, the authors were able to determine the mutation in seven patients of nineteen patients inclued in this study. Of these, three patients were diagnosed with homozygous mutations in gene CLRN1, and had previous clinical diagnosis of type 2. Two patients had heterozygous mutations in gene MYO7A, both with previous clinical diagnosis of type 1. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-12-16 |
dc.date.accessioned.fl_str_mv |
2023-05-11T12:05:19Z |
dc.date.available.fl_str_mv |
2023-05-11T12:05:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CRUVINEL FILHO, R. C. Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás. 2014. 86 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/12828 |
dc.identifier.dark.fl_str_mv |
ark:/38995/0013000000fgb |
identifier_str_mv |
CRUVINEL FILHO, R. C. Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás. 2014. 86 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2014. ark:/38995/0013000000fgb |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/12828 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
25 |
dc.relation.confidence.fl_str_mv |
500 500 500 500 |
dc.relation.department.fl_str_mv |
19 |
dc.relation.cnpq.fl_str_mv |
182 |
dc.relation.sponsorship.fl_str_mv |
5 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Ciências da Saúde (FM) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Faculdade de Medicina - FM (RMG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
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UFG |
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UFG |
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Repositório Institucional da UFG |
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