Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás

Detalhes bibliográficos
Autor(a) principal: Cruvinel Filho, Ricardo Campos
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/0013000000fgb
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/12828
Resumo: Cross-sectional study conducted at the Center of Reference in Ophthalmology UFG in conjunction with Oregon Health and Science University and the Brazilian Center for Eye Surgery (CBCO). To evaluate the genotype of patients with Usher syndrome of Reference Center for Ophthalmology, Federal University of Goias (UFG-CEROF). Patients clinically diagnosed with SU underwent complete ophthalmic examination, Goldmann manual kinetic perimetry, audiometry and subsequent collection of peripheral blood chromosomal microarray for sequencing. We examined 19 patients with clinical suspicion of SU with a mean age at first visit was 42.5 years (± 12.2) and a slight predominance of males (52.63%). The most prevalent subtype in clinical diagnosis of type I disease (68.4%). The visual acuity measured on the day of the exam for eye examination was 20/92 on the Snellen chart. Examinations audiometry showed hearing loss in all patients ranging from moderate in 12.5% of patients, deep (56.25%) and severe (31.25%). In 36.8% of patients analyzed, we found at least two mutations in the same gene, and of these, 21% were heterozygous mutations, and 15.8% homozygous. The homozygous mutations, which were of the type no sense, occurred in the gene CLRN1 whose patients had a previous diagnosis of USH 2. Met 26.31% of the sample analyzed in heterozygous. Of these, two patients showed mutations in the MYO7A gene (40%), both with clinical suspicion of USH 1. For the proposed methodology, we found no disease-causing mutations in 79% of the sample analyzed. Following the proposed methodology, the authors were able to determine the mutation in seven patients of nineteen patients inclued in this study. Of these, three patients were diagnosed with homozygous mutations in gene CLRN1, and had previous clinical diagnosis of type 2. Two patients had heterozygous mutations in gene MYO7A, both with previous clinical diagnosis of type 1.
id UFG-2_799c76a2073474776829a12d0cf139b8
oai_identifier_str oai:repositorio.bc.ufg.br:tede/12828
network_acronym_str UFG-2
network_name_str Repositório Institucional da UFG
repository_id_str
spelling Ávila, Marcos Pereira dehttp://lattes.cnpq.br/3335187297522447Ávila, Marcos Pereira deRassi, Alan RicardoLima, Francisco Eduardo Lopes deSilva, Leopoldo Magacho dos Santoshttp://lattes.cnpq.br/3835239829040839Cruvinel Filho, Ricardo Campos2023-05-11T12:05:19Z2023-05-11T12:05:19Z2014-12-16CRUVINEL FILHO, R. C. Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás. 2014. 86 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2014.http://repositorio.bc.ufg.br/tede/handle/tede/12828ark:/38995/0013000000fgbCross-sectional study conducted at the Center of Reference in Ophthalmology UFG in conjunction with Oregon Health and Science University and the Brazilian Center for Eye Surgery (CBCO). To evaluate the genotype of patients with Usher syndrome of Reference Center for Ophthalmology, Federal University of Goias (UFG-CEROF). Patients clinically diagnosed with SU underwent complete ophthalmic examination, Goldmann manual kinetic perimetry, audiometry and subsequent collection of peripheral blood chromosomal microarray for sequencing. We examined 19 patients with clinical suspicion of SU with a mean age at first visit was 42.5 years (± 12.2) and a slight predominance of males (52.63%). The most prevalent subtype in clinical diagnosis of type I disease (68.4%). The visual acuity measured on the day of the exam for eye examination was 20/92 on the Snellen chart. Examinations audiometry showed hearing loss in all patients ranging from moderate in 12.5% of patients, deep (56.25%) and severe (31.25%). In 36.8% of patients analyzed, we found at least two mutations in the same gene, and of these, 21% were heterozygous mutations, and 15.8% homozygous. The homozygous mutations, which were of the type no sense, occurred in the gene CLRN1 whose patients had a previous diagnosis of USH 2. Met 26.31% of the sample analyzed in heterozygous. Of these, two patients showed mutations in the MYO7A gene (40%), both with clinical suspicion of USH 1. For the proposed methodology, we found no disease-causing mutations in 79% of the sample analyzed. Following the proposed methodology, the authors were able to determine the mutation in seven patients of nineteen patients inclued in this study. Of these, three patients were diagnosed with homozygous mutations in gene CLRN1, and had previous clinical diagnosis of type 2. Two patients had heterozygous mutations in gene MYO7A, both with previous clinical diagnosis of type 1.Estudo transversal, desenvolvido no Centro de Referência em Oftalmologia da UFG em conjunto com a Oregon Health and Science University e Centro Brasileiro de Cirurgia de Olhos (CBCO), que teve como objetivo avaliar o genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goias (CEROF-UFG). Pacientes clinicamente diagnosticados com SU foram submetidos a exame oftalmológico completo, perimetria cinética manual de Goldmann, audiometria e posterior coleta de sangue periférico para sequenciamento cromossômico por microarray. Foram examinados 19 pacientes com diagnostico clínico de SU com média de idade na primeira consulta de 42,5 anos (± 12,2) e pequena predominância do sexo masculino (52,63%). O subtipo mais prevalente no diagnóstico clínico foi do tipo I da doença (68,4%). A acuidade visual média medida no dia do exame por olho examinado foi de 20/92 na escala de Snellen. Os exames audiométricos mostraram perda de audição em todos pacientes variando de moderada em 12,5% dos pacientes, profunda (56,25%) e severa (31,25%). Em 36,8% dos pacientes analisados, encontraram-se ao menos duas mutações em um mesmo gene, sendo que destes, 21% eram mutações heterozigotas e, 15,8% homozigotas. As mutações homozigotas, as quais eram do tipo sem senso, ocorreram no gene CLRN1, cujos pacientes tinham o diagnóstico clínico prévio de USH 2. Encontrou-se 26,31% da amostra analisada em heterozigose. Desses, dois pacientes mostraram mutações para o gene MYO7A (40%), ambos com suspeita clínica de USH 1. Pela metodologia proposta, não foram encontradas mutações causadoras de doença em 79% da amostra analisada. Dos 19 pacientes incluídos no presente estudo os autores conseguiram determinar a mutação de sete deles segundo a metodologia proposta. Desses, três pacientes foram diagnosticados com mutações homozigoticas todas no gene CLRN1 e possuíam diagnostico clinico prévio de SU tipo 2. Dois pacientes apresentaram mutações heterozigóticas para o gene MYO7A, ambos com diagnostico clinico prévio de SU tipo 1 e um paciente apresentou mutação heterozigótica para o gene ALMS1 que apresentava diagnostico clinico de SU tipo 1Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2023-05-10T20:31:33Z No. of bitstreams: 3 Dissertação - Ricardo Campos Cruvinel Filho - 2014.pdf: 8522041 bytes, checksum: 659668f14255c2cc2bc672ca7e68b69d (MD5) Dissertação - Ricardo Campos Cruvinel Filho - 2014 - Teca Desembargo.pdf: 147697 bytes, checksum: 001015a3b708d5ed1ba4b77170883da8 (MD5) license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2023-05-11T12:05:19Z (GMT) No. of bitstreams: 3 Dissertação - Ricardo Campos Cruvinel Filho - 2014.pdf: 8522041 bytes, checksum: 659668f14255c2cc2bc672ca7e68b69d (MD5) Dissertação - Ricardo Campos Cruvinel Filho - 2014 - Teca Desembargo.pdf: 147697 bytes, checksum: 001015a3b708d5ed1ba4b77170883da8 (MD5) license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5)Made available in DSpace on 2023-05-11T12:05:19Z (GMT). No. of bitstreams: 3 Dissertação - Ricardo Campos Cruvinel Filho - 2014.pdf: 8522041 bytes, checksum: 659668f14255c2cc2bc672ca7e68b69d (MD5) Dissertação - Ricardo Campos Cruvinel Filho - 2014 - Teca Desembargo.pdf: 147697 bytes, checksum: 001015a3b708d5ed1ba4b77170883da8 (MD5) license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5) Previous issue date: 2014-12-16OutroporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências da Saúde (FM)UFGBrasilFaculdade de Medicina - FM (RMG)Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessRetinose pigmentar/diagnósticoRetinose pigmentar/genéticaPerda auditiva neurosensorial/genéticaSíndrome de Usher/diagnóstico molecularRetinitis pigmentosa/ diagnosisRetinitis pigmentosa/ geneticsSensorineural hearing loss / geneticsUsher / molecular diagnostic syndromeCIENCIAS DA SAUDEAvaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de GoiásEvaluation of patients with genotype Reference Center Ophthalmology, Federal University of Goiás Usher syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis25500500500500191825reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.bc.ufg.br/tede/bitstreams/c64eabd3-fe98-4d91-8149-4d5d54e13c91/download4460e5956bc1d1639be9ae6146a50347MD52ORIGINALDissertação - Ricardo Campos Cruvinel Filho - 2014.pdfDissertação - Ricardo Campos Cruvinel Filho - 2014.pdfapplication/pdf8522041http://repositorio.bc.ufg.br/tede/bitstreams/02f315c4-cf81-457a-b8e9-eb8fb198e87b/download659668f14255c2cc2bc672ca7e68b69dMD53Dissertação - Ricardo Campos Cruvinel Filho - 2014 - Teca Desembargo.pdfDissertação - Ricardo Campos Cruvinel Filho - 2014 - Teca Desembargo.pdfapplication/pdf147697http://repositorio.bc.ufg.br/tede/bitstreams/eb333fa2-89fe-43ac-9bcd-fd73d97b1a1b/download001015a3b708d5ed1ba4b77170883da8MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.bc.ufg.br/tede/bitstreams/6b21ea19-f865-47b8-9afd-45fa48e8c815/download8a4605be74aa9ea9d79846c1fba20a33MD51tede/128282023-05-11 09:05:19.626http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accessoai:repositorio.bc.ufg.br:tede/12828http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttp://repositorio.bc.ufg.br/oai/requesttasesdissertacoes.bc@ufg.bropendoar:2023-05-11T12:05:19Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)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
dc.title.pt_BR.fl_str_mv Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás
dc.title.alternative.eng.fl_str_mv Evaluation of patients with genotype Reference Center Ophthalmology, Federal University of Goiás Usher syndrome
title Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás
spellingShingle Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás
Cruvinel Filho, Ricardo Campos
Retinose pigmentar/diagnóstico
Retinose pigmentar/genética
Perda auditiva neurosensorial/genética
Síndrome de Usher/diagnóstico molecular
Retinitis pigmentosa/ diagnosis
Retinitis pigmentosa/ genetics
Sensorineural hearing loss / genetics
Usher / molecular diagnostic syndrome
CIENCIAS DA SAUDE
title_short Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás
title_full Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás
title_fullStr Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás
title_full_unstemmed Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás
title_sort Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás
author Cruvinel Filho, Ricardo Campos
author_facet Cruvinel Filho, Ricardo Campos
author_role author
dc.contributor.advisor1.fl_str_mv Ávila, Marcos Pereira de
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3335187297522447
dc.contributor.referee1.fl_str_mv Ávila, Marcos Pereira de
dc.contributor.referee2.fl_str_mv Rassi, Alan Ricardo
dc.contributor.referee3.fl_str_mv Lima, Francisco Eduardo Lopes de
dc.contributor.referee4.fl_str_mv Silva, Leopoldo Magacho dos Santos
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3835239829040839
dc.contributor.author.fl_str_mv Cruvinel Filho, Ricardo Campos
contributor_str_mv Ávila, Marcos Pereira de
Ávila, Marcos Pereira de
Rassi, Alan Ricardo
Lima, Francisco Eduardo Lopes de
Silva, Leopoldo Magacho dos Santos
dc.subject.por.fl_str_mv Retinose pigmentar/diagnóstico
Retinose pigmentar/genética
Perda auditiva neurosensorial/genética
Síndrome de Usher/diagnóstico molecular
topic Retinose pigmentar/diagnóstico
Retinose pigmentar/genética
Perda auditiva neurosensorial/genética
Síndrome de Usher/diagnóstico molecular
Retinitis pigmentosa/ diagnosis
Retinitis pigmentosa/ genetics
Sensorineural hearing loss / genetics
Usher / molecular diagnostic syndrome
CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv Retinitis pigmentosa/ diagnosis
Retinitis pigmentosa/ genetics
Sensorineural hearing loss / genetics
Usher / molecular diagnostic syndrome
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
description Cross-sectional study conducted at the Center of Reference in Ophthalmology UFG in conjunction with Oregon Health and Science University and the Brazilian Center for Eye Surgery (CBCO). To evaluate the genotype of patients with Usher syndrome of Reference Center for Ophthalmology, Federal University of Goias (UFG-CEROF). Patients clinically diagnosed with SU underwent complete ophthalmic examination, Goldmann manual kinetic perimetry, audiometry and subsequent collection of peripheral blood chromosomal microarray for sequencing. We examined 19 patients with clinical suspicion of SU with a mean age at first visit was 42.5 years (± 12.2) and a slight predominance of males (52.63%). The most prevalent subtype in clinical diagnosis of type I disease (68.4%). The visual acuity measured on the day of the exam for eye examination was 20/92 on the Snellen chart. Examinations audiometry showed hearing loss in all patients ranging from moderate in 12.5% of patients, deep (56.25%) and severe (31.25%). In 36.8% of patients analyzed, we found at least two mutations in the same gene, and of these, 21% were heterozygous mutations, and 15.8% homozygous. The homozygous mutations, which were of the type no sense, occurred in the gene CLRN1 whose patients had a previous diagnosis of USH 2. Met 26.31% of the sample analyzed in heterozygous. Of these, two patients showed mutations in the MYO7A gene (40%), both with clinical suspicion of USH 1. For the proposed methodology, we found no disease-causing mutations in 79% of the sample analyzed. Following the proposed methodology, the authors were able to determine the mutation in seven patients of nineteen patients inclued in this study. Of these, three patients were diagnosed with homozygous mutations in gene CLRN1, and had previous clinical diagnosis of type 2. Two patients had heterozygous mutations in gene MYO7A, both with previous clinical diagnosis of type 1.
publishDate 2014
dc.date.issued.fl_str_mv 2014-12-16
dc.date.accessioned.fl_str_mv 2023-05-11T12:05:19Z
dc.date.available.fl_str_mv 2023-05-11T12:05:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv CRUVINEL FILHO, R. C. Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás. 2014. 86 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2014.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/12828
dc.identifier.dark.fl_str_mv ark:/38995/0013000000fgb
identifier_str_mv CRUVINEL FILHO, R. C. Avaliação do genótipo de pacientes com síndrome de Usher do Centro de Referência em Oftalmologia da Universidade Federal de Goiás. 2014. 86 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2014.
ark:/38995/0013000000fgb
url http://repositorio.bc.ufg.br/tede/handle/tede/12828
dc.language.iso.fl_str_mv por
language por
dc.relation.program.fl_str_mv 25
dc.relation.confidence.fl_str_mv 500
500
500
500
dc.relation.department.fl_str_mv 19
dc.relation.cnpq.fl_str_mv 182
dc.relation.sponsorship.fl_str_mv 5
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Goiás
dc.publisher.program.fl_str_mv Programa de Pós-graduação em Ciências da Saúde (FM)
dc.publisher.initials.fl_str_mv UFG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Faculdade de Medicina - FM (RMG)
publisher.none.fl_str_mv Universidade Federal de Goiás
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFG
instname:Universidade Federal de Goiás (UFG)
instacron:UFG
instname_str Universidade Federal de Goiás (UFG)
instacron_str UFG
institution UFG
reponame_str Repositório Institucional da UFG
collection Repositório Institucional da UFG
bitstream.url.fl_str_mv http://repositorio.bc.ufg.br/tede/bitstreams/c64eabd3-fe98-4d91-8149-4d5d54e13c91/download
http://repositorio.bc.ufg.br/tede/bitstreams/02f315c4-cf81-457a-b8e9-eb8fb198e87b/download
http://repositorio.bc.ufg.br/tede/bitstreams/eb333fa2-89fe-43ac-9bcd-fd73d97b1a1b/download
http://repositorio.bc.ufg.br/tede/bitstreams/6b21ea19-f865-47b8-9afd-45fa48e8c815/download
bitstream.checksum.fl_str_mv 4460e5956bc1d1639be9ae6146a50347
659668f14255c2cc2bc672ca7e68b69d
001015a3b708d5ed1ba4b77170883da8
8a4605be74aa9ea9d79846c1fba20a33
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)
repository.mail.fl_str_mv tasesdissertacoes.bc@ufg.br
_version_ 1815172512983547904