Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/4152 |
Resumo: | OBJECTIVE: To describe tuberculosis treatment rates of cure, failure and default of a self administered regimen, with rifampin, isoniazid, pyrazinamide and ethambutol in the first two months of treatment followed by isoniazid and rifampcina in the four last months (2RHZE/4RH) in four-drug fixed-dose combination (FDC), implemented in Brazil since 2010 to replace a regimen of separately administered rifampicin, isoniazid and pyrazinamide in the first two months of treatment followed by isoniazid and rifampcina for four months (2RHZ/4RH). METHODS: Descriptive study using prospectively collected data from medical records of TB cases, older than18 years of age undergoing treatment with 2RHZE/4RH in two units of primary health care in the metropolitan area of Goiânia. RESULTS: The study included 40 cases of TB. The cure rate was 67.5% (27/40), the abandonment was 17.5% (7/40) and there were no cases of failure. There was reports of adverse reactions in 47% (19/40) of the cases. Of these, 87% were mild and 13% were moderate. There was no need for change or suspension of the scheme. CONCLUSIONS: The cure rate in FDC 4RHZE/2RH scheme under self-administered regimen was similar to historical rates of cure with 2RHZ/4RH. The default rate in the sample studied was much higher than the rate recommended as appropriate (up to 5%). |
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Rabahi, Marcelo Fouadhttp://lattes.cnpq.br/1489771770609266Kipnis, Ana Paula JunqueiraRabahi, Marcelo FouadGuilarde, Adriana OliveiraSilva, Nilzio Antoniohttp://lattes.cnpq.br/3405154905605616Ferreira, Anna Carolina Galvão2015-02-13T20:16:17Z2012-05-28FERREIRA, A. C. G. Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada. 2012. 72 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2012.http://repositorio.bc.ufg.br/tede/handle/tede/4152ark:/38995/0013000008mrnOBJECTIVE: To describe tuberculosis treatment rates of cure, failure and default of a self administered regimen, with rifampin, isoniazid, pyrazinamide and ethambutol in the first two months of treatment followed by isoniazid and rifampcina in the four last months (2RHZE/4RH) in four-drug fixed-dose combination (FDC), implemented in Brazil since 2010 to replace a regimen of separately administered rifampicin, isoniazid and pyrazinamide in the first two months of treatment followed by isoniazid and rifampcina for four months (2RHZ/4RH). METHODS: Descriptive study using prospectively collected data from medical records of TB cases, older than18 years of age undergoing treatment with 2RHZE/4RH in two units of primary health care in the metropolitan area of Goiânia. RESULTS: The study included 40 cases of TB. The cure rate was 67.5% (27/40), the abandonment was 17.5% (7/40) and there were no cases of failure. There was reports of adverse reactions in 47% (19/40) of the cases. Of these, 87% were mild and 13% were moderate. There was no need for change or suspension of the scheme. CONCLUSIONS: The cure rate in FDC 4RHZE/2RH scheme under self-administered regimen was similar to historical rates of cure with 2RHZ/4RH. The default rate in the sample studied was much higher than the rate recommended as appropriate (up to 5%).INTRODUÇÃO: O esquema de tratamento da TB tem alta eficácia em torno de 95% e com possibilidade de cura de aproximadamente 100% dos casos e reduz rapidamente a transmissão, e assim pode-se reduzir a incidência da doença. Embora a distribuição da medicação seja gratuita em todo país pelo Sistema Único de Saúde, a efetividade do tratamento da TB varia muito nos diferentes locais. JUSTIFICAVA: Conhecer as taxas de sucesso de tratamento ,falência e abandono além de verificar a segurança do tratamento da TB com 4 medicamentos em apresentação dose fixa combinada. OBJETIVO: Descrever as taxas de cura, falência e abandono do tratamento da tuberculose com o esquema básico com rifampicina, isoniazida, pirazinamida e etambutol nos dois primeiros meses de tratamento seguidos de isoniazida e rifampcina por quatro meses (2RHZE/4RH), sob forma de comprimidos em dose fixa combinada (DFC), em regime auto administrado implementado no Brasil desde 2010, em substituição ao esquema utilizando cápsulas e comprimidos com rifampicina, isoniazida e pirazinamida nos dois primeiros meses de tratamento, seguidos de isoniazida e rifampcina por quatro meses (2RHZ/4RH). MÉTODOS: Estudo descritivo utilizando dados secundários coletados prospectivamente de prontuários de casos de TB, maiores de 18anos, submetidos ao tratamento com esquema básico para tuberculose, em duas Unidades Básicas de Saúde da região metropolitana de Goiânia. RESULTADOS: Foram incluídos no estudo 40 casos de TB. A taxa de cura foi de 67,5% (27/40), a de abandono de 17,5% (7/40) e a não ocorreram casos de falência. Houve relato de reações adversas em 47% (19/40) num total de 31 ocorrências. Dessas, 87% foram leves e 13% moderadas. Em nenhum caso houve necessidade de mudança ou suspensão do esquema. CONCLUSÕES: A taxa de cura do esquema 4RHZE/2RH em DFC sob regime autoadministrado foi semelhante às taxas históricas do tratamento com 2RHZ/4RH. A taxa de abandono na amostra estudada foi superior a taxa preconizada como adequada (até 5%).Submitted by Erika Demachki (erikademachki@gmail.com) on 2015-02-13T20:15:11Z No. of bitstreams: 2 Dissertação - Anna Carolina Galvão Ferreira - 2012.pdf: 1738587 bytes, checksum: b4a75ebc8af8f8a234573009292ed508 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2015-02-13T20:16:17Z (GMT) No. of bitstreams: 2 Dissertação - Anna Carolina Galvão Ferreira - 2012.pdf: 1738587 bytes, checksum: b4a75ebc8af8f8a234573009292ed508 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-02-13T20:16:17Z (GMT). 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dc.title.eng.fl_str_mv |
Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada |
dc.title.alternative.eng.fl_str_mv |
Clinical outcomes of tuberculosis treatment using fourdrug fixed-dose combination regimen |
title |
Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada |
spellingShingle |
Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada Ferreira, Anna Carolina Galvão Tuberculose Resultado de tratamento Combinação de medicamentos Tuberculosis Treatment outcome Drug combinations CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS |
title_short |
Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada |
title_full |
Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada |
title_fullStr |
Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada |
title_full_unstemmed |
Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada |
title_sort |
Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada |
author |
Ferreira, Anna Carolina Galvão |
author_facet |
Ferreira, Anna Carolina Galvão |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Rabahi, Marcelo Fouad |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1489771770609266 |
dc.contributor.advisor-co1.fl_str_mv |
Kipnis, Ana Paula Junqueira |
dc.contributor.referee1.fl_str_mv |
Rabahi, Marcelo Fouad |
dc.contributor.referee2.fl_str_mv |
Guilarde, Adriana Oliveira |
dc.contributor.referee3.fl_str_mv |
Silva, Nilzio Antonio |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3405154905605616 |
dc.contributor.author.fl_str_mv |
Ferreira, Anna Carolina Galvão |
contributor_str_mv |
Rabahi, Marcelo Fouad Kipnis, Ana Paula Junqueira Rabahi, Marcelo Fouad Guilarde, Adriana Oliveira Silva, Nilzio Antonio |
dc.subject.por.fl_str_mv |
Tuberculose Resultado de tratamento Combinação de medicamentos |
topic |
Tuberculose Resultado de tratamento Combinação de medicamentos Tuberculosis Treatment outcome Drug combinations CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS |
dc.subject.eng.fl_str_mv |
Tuberculosis Treatment outcome Drug combinations |
dc.subject.cnpq.fl_str_mv |
CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS |
description |
OBJECTIVE: To describe tuberculosis treatment rates of cure, failure and default of a self administered regimen, with rifampin, isoniazid, pyrazinamide and ethambutol in the first two months of treatment followed by isoniazid and rifampcina in the four last months (2RHZE/4RH) in four-drug fixed-dose combination (FDC), implemented in Brazil since 2010 to replace a regimen of separately administered rifampicin, isoniazid and pyrazinamide in the first two months of treatment followed by isoniazid and rifampcina for four months (2RHZ/4RH). METHODS: Descriptive study using prospectively collected data from medical records of TB cases, older than18 years of age undergoing treatment with 2RHZE/4RH in two units of primary health care in the metropolitan area of Goiânia. RESULTS: The study included 40 cases of TB. The cure rate was 67.5% (27/40), the abandonment was 17.5% (7/40) and there were no cases of failure. There was reports of adverse reactions in 47% (19/40) of the cases. Of these, 87% were mild and 13% were moderate. There was no need for change or suspension of the scheme. CONCLUSIONS: The cure rate in FDC 4RHZE/2RH scheme under self-administered regimen was similar to historical rates of cure with 2RHZ/4RH. The default rate in the sample studied was much higher than the rate recommended as appropriate (up to 5%). |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-05-28 |
dc.date.accessioned.fl_str_mv |
2015-02-13T20:16:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERREIRA, A. C. G. Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada. 2012. 72 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/4152 |
dc.identifier.dark.fl_str_mv |
ark:/38995/0013000008mrn |
identifier_str_mv |
FERREIRA, A. C. G. Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada. 2012. 72 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2012. ark:/38995/0013000008mrn |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/4152 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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6085308344741430434 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
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-7769011444564556288 |
dc.relation.cnpq.fl_str_mv |
1767748423488408711 |
dc.relation.sponsorship.fl_str_mv |
-961409807440757778 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
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dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
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Universidade Federal de Goiás (UFG) |
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UFG |
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UFG |
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Repositório Institucional da UFG |
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bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f b292a83e42bd8ad62533bba1395b83ff 9da0b6dfac957114c6a7714714b86306 b4a75ebc8af8f8a234573009292ed508 3823045ef0aebdc1fff071dc3390b4dd df4226004860f7ceff597c3c3b8ad308 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1811721452857065472 |