Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/4159 |
Resumo: | HLA-G is a molecule of the major histocompatibility complex (MHC) class I nonclassical that plays an inhibitory effect on immunocompetent cells that are fundamental in the development of an antitumoral response. In this context, the aim of this study was to evaluate the expression of HLA-G in the microenvironment of oral cavity squamous cell carcinoma (OCSCC) as well as their relationship with clinical and microscopic parameters. In addition, we aimed also to compare the salivary concentration of soluble HLA-G (sHLA-G) in patients with OCSCC with healthy individuals (control group). The techniques of immunohistochemistry and Enzyme- Linked Immunosorbent Assay (ELISA) were used. The results revealed, with the immunohistochemistry technique, that expression of HLA-G by tumor cells was significantly higher in metastatic OCSCC (n=30) (72% of samples) when compared with non-metastatic OCSCC (n=30) (28% of samples) (P=0.01 ). Moreover, patients with a lower expression of HLA-G presented a tendency to survival longer (22 months) when compared with those with a higher expression of the molecule (16 months). With reference to other clinicopathological parameters analyzed, only the presence of lymph node metastasis (P=0.01) and depth of tumor invasion (P=0.02) were significantly associated with the expression of HLA-G. By ELISA technique, we showed that the salivary concentration of soluble HLA-G provided no differentiation between patients with OCSCC from healthy individuals, since there was no statistically significant difference between the analyzed groups (P=0.17). The findings of this study revealed that high expression of HLA-G in the microenvironment of metastatic OCSCC may represent a tumor escape mechanism which contributes to lower survival and an unfavorable clinical prognosis. However, concentration of soluble HLA-G in saliva of patients with OCSCC is similar to healthy individuals; thereby sHLA-G does not represent a salivary biomarker prognostic. |
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Batista, Aline Carvalhohttp://lattes.cnpq.br/0199082642322002Wastowski, Isabela JubéBatista, Aline CarvalhoBernardes, Vanessa de FátimaDias, Fátima RibeiroWastowski, Isabela Jubéhttp://lattes.cnpq.br/4263904060187501Gonçalves, Andréia de Souza2015-02-19T12:08:09Z2014-01-31GONÇALVES, A. S. Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral. 2014. 105 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Goiás, Goiânia, 2014.http://repositorio.bc.ufg.br/tede/handle/tede/4159HLA-G is a molecule of the major histocompatibility complex (MHC) class I nonclassical that plays an inhibitory effect on immunocompetent cells that are fundamental in the development of an antitumoral response. In this context, the aim of this study was to evaluate the expression of HLA-G in the microenvironment of oral cavity squamous cell carcinoma (OCSCC) as well as their relationship with clinical and microscopic parameters. In addition, we aimed also to compare the salivary concentration of soluble HLA-G (sHLA-G) in patients with OCSCC with healthy individuals (control group). The techniques of immunohistochemistry and Enzyme- Linked Immunosorbent Assay (ELISA) were used. The results revealed, with the immunohistochemistry technique, that expression of HLA-G by tumor cells was significantly higher in metastatic OCSCC (n=30) (72% of samples) when compared with non-metastatic OCSCC (n=30) (28% of samples) (P=0.01 ). Moreover, patients with a lower expression of HLA-G presented a tendency to survival longer (22 months) when compared with those with a higher expression of the molecule (16 months). With reference to other clinicopathological parameters analyzed, only the presence of lymph node metastasis (P=0.01) and depth of tumor invasion (P=0.02) were significantly associated with the expression of HLA-G. By ELISA technique, we showed that the salivary concentration of soluble HLA-G provided no differentiation between patients with OCSCC from healthy individuals, since there was no statistically significant difference between the analyzed groups (P=0.17). The findings of this study revealed that high expression of HLA-G in the microenvironment of metastatic OCSCC may represent a tumor escape mechanism which contributes to lower survival and an unfavorable clinical prognosis. However, concentration of soluble HLA-G in saliva of patients with OCSCC is similar to healthy individuals; thereby sHLA-G does not represent a salivary biomarker prognostic.O HLA-G é uma molécula do Complexo Principal de Histocompatibilidade (MHC) de classe I não-clássica que exerce efeito inibidor em células imunocompetentes que são fundamentais no desenvolvimento de uma resposta antitumoral. Nesse contexto, o objetivo deste estudo foi avaliar a expressão do HLA-G no microambiente do carcinoma espinocelular (CEC) de cavidade oral, bem como a relação dessa molécula com parâmetros clínicos e microscópicos de prognóstico. Além disso, objetivou-se comparar a concentração salivar de HLA-G solúvel (HLA-Gs) nos pacientes com CEC de cavidade oral com indivíduos saudáveis (grupo controle). Técnicas de imunoistoquímica e ensaio imunoenzimático (ELISA) foram utilizadas. Os resultados revelaram, com a técnica de imunoistoquímica, que a expressão de HLA-G pelas células neoplásicas foi significativamente maior nos casos de CEC de cavidade oral metastático (n=30) (72% das amostras) quando comparado ao CEC não-metastático (n=30) (28% das amostras) (P=0,01). Em adição, pacientes com uma menor expressão de HLA-G apresentaram uma tendência para um maior período de sobrevida (22 meses) em comparação aqueles com uma maior expressão da molécula (16 meses). Com referência aos outros parâmetros clínicopatológicos analisados, evidenciou-se que somente a presença de metástase linfonodal (P=0,01) e profundidade de invasão do tumor (P=0,02) foram significativamente associadas com a expressão de HLA-G. Por meio da técnica de ELISA, foi detectado que a concentração salivar de HLA-G solúvel não possibilitou distinguir pacientes com CEC de cavidade oral dos indivíduos saudáveis, uma vez que não houve diferença estatisticamente significativa entre os grupos analisados (P=0,17). Os achados do presente estudo revelaram que a alta expressão de HLA-G no microambiente do CEC com metástase linfonodal pode representar um mecanismo de escape tumoral que contribui para um menor tempo de sobrevida e, consequentemente, pior prognóstico clínico dos pacientes. Entretanto, a quantidade da HLA-Gs na saliva dos pacientes com CEC é semelhante àquela de indivíduos saudáveis, assim a HLA-Gs não representa um marcador salivar de prognóstico.Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2015-02-06T10:04:11Z No. of bitstreams: 2 Dissertação - Andréia de Souza Gonçalves - 2014.pdf: 1517359 bytes, checksum: 5b0389aea64b9b32f1ae83e69d872ece (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-02-19T12:08:08Z (GMT) No. of bitstreams: 2 Dissertação - Andréia de Souza Gonçalves - 2014.pdf: 1517359 bytes, checksum: 5b0389aea64b9b32f1ae83e69d872ece (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-02-19T12:08:09Z (GMT). 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dc.title.eng.fl_str_mv |
Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral |
dc.title.alternative.eng.fl_str_mv |
Evaluation of expression of molecule HLA-G in the microenvironment tumor and saliva of patients with oral squamous cell carcinoma |
title |
Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral |
spellingShingle |
Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral Gonçalves, Andréia de Souza Neoplasia bucal Antígenos HLA Metástase Saliva Evasão tumoral Oral cancer HLA antigens Metastasis Saliva Tumor escape ODONTOLOGIA::CLINICA ODONTOLOGICA |
title_short |
Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral |
title_full |
Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral |
title_fullStr |
Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral |
title_full_unstemmed |
Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral |
title_sort |
Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral |
author |
Gonçalves, Andréia de Souza |
author_facet |
Gonçalves, Andréia de Souza |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Batista, Aline Carvalho |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0199082642322002 |
dc.contributor.advisor-co1.fl_str_mv |
Wastowski, Isabela Jubé |
dc.contributor.referee1.fl_str_mv |
Batista, Aline Carvalho |
dc.contributor.referee2.fl_str_mv |
Bernardes, Vanessa de Fátima |
dc.contributor.referee3.fl_str_mv |
Dias, Fátima Ribeiro |
dc.contributor.referee4.fl_str_mv |
Wastowski, Isabela Jubé |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4263904060187501 |
dc.contributor.author.fl_str_mv |
Gonçalves, Andréia de Souza |
contributor_str_mv |
Batista, Aline Carvalho Wastowski, Isabela Jubé Batista, Aline Carvalho Bernardes, Vanessa de Fátima Dias, Fátima Ribeiro Wastowski, Isabela Jubé |
dc.subject.por.fl_str_mv |
Neoplasia bucal Antígenos HLA Metástase Saliva Evasão tumoral |
topic |
Neoplasia bucal Antígenos HLA Metástase Saliva Evasão tumoral Oral cancer HLA antigens Metastasis Saliva Tumor escape ODONTOLOGIA::CLINICA ODONTOLOGICA |
dc.subject.eng.fl_str_mv |
Oral cancer HLA antigens Metastasis Saliva Tumor escape |
dc.subject.cnpq.fl_str_mv |
ODONTOLOGIA::CLINICA ODONTOLOGICA |
description |
HLA-G is a molecule of the major histocompatibility complex (MHC) class I nonclassical that plays an inhibitory effect on immunocompetent cells that are fundamental in the development of an antitumoral response. In this context, the aim of this study was to evaluate the expression of HLA-G in the microenvironment of oral cavity squamous cell carcinoma (OCSCC) as well as their relationship with clinical and microscopic parameters. In addition, we aimed also to compare the salivary concentration of soluble HLA-G (sHLA-G) in patients with OCSCC with healthy individuals (control group). The techniques of immunohistochemistry and Enzyme- Linked Immunosorbent Assay (ELISA) were used. The results revealed, with the immunohistochemistry technique, that expression of HLA-G by tumor cells was significantly higher in metastatic OCSCC (n=30) (72% of samples) when compared with non-metastatic OCSCC (n=30) (28% of samples) (P=0.01 ). Moreover, patients with a lower expression of HLA-G presented a tendency to survival longer (22 months) when compared with those with a higher expression of the molecule (16 months). With reference to other clinicopathological parameters analyzed, only the presence of lymph node metastasis (P=0.01) and depth of tumor invasion (P=0.02) were significantly associated with the expression of HLA-G. By ELISA technique, we showed that the salivary concentration of soluble HLA-G provided no differentiation between patients with OCSCC from healthy individuals, since there was no statistically significant difference between the analyzed groups (P=0.17). The findings of this study revealed that high expression of HLA-G in the microenvironment of metastatic OCSCC may represent a tumor escape mechanism which contributes to lower survival and an unfavorable clinical prognosis. However, concentration of soluble HLA-G in saliva of patients with OCSCC is similar to healthy individuals; thereby sHLA-G does not represent a salivary biomarker prognostic. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-01-31 |
dc.date.accessioned.fl_str_mv |
2015-02-19T12:08:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GONÇALVES, A. S. Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral. 2014. 105 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Goiás, Goiânia, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/4159 |
identifier_str_mv |
GONÇALVES, A. S. Avaliação da expressão da molécula HLA-G no microambiente tumoral e na saliva de pacientes com carcinoma espinocelular de cavidade oral. 2014. 105 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Goiás, Goiânia, 2014. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/4159 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-2325576619034292269 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-5569154581575113691 |
dc.relation.cnpq.fl_str_mv |
-1816740449898491657 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Odontologia (FO) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Faculdade de Odontologia - FO (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/af66a87a-b71c-43b3-bc02-1aa583a71e7c/download http://repositorio.bc.ufg.br/tede/bitstreams/00480038-faa6-4b88-b2fd-09369bf99327/download http://repositorio.bc.ufg.br/tede/bitstreams/ca62481f-2ae0-42c1-93ca-0ab42d9c1449/download http://repositorio.bc.ufg.br/tede/bitstreams/8f0c3204-0f2c-4a3e-a9be-d9ea72c0f18f/download http://repositorio.bc.ufg.br/tede/bitstreams/a03495b2-8f3f-4a8f-9c72-e45d4863aec2/download http://repositorio.bc.ufg.br/tede/bitstreams/13293938-4363-4701-934c-dda16f8a9b86/download http://repositorio.bc.ufg.br/tede/bitstreams/5628e559-5e89-4804-8d9b-e2c22aeb999b/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f 29b9d5e95be03707f9d4a2e110421c11 9da0b6dfac957114c6a7714714b86306 5b0389aea64b9b32f1ae83e69d872ece 1a5b2fd9e2aead237c5553a779d54eb4 cc73c4c239a4c332d642ba1e7c7a9fb2 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044349630513152 |