Lesão tecidual e perfil de citocinas na neurocisticercose experimental
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/5282 |
Resumo: | The cysticercosis is endemic and is considered neglected by the World Health Organization. The neurocysticercosis (NCC) is the most common and severe form of cysticercosis, accounting for over 50,000 deaths annually. The use of experimental models in research, has been essential to the advancement of knowledge of various diseases, such as in understanding the pathophysiology, immune response and parasite host reactions. This study aimed to characterize the cellular immune response in situ and systemic, and the role of inflammatory cells in triggering changes in myelin standards. For this, we used an experimental model to evaluate the NCC intraventricular concentrations of cytokine in situ and systemically, by spleen cell culture, and changes in parenchymal patterns and periventricular desmielinizarão throughout the experimental period. No changes were detected in cytokine concentration at the infection site. Systemically, it is observed the presence of IL-10 initially and after 30 days of infection, there is a significant presence of all the cytokines analyzed as IL-4, IL-10, IL-17 and IFN-γ in the infected group. At the end of the infection, the Th2 profile was predominant. In evaluating pathological observed breaking the blood-brain barrier (BBB) allowing the initial influx of inflammatory cells in the two groups. At 30 days, there was a mixed inflammatory process, ventriculomegaly, foamy macrophages and periventricular desmielinizarão. At the end of the infection, predominance of mononuclear cells, ventriculomegaly, foamy macrophages and demyelination in the parenchyma mostly. In conclusion, the systemic immune response of BALB / c mice induced by cysticercus T. crassiceps, was characterized by a Th2-type immune profile and desmielinizarão parenchymal infection possibly at the end of the inflammatory process as well as the compressive effect on the parenchyma of the parasite brain. |
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Lino Júnior, Ruy de Souzahttp://lattes.cnpq.br/0372118837748010Vinaud, Marina Clarehttp://lattes.cnpq.br/1921551651088660Loyola, Patricia Resende Alo Nagibhttp://lattes.cnpq.br/7172668220681444Lino Júnior, Ruy de SouzaSilva, Juliana Reis Machado eFaleiros, Ana Carolina GiomarãesPansani, Aline PriscilaAraújo Filho, João Alves dehttp://lattes.cnpq.br/9984425507466238Moura, Vânia Beatriz Lopes2016-03-03T13:44:17Z2015-11-09MOURA, V. B. L. Lesão tecidual e perfil de citocinas na neurocisticercose experimental. 2015. 85 f. Tese (Doutorado em Medicina Tropical e Saúde Pública) - Universidade Federal de Goiás, Goiânia, 2015.http://repositorio.bc.ufg.br/tede/handle/tede/5282The cysticercosis is endemic and is considered neglected by the World Health Organization. The neurocysticercosis (NCC) is the most common and severe form of cysticercosis, accounting for over 50,000 deaths annually. The use of experimental models in research, has been essential to the advancement of knowledge of various diseases, such as in understanding the pathophysiology, immune response and parasite host reactions. This study aimed to characterize the cellular immune response in situ and systemic, and the role of inflammatory cells in triggering changes in myelin standards. For this, we used an experimental model to evaluate the NCC intraventricular concentrations of cytokine in situ and systemically, by spleen cell culture, and changes in parenchymal patterns and periventricular desmielinizarão throughout the experimental period. No changes were detected in cytokine concentration at the infection site. Systemically, it is observed the presence of IL-10 initially and after 30 days of infection, there is a significant presence of all the cytokines analyzed as IL-4, IL-10, IL-17 and IFN-γ in the infected group. At the end of the infection, the Th2 profile was predominant. In evaluating pathological observed breaking the blood-brain barrier (BBB) allowing the initial influx of inflammatory cells in the two groups. At 30 days, there was a mixed inflammatory process, ventriculomegaly, foamy macrophages and periventricular desmielinizarão. At the end of the infection, predominance of mononuclear cells, ventriculomegaly, foamy macrophages and demyelination in the parenchyma mostly. In conclusion, the systemic immune response of BALB / c mice induced by cysticercus T. crassiceps, was characterized by a Th2-type immune profile and desmielinizarão parenchymal infection possibly at the end of the inflammatory process as well as the compressive effect on the parenchyma of the parasite brain.A cisticercose é uma doença endêmica e é considerada negligenciada pela Organização Mundial de Saúde. A neurocisticercose (NCC) é a forma mais frequente e grave da cisticercose, sendo responsável por mais de 50 mil mortes anuais. A utilização de modelos experimentais em pesquisa tem sido essencial para o avanço do conhecimento de diversas doenças, como no entendimento da fisiopatologia, da resposta imune e das relações parasito hospedeiro. O presente estudo objetivou a caracterização da resposta imune celular in situ e sistêmica, e o papel das células inflamatórias em desencadear alterações nos padrões de mielina. Para isto, utilizou-se um modelo experimental de NCC intraventricular para avaliar as concentrações de citocinas in situ e sistemicamente, pela cultura de células do baço, e as alterações nos padrões de desmielinizarão periventricular e parenquimal ao longo do período experimental. Não foram detectadas alterações nas concentrações de citocinas no local da infecção. Sistemicamente, observa-se a presença de IL-10 inicialmente e aos 30 dias de infecção, observa-se a presença significante de todas as citocinas analisadas como, IL-4, IL-10, IL-17 e IFN-γ no grupo infectado. No final da infecção, o perfil Th2, foi predominante. Na avaliação anatomopatológica observou quebra da barreira hemato encefálica (BHE), que permitiu o influxo inicial de células inflamatórias nos dois grupos analisados. Aos 30 dias, observou-se processo inflamatório misto, ventriculomegalia, macrófagos espumosos e desmielinizarão periventricular. No final da infecção, predomínio de células mononucleares, ventriculomegalia, macrófagos espumosos e desmielinização no parênquima em sua maioria. Em conclusão, a resposta imune sistêmica dos camundongos BALB/c induzida por cisticercos de T. crassiceps, foi caracterizada por um perfil imune do tipo Th2e desmielinizarão parenquimal no final da infecção possivelmente pelo processo inflamatório como também pelo efeito compressivo do parasito sobre o parênquima encefálico.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-03-03T13:38:21Z No. of bitstreams: 2 Tese - Vânia Beatriz Lopes - 2015.pdf: 1571381 bytes, checksum: 95d706025dea6373e88193f8224608f3 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-03-03T13:44:17Z (GMT) No. of bitstreams: 2 Tese - Vânia Beatriz Lopes - 2015.pdf: 1571381 bytes, checksum: 95d706025dea6373e88193f8224608f3 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2016-03-03T13:44:17Z (GMT). No. of bitstreams: 2 Tese - Vânia Beatriz Lopes - 2015.pdf: 1571381 bytes, checksum: 95d706025dea6373e88193f8224608f3 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2015-11-09Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPqapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessNeurocisticercose experimentalResposta imuneCitocinasLesão tecidualDesmielinizarão periventricularDesmielinizarão parenquimalTaenia crassicepsExperimental neurocysticercosis tissue injuryImmune responseDemyelination periventricularParenchymal demyelinationTaenia crassicepsCIENCIAS DA SAUDELesão tecidual e perfil de citocinas na neurocisticercose experimentalTissue injury and cytokine profile in the experimental neurocysticercosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis6085308344741430434600600600600-77690114445645562888765449414823306929-2555911436985713659reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Lesão tecidual e perfil de citocinas na neurocisticercose experimental |
dc.title.alternative.eng.fl_str_mv |
Tissue injury and cytokine profile in the experimental neurocysticercosis |
title |
Lesão tecidual e perfil de citocinas na neurocisticercose experimental |
spellingShingle |
Lesão tecidual e perfil de citocinas na neurocisticercose experimental Moura, Vânia Beatriz Lopes Neurocisticercose experimental Resposta imune Citocinas Lesão tecidual Desmielinizarão periventricular Desmielinizarão parenquimal Taenia crassiceps Experimental neurocysticercosis tissue injury Immune response Demyelination periventricular Parenchymal demyelination Taenia crassiceps CIENCIAS DA SAUDE |
title_short |
Lesão tecidual e perfil de citocinas na neurocisticercose experimental |
title_full |
Lesão tecidual e perfil de citocinas na neurocisticercose experimental |
title_fullStr |
Lesão tecidual e perfil de citocinas na neurocisticercose experimental |
title_full_unstemmed |
Lesão tecidual e perfil de citocinas na neurocisticercose experimental |
title_sort |
Lesão tecidual e perfil de citocinas na neurocisticercose experimental |
author |
Moura, Vânia Beatriz Lopes |
author_facet |
Moura, Vânia Beatriz Lopes |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Lino Júnior, Ruy de Souza |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0372118837748010 |
dc.contributor.advisor-co1.fl_str_mv |
Vinaud, Marina Clare |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/1921551651088660 |
dc.contributor.advisor-co2.fl_str_mv |
Loyola, Patricia Resende Alo Nagib |
dc.contributor.advisor-co2Lattes.fl_str_mv |
http://lattes.cnpq.br/7172668220681444 |
dc.contributor.referee1.fl_str_mv |
Lino Júnior, Ruy de Souza |
dc.contributor.referee2.fl_str_mv |
Silva, Juliana Reis Machado e |
dc.contributor.referee3.fl_str_mv |
Faleiros, Ana Carolina Giomarães |
dc.contributor.referee4.fl_str_mv |
Pansani, Aline Priscila |
dc.contributor.referee5.fl_str_mv |
Araújo Filho, João Alves de |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9984425507466238 |
dc.contributor.author.fl_str_mv |
Moura, Vânia Beatriz Lopes |
contributor_str_mv |
Lino Júnior, Ruy de Souza Vinaud, Marina Clare Loyola, Patricia Resende Alo Nagib Lino Júnior, Ruy de Souza Silva, Juliana Reis Machado e Faleiros, Ana Carolina Giomarães Pansani, Aline Priscila Araújo Filho, João Alves de |
dc.subject.por.fl_str_mv |
Neurocisticercose experimental Resposta imune Citocinas Lesão tecidual Desmielinizarão periventricular Desmielinizarão parenquimal Taenia crassiceps |
topic |
Neurocisticercose experimental Resposta imune Citocinas Lesão tecidual Desmielinizarão periventricular Desmielinizarão parenquimal Taenia crassiceps Experimental neurocysticercosis tissue injury Immune response Demyelination periventricular Parenchymal demyelination Taenia crassiceps CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Experimental neurocysticercosis tissue injury Immune response Demyelination periventricular Parenchymal demyelination Taenia crassiceps |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
The cysticercosis is endemic and is considered neglected by the World Health Organization. The neurocysticercosis (NCC) is the most common and severe form of cysticercosis, accounting for over 50,000 deaths annually. The use of experimental models in research, has been essential to the advancement of knowledge of various diseases, such as in understanding the pathophysiology, immune response and parasite host reactions. This study aimed to characterize the cellular immune response in situ and systemic, and the role of inflammatory cells in triggering changes in myelin standards. For this, we used an experimental model to evaluate the NCC intraventricular concentrations of cytokine in situ and systemically, by spleen cell culture, and changes in parenchymal patterns and periventricular desmielinizarão throughout the experimental period. No changes were detected in cytokine concentration at the infection site. Systemically, it is observed the presence of IL-10 initially and after 30 days of infection, there is a significant presence of all the cytokines analyzed as IL-4, IL-10, IL-17 and IFN-γ in the infected group. At the end of the infection, the Th2 profile was predominant. In evaluating pathological observed breaking the blood-brain barrier (BBB) allowing the initial influx of inflammatory cells in the two groups. At 30 days, there was a mixed inflammatory process, ventriculomegaly, foamy macrophages and periventricular desmielinizarão. At the end of the infection, predominance of mononuclear cells, ventriculomegaly, foamy macrophages and demyelination in the parenchyma mostly. In conclusion, the systemic immune response of BALB / c mice induced by cysticercus T. crassiceps, was characterized by a Th2-type immune profile and desmielinizarão parenchymal infection possibly at the end of the inflammatory process as well as the compressive effect on the parenchyma of the parasite brain. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-11-09 |
dc.date.accessioned.fl_str_mv |
2016-03-03T13:44:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MOURA, V. B. L. Lesão tecidual e perfil de citocinas na neurocisticercose experimental. 2015. 85 f. Tese (Doutorado em Medicina Tropical e Saúde Pública) - Universidade Federal de Goiás, Goiânia, 2015. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/5282 |
identifier_str_mv |
MOURA, V. B. L. Lesão tecidual e perfil de citocinas na neurocisticercose experimental. 2015. 85 f. Tese (Doutorado em Medicina Tropical e Saúde Pública) - Universidade Federal de Goiás, Goiânia, 2015. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/5282 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6085308344741430434 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-7769011444564556288 |
dc.relation.cnpq.fl_str_mv |
8765449414823306929 |
dc.relation.sponsorship.fl_str_mv |
-2555911436985713659 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
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application/pdf |
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Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
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UFG |
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bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f ef48816a10f2d45f2e2fee2f478e2faf 9da0b6dfac957114c6a7714714b86306 95d706025dea6373e88193f8224608f3 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
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1798044418119303168 |