Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/5726 |
Resumo: | Normal prostate development is highly dependent of an equilibrated hormonal regulation, so that sensible interferences during this period may predispose the gland to lesions during ageing. Industrial activities have increased the exposure of this gland to active elements found in environment. Within these elements, we find aluminum, the first metal being and the third chemical element more abundant in earth crust. Independently from the complex form in which it can be found, it presents toxic effect for living beings having the potential to disrupt the development and growth of several organs and systems, when ingested in high doses. However, little scientific evidence shows the effects of exposure in the reproductive system. Therefore, the aim of this study was to evaluate whether the intrauterine exposure to aluminum chloride (AlCl3) may alter the male and female ventral prostate of neonatal and adult gerbil. Two groups where formed: control and AlCl3. The pregnant females received daily doses of AlCl3 (100 mg/Kg/day) or from the dilution vehicle, from 17th to 24th gestational day. Following the birth, males and females were separated and euthanized with 1 (PN1) and 90-days-old (PN90). The ventral prostates of male and females of the experimental groups were removed and collected, and later, structural, cytochemical and immunohistochemical analysis were conducted. Furthermore, the branching pattern of the prostate in one day-old animals was described by three dimensional reconstruction. Here, we demonstrate that the Al decreases the body weight of PN1 males and females, and also reduce the anogenital distance (AGD) of PN1 females. Moreover, Al changed the prostate developmental patterns of PN1 animals, causing an increase in proliferative status and decreasing androgen receptor (AR) immunomarking. These data suggests that the aluminum-promoted changes were permanent, since these differences in AR immunomarking were also observed either in adult females or males. Therefore, we reveal that the Al acts as an endocrine-disrupting chemical, changing the antiandrogenic activity of prostate epithelial and stromal cells. |
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Santos, Fernanda Cristina Alcântara doshttp://lattes.cnpq.br/3025583084190459Ghedini, Paulo Césarhttp://lattes.cnpq.br/5789550234984454http://lattes.cnpq.br/6170269977013851Gomes, Liana da Silva2016-07-14T13:35:50Z2016-03-29GOMES, L. S. Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos. 2016. 77 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2016.http://repositorio.bc.ufg.br/tede/handle/tede/5726Normal prostate development is highly dependent of an equilibrated hormonal regulation, so that sensible interferences during this period may predispose the gland to lesions during ageing. Industrial activities have increased the exposure of this gland to active elements found in environment. Within these elements, we find aluminum, the first metal being and the third chemical element more abundant in earth crust. Independently from the complex form in which it can be found, it presents toxic effect for living beings having the potential to disrupt the development and growth of several organs and systems, when ingested in high doses. However, little scientific evidence shows the effects of exposure in the reproductive system. Therefore, the aim of this study was to evaluate whether the intrauterine exposure to aluminum chloride (AlCl3) may alter the male and female ventral prostate of neonatal and adult gerbil. Two groups where formed: control and AlCl3. The pregnant females received daily doses of AlCl3 (100 mg/Kg/day) or from the dilution vehicle, from 17th to 24th gestational day. Following the birth, males and females were separated and euthanized with 1 (PN1) and 90-days-old (PN90). The ventral prostates of male and females of the experimental groups were removed and collected, and later, structural, cytochemical and immunohistochemical analysis were conducted. Furthermore, the branching pattern of the prostate in one day-old animals was described by three dimensional reconstruction. Here, we demonstrate that the Al decreases the body weight of PN1 males and females, and also reduce the anogenital distance (AGD) of PN1 females. Moreover, Al changed the prostate developmental patterns of PN1 animals, causing an increase in proliferative status and decreasing androgen receptor (AR) immunomarking. These data suggests that the aluminum-promoted changes were permanent, since these differences in AR immunomarking were also observed either in adult females or males. Therefore, we reveal that the Al acts as an endocrine-disrupting chemical, changing the antiandrogenic activity of prostate epithelial and stromal cells.desenvolvimento prostático, desde a etapa pré-natal até a puberdade, é controlado por ações hormonais de forma que sensíveis intervenções ambientais durante estes períodos podem predispor a glândula a desenvolver lesões durante a vida senil. Com o avanço da industrialização, tem sido cada vez maior a exposição aos elementos ativos no meio ambiente. Entre esses elementos, temos o alumínio (Al), sendo o primeiro metal e o terceiro elemento químico em massa mais abundante na crosta terrestre. Independente da forma complexada que pode vir a ser encontrado, ele apresenta um efeito tóxico significativo no ser humano que podendo causar alterações no crescimento e no desenvolvimento de sistemas distintos, quando ingerido em altas doses. Porém, poucas evidências científicas demonstram os efeitos da exposição no sistema reprodutor. Assim, o objetivo desta pesquisa foi avaliar se a exposição intrauterina ao cloreto de alumínio (AlCl3) pode alterar a próstata ventral masculina e feminina de gerbilos neonatos e adultos. Foram formados dois grupos: controle e AlCl3. As fêmeas grávidas receberam doses diárias de AlCl3 (100 mg/Kg/dia) ou do veículo de diluição (solução salina 0,9%), do dia 17 a 24 de gestação. Após nascimento, os machos e fêmeas foram separados e eutanaziados com um dia (PN1) e noventa dias (PN90) de idade. As próstatas ventrais dos machos e fêmeas dos grupos experimentais foram removidas e coletadas, e posteriormente, foram realizadas análises estruturais, citoquímicas e imunohistoquímicas. Além disso, o padrão de ramificação da próstata nos animais de um dia de idade foi descrito mediante reconstrução tridimensional (3D). Os resultados demonstraram que a exposição ao Al diminuiu o peso corpóreo das fêmeas e machos PN1, e reduziu a distância anogenital das fêmeas PN1. Além disso, o Al alterou o padrão de desenvolvimento prostático de machos e fêmeas PN1, tornando estas glândulas mais proliferativas e com reduzida imunomarcação para AR. As alterações promovidas pela exposição ao Al parecem ser permanentes, visto que modificações na expressão de receptores hormonais e altos índices de proliferação celular também são observados nas fêmeas e machos adultos. Estes dados indicam que o Al agiu como um desregulador endócrino sobre a próstata, exercendo atividade antiandrogênica sobre as células epiteliais e estromais prostáticas.Submitted by Cláudia Bueno (claudiamoura18@gmail.com) on 2016-07-13T19:34:20Z No. of bitstreams: 2 Dissertação - Liana da Silva Gomes - 2016.pdf: 2370951 bytes, checksum: 095accbdb536c0767a23abc7d237e045 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-07-14T13:35:50Z (GMT) No. of bitstreams: 2 Dissertação - Liana da Silva Gomes - 2016.pdf: 2370951 bytes, checksum: 095accbdb536c0767a23abc7d237e045 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2016-07-14T13:35:50Z (GMT). No. of bitstreams: 2 Dissertação - Liana da Silva Gomes - 2016.pdf: 2370951 bytes, checksum: 095accbdb536c0767a23abc7d237e045 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-03-29Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Biologia (ICB)UFGBrasilInstituto de Ciências Biológicas - ICB (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessCloreto de alumínioSeio urogenitalPróstata ventralReceptores hormonaisPróstata femininaGerbiloAluminum chlorideUrogenital sinusVentral prostateHormone receptorsFemale prostateGerbilBIOQUIMICA::BIOLOGIA MOLECULAREfeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis6883982777473437920600600600600-387277211782737340439621439903280520722075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos |
title |
Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos |
spellingShingle |
Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos Gomes, Liana da Silva Cloreto de alumínio Seio urogenital Próstata ventral Receptores hormonais Próstata feminina Gerbilo Aluminum chloride Urogenital sinus Ventral prostate Hormone receptors Female prostate Gerbil BIOQUIMICA::BIOLOGIA MOLECULAR |
title_short |
Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos |
title_full |
Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos |
title_fullStr |
Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos |
title_full_unstemmed |
Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos |
title_sort |
Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos |
author |
Gomes, Liana da Silva |
author_facet |
Gomes, Liana da Silva |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Santos, Fernanda Cristina Alcântara dos |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3025583084190459 |
dc.contributor.advisor-co1.fl_str_mv |
Ghedini, Paulo César |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/5789550234984454 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6170269977013851 |
dc.contributor.author.fl_str_mv |
Gomes, Liana da Silva |
contributor_str_mv |
Santos, Fernanda Cristina Alcântara dos Ghedini, Paulo César |
dc.subject.por.fl_str_mv |
Cloreto de alumínio Seio urogenital Próstata ventral Receptores hormonais Próstata feminina Gerbilo |
topic |
Cloreto de alumínio Seio urogenital Próstata ventral Receptores hormonais Próstata feminina Gerbilo Aluminum chloride Urogenital sinus Ventral prostate Hormone receptors Female prostate Gerbil BIOQUIMICA::BIOLOGIA MOLECULAR |
dc.subject.eng.fl_str_mv |
Aluminum chloride Urogenital sinus Ventral prostate Hormone receptors Female prostate Gerbil |
dc.subject.cnpq.fl_str_mv |
BIOQUIMICA::BIOLOGIA MOLECULAR |
description |
Normal prostate development is highly dependent of an equilibrated hormonal regulation, so that sensible interferences during this period may predispose the gland to lesions during ageing. Industrial activities have increased the exposure of this gland to active elements found in environment. Within these elements, we find aluminum, the first metal being and the third chemical element more abundant in earth crust. Independently from the complex form in which it can be found, it presents toxic effect for living beings having the potential to disrupt the development and growth of several organs and systems, when ingested in high doses. However, little scientific evidence shows the effects of exposure in the reproductive system. Therefore, the aim of this study was to evaluate whether the intrauterine exposure to aluminum chloride (AlCl3) may alter the male and female ventral prostate of neonatal and adult gerbil. Two groups where formed: control and AlCl3. The pregnant females received daily doses of AlCl3 (100 mg/Kg/day) or from the dilution vehicle, from 17th to 24th gestational day. Following the birth, males and females were separated and euthanized with 1 (PN1) and 90-days-old (PN90). The ventral prostates of male and females of the experimental groups were removed and collected, and later, structural, cytochemical and immunohistochemical analysis were conducted. Furthermore, the branching pattern of the prostate in one day-old animals was described by three dimensional reconstruction. Here, we demonstrate that the Al decreases the body weight of PN1 males and females, and also reduce the anogenital distance (AGD) of PN1 females. Moreover, Al changed the prostate developmental patterns of PN1 animals, causing an increase in proliferative status and decreasing androgen receptor (AR) immunomarking. These data suggests that the aluminum-promoted changes were permanent, since these differences in AR immunomarking were also observed either in adult females or males. Therefore, we reveal that the Al acts as an endocrine-disrupting chemical, changing the antiandrogenic activity of prostate epithelial and stromal cells. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-07-14T13:35:50Z |
dc.date.issued.fl_str_mv |
2016-03-29 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOMES, L. S. Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos. 2016. 77 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/5726 |
identifier_str_mv |
GOMES, L. S. Efeitos da exposição pré-natal ao cloreto de alumínio sobre o desenvolvimento da próstata de gerbilos. 2016. 77 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2016. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/5726 |
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por |
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por |
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6883982777473437920 |
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3962143990328052072 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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UFG |
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Brasil |
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Instituto de Ciências Biológicas - ICB (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
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