MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional

Detalhes bibliográficos
Autor(a) principal: Silva, Pedro Henrique Costa Matos da
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/0013000002733
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/13043
Resumo: Gestational diabetes mellitus (GDM) is a common condition during pregnancy and can be diagnosed from the beginning of prenatal care. Studies have highlighted the role of microRNAs (miRNAs) in the pathophysiological mechanism and as possible biomarkers for the diagnosis and treatment of GDM. miRNAs, a class of small non-coding RNAs, play a role in post-transcriptional gene expression. Therefore, this study aimed to perform a systematic review of miRNAs associated with GDM, to build a panel of miRNAs. A bibliographic search was carried out in PubMed/Medline, Virtual Health Library (VHL), Web of Science and EMBASE databases, selecting observational studies in English, without time restriction. The protocol is registered on the PROSPERO platform (number CRD42021291791). Fifty-five studies were included in this systematic review, and 82 altered miRNAs in DMG were identified. Furthermore, four miRNAs were more frequently upregulated in GDM (mir-16-5p, mir-20a-5p, mir-222- 3p and mir-330-3p). The dysregulation of these miRNAs is associated with mechanisms of cell cycle homeostasis, growth and proliferation of pancreatic β cells, glucose uptake and metabolism, insulin secretion and resistance. Therefore, identifying miRNAs associated with GDM and elucidating its main mechanisms can help in the characterization and definition of possible biomarkers for the diagnosis and treatment of GDM.
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spelling Reis, Angela Adamski da Silvahttp://lattes.cnpq.br/3243656364470085Santos, Rodrigo da Silvahttp://lattes.cnpq.br/4806187026900959Reis, Angela Adamski da SilvaSoares, Leonardo RibeiroFranchi, Leonardo Pereirahttp://lattes.cnpq.br/2762321350163489Silva, Pedro Henrique Costa Matos da2023-09-26T18:22:55Z2023-09-26T18:22:55Z2023-09-19SILVA, P. H. C. M. MicroRNAs associados aos mecanismos fisiopatológicos do diabetes mellitus gestacional. 2023. 88 f. Dissertação (Mestrado em Ciências da Saúde) - Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, 2023.http://repositorio.bc.ufg.br/tede/handle/tede/13043ark:/38995/0013000002733Gestational diabetes mellitus (GDM) is a common condition during pregnancy and can be diagnosed from the beginning of prenatal care. Studies have highlighted the role of microRNAs (miRNAs) in the pathophysiological mechanism and as possible biomarkers for the diagnosis and treatment of GDM. miRNAs, a class of small non-coding RNAs, play a role in post-transcriptional gene expression. Therefore, this study aimed to perform a systematic review of miRNAs associated with GDM, to build a panel of miRNAs. A bibliographic search was carried out in PubMed/Medline, Virtual Health Library (VHL), Web of Science and EMBASE databases, selecting observational studies in English, without time restriction. The protocol is registered on the PROSPERO platform (number CRD42021291791). Fifty-five studies were included in this systematic review, and 82 altered miRNAs in DMG were identified. Furthermore, four miRNAs were more frequently upregulated in GDM (mir-16-5p, mir-20a-5p, mir-222- 3p and mir-330-3p). The dysregulation of these miRNAs is associated with mechanisms of cell cycle homeostasis, growth and proliferation of pancreatic β cells, glucose uptake and metabolism, insulin secretion and resistance. Therefore, identifying miRNAs associated with GDM and elucidating its main mechanisms can help in the characterization and definition of possible biomarkers for the diagnosis and treatment of GDM.O diabetes mellitus gestacional (DMG) é uma frequente durante a gravidez, podendo ser diagnosticada desde o início do pré-natal. Estudos têm destacado o papel dos microRNAs (miRNAs) no mecanismo fisiopatológico e como possíveis biomarcadores para o diagnóstico e tratamento do DMG. miRNAs são uma classe de pequenos RNAs não codificantes, os quais desempenham um papel na expressão gênica póstranscricional. Portanto, este estudo teve como objetivo realizar uma revisão sistemática de miRNAs associados ao DMG, para construir um painel de miRNAs. Foi realizado uma pesquisa bibliográfica nas bases de dados PubMed/Medline, Biblioteca Virtual da Saúde (BVS), Web of Science e EMBASE, selecionando estudos observacionais em inglês, sem restrição de tempo. O protocolo está registrado na plataforma PROSPERO (número CRD42021291791). Cinquenta e cinco estudos foram incluídos nesta revisão sistemática e 82 miRNAs alterados no DMG foram identificados. Além disso, quatro miRNAs foram mais frequentemente regulados positivamente no GDM (mir-16-5p, mir-20a-5p, mir-222-3p e mir-330-3p). A desregulação desses miRNAs está associada a mecanismos de homeostase do ciclo celular, crescimento e proliferação de células β pancreáticas, captação e metabolismo de glicose, secreção e resistência à insulina. Portanto, identificar miRNAs associados ao DMG e elucidar seus principais mecanismos pode auxiliar na caracterização e definição de possíveis biomarcadores para o diagnóstico e tratamento do DMG.Submitted by Leandro Machado (leandromachado@ufg.br) on 2023-09-26T16:14:12Z workflow start=Step: editstep - action:claimaction No. of bitstreams: 2 license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5) Dissertação - Pedro Henrique Costa Matos da Silva - 2023.pdf: 4665285 bytes, checksum: d9e8ccbdd66fbd44e61d23c9c414d895 (MD5)Step: editstep - action:editaction Approved for entry into archive by Cláudia Bueno(claudiamoura18@gmail.com) on 2023-09-26T18:22:55Z (GMT)Made available in DSpace on 2023-09-26T18:22:55Z (GMT). No. of bitstreams: 2 license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5) Dissertação - Pedro Henrique Costa Matos da Silva - 2023.pdf: 4665285 bytes, checksum: d9e8ccbdd66fbd44e61d23c9c414d895 (MD5) Previous issue date: 2023-09-19porUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências da Saúde (FM)UFGBrasilFaculdade de Medicina - FM (RG)1. Caughey, A.B.; Turrentine, M. ACOG practice bulletin No. 190 Summary: Gestational diabetes mellitus. Obs. Gynecol. 2018, 131, 406–408. 2. Durnwald, C. Gestational Diabetes Mellitus: Screening, Diagnosis, and Prevention; Nathan, D.M., Werner, E.F., Eds.; UpToDate: Wellesley, MA, USA, 2022. 3. Carracher, A.M.; Marathe, P.H.; Close, K.L. International Diabetes Federation 2017. J. Diabetes 2018, 10, 353–356. [CrossRef] 4. McIntyre, H.D.; Catalano, P.; Zhang, C.; Desoye, G.; Mathiesen, E.R.; Damm, P. Gestational diabetes mellitus. Nat. Rev. Dis. Prim. 2019, 5, 48. [CrossRef] 5. Yang, X.; Wu, N. 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[CrossRef] [PubMed]Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessDMGDiabetesmiRNAGenéticaGDMDiabetesmiRNAGeneticCIENCIAS DA SAUDE::MEDICINAMicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacionalMicroRNAs associated with the pathophysiological mechanisms of gestational diabetes mellitusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisreponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.bc.ufg.br/tede/bitstreams/cdb10a80-17d7-4c9a-945f-b78327df0b1a/download8a4605be74aa9ea9d79846c1fba20a33MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.bc.ufg.br/tede/bitstreams/3785a5a7-5212-4223-a60a-1b81a107e0e7/download4460e5956bc1d1639be9ae6146a50347MD52ORIGINALDissertação - Pedro Henrique Costa Matos da Silva - 2023.pdfDissertação - Pedro Henrique Costa Matos da Silva - 2023.pdfapplication/pdf4665285http://repositorio.bc.ufg.br/tede/bitstreams/c6b8e37e-31f1-45a2-b89d-296b766acd84/downloadd9e8ccbdd66fbd44e61d23c9c414d895MD53tede/130432023-09-26 15:22:55.849http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accessoai:repositorio.bc.ufg.br:tede/13043http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttp://repositorio.bc.ufg.br/oai/requesttasesdissertacoes.bc@ufg.bropendoar:2023-09-26T18:22:55Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)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
dc.title.none.fl_str_mv MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
dc.title.alternative.eng.fl_str_mv MicroRNAs associated with the pathophysiological mechanisms of gestational diabetes mellitus
title MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
spellingShingle MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
Silva, Pedro Henrique Costa Matos da
DMG
Diabetes
miRNA
Genética
GDM
Diabetes
miRNA
Genetic
CIENCIAS DA SAUDE::MEDICINA
title_short MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
title_full MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
title_fullStr MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
title_full_unstemmed MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
title_sort MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
author Silva, Pedro Henrique Costa Matos da
author_facet Silva, Pedro Henrique Costa Matos da
author_role author
dc.contributor.advisor1.fl_str_mv Reis, Angela Adamski da Silva
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3243656364470085
dc.contributor.advisor-co1.fl_str_mv Santos, Rodrigo da Silva
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/4806187026900959
dc.contributor.referee1.fl_str_mv Reis, Angela Adamski da Silva
dc.contributor.referee2.fl_str_mv Soares, Leonardo Ribeiro
dc.contributor.referee3.fl_str_mv Franchi, Leonardo Pereira
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2762321350163489
dc.contributor.author.fl_str_mv Silva, Pedro Henrique Costa Matos da
contributor_str_mv Reis, Angela Adamski da Silva
Santos, Rodrigo da Silva
Reis, Angela Adamski da Silva
Soares, Leonardo Ribeiro
Franchi, Leonardo Pereira
dc.subject.por.fl_str_mv DMG
Diabetes
miRNA
Genética
topic DMG
Diabetes
miRNA
Genética
GDM
Diabetes
miRNA
Genetic
CIENCIAS DA SAUDE::MEDICINA
dc.subject.eng.fl_str_mv GDM
Diabetes
miRNA
Genetic
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::MEDICINA
description Gestational diabetes mellitus (GDM) is a common condition during pregnancy and can be diagnosed from the beginning of prenatal care. Studies have highlighted the role of microRNAs (miRNAs) in the pathophysiological mechanism and as possible biomarkers for the diagnosis and treatment of GDM. miRNAs, a class of small non-coding RNAs, play a role in post-transcriptional gene expression. Therefore, this study aimed to perform a systematic review of miRNAs associated with GDM, to build a panel of miRNAs. A bibliographic search was carried out in PubMed/Medline, Virtual Health Library (VHL), Web of Science and EMBASE databases, selecting observational studies in English, without time restriction. The protocol is registered on the PROSPERO platform (number CRD42021291791). Fifty-five studies were included in this systematic review, and 82 altered miRNAs in DMG were identified. Furthermore, four miRNAs were more frequently upregulated in GDM (mir-16-5p, mir-20a-5p, mir-222- 3p and mir-330-3p). The dysregulation of these miRNAs is associated with mechanisms of cell cycle homeostasis, growth and proliferation of pancreatic β cells, glucose uptake and metabolism, insulin secretion and resistance. Therefore, identifying miRNAs associated with GDM and elucidating its main mechanisms can help in the characterization and definition of possible biomarkers for the diagnosis and treatment of GDM.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-09-26T18:22:55Z
dc.date.available.fl_str_mv 2023-09-26T18:22:55Z
dc.date.issued.fl_str_mv 2023-09-19
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, P. H. C. M. MicroRNAs associados aos mecanismos fisiopatológicos do diabetes mellitus gestacional. 2023. 88 f. Dissertação (Mestrado em Ciências da Saúde) - Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, 2023.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/13043
dc.identifier.dark.fl_str_mv ark:/38995/0013000002733
identifier_str_mv SILVA, P. H. C. M. MicroRNAs associados aos mecanismos fisiopatológicos do diabetes mellitus gestacional. 2023. 88 f. Dissertação (Mestrado em Ciências da Saúde) - Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, 2023.
ark:/38995/0013000002733
url http://repositorio.bc.ufg.br/tede/handle/tede/13043
dc.language.iso.fl_str_mv por
language por
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