Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/8687 |
Resumo: | Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over fifty years of age. Management centers around prevention of second eye involvement, without uniformly accepted therapeutic intervention for the involved eye. Several researchers have assessed the benefit of steroids with conflicting results. Animal models based on selective photothrombosis of the microcirculation within the optic nerve head have contributed both to a better understanding of pathophysiological mechanisms associated to NAION; also, it has enabled the testing of potential therapeutic approaches. This study was deisigned to evaluate the efficacy of a single intravitreal triamcinolone acetonide injection (IVTA) in preserving retinal ganglion cells (RGCs) in a rodent model of anterior ischemic optic neuropathy (rNAION). Rodent NAION (rNAION) was induced in female Wistar rats. Animals were randomized into three groups: 1) untreated, 2) treated with 56 μg IVTA, and 3) treated with placebo (intravitreal saline). Procedures were performed in the left eye, with the right eye serving as an internal control. After 30 days, animals were sacrificed and eyes were assessed histologically for RGC number. The average number of RGCs was significantly higher in the control group when compared to rNAION subgroups (p < 0.001). No significant difference was seen between rNAION eyes treated with IVTA, placebo, and untreated eyes (P > 0.05%). In this rodent model for NAION, no therapeutic benefit of intravitreal steroid injection was identified. |
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Ávila, Marcos Pereira dehttp://lattes.cnpq.br/3335187297522447Ávila, Marcos Pereira deMonteiro, Mário Luiz RibeiroCohen, RalphEjzembaum, FábioTaleb, Alexandre Chaterhttp://lattes.cnpq.br/9842717326456855Pereira, Luciano de Sousa2018-07-12T11:26:01Z2017-03-14PEREIRA, Luciano de Sousa. Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos. 2017. 80 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017.http://repositorio.bc.ufg.br/tede/handle/tede/8687Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over fifty years of age. Management centers around prevention of second eye involvement, without uniformly accepted therapeutic intervention for the involved eye. Several researchers have assessed the benefit of steroids with conflicting results. Animal models based on selective photothrombosis of the microcirculation within the optic nerve head have contributed both to a better understanding of pathophysiological mechanisms associated to NAION; also, it has enabled the testing of potential therapeutic approaches. This study was deisigned to evaluate the efficacy of a single intravitreal triamcinolone acetonide injection (IVTA) in preserving retinal ganglion cells (RGCs) in a rodent model of anterior ischemic optic neuropathy (rNAION). Rodent NAION (rNAION) was induced in female Wistar rats. Animals were randomized into three groups: 1) untreated, 2) treated with 56 μg IVTA, and 3) treated with placebo (intravitreal saline). Procedures were performed in the left eye, with the right eye serving as an internal control. After 30 days, animals were sacrificed and eyes were assessed histologically for RGC number. The average number of RGCs was significantly higher in the control group when compared to rNAION subgroups (p < 0.001). No significant difference was seen between rNAION eyes treated with IVTA, placebo, and untreated eyes (P > 0.05%). In this rodent model for NAION, no therapeutic benefit of intravitreal steroid injection was identified.A neuropatia óptica isquêmica anterior não-arterítica (NOIA-NA) é a neuropatia óptica aguda mais frequente após os 50 anos de idade. Atualmente, a conduta é centrada na prevenção do acometimento do segundo olho, não havendo, ainda, consenso referente à intervenção terapêutica para o olho acometido. Muitos pesquisadores avaliaram o benefício dos corticosteroides na NOIA-NA, com resultados controversos. Modelos animais baseados na fototrombose seletiva da microcirculação da cabeça do nervo óptico têm contribuído tanto para um maior conhecimento dos mecanismos fisiopatológicos associados a NOIA-NA, quanto para a identificação de potenciais abordagens terapêuticas. O objetivo desse estudo foi avaliar a eficácia da triancinolona intravítrea (TAIV) na preservação das células ganglionares da retina (CGRs) em um modelo animal de NOIA-NA em ratos (rNOIA). A rNOIA foi induzida em 30 ratas da linhagem Wistar. Os animais foram aleatoriamente selecionados em 3 grupos: 1) rNOIA não tratado, 2) rNOIA tratado com 5,6 μg de TAIV, 3) rNOIA tratado com placebo (solução salina intravítrea). Os procedimentos foram realizados no olho esquerdo de cada animal; o olho direito serviu como controle interno. Os tratamentos foram realizados dentro dos primeiros 15 minutos após a indução da rNOIA. Trinta dias após o experimento, os animais foram sacrificados e os olhos foram avaliados histologicamente para contagem e comparação do número de CGRs. A média do número de CGRs foi significamente menor nos subgrupos de rNOIA quando comparados ao grupo controle (p < 0,001). Não foi encontrada diferença estatística entre olhos com rNOIA tratados com TAIV, placebo e não tratados (p > 0,05). Neste modelo animal, a triancinolona intravítrea não se mostrou eficaz na preservação do número de células ganglionares da retina.Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2018-07-11T17:48:42Z No. of bitstreams: 2 Tese - Luciano de Sousa Pereira - 2017.pdf: 2889362 bytes, checksum: cfbc7fe755a68223cf99e2cd3795be90 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-07-12T11:26:01Z (GMT) No. of bitstreams: 2 Tese - Luciano de Sousa Pereira - 2017.pdf: 2889362 bytes, checksum: cfbc7fe755a68223cf99e2cd3795be90 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2018-07-12T11:26:01Z (GMT). No. of bitstreams: 2 Tese - Luciano de Sousa Pereira - 2017.pdf: 2889362 bytes, checksum: cfbc7fe755a68223cf99e2cd3795be90 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-03-14application/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências da Saúde (FM)UFGBrasilFaculdade de Medicina - FM (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessTriancinolona intravítreaModelo de neuropatia óptica isquêmica em ratosCélulas ganglionares da retinaNeuroproteçãoIntravitreal triamcinoloneRodent model of ischemic optic neuropathyRetinal ganglion cellsNeuroprotectionCIENCIAS DA SAUDEAvaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratosAssessment of the efficacy of intravitreal triamcinolone on retinal ganglion cell preservation in a rodent model of anterior ischemic optic neuropathyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis-100686431261774531060060060015457724759504863388765449414823306929reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.eng.fl_str_mv |
Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos |
dc.title.alternative.eng.fl_str_mv |
Assessment of the efficacy of intravitreal triamcinolone on retinal ganglion cell preservation in a rodent model of anterior ischemic optic neuropathy |
title |
Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos |
spellingShingle |
Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos Pereira, Luciano de Sousa Triancinolona intravítrea Modelo de neuropatia óptica isquêmica em ratos Células ganglionares da retina Neuroproteção Intravitreal triamcinolone Rodent model of ischemic optic neuropathy Retinal ganglion cells Neuroprotection CIENCIAS DA SAUDE |
title_short |
Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos |
title_full |
Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos |
title_fullStr |
Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos |
title_full_unstemmed |
Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos |
title_sort |
Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos |
author |
Pereira, Luciano de Sousa |
author_facet |
Pereira, Luciano de Sousa |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Ávila, Marcos Pereira de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3335187297522447 |
dc.contributor.referee1.fl_str_mv |
Ávila, Marcos Pereira de |
dc.contributor.referee2.fl_str_mv |
Monteiro, Mário Luiz Ribeiro |
dc.contributor.referee3.fl_str_mv |
Cohen, Ralph |
dc.contributor.referee4.fl_str_mv |
Ejzembaum, Fábio |
dc.contributor.referee5.fl_str_mv |
Taleb, Alexandre Chater |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9842717326456855 |
dc.contributor.author.fl_str_mv |
Pereira, Luciano de Sousa |
contributor_str_mv |
Ávila, Marcos Pereira de Ávila, Marcos Pereira de Monteiro, Mário Luiz Ribeiro Cohen, Ralph Ejzembaum, Fábio Taleb, Alexandre Chater |
dc.subject.por.fl_str_mv |
Triancinolona intravítrea Modelo de neuropatia óptica isquêmica em ratos Células ganglionares da retina Neuroproteção |
topic |
Triancinolona intravítrea Modelo de neuropatia óptica isquêmica em ratos Células ganglionares da retina Neuroproteção Intravitreal triamcinolone Rodent model of ischemic optic neuropathy Retinal ganglion cells Neuroprotection CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Intravitreal triamcinolone Rodent model of ischemic optic neuropathy Retinal ganglion cells Neuroprotection |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over fifty years of age. Management centers around prevention of second eye involvement, without uniformly accepted therapeutic intervention for the involved eye. Several researchers have assessed the benefit of steroids with conflicting results. Animal models based on selective photothrombosis of the microcirculation within the optic nerve head have contributed both to a better understanding of pathophysiological mechanisms associated to NAION; also, it has enabled the testing of potential therapeutic approaches. This study was deisigned to evaluate the efficacy of a single intravitreal triamcinolone acetonide injection (IVTA) in preserving retinal ganglion cells (RGCs) in a rodent model of anterior ischemic optic neuropathy (rNAION). Rodent NAION (rNAION) was induced in female Wistar rats. Animals were randomized into three groups: 1) untreated, 2) treated with 56 μg IVTA, and 3) treated with placebo (intravitreal saline). Procedures were performed in the left eye, with the right eye serving as an internal control. After 30 days, animals were sacrificed and eyes were assessed histologically for RGC number. The average number of RGCs was significantly higher in the control group when compared to rNAION subgroups (p < 0.001). No significant difference was seen between rNAION eyes treated with IVTA, placebo, and untreated eyes (P > 0.05%). In this rodent model for NAION, no therapeutic benefit of intravitreal steroid injection was identified. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-03-14 |
dc.date.accessioned.fl_str_mv |
2018-07-12T11:26:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
PEREIRA, Luciano de Sousa. Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos. 2017. 80 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/8687 |
identifier_str_mv |
PEREIRA, Luciano de Sousa. Avaliação da eficácia da triancinolona intravítrea na preservação de células ganglionares de retina em um modelo de neuropatia óptica Isquêmica anterior em ratos. 2017. 80 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/8687 |
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por |
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por |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Universidade Federal de Goiás |
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Programa de Pós-graduação em Ciências da Saúde (FM) |
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UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Faculdade de Medicina - FM (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
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