Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/4933 |
Resumo: | Obesity and chronic stress have been considered major public health problems that affect millions of people worldwide. The objective of this study was to analyze the effect of obesity associated with chronic stress on neurobehavioral parameters, hematological and biochemical in rats, considering that the association of these diseases can enhance their negative effects on homeostasis of the organism. For this, female Wistar rats were distributed in the following groups: standard diet (SD), standard diet + stress (DP + stress), cafeteria diet (Cafe) and cafeteria diet + stress (Cafe + stress) groups (n=12 rats, per group). The animals of the DP and DP + stress groups were fed standard food. Groups Cafe and Cafe + stress, additionally to the standard feed, were offered palatable and calorie-rich processed food, water with sucrose (300 g/L)and cola-type soft drink ad libitum. From the eighth experimental week, groups Std + stress and Cafe + stress were subjected to restraint chronic stress model (50 days). After the restraint chronic stress the animals were subjected to predictive anxiety tests (open field and elevated plus maze tests) and depression (forced swimming test). At the end of the experiment was evaluated hematological parameters (erythrogram, leucogram and platelet parameters) and biochemical (lipid profile, blood glucose, total proteins and fractions). The results demonstrate that cafeteria diet was able to induce obesity in the above animals, increasing body mass, weight of retroperitoneal and visceral fat, body mass index, specific rate of weight gain, weight delta efficacy coefficient food, weight gain coefficient for calorie intake, nasoanal length, abdominal circumference and kilocalories ingested. The ratio locomotion in the central quadrants/total locomotion evaluated during the open field test was not indicative of anxiogenic or anxiolytic effect in the animal’s behavior. However, the elevated plus maze test showed that obese and stressed animals were prone to higher anxiety levels. In addition, the obese and stressed animals display less climbing behavior than all the other groups, which can be considered an indicator of depression-like behavior. No damaging effects caused by the interaction of obesity and stress were observed on the biochemical and hematological parameters. Only individual effects of the factor obesity on leukocyte and glycemic parameters were observed. The obese animals presented hypoglycemia and leukocytosis by neutrophilia and lymphocytosis. |
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Pinto, Guilherme Malafaiahttp://lattes.cnpq.br/7222293518573336Pinto, Guilherme MalafaiaMazaro e Costa, RenataDias Júnior, Walterhttp://lattes.cnpq.br/9311705686355586Estrela, Dieferson da Costa2015-11-20T10:56:04Z2015-08-17ESTRELA, D. C. Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica. 2015. 89 f. Dissertação (Mestrado em Biodiversidade Animal) - Universidade Federal de Goiás, Goiânia, 2015.http://repositorio.bc.ufg.br/tede/handle/tede/4933ark:/38995/00130000061kgObesity and chronic stress have been considered major public health problems that affect millions of people worldwide. The objective of this study was to analyze the effect of obesity associated with chronic stress on neurobehavioral parameters, hematological and biochemical in rats, considering that the association of these diseases can enhance their negative effects on homeostasis of the organism. For this, female Wistar rats were distributed in the following groups: standard diet (SD), standard diet + stress (DP + stress), cafeteria diet (Cafe) and cafeteria diet + stress (Cafe + stress) groups (n=12 rats, per group). The animals of the DP and DP + stress groups were fed standard food. Groups Cafe and Cafe + stress, additionally to the standard feed, were offered palatable and calorie-rich processed food, water with sucrose (300 g/L)and cola-type soft drink ad libitum. From the eighth experimental week, groups Std + stress and Cafe + stress were subjected to restraint chronic stress model (50 days). After the restraint chronic stress the animals were subjected to predictive anxiety tests (open field and elevated plus maze tests) and depression (forced swimming test). At the end of the experiment was evaluated hematological parameters (erythrogram, leucogram and platelet parameters) and biochemical (lipid profile, blood glucose, total proteins and fractions). The results demonstrate that cafeteria diet was able to induce obesity in the above animals, increasing body mass, weight of retroperitoneal and visceral fat, body mass index, specific rate of weight gain, weight delta efficacy coefficient food, weight gain coefficient for calorie intake, nasoanal length, abdominal circumference and kilocalories ingested. The ratio locomotion in the central quadrants/total locomotion evaluated during the open field test was not indicative of anxiogenic or anxiolytic effect in the animal’s behavior. However, the elevated plus maze test showed that obese and stressed animals were prone to higher anxiety levels. In addition, the obese and stressed animals display less climbing behavior than all the other groups, which can be considered an indicator of depression-like behavior. No damaging effects caused by the interaction of obesity and stress were observed on the biochemical and hematological parameters. Only individual effects of the factor obesity on leukocyte and glycemic parameters were observed. The obese animals presented hypoglycemia and leukocytosis by neutrophilia and lymphocytosis.A obesidade e estresse crônico têm sido considerados importantes problemas de saúde pública que afetam milhões de pessoas em todo o mundo. Assim, o objetivo deste estudo foi analisar o efeito da obesidade associada ao estresse crônico sobre os parâmetros neurocomportamentais, hematológicos e bioquímicos em ratas, considerando que a associação dessas doenças pode potencializar seus efeitos negativos sobre a homeostase no organismo. Para isso, ratas Wistar foram distribuídas nos seguintes grupos experimentais: dieta padrão (DP), dieta padrão + estresse (DP + estresse), dieta de cafeteria (Cafe) e dieta de cafeteria + estresse (Cafe + estresse) grupos, com 12 animais por grupo. Os animais dos grupos e DP e DP + estresse foram alimentados com ração padrão roedoroes. Aos animais dos grupos Cafe e Cafe + estresse, adicionalmente à ração padrão, foram oferecidos diferentes alimentos palatáveis (calóricos e in natura), água com sacarose (300 g/L) e refrigerante do tipo cola, ad libitum. A partir da oitava semana experimental, os grupos DP + estresse e Cafe + estresse foram submetidos ao modelo de estresse crônico por restrição, durante 50 dias. Após o protocolo de estresse os animais foram submetidos a testes neucomportamentais preditivos de ansiedade (tesde do campo aberto e labirinto em cruz elevado) e depressão (teste do nado forçado). Ao final do experimento, avaliou-se parâmetros hematológicos (eritograma, leucograma e plaquetograma) e bioquímicos (lipidograma, glicemia, proteínas totais e frações). Os resultados demonstram que a dieta de cafeteria foi capaz de induzir um quadro de obesidade nos animais, aumentando a massa corpórea, massa das gorduras retroperitoneal e visceral, índice de massa corpórea, taxa específica de ganho de peso, delta do peso, coeficiente de eficácia alimentar, coeficiente de ganho de peso por consumo calórico, comprimento naso-anal, circunferência abdominal e quilocalorias ingeridas. A proporção da locomoção nos quadrantes centrais/locomoção total, avaliado durante o teste de campo aberto não indicou comportamento ansiolítico ou ansiogênico nos animais. No entanto, o teste de labirinto em cruz elevado mostrou que os animais obesos e estressados apresentaram maior índice de ansiedade. Além disso, os animais estressados e obesos exibiram menor comportamento de escalada em relação aos demais grupos, o que pode ser considerado um comportamento preditivo de depressão. Não foram observados efeitos prejudiciais da interação obesidade e estresse sobre os parâmetros bioquímicos e hematológicos avaliados. Evidenciaram-se apenas efeitos individuais do fator “nutrição” (fator 1) sobre os parâmetros leucocitários e glicêmicos avaliados. Os animais obesos apresentaram-se hiperglicêmicos e com quadro de leucocitose por neutrofilia e lifocitose.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2015-11-20T10:54:01Z No. of bitstreams: 2 Dissertação - Dieferson da Costa Estrela - 2015.pdf: 2754827 bytes, checksum: 254f2e157991239ed42ccec84b03e2dd (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-11-20T10:56:04Z (GMT) No. of bitstreams: 2 Dissertação - Dieferson da Costa Estrela - 2015.pdf: 2754827 bytes, checksum: 254f2e157991239ed42ccec84b03e2dd (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-11-20T10:56:04Z (GMT). No. of bitstreams: 2 Dissertação - Dieferson da Costa Estrela - 2015.pdf: 2754827 bytes, checksum: 254f2e157991239ed42ccec84b03e2dd (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2015-08-17Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Biodiversidade Animal (ICB)UFGBrasilInstituto de Ciências Biológicas - ICB (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessModelos experimentaisSobrepesoAlimentos palatáveisEstresseNeurocomportamentoExperimental modelsOverweightPalatable foodStressNeurobehavioralCIENCIAS BIOLOGICAS::BIOQUIMICAObesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológicaObesity and chronic stress in female rats Wistar: behavioral assessment, biochemical and hematologicalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis9149394957166913506600600600600-38727721178273734048934779903292661142075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica |
dc.title.alternative.eng.fl_str_mv |
Obesity and chronic stress in female rats Wistar: behavioral assessment, biochemical and hematological |
title |
Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica |
spellingShingle |
Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica Estrela, Dieferson da Costa Modelos experimentais Sobrepeso Alimentos palatáveis Estresse Neurocomportamento Experimental models Overweight Palatable food Stress Neurobehavioral CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica |
title_full |
Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica |
title_fullStr |
Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica |
title_full_unstemmed |
Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica |
title_sort |
Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica |
author |
Estrela, Dieferson da Costa |
author_facet |
Estrela, Dieferson da Costa |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Pinto, Guilherme Malafaia |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7222293518573336 |
dc.contributor.referee1.fl_str_mv |
Pinto, Guilherme Malafaia |
dc.contributor.referee2.fl_str_mv |
Mazaro e Costa, Renata |
dc.contributor.referee3.fl_str_mv |
Dias Júnior, Walter |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9311705686355586 |
dc.contributor.author.fl_str_mv |
Estrela, Dieferson da Costa |
contributor_str_mv |
Pinto, Guilherme Malafaia Pinto, Guilherme Malafaia Mazaro e Costa, Renata Dias Júnior, Walter |
dc.subject.por.fl_str_mv |
Modelos experimentais Sobrepeso Alimentos palatáveis Estresse Neurocomportamento |
topic |
Modelos experimentais Sobrepeso Alimentos palatáveis Estresse Neurocomportamento Experimental models Overweight Palatable food Stress Neurobehavioral CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.eng.fl_str_mv |
Experimental models Overweight Palatable food Stress Neurobehavioral |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
Obesity and chronic stress have been considered major public health problems that affect millions of people worldwide. The objective of this study was to analyze the effect of obesity associated with chronic stress on neurobehavioral parameters, hematological and biochemical in rats, considering that the association of these diseases can enhance their negative effects on homeostasis of the organism. For this, female Wistar rats were distributed in the following groups: standard diet (SD), standard diet + stress (DP + stress), cafeteria diet (Cafe) and cafeteria diet + stress (Cafe + stress) groups (n=12 rats, per group). The animals of the DP and DP + stress groups were fed standard food. Groups Cafe and Cafe + stress, additionally to the standard feed, were offered palatable and calorie-rich processed food, water with sucrose (300 g/L)and cola-type soft drink ad libitum. From the eighth experimental week, groups Std + stress and Cafe + stress were subjected to restraint chronic stress model (50 days). After the restraint chronic stress the animals were subjected to predictive anxiety tests (open field and elevated plus maze tests) and depression (forced swimming test). At the end of the experiment was evaluated hematological parameters (erythrogram, leucogram and platelet parameters) and biochemical (lipid profile, blood glucose, total proteins and fractions). The results demonstrate that cafeteria diet was able to induce obesity in the above animals, increasing body mass, weight of retroperitoneal and visceral fat, body mass index, specific rate of weight gain, weight delta efficacy coefficient food, weight gain coefficient for calorie intake, nasoanal length, abdominal circumference and kilocalories ingested. The ratio locomotion in the central quadrants/total locomotion evaluated during the open field test was not indicative of anxiogenic or anxiolytic effect in the animal’s behavior. However, the elevated plus maze test showed that obese and stressed animals were prone to higher anxiety levels. In addition, the obese and stressed animals display less climbing behavior than all the other groups, which can be considered an indicator of depression-like behavior. No damaging effects caused by the interaction of obesity and stress were observed on the biochemical and hematological parameters. Only individual effects of the factor obesity on leukocyte and glycemic parameters were observed. The obese animals presented hypoglycemia and leukocytosis by neutrophilia and lymphocytosis. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-11-20T10:56:04Z |
dc.date.issued.fl_str_mv |
2015-08-17 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ESTRELA, D. C. Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica. 2015. 89 f. Dissertação (Mestrado em Biodiversidade Animal) - Universidade Federal de Goiás, Goiânia, 2015. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/4933 |
dc.identifier.dark.fl_str_mv |
ark:/38995/00130000061kg |
identifier_str_mv |
ESTRELA, D. C. Obesidade e estresse crônico em fêmeas de ratos wistar: avaliação comportamental, bioquímica e hematológica. 2015. 89 f. Dissertação (Mestrado em Biodiversidade Animal) - Universidade Federal de Goiás, Goiânia, 2015. ark:/38995/00130000061kg |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/4933 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
9149394957166913506 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-3872772117827373404 |
dc.relation.cnpq.fl_str_mv |
893477990329266114 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Biodiversidade Animal (ICB) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Ciências Biológicas - ICB (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/2598ce13-11f9-42a5-a4af-aaba70c7edfc/download http://repositorio.bc.ufg.br/tede/bitstreams/ffb6bb93-f6dc-46d0-b9fd-ed5289aa7db7/download http://repositorio.bc.ufg.br/tede/bitstreams/565ac1f8-206e-43c0-ab36-b0c7ed0dea05/download http://repositorio.bc.ufg.br/tede/bitstreams/f0774bbd-07ef-464b-8171-a9a80d3b23be/download http://repositorio.bc.ufg.br/tede/bitstreams/112fb8d8-0ab5-4f0d-a4e7-d16ebb28bb2f/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f ae2fe251842ade1134c5d9bb99b6eefe 9da0b6dfac957114c6a7714714b86306 254f2e157991239ed42ccec84b03e2dd |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1811721410023784448 |