Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
dARK ID: | ark:/38995/001300000cmxd |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/7192 |
Resumo: | This work describes a practical method for intramolecular heterocyclization of the (-)-α-bisabolol to obtain cyclic arylselenoethers and arylthioethers. The electrophilic cyclization addition is promoted by arylselenenyl bromide (ArSeBr) and arylsulfenyl chloride (ArSCl) through electrophilic addition across the terminally disubstituted double bond of the alfa-bisabolol. The cyclization reaction preceeded cleanly and smoothly under mild reaction conditions and provided the cyclic arylselenoethers and arylthioethers with 71% and 47% of yield respectively, employing pyridine as addictive under inert atmosphere. The methodology showed to be highly regioselective since the tetrahydrofuranes were obtained as unique products, presumably because of electronic and conformational factors. It is well known that cyclic ethers are present in the skeletons of several groups of natural compounds exhibiting important biological activities. |
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Barros, Olga Soares do Rêgohttp://lattes.cnpq.br/8311808341863723Marques, Monique FerreiraQueiroz Júnior, Luiz Henrique Kenghttp://lattes.cnpq.br/9788043570082278Melo, Diêgo de2017-04-20T12:38:31Z2017-03-07MELO, D. Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla. 2017. 49 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2017.http://repositorio.bc.ufg.br/tede/handle/tede/7192ark:/38995/001300000cmxdThis work describes a practical method for intramolecular heterocyclization of the (-)-α-bisabolol to obtain cyclic arylselenoethers and arylthioethers. The electrophilic cyclization addition is promoted by arylselenenyl bromide (ArSeBr) and arylsulfenyl chloride (ArSCl) through electrophilic addition across the terminally disubstituted double bond of the alfa-bisabolol. The cyclization reaction preceeded cleanly and smoothly under mild reaction conditions and provided the cyclic arylselenoethers and arylthioethers with 71% and 47% of yield respectively, employing pyridine as addictive under inert atmosphere. The methodology showed to be highly regioselective since the tetrahydrofuranes were obtained as unique products, presumably because of electronic and conformational factors. It is well known that cyclic ethers are present in the skeletons of several groups of natural compounds exhibiting important biological activities.Este trabalho descreve um método simples para a heterociclização Intramolecular do (-)-α-bisabolol para obtenção de ariltioeteres e arilselenoeteres cíclicos. A ciclização eletrofílica é promovida por brometo de arilselenenila (ArSeBr) e cloreto de arilsulfenila (ArSCl) através da adição eletrofílica na dupla ligação terminal dissubstituída do (-)-α-bisabolol A reação de ciclização procedeu-se sob condições brandas fornecendo arilselenoeteres e ariltioeteres cíclicos com 71% e 47% de rendimento respectivamente, empregando piridina como aditivo, em atmosfera inerte. A metodologia mostrou-se altamente regiosseletiva, uma vez que se obteve como produto principal somente tetrahidrofuranos organocalcogeno funcionalizados em consequência de fatores eletrônicos e conformacionais. Adicionalmente, sabe-se que, os éteres cíclicos estão presentes nos esqueletos de vários grupos de compostos naturais, apresentando importantes atividades biológicas.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-04-20T11:29:02Z No. of bitstreams: 2 Dissertação - Diêgo de Melo - 2017.pdf: 12963482 bytes, checksum: 14979af9bcf3df3d1a038ba4bc54e354 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-04-20T12:38:31Z (GMT) No. of bitstreams: 2 Dissertação - Diêgo de Melo - 2017.pdf: 12963482 bytes, checksum: 14979af9bcf3df3d1a038ba4bc54e354 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-04-20T12:38:31Z (GMT). No. of bitstreams: 2 Dissertação - Diêgo de Melo - 2017.pdf: 12963482 bytes, checksum: 14979af9bcf3df3d1a038ba4bc54e354 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-03-07Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Química (IQ)UFGBrasilInstituto de Química - IQ (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccess(-)-α-bisabolol, ciclização eletrofílica(-)-α-bisabolol, electrophilic cyclizationCIENCIAS EXATAS E DA TERRA::QUIMICASíntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoílaIntramolecular cyclization of alfa-bisabolol promoted by arylselenyl halides or arylthionyl halidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis663693921325415158600600600600782606674374119727815717003253031171952075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla |
dc.title.alternative.eng.fl_str_mv |
Intramolecular cyclization of alfa-bisabolol promoted by arylselenyl halides or arylthionyl halides |
title |
Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla |
spellingShingle |
Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla Melo, Diêgo de (-)-α-bisabolol, ciclização eletrofílica (-)-α-bisabolol, electrophilic cyclization CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla |
title_full |
Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla |
title_fullStr |
Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla |
title_full_unstemmed |
Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla |
title_sort |
Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla |
author |
Melo, Diêgo de |
author_facet |
Melo, Diêgo de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Barros, Olga Soares do Rêgo |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8311808341863723 |
dc.contributor.referee1.fl_str_mv |
Marques, Monique Ferreira |
dc.contributor.referee2.fl_str_mv |
Queiroz Júnior, Luiz Henrique Keng |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9788043570082278 |
dc.contributor.author.fl_str_mv |
Melo, Diêgo de |
contributor_str_mv |
Barros, Olga Soares do Rêgo Marques, Monique Ferreira Queiroz Júnior, Luiz Henrique Keng |
dc.subject.por.fl_str_mv |
(-)-α-bisabolol, ciclização eletrofílica |
topic |
(-)-α-bisabolol, ciclização eletrofílica (-)-α-bisabolol, electrophilic cyclization CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
(-)-α-bisabolol, electrophilic cyclization |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
This work describes a practical method for intramolecular heterocyclization of the (-)-α-bisabolol to obtain cyclic arylselenoethers and arylthioethers. The electrophilic cyclization addition is promoted by arylselenenyl bromide (ArSeBr) and arylsulfenyl chloride (ArSCl) through electrophilic addition across the terminally disubstituted double bond of the alfa-bisabolol. The cyclization reaction preceeded cleanly and smoothly under mild reaction conditions and provided the cyclic arylselenoethers and arylthioethers with 71% and 47% of yield respectively, employing pyridine as addictive under inert atmosphere. The methodology showed to be highly regioselective since the tetrahydrofuranes were obtained as unique products, presumably because of electronic and conformational factors. It is well known that cyclic ethers are present in the skeletons of several groups of natural compounds exhibiting important biological activities. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-04-20T12:38:31Z |
dc.date.issued.fl_str_mv |
2017-03-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MELO, D. Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla. 2017. 49 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2017. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/7192 |
dc.identifier.dark.fl_str_mv |
ark:/38995/001300000cmxd |
identifier_str_mv |
MELO, D. Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla. 2017. 49 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2017. ark:/38995/001300000cmxd |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/7192 |
dc.language.iso.fl_str_mv |
por |
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por |
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663693921325415158 |
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600 600 600 600 |
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7826066743741197278 |
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1571700325303117195 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Universidade Federal de Goiás |
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Programa de Pós-graduação em Química (IQ) |
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UFG |
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Brasil |
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Instituto de Química - IQ (RG) |
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Universidade Federal de Goiás |
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