Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla

Detalhes bibliográficos
Autor(a) principal: Melo, Diêgo de
Data de Publicação: 2017
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/001300000cmxd
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/7192
Resumo: This work describes a practical method for intramolecular heterocyclization of the (-)-α-bisabolol to obtain cyclic arylselenoethers and arylthioethers. The electrophilic cyclization addition is promoted by arylselenenyl bromide (ArSeBr) and arylsulfenyl chloride (ArSCl) through electrophilic addition across the terminally disubstituted double bond of the alfa-bisabolol. The cyclization reaction preceeded cleanly and smoothly under mild reaction conditions and provided the cyclic arylselenoethers and arylthioethers with 71% and 47% of yield respectively, employing pyridine as addictive under inert atmosphere. The methodology showed to be highly regioselective since the tetrahydrofuranes were obtained as unique products, presumably because of electronic and conformational factors. It is well known that cyclic ethers are present in the skeletons of several groups of natural compounds exhibiting important biological activities.
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spelling Barros, Olga Soares do Rêgohttp://lattes.cnpq.br/8311808341863723Marques, Monique FerreiraQueiroz Júnior, Luiz Henrique Kenghttp://lattes.cnpq.br/9788043570082278Melo, Diêgo de2017-04-20T12:38:31Z2017-03-07MELO, D. Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla. 2017. 49 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2017.http://repositorio.bc.ufg.br/tede/handle/tede/7192ark:/38995/001300000cmxdThis work describes a practical method for intramolecular heterocyclization of the (-)-α-bisabolol to obtain cyclic arylselenoethers and arylthioethers. The electrophilic cyclization addition is promoted by arylselenenyl bromide (ArSeBr) and arylsulfenyl chloride (ArSCl) through electrophilic addition across the terminally disubstituted double bond of the alfa-bisabolol. The cyclization reaction preceeded cleanly and smoothly under mild reaction conditions and provided the cyclic arylselenoethers and arylthioethers with 71% and 47% of yield respectively, employing pyridine as addictive under inert atmosphere. The methodology showed to be highly regioselective since the tetrahydrofuranes were obtained as unique products, presumably because of electronic and conformational factors. It is well known that cyclic ethers are present in the skeletons of several groups of natural compounds exhibiting important biological activities.Este trabalho descreve um método simples para a heterociclização Intramolecular do (-)-α-bisabolol para obtenção de ariltioeteres e arilselenoeteres cíclicos. A ciclização eletrofílica é promovida por brometo de arilselenenila (ArSeBr) e cloreto de arilsulfenila (ArSCl) através da adição eletrofílica na dupla ligação terminal dissubstituída do (-)-α-bisabolol A reação de ciclização procedeu-se sob condições brandas fornecendo arilselenoeteres e ariltioeteres cíclicos com 71% e 47% de rendimento respectivamente, empregando piridina como aditivo, em atmosfera inerte. A metodologia mostrou-se altamente regiosseletiva, uma vez que se obteve como produto principal somente tetrahidrofuranos organocalcogeno funcionalizados em consequência de fatores eletrônicos e conformacionais. Adicionalmente, sabe-se que, os éteres cíclicos estão presentes nos esqueletos de vários grupos de compostos naturais, apresentando importantes atividades biológicas.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-04-20T11:29:02Z No. of bitstreams: 2 Dissertação - Diêgo de Melo - 2017.pdf: 12963482 bytes, checksum: 14979af9bcf3df3d1a038ba4bc54e354 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-04-20T12:38:31Z (GMT) No. of bitstreams: 2 Dissertação - Diêgo de Melo - 2017.pdf: 12963482 bytes, checksum: 14979af9bcf3df3d1a038ba4bc54e354 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-04-20T12:38:31Z (GMT). No. of bitstreams: 2 Dissertação - Diêgo de Melo - 2017.pdf: 12963482 bytes, checksum: 14979af9bcf3df3d1a038ba4bc54e354 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-03-07Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Química (IQ)UFGBrasilInstituto de Química - IQ (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccess(-)-α-bisabolol, ciclização eletrofílica(-)-α-bisabolol, electrophilic cyclizationCIENCIAS EXATAS E DA TERRA::QUIMICASíntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoílaIntramolecular cyclization of alfa-bisabolol promoted by arylselenyl halides or arylthionyl halidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis663693921325415158600600600600782606674374119727815717003253031171952075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla
dc.title.alternative.eng.fl_str_mv Intramolecular cyclization of alfa-bisabolol promoted by arylselenyl halides or arylthionyl halides
title Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla
spellingShingle Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla
Melo, Diêgo de
(-)-α-bisabolol, ciclização eletrofílica
(-)-α-bisabolol, electrophilic cyclization
CIENCIAS EXATAS E DA TERRA::QUIMICA
title_short Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla
title_full Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla
title_fullStr Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla
title_full_unstemmed Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla
title_sort Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla
author Melo, Diêgo de
author_facet Melo, Diêgo de
author_role author
dc.contributor.advisor1.fl_str_mv Barros, Olga Soares do Rêgo
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/8311808341863723
dc.contributor.referee1.fl_str_mv Marques, Monique Ferreira
dc.contributor.referee2.fl_str_mv Queiroz Júnior, Luiz Henrique Keng
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/9788043570082278
dc.contributor.author.fl_str_mv Melo, Diêgo de
contributor_str_mv Barros, Olga Soares do Rêgo
Marques, Monique Ferreira
Queiroz Júnior, Luiz Henrique Keng
dc.subject.por.fl_str_mv (-)-α-bisabolol, ciclização eletrofílica
topic (-)-α-bisabolol, ciclização eletrofílica
(-)-α-bisabolol, electrophilic cyclization
CIENCIAS EXATAS E DA TERRA::QUIMICA
dc.subject.eng.fl_str_mv (-)-α-bisabolol, electrophilic cyclization
dc.subject.cnpq.fl_str_mv CIENCIAS EXATAS E DA TERRA::QUIMICA
description This work describes a practical method for intramolecular heterocyclization of the (-)-α-bisabolol to obtain cyclic arylselenoethers and arylthioethers. The electrophilic cyclization addition is promoted by arylselenenyl bromide (ArSeBr) and arylsulfenyl chloride (ArSCl) through electrophilic addition across the terminally disubstituted double bond of the alfa-bisabolol. The cyclization reaction preceeded cleanly and smoothly under mild reaction conditions and provided the cyclic arylselenoethers and arylthioethers with 71% and 47% of yield respectively, employing pyridine as addictive under inert atmosphere. The methodology showed to be highly regioselective since the tetrahydrofuranes were obtained as unique products, presumably because of electronic and conformational factors. It is well known that cyclic ethers are present in the skeletons of several groups of natural compounds exhibiting important biological activities.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-04-20T12:38:31Z
dc.date.issued.fl_str_mv 2017-03-07
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv MELO, D. Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla. 2017. 49 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2017.
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dc.identifier.dark.fl_str_mv ark:/38995/001300000cmxd
identifier_str_mv MELO, D. Síntese de derivados do bisabolol através de reações de heterociclização intramolecular promovidas por calcogenetos de organoíla. 2017. 49 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2017.
ark:/38995/001300000cmxd
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dc.publisher.initials.fl_str_mv UFG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Instituto de Química - IQ (RG)
publisher.none.fl_str_mv Universidade Federal de Goiás
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