Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/11576 |
Resumo: | Background: Obesity is a complex pathology, in which behavioral, endocrinological, metabolic, genetic and epigenetic factors interact. It is known that the genetic component is responsible for up to 70% of the variation in body mass index (BMI). Genetic polymorphisms that affect dopamine availability and secretion can alter the risk of obesity. Objectives: To determine the allele and genotype frequencies of the polymorphisms of FTO (rs9939609), DRD2 (rs6277) and ANKK1 (rs18000497) genes in children and adolescents from Goiás. To investigate the relationship between pediatric obesity, insulin sensitivity and cardiovascular risk factors (CRF) with the studied genes. Methods: Case-Control study conducted with adolescents and children over five years. The two main groups, Obese (O) and Eutrophic (E), were subdivided according to the value of HOMA-IR into Obese with insulin resistance (ORI) or insulin sensitivity (OSI) and Eutrophic resistant (ERI) or sensitive (ESI) to insulin. According to the presence of two or more CRF, they were subdivided into metabolically unhealthy (MU) or metabolically healthy (MH) groups: OMU, OMH, EMU, EMH. Polymorphisms were determined by real-time PCR or PCR-RFLP. The SPSS program was used for statistical calculations Results: The research assessed 124 obese and 102 eutrophic children and adolescents aged from 5 to 16 years. In the obese group, the higher the number of risk alleles of FTO and ANKK1 genes isolated and the three genes combined, the higher the mean BMI (p<0,0001). Regarding the FTO gene: the frequency of the risk allele was: 57.7%-ERI, 37.4%-ESI (p=0,048), and the homozygous wild genotype was: 29.5%-OMU, 37.5%-OMH (p=0,02). Regarding the DRD2 gene: the genotypes with the risk allele were present in 84.6%-OMU and 67.5%-OMH (p=0,031). Regarding the ANKK1 gene: the frequency of the homozygous risk genotype was current in 15.4%-ERI and 13.5%-ESI (p<0,0001) and 62.5%-EMU and 41.5%-OMH (p=0,031). Conclusions: The risk alleles of the FTO, DRD2 and ANKK1 genes showed an additive effect on the outcome of pediatric obesity in the population of Goiás. In eutrophic individuals, the ANKK1 and FTO genes were associated with insulin resistance. The presence of risk alleles of the ANKK1 and DRD2 genes increased the risk for FRCV in eutrophic and obese individuals, respectively, while the wild allele of the FTO gene had a protective effect for FRCV in obese individuals. |
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Curado, Maria Paulahttp://lattes.cnpq.br/3397823736381748Cruz, Aparecido Divino dahttp://lattes.cnpq.br/7868817504129985Cruz, Aparecido Divino daMinasi, Lysa BernardesGigonzac, Thais Cidália VieiraCosta, Paulo Sérgio Sucasas daMarques, Solomar Martinshttp://lattes.cnpq.br/4273540655925669Pinto, Renata Machado2021-08-26T11:46:57Z2021-08-26T11:46:57Z2020-07-06PINTO, Renata Machado. Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle. 2020. 104 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2020.http://repositorio.bc.ufg.br/tede/handle/tede/11576ark:/38995/0013000001w3pBackground: Obesity is a complex pathology, in which behavioral, endocrinological, metabolic, genetic and epigenetic factors interact. It is known that the genetic component is responsible for up to 70% of the variation in body mass index (BMI). Genetic polymorphisms that affect dopamine availability and secretion can alter the risk of obesity. Objectives: To determine the allele and genotype frequencies of the polymorphisms of FTO (rs9939609), DRD2 (rs6277) and ANKK1 (rs18000497) genes in children and adolescents from Goiás. To investigate the relationship between pediatric obesity, insulin sensitivity and cardiovascular risk factors (CRF) with the studied genes. Methods: Case-Control study conducted with adolescents and children over five years. The two main groups, Obese (O) and Eutrophic (E), were subdivided according to the value of HOMA-IR into Obese with insulin resistance (ORI) or insulin sensitivity (OSI) and Eutrophic resistant (ERI) or sensitive (ESI) to insulin. According to the presence of two or more CRF, they were subdivided into metabolically unhealthy (MU) or metabolically healthy (MH) groups: OMU, OMH, EMU, EMH. Polymorphisms were determined by real-time PCR or PCR-RFLP. The SPSS program was used for statistical calculations Results: The research assessed 124 obese and 102 eutrophic children and adolescents aged from 5 to 16 years. In the obese group, the higher the number of risk alleles of FTO and ANKK1 genes isolated and the three genes combined, the higher the mean BMI (p<0,0001). Regarding the FTO gene: the frequency of the risk allele was: 57.7%-ERI, 37.4%-ESI (p=0,048), and the homozygous wild genotype was: 29.5%-OMU, 37.5%-OMH (p=0,02). Regarding the DRD2 gene: the genotypes with the risk allele were present in 84.6%-OMU and 67.5%-OMH (p=0,031). Regarding the ANKK1 gene: the frequency of the homozygous risk genotype was current in 15.4%-ERI and 13.5%-ESI (p<0,0001) and 62.5%-EMU and 41.5%-OMH (p=0,031). Conclusions: The risk alleles of the FTO, DRD2 and ANKK1 genes showed an additive effect on the outcome of pediatric obesity in the population of Goiás. In eutrophic individuals, the ANKK1 and FTO genes were associated with insulin resistance. The presence of risk alleles of the ANKK1 and DRD2 genes increased the risk for FRCV in eutrophic and obese individuals, respectively, while the wild allele of the FTO gene had a protective effect for FRCV in obese individuals.Introdução: A obesidade é uma patologia complexa, na qual fatores comportamentais, endocrinológicos, metabólicos, genéticos e epigenéticos interagem. Sabe-se que o componente genético é responsável por até 70% da variação do índice de massa corporal (IMC). Polimorfismos genéticos que afetam a disponibilidade e secreção de dopamina podem alterar o risco de obesidade. Objetivos: Determinar as frequências alélica e genotípica dos polimorfismos dos genes FTO (rs9939609), DRD2 (rs6277) e ANKK1 (rs18000497) em crianças e adolescentes goianos. Investigar a relação entre obesidade pediátrica, sensibilidade insulínica e fatores de risco cardiovascular (FRCV) com os genes estudados. Métodos: Estudo tipo Caso-Controle, conduzido com adolescentes e crianças acima de 5 anos de díade. Os dois grupos principais, Obeso (O) e eutrófico (E) foram subdivididos de acordo com o valor de HOMA-IR em Obeso resistente à insulina (ORI) ou sensível à insulina (OSI) e Eutrófico resistente (ERI) ou sensível (ESI) à insulina. De acordo com a presença de dois ou mais FRCV, os grupos foram subdivididos em metabolicamente doentes (MD) ou metabolicamente saudáveis (MS) nos seguintes: OMD, OMS, EMD, EMS. Os polimorfismos foram determinados por PCR em tempo real ou PCR-RFLP. Utilizado o programa SPSS para cálculos estatísticos. Resultados: A pesquisa avaliou crianças e adolescentes com idade entre 5 e 16 anos, sendo 124 obesos e 102 eutróficos. No grupo obeso, quanto maior o número de alelos de risco dos genes FTO e ANKK1 isolados e os três genes combinados, maior o IMC médio (p <0,0001). Em relação ao gene FTO: a frequência do alelo de risco foi: 57,7% -ERI, 37,4% -ESI (p = 0,048), e o genótipo selvagem homozigoto foi: 29,5% -OMD, 37,5% -OMS (p = 0,02 ) Em relação ao gene DRD2: os genótipos com alelo de risco estavam presentes em 84,6% -OMD e 67,5% -OMS (p = 0,031). Em relação ao gene ANKK1: a frequência do genótipo de risco homozigoto estava presente em 15,4% -ERI e 13,5% -ESI (p <0,0001) e 62,5% -EMD e 41,5% -OMS (p = 0,031). Conclusões: Os alelos de risco dos genes FTO, DRD2 e ANKK1 mostraram efeito aditivo no desfecho da obesidade pediátrica na população goiana. Nos eutróficos, os genes ANKK1 e FTO associaram-se a resistência insulínica. A presença dos alelos de risco dos genes ANKK1 e DRD2 aumentou o risco para FRCV em eutróficos e obesos respectivamente, enquanto o alelo selvagem do gene FTO teve efeito protetor para FRCV em obesos.Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2021-08-24T18:14:00Z No. of bitstreams: 2 Tese - Renata Machado Pinto - 2020.pdf: 6526416 bytes, checksum: 1acf6020a9356ec2d2d151cdf5c1b7c7 (MD5) license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2021-08-26T11:46:57Z (GMT) No. of bitstreams: 2 Tese - Renata Machado Pinto - 2020.pdf: 6526416 bytes, checksum: 1acf6020a9356ec2d2d151cdf5c1b7c7 (MD5) license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5)Made available in DSpace on 2021-08-26T11:46:57Z (GMT). No. of bitstreams: 2 Tese - Renata Machado Pinto - 2020.pdf: 6526416 bytes, checksum: 1acf6020a9356ec2d2d151cdf5c1b7c7 (MD5) license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5) Previous issue date: 2020-07-06Fundação de Amparo à Pesquisa do Estado de GoiásporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências da Saúde (FM)UFGBrasilFaculdade de Medicina - FM (RG)Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessObesidade pediátricaPolimorfismo genéticoResistência insulínicaSíndrome metabólicaDopaminaPediatric obesityGenetic polymorphismInsulin resistanceMetabolic syndromeDopamineCIENCIAS DA SAUDE::SAUDE COLETIVA::SAUDE PUBLICAAssociação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controleAssociation of FTO, DRD2 and ANKK1 genes with pediatric obesity and metabolic risk: a case-control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis255005005005001911383reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.bc.ufg.br/tede/bitstreams/86ce8642-00c0-4434-8ed9-99c6f1435ab8/download8a4605be74aa9ea9d79846c1fba20a33MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.bc.ufg.br/tede/bitstreams/78206cc9-62fd-41b3-a3ed-0188d753e6ed/download4460e5956bc1d1639be9ae6146a50347MD52ORIGINALTese - Renata Machado Pinto - 2020.pdfTese - Renata Machado Pinto - 2020.pdfapplication/pdf6526416http://repositorio.bc.ufg.br/tede/bitstreams/08b0fa55-a743-4492-a8d0-922855f3a28c/download1acf6020a9356ec2d2d151cdf5c1b7c7MD53tede/115762021-08-26 08:46:57.93http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accessoai:repositorio.bc.ufg.br:tede/11576http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttp://repositorio.bc.ufg.br/oai/requesttasesdissertacoes.bc@ufg.bropendoar:2021-08-26T11:46:57Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)falseTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |
dc.title.pt_BR.fl_str_mv |
Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle |
dc.title.alternative.eng.fl_str_mv |
Association of FTO, DRD2 and ANKK1 genes with pediatric obesity and metabolic risk: a case-control study |
title |
Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle |
spellingShingle |
Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle Pinto, Renata Machado Obesidade pediátrica Polimorfismo genético Resistência insulínica Síndrome metabólica Dopamina Pediatric obesity Genetic polymorphism Insulin resistance Metabolic syndrome Dopamine CIENCIAS DA SAUDE::SAUDE COLETIVA::SAUDE PUBLICA |
title_short |
Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle |
title_full |
Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle |
title_fullStr |
Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle |
title_full_unstemmed |
Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle |
title_sort |
Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle |
author |
Pinto, Renata Machado |
author_facet |
Pinto, Renata Machado |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Curado, Maria Paula |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3397823736381748 |
dc.contributor.advisor-co1.fl_str_mv |
Cruz, Aparecido Divino da |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/7868817504129985 |
dc.contributor.referee1.fl_str_mv |
Cruz, Aparecido Divino da |
dc.contributor.referee2.fl_str_mv |
Minasi, Lysa Bernardes |
dc.contributor.referee3.fl_str_mv |
Gigonzac, Thais Cidália Vieira |
dc.contributor.referee4.fl_str_mv |
Costa, Paulo Sérgio Sucasas da |
dc.contributor.referee5.fl_str_mv |
Marques, Solomar Martins |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4273540655925669 |
dc.contributor.author.fl_str_mv |
Pinto, Renata Machado |
contributor_str_mv |
Curado, Maria Paula Cruz, Aparecido Divino da Cruz, Aparecido Divino da Minasi, Lysa Bernardes Gigonzac, Thais Cidália Vieira Costa, Paulo Sérgio Sucasas da Marques, Solomar Martins |
dc.subject.por.fl_str_mv |
Obesidade pediátrica Polimorfismo genético Resistência insulínica Síndrome metabólica Dopamina |
topic |
Obesidade pediátrica Polimorfismo genético Resistência insulínica Síndrome metabólica Dopamina Pediatric obesity Genetic polymorphism Insulin resistance Metabolic syndrome Dopamine CIENCIAS DA SAUDE::SAUDE COLETIVA::SAUDE PUBLICA |
dc.subject.eng.fl_str_mv |
Pediatric obesity Genetic polymorphism Insulin resistance Metabolic syndrome Dopamine |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::SAUDE COLETIVA::SAUDE PUBLICA |
description |
Background: Obesity is a complex pathology, in which behavioral, endocrinological, metabolic, genetic and epigenetic factors interact. It is known that the genetic component is responsible for up to 70% of the variation in body mass index (BMI). Genetic polymorphisms that affect dopamine availability and secretion can alter the risk of obesity. Objectives: To determine the allele and genotype frequencies of the polymorphisms of FTO (rs9939609), DRD2 (rs6277) and ANKK1 (rs18000497) genes in children and adolescents from Goiás. To investigate the relationship between pediatric obesity, insulin sensitivity and cardiovascular risk factors (CRF) with the studied genes. Methods: Case-Control study conducted with adolescents and children over five years. The two main groups, Obese (O) and Eutrophic (E), were subdivided according to the value of HOMA-IR into Obese with insulin resistance (ORI) or insulin sensitivity (OSI) and Eutrophic resistant (ERI) or sensitive (ESI) to insulin. According to the presence of two or more CRF, they were subdivided into metabolically unhealthy (MU) or metabolically healthy (MH) groups: OMU, OMH, EMU, EMH. Polymorphisms were determined by real-time PCR or PCR-RFLP. The SPSS program was used for statistical calculations Results: The research assessed 124 obese and 102 eutrophic children and adolescents aged from 5 to 16 years. In the obese group, the higher the number of risk alleles of FTO and ANKK1 genes isolated and the three genes combined, the higher the mean BMI (p<0,0001). Regarding the FTO gene: the frequency of the risk allele was: 57.7%-ERI, 37.4%-ESI (p=0,048), and the homozygous wild genotype was: 29.5%-OMU, 37.5%-OMH (p=0,02). Regarding the DRD2 gene: the genotypes with the risk allele were present in 84.6%-OMU and 67.5%-OMH (p=0,031). Regarding the ANKK1 gene: the frequency of the homozygous risk genotype was current in 15.4%-ERI and 13.5%-ESI (p<0,0001) and 62.5%-EMU and 41.5%-OMH (p=0,031). Conclusions: The risk alleles of the FTO, DRD2 and ANKK1 genes showed an additive effect on the outcome of pediatric obesity in the population of Goiás. In eutrophic individuals, the ANKK1 and FTO genes were associated with insulin resistance. The presence of risk alleles of the ANKK1 and DRD2 genes increased the risk for FRCV in eutrophic and obese individuals, respectively, while the wild allele of the FTO gene had a protective effect for FRCV in obese individuals. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-07-06 |
dc.date.accessioned.fl_str_mv |
2021-08-26T11:46:57Z |
dc.date.available.fl_str_mv |
2021-08-26T11:46:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PINTO, Renata Machado. Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle. 2020. 104 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2020. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/11576 |
dc.identifier.dark.fl_str_mv |
ark:/38995/0013000001w3p |
identifier_str_mv |
PINTO, Renata Machado. Associação dos genes FTO, DRD2 e ANKK1 com risco metabólico e efeito na obesidade pediátrica: estudo tipo caso controle. 2020. 104 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2020. ark:/38995/0013000001w3p |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/11576 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
25 |
dc.relation.confidence.fl_str_mv |
500 500 500 500 |
dc.relation.department.fl_str_mv |
19 |
dc.relation.cnpq.fl_str_mv |
1138 |
dc.relation.sponsorship.fl_str_mv |
3 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Ciências da Saúde (FM) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Faculdade de Medicina - FM (RG) |
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Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
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Universidade Federal de Goiás (UFG) |
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UFG |
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UFG |
reponame_str |
Repositório Institucional da UFG |
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Repositório Institucional da UFG |
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MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
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1811721341836984320 |