Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina

Detalhes bibliográficos
Autor(a) principal: Mercês, Thais Machado das
Data de Publicação: 2019
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/0013000009cfh
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/10305
Resumo: Status epilepticus (SE) is a condition caused by failure of the mechanisms responsible for the termination of the seizure or the onset of the mechanism leading to abnormally prolonged seizures. An epileptic seizure is defined as “the transient occurrence of signs and/or secondary symptoms of abnormal brain neuronal activity”. Epilepsy is a brain syndrome defined by at least one of the following conditions: (1) less than 2 unprovoked epileptic seizures within 24 hours; (2) an unprovoked seizure in individuals who have factors associated with a higher likelihood of having a decreased epileptic threshold; (3) diagnosis of epilepsy syndrome. Individuals with epilepsy are more likely to suffer sudden death, with sudden and unexpected death in epilepsy (SUDEP) a more common category. The pilocarpine-induced epilepsy (PIE) model was the most used to study temporal lobe epilepsy (TLE). The renin angiotensin system (RAS) is known to be involved in some neurodegenerative diseases as well as epilepsy. And, it has been shown that the central nervous system (CNS) areas are responsible for thirst behavior and appetite for waste affected by the epilepsy model. Thus, this study aimed to study cardiovascular control in the face of changes in central levels of angiotensin II (Ang II), carbachol and plasma osmolarity in the PIE model. We used Wistar rats (250-280 g), preused with methylscopolamine (1mg / kg intraperitoneal -ip), after receiving a pilocarpine injection (350 mg / kg-ip) to induce SE. After 3 hours of SE, dizepam (10 mg / kg -i.p.) was injected to stop a seizure. Daily intake of water and 1,8% NaCl, no difference between groups, and body weight were made in which epilepsy group uses a lower weight gain when using a control group (358 ± 13 vs. 406 ± 6 g, respectively). Animals prepared with cannulae directed to the lateral ventricle (VL) were divided into two groups with which cardiovascular records were recorded: one group that removes intracerebroventricular (icv) injection from Ang II and the other one with carbachol. We observed that the pressor response was higher in the epilepsy group when compared to the control after Ang II injection (Epilepsy: 28,0 ± 3,3 vs. Control: 13,3 ± 0,7 mmHg, p <0,05). , a variation in heart rate (ΔHR) was not different between groups. In animals receiving icv carbacol injection, the response was not different between groups, but there was a difference between groups compared with baseline (-0,5 ± 1,4 vs. 22,3 ± 4,6 mmHg, epilepsy and 1,0 ± 2,3 vs. 24,3 ± 4,0 mmHg, control, p <0,05), ΔHR was different between groups (Epilepsy: -24,3 ± 6,1 vs. Control: - 56,3 ± 13,2 bpm), as well as within the control group, comparing their baseline period to the post-carbachol injection period (396,7 ± 17,0 vs. -56,3 ± 13,2 bpm, respectively). In another experiment, the animals were recorded after an intrinsic 12% NaCl overload, which showed a pressure drop at 30, 40 and 50 min in the epilepsy group when compared to 10 minutes after gavage ( 10 ': 5,6 ± 2,9 vs. 30': -8,0 ± 5,3 mmHg; 40 ': -11,5 ± 4,9 mmHg; 50': -9,0 ± 4,5 mmHg ). This was not observed in control animals. Regarding HR there was no difference between the groups, but no group with epilepsy increased after gavage when comparing the times -10, -1, 40, 50 and 60 minutes (10 ': 49,2 ± 23,0 vs. -10 ': 0,0 ± 0,0 bpm; -1': -5,7 ± 11,1 bpm; 40 ': 3,5 ± 7,3 bpm; 50': -7,0 ± 9,6 bpm and 60 ': -5,7 ± 11,3 bpm). Our results suggest that pilocarpine-induced epilepsy is capable of altering angiotensin, carbachol-dependent mechanisms and increased plasma osmolarity, which alter or control harmful blood pressure or corrective substance use and contribute to SUDEP.
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spelling Oliveira, André Henrique Freiria dehttp://lattes.cnpq.br/0152151142555605Colugnati, Diego Basilehttp://lattes.cnpq.br/3875833705952056Almeida, Roberto Lopes deMendes, Elizabeth PereiraOliveira, André Henrique Freiria dehttp://lattes.cnpq.br/1597945297203230Mercês, Thais Machado das2020-01-17T12:10:55Z2019-11-29MERCÊS, T. M. Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina. 2019. 58 f. Dissertação (Mestrado em Ciências Fisiológicas) - Universidade Federal de Goiás, Goiânia, 2019.http://repositorio.bc.ufg.br/tede/handle/tede/10305ark:/38995/0013000009cfhStatus epilepticus (SE) is a condition caused by failure of the mechanisms responsible for the termination of the seizure or the onset of the mechanism leading to abnormally prolonged seizures. An epileptic seizure is defined as “the transient occurrence of signs and/or secondary symptoms of abnormal brain neuronal activity”. Epilepsy is a brain syndrome defined by at least one of the following conditions: (1) less than 2 unprovoked epileptic seizures within 24 hours; (2) an unprovoked seizure in individuals who have factors associated with a higher likelihood of having a decreased epileptic threshold; (3) diagnosis of epilepsy syndrome. Individuals with epilepsy are more likely to suffer sudden death, with sudden and unexpected death in epilepsy (SUDEP) a more common category. The pilocarpine-induced epilepsy (PIE) model was the most used to study temporal lobe epilepsy (TLE). The renin angiotensin system (RAS) is known to be involved in some neurodegenerative diseases as well as epilepsy. And, it has been shown that the central nervous system (CNS) areas are responsible for thirst behavior and appetite for waste affected by the epilepsy model. Thus, this study aimed to study cardiovascular control in the face of changes in central levels of angiotensin II (Ang II), carbachol and plasma osmolarity in the PIE model. We used Wistar rats (250-280 g), preused with methylscopolamine (1mg / kg intraperitoneal -ip), after receiving a pilocarpine injection (350 mg / kg-ip) to induce SE. After 3 hours of SE, dizepam (10 mg / kg -i.p.) was injected to stop a seizure. Daily intake of water and 1,8% NaCl, no difference between groups, and body weight were made in which epilepsy group uses a lower weight gain when using a control group (358 ± 13 vs. 406 ± 6 g, respectively). Animals prepared with cannulae directed to the lateral ventricle (VL) were divided into two groups with which cardiovascular records were recorded: one group that removes intracerebroventricular (icv) injection from Ang II and the other one with carbachol. We observed that the pressor response was higher in the epilepsy group when compared to the control after Ang II injection (Epilepsy: 28,0 ± 3,3 vs. Control: 13,3 ± 0,7 mmHg, p <0,05). , a variation in heart rate (ΔHR) was not different between groups. In animals receiving icv carbacol injection, the response was not different between groups, but there was a difference between groups compared with baseline (-0,5 ± 1,4 vs. 22,3 ± 4,6 mmHg, epilepsy and 1,0 ± 2,3 vs. 24,3 ± 4,0 mmHg, control, p <0,05), ΔHR was different between groups (Epilepsy: -24,3 ± 6,1 vs. Control: - 56,3 ± 13,2 bpm), as well as within the control group, comparing their baseline period to the post-carbachol injection period (396,7 ± 17,0 vs. -56,3 ± 13,2 bpm, respectively). In another experiment, the animals were recorded after an intrinsic 12% NaCl overload, which showed a pressure drop at 30, 40 and 50 min in the epilepsy group when compared to 10 minutes after gavage ( 10 ': 5,6 ± 2,9 vs. 30': -8,0 ± 5,3 mmHg; 40 ': -11,5 ± 4,9 mmHg; 50': -9,0 ± 4,5 mmHg ). This was not observed in control animals. Regarding HR there was no difference between the groups, but no group with epilepsy increased after gavage when comparing the times -10, -1, 40, 50 and 60 minutes (10 ': 49,2 ± 23,0 vs. -10 ': 0,0 ± 0,0 bpm; -1': -5,7 ± 11,1 bpm; 40 ': 3,5 ± 7,3 bpm; 50': -7,0 ± 9,6 bpm and 60 ': -5,7 ± 11,3 bpm). Our results suggest that pilocarpine-induced epilepsy is capable of altering angiotensin, carbachol-dependent mechanisms and increased plasma osmolarity, which alter or control harmful blood pressure or corrective substance use and contribute to SUDEP.O status epilepticus (SE), é uma condição resultante da falha dos mecanismos responsáveis pelo término da crise ou pelo início de mecanismos que levam a crises anormalmente prolongadas. Uma crise epiléptica é definida como “a ocorrência transitória de sinais e/ou sintomas secundários a atividade neuronal cerebral anormal”. A epilepsia é uma síndrome encefálica definida por pelo menos uma das seguintes condições: (1) pelo menos 2 crises epilépticas não provocadas em um intervalo superior a 24 horas; (2) uma convulsão não provocada em indivíduos que possuem fatores associados a uma maior probabilidade de apresentar um limiar epiléptico diminuído; (3) diagnóstico de síndrome da epilepsia. Indivíduos com epilepsia apresentam mais chances de sofrer morte súbita, sendo a morte súbita e inesperada na epilepsia (SUDEP) a categoria mais comum. O modelo de epilepsia induzida por pilocarpina (EIP) têm sido o mais usado para estudar a epilepsia do lobo temporal (ELT). Sabe-se que o sistema renina angiotensina (SRA) está envolvido em algumas doenças neurodegenerativas, bem como na epilepsia. E, já foi demonstrado que áreas do sistema nervoso central (SNC) responsáveis pelo comportamento de sede e apetite ao sódio são afetadas por este modelo de epilepsia. Desta forma, este estudo buscou estudar o controle cardiovascular frente a alterações dos níveis centrais de angiotensina II (Ang II), carbacol e osmolaridade plasmática no modelo EIP. Para isso foram utilizados ratos Wistar (250-280 g), pré tratados com metilescopolamina (1mg/kg intraperitoneal -i.p.) em seguida receberam uma injeção de pilocarpina (350 mg/kg –ip) para indução do SE. Após 3 horas de SE, foi injetado dizepam (10 mg/kg -i.p.) para interromper a crise. Foram feitos o acompanhamento de ingestão diária de água e NaCl 1,8%, em que não foi encontrada diferença entre os grupos, e do peso corporal em que o grupo com epilepsia obteve um ganho de peso menor quando comparado ao grupo controle (358 ± 13 vs. 406 ± 6 g, respectivamente). Animais previamente preparados com cânulas direcionadas ao ventrículo lateral (VL) foram divididos em dois grupos os quais foram submetidos a registro dos parâmetros cardiovasculares: um grupo que recebeu injeção intracerebroventricular (icv) de Ang II e outro de carbacol. Observamos que a resposta pressora foi maior no grupo com epilepsia quando comparado ao controle após a injeção de Ang II (epilepsia: 28,0 ± 3,3 vs. Controle: 13,3 ± 0,7 mmHg, p<0,05), a variação da frequência cardíaca (ΔFC) não foi diferente entre os grupos. Nos animais que receberam injeção icv de carbacol, a resposta pressora não foi diferente entre os grupos, mas houve diferença dentro dos grupos comparando com o basal (-0,5 ± 1,4 vs. 22,3 ± 4,6 mmHg, epilepsia e 1,0 ± 2,3 vs. 24,3 ± 4,0 mmHg, controle, p<0,05), a Δ FC foi diferente entre os grupos (Epilepsia: -24,3 ± 6,1 vs. Controle: -56,3 ± 13,2 bpm), bem como dentro do grupo controle comparando seu período basal ao período pós-injeção de carbacol (396,7 ± 17,0 vs. -56,3 ± 13,2 bpm, respectivamente). Em outro experimento, os animais foram submetidos ao registro após a sobrecarga intragástrica de NaCl 12%, os quais apresentaram uma queda da pressão nos tempos 30, 40 e 50 min no grupo com epilepsia quando comparamos ao período de 10 minutos após a gavagem (10’: 5,6 ± 2,9 vs. 30’: -8,0 ± 5,3 mmHg; 40’: -11,5 ± 4,9 mmHg; 50’: -9,0 ± 4,5 mmHg). Esta queda não foi observada nos animais controle. Quanto à Δ FC não houve diferença entre os grupos, porém no grupo com epilepsia houve um aumento após a gavagem quando comparamos os tempos -10, -1, 40, 50 e 60 minutos (10’: 49,2 ± 23,0 vs. -10’: 0,0 ± 0,0 bpm; -1’: -5,7 ± 11,1 bpm; 40’: 3,5 ± 7,3 bpm; 50’: -7,0 ± 9,6 bpm e 60’: -5,7 ± 11,3 bpm). Nossos resultados sugerem que a epilepsia induzida por pilocarpina é capaz de alterar mecanismos centrais dependentes de angiotensina, carbacol e aumento da osmolaridade plasmática que alteram o controle da pressão arterial prejudicando o organismo em situações corriqueiras e contribuindo para a SUDEP.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2020-01-16T14:53:04Z No. of bitstreams: 2 Dissertação - Thais Machado das Mercês - 2019.pdf: 1445548 bytes, checksum: 13a17863fea129945950cb0b3226b4d8 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2020-01-17T12:10:55Z (GMT) No. of bitstreams: 2 Dissertação - Thais Machado das Mercês - 2019.pdf: 1445548 bytes, checksum: 13a17863fea129945950cb0b3226b4d8 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2020-01-17T12:10:55Z (GMT). No. of bitstreams: 2 Dissertação - Thais Machado das Mercês - 2019.pdf: 1445548 bytes, checksum: 13a17863fea129945950cb0b3226b4d8 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2019-11-29Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPqapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências Fisiológicas - Multicêntrico (ICB)UFGBrasilInstituto de Ciências Biológicas - ICB (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessEpilepsia do lobo temporalPilocarpinaStatus epilepticusSistema renina angiotensinaAngiotensina IICarbacolGavagemPressão arterialFrequência cardíacaTemporal lobe epilepsyPilocarpineStatus epilepticusRenin system angiotensinAngiotensin IICarbacholGavageBlood pressureHeart rateCIENCIAS BIOLOGICAS::FISIOLOGIAControle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpinaHydroelectrolytic control and cardiovascular responses to central angII, carbacol injection and plasma hyperosmolarity in rats with pilocarpine-induced epilepsyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis1337318928839825463600600600600-38727721178273734047737708247419018223-2555911436985713659reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.eng.fl_str_mv Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina
dc.title.alternative.eng.fl_str_mv Hydroelectrolytic control and cardiovascular responses to central angII, carbacol injection and plasma hyperosmolarity in rats with pilocarpine-induced epilepsy
title Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina
spellingShingle Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina
Mercês, Thais Machado das
Epilepsia do lobo temporal
Pilocarpina
Status epilepticus
Sistema renina angiotensina
Angiotensina II
Carbacol
Gavagem
Pressão arterial
Frequência cardíaca
Temporal lobe epilepsy
Pilocarpine
Status epilepticus
Renin system angiotensin
Angiotensin II
Carbachol
Gavage
Blood pressure
Heart rate
CIENCIAS BIOLOGICAS::FISIOLOGIA
title_short Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina
title_full Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina
title_fullStr Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina
title_full_unstemmed Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina
title_sort Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina
author Mercês, Thais Machado das
author_facet Mercês, Thais Machado das
author_role author
dc.contributor.advisor1.fl_str_mv Oliveira, André Henrique Freiria de
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/0152151142555605
dc.contributor.advisor-co1.fl_str_mv Colugnati, Diego Basile
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/3875833705952056
dc.contributor.referee1.fl_str_mv Almeida, Roberto Lopes de
dc.contributor.referee2.fl_str_mv Mendes, Elizabeth Pereira
dc.contributor.referee3.fl_str_mv Oliveira, André Henrique Freiria de
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1597945297203230
dc.contributor.author.fl_str_mv Mercês, Thais Machado das
contributor_str_mv Oliveira, André Henrique Freiria de
Colugnati, Diego Basile
Almeida, Roberto Lopes de
Mendes, Elizabeth Pereira
Oliveira, André Henrique Freiria de
dc.subject.por.fl_str_mv Epilepsia do lobo temporal
Pilocarpina
Status epilepticus
Sistema renina angiotensina
Angiotensina II
Carbacol
Gavagem
Pressão arterial
Frequência cardíaca
topic Epilepsia do lobo temporal
Pilocarpina
Status epilepticus
Sistema renina angiotensina
Angiotensina II
Carbacol
Gavagem
Pressão arterial
Frequência cardíaca
Temporal lobe epilepsy
Pilocarpine
Status epilepticus
Renin system angiotensin
Angiotensin II
Carbachol
Gavage
Blood pressure
Heart rate
CIENCIAS BIOLOGICAS::FISIOLOGIA
dc.subject.eng.fl_str_mv Temporal lobe epilepsy
Pilocarpine
Status epilepticus
Renin system angiotensin
Angiotensin II
Carbachol
Gavage
Blood pressure
Heart rate
dc.subject.cnpq.fl_str_mv CIENCIAS BIOLOGICAS::FISIOLOGIA
description Status epilepticus (SE) is a condition caused by failure of the mechanisms responsible for the termination of the seizure or the onset of the mechanism leading to abnormally prolonged seizures. An epileptic seizure is defined as “the transient occurrence of signs and/or secondary symptoms of abnormal brain neuronal activity”. Epilepsy is a brain syndrome defined by at least one of the following conditions: (1) less than 2 unprovoked epileptic seizures within 24 hours; (2) an unprovoked seizure in individuals who have factors associated with a higher likelihood of having a decreased epileptic threshold; (3) diagnosis of epilepsy syndrome. Individuals with epilepsy are more likely to suffer sudden death, with sudden and unexpected death in epilepsy (SUDEP) a more common category. The pilocarpine-induced epilepsy (PIE) model was the most used to study temporal lobe epilepsy (TLE). The renin angiotensin system (RAS) is known to be involved in some neurodegenerative diseases as well as epilepsy. And, it has been shown that the central nervous system (CNS) areas are responsible for thirst behavior and appetite for waste affected by the epilepsy model. Thus, this study aimed to study cardiovascular control in the face of changes in central levels of angiotensin II (Ang II), carbachol and plasma osmolarity in the PIE model. We used Wistar rats (250-280 g), preused with methylscopolamine (1mg / kg intraperitoneal -ip), after receiving a pilocarpine injection (350 mg / kg-ip) to induce SE. After 3 hours of SE, dizepam (10 mg / kg -i.p.) was injected to stop a seizure. Daily intake of water and 1,8% NaCl, no difference between groups, and body weight were made in which epilepsy group uses a lower weight gain when using a control group (358 ± 13 vs. 406 ± 6 g, respectively). Animals prepared with cannulae directed to the lateral ventricle (VL) were divided into two groups with which cardiovascular records were recorded: one group that removes intracerebroventricular (icv) injection from Ang II and the other one with carbachol. We observed that the pressor response was higher in the epilepsy group when compared to the control after Ang II injection (Epilepsy: 28,0 ± 3,3 vs. Control: 13,3 ± 0,7 mmHg, p <0,05). , a variation in heart rate (ΔHR) was not different between groups. In animals receiving icv carbacol injection, the response was not different between groups, but there was a difference between groups compared with baseline (-0,5 ± 1,4 vs. 22,3 ± 4,6 mmHg, epilepsy and 1,0 ± 2,3 vs. 24,3 ± 4,0 mmHg, control, p <0,05), ΔHR was different between groups (Epilepsy: -24,3 ± 6,1 vs. Control: - 56,3 ± 13,2 bpm), as well as within the control group, comparing their baseline period to the post-carbachol injection period (396,7 ± 17,0 vs. -56,3 ± 13,2 bpm, respectively). In another experiment, the animals were recorded after an intrinsic 12% NaCl overload, which showed a pressure drop at 30, 40 and 50 min in the epilepsy group when compared to 10 minutes after gavage ( 10 ': 5,6 ± 2,9 vs. 30': -8,0 ± 5,3 mmHg; 40 ': -11,5 ± 4,9 mmHg; 50': -9,0 ± 4,5 mmHg ). This was not observed in control animals. Regarding HR there was no difference between the groups, but no group with epilepsy increased after gavage when comparing the times -10, -1, 40, 50 and 60 minutes (10 ': 49,2 ± 23,0 vs. -10 ': 0,0 ± 0,0 bpm; -1': -5,7 ± 11,1 bpm; 40 ': 3,5 ± 7,3 bpm; 50': -7,0 ± 9,6 bpm and 60 ': -5,7 ± 11,3 bpm). Our results suggest that pilocarpine-induced epilepsy is capable of altering angiotensin, carbachol-dependent mechanisms and increased plasma osmolarity, which alter or control harmful blood pressure or corrective substance use and contribute to SUDEP.
publishDate 2019
dc.date.issued.fl_str_mv 2019-11-29
dc.date.accessioned.fl_str_mv 2020-01-17T12:10:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
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dc.identifier.citation.fl_str_mv MERCÊS, T. M. Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina. 2019. 58 f. Dissertação (Mestrado em Ciências Fisiológicas) - Universidade Federal de Goiás, Goiânia, 2019.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/10305
dc.identifier.dark.fl_str_mv ark:/38995/0013000009cfh
identifier_str_mv MERCÊS, T. M. Controle hidroeletrolítico e respostas cardiovasculares à injeção central de angII, carbacol e hiperosmolaridade plasmática em ratos com epilepsia induzida por pilocarpina. 2019. 58 f. Dissertação (Mestrado em Ciências Fisiológicas) - Universidade Federal de Goiás, Goiânia, 2019.
ark:/38995/0013000009cfh
url http://repositorio.bc.ufg.br/tede/handle/tede/10305
dc.language.iso.fl_str_mv por
language por
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600
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dc.relation.cnpq.fl_str_mv 7737708247419018223
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dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Universidade Federal de Goiás
dc.publisher.program.fl_str_mv Programa de Pós-graduação em Ciências Fisiológicas - Multicêntrico (ICB)
dc.publisher.initials.fl_str_mv UFG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Instituto de Ciências Biológicas - ICB (RG)
publisher.none.fl_str_mv Universidade Federal de Goiás
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