CASE REPORT: ALKALINE PHOSPHATASE, ?-GLUTAMYLTRANSFERASE, UREA AND CREATININE SERUM CONCENTRATION IN RABBITS (Oryctolagus cuniculus)

• Autor(a) principal: Emanuelli, Mauren Picada
• Data de Publicação: 2008
• Outros Autores: Lopes, Sonia Terezinha dos Anjos, Maciel, Roberto Marinho, Garmatz, Bruna Carolina, Tavares, Maurício de Oliveira
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Ciência animal brasileira (Online)
• DOI: 10.5216/cab.v9i1.3694
• Texto Completo: https://revistas.ufg.br/vet/article/view/3694
• topic: Sanidade Animal

The enzymes γ-Glutamyltransferase (GGT) and Akaline phosphatase (AP) are serum markers of cholestasis process, becoming an important way of diagnosis in hepatic diseases.  Urea and creatinine are eliminated by urine. When these metabolic elements are higher then normal, it is subside to diagnosis mammals’ renal dysfunction. This present study aimed to establish reference values for these enzymes in rabbits (laboratory animals), to obtain data for their use in scientific experiments. Thus, it was collected blood samples in 45 animals; three samples each one, making a total of 135 blood samples. Serum was separated by immediate centrifugation. Colorimetric method was realized and values from 36.44+/-10.66mg/dl for urea, minimum at 9.24mg/dl and a maximum at 66.06mg/dl; 0.94+/-0.22 mg/dl for creatinine, minimum at 0.51mg/dl and a maximum at 1.53mg/dl; and 72.41+/-29.68UI for AP, minimum at 10.66UI and a maximum at 167.39UI, were determinate. The GGT was determined for kinetic method and values from 6.85+/-3.31, minimum at 2UI and a maximum at 15UI.KEY WORDS: Hepatic function, rabbits, renal function, serum biochemistry