THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II

Detalhes bibliográficos
Autor(a) principal: Santin, Flávia
Data de Publicação: 2010
Outros Autores: Vailati, Maria do Carmo Fernandez, Pinto Rodrigues, Marcela Marcondes, Michelucci, David, Martin, Luis Cuadrado, Schwartz, Denise Saretta
Tipo de documento: Artigo
Idioma: por
Título da fonte: Ciência animal brasileira (Online)
Texto Completo: https://revistas.ufg.br/vet/article/view/4635
Resumo: Angiotensin II (ANGII) is a vasoconstrictor which action on inflammation has been studied. The objective of this study was to verify the stimulation of cyclooxigenase-2 and blood pressure on renal damage by ANGII. Wistar rats were distributed into four groups, as follows: group 1 – control; group 2 – ANGII; group 3 – ANGII + celecoxib; and group 4 – celecoxib. The ANGII was infused in the animals by subcutaneous osmotic mini-pumps during 72 hours. After that, euthanasia was performed. The blood pressure was measured before the drugs administration and before the euthanasia. Histopathological and immunohistochemical evaluations were performed in kidneys to assess the expression of COX-2. It was concluded that ANGII caused renal damage, regardless of blood pressure values. ANGII associated with celeboxib increased blood pressure. Celecoxib did not protect the kidneys against ANGII activities.KEYWORDS: Blood pressure, celecoxib, nephrotoxicity.
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spelling THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN IIO PAPEL DA CICLOOXIGENASE-2 E DA PRESSÃO ARTERIAL NA LESÃO RENAL DE RATOS SUBMETIDOS À INFUSÃO CONTÍNUA DE ANGIOTENSINA IIAnimal Sanityanimais de experimentaçãoAngiotensin II (ANGII) is a vasoconstrictor which action on inflammation has been studied. The objective of this study was to verify the stimulation of cyclooxigenase-2 and blood pressure on renal damage by ANGII. Wistar rats were distributed into four groups, as follows: group 1 – control; group 2 – ANGII; group 3 – ANGII + celecoxib; and group 4 – celecoxib. The ANGII was infused in the animals by subcutaneous osmotic mini-pumps during 72 hours. After that, euthanasia was performed. The blood pressure was measured before the drugs administration and before the euthanasia. Histopathological and immunohistochemical evaluations were performed in kidneys to assess the expression of COX-2. It was concluded that ANGII caused renal damage, regardless of blood pressure values. ANGII associated with celeboxib increased blood pressure. Celecoxib did not protect the kidneys against ANGII activities.KEYWORDS: Blood pressure, celecoxib, nephrotoxicity.A angiotensina II (ANGII) é um vasoconstritor, entretanto, sua atuação na inflamação tem sido estudada. Objetivou-se verificar o estímulo da ciclooxigenase-2 e da pressão arterial na lesão renal por ANGII. Para tanto, utilizaram-se ratos Wistar, distribuídos no grupo 1: controle, grupo 2: ANGII, grupo 3: ANGII + celecoxibe, grupo 4: celecoxibe. A ANGII foi administrada via minibomba no subcutâneo dos animais durante 72 horas, sendo então realizada a eutanásia. A pressão arterial foi aferida antes da administração dos fármacos e antes da eutanásia. Colheram-se os rins dos animais para histopatologia e para imunoistoquímica, avaliando-se a expressão de COX-2. Concluiu-se que a ANGII promoveu lesões renais, independentemente dos valores da pressão arterial; ANGII associada ao celecoxibe levou ao aumento da pressão arterial. O celecoxibe não protegeu os rins contra as ações da angiotensina II. PALAVRAS-CHAVES: Celecoxibe, nefrotoxicidade, pressão arterial.Universidade Federal de Goiás2010-12-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionResearchAvaliado por parespesquisa científicaapplication/pdftext/htmlhttps://revistas.ufg.br/vet/article/view/463510.5216/cab.v11i4.4635Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 11 No. 4 (2010); 867 - 873Ciência Animal Brasileira / Brazilian Animal Science; v. 11 n. 4 (2010); 867 - 8731809-68911518-2797reponame:Ciência animal brasileira (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporhttps://revistas.ufg.br/vet/article/view/4635/8361https://revistas.ufg.br/vet/article/view/4635/8728Santin, FláviaVailati, Maria do Carmo FernandezPinto Rodrigues, Marcela MarcondesMichelucci, DavidMartin, Luis CuadradoSchwartz, Denise Sarettainfo:eu-repo/semantics/openAccess2010-12-21T13:36:26Zoai:ojs.revistas.ufg.br:article/4635Revistahttps://revistas.ufg.br/vetPUBhttps://revistas.ufg.br/vet/oai||revistacab@gmail.com1809-68911518-2797opendoar:2024-05-21T19:55:16.677269Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)true
dc.title.none.fl_str_mv THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II
O PAPEL DA CICLOOXIGENASE-2 E DA PRESSÃO ARTERIAL NA LESÃO RENAL DE RATOS SUBMETIDOS À INFUSÃO CONTÍNUA DE ANGIOTENSINA II
title THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II
spellingShingle THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II
Santin, Flávia
Animal Sanity
animais de experimentação
title_short THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II
title_full THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II
title_fullStr THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II
title_full_unstemmed THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II
title_sort THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II
author Santin, Flávia
author_facet Santin, Flávia
Vailati, Maria do Carmo Fernandez
Pinto Rodrigues, Marcela Marcondes
Michelucci, David
Martin, Luis Cuadrado
Schwartz, Denise Saretta
author_role author
author2 Vailati, Maria do Carmo Fernandez
Pinto Rodrigues, Marcela Marcondes
Michelucci, David
Martin, Luis Cuadrado
Schwartz, Denise Saretta
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santin, Flávia
Vailati, Maria do Carmo Fernandez
Pinto Rodrigues, Marcela Marcondes
Michelucci, David
Martin, Luis Cuadrado
Schwartz, Denise Saretta
dc.subject.por.fl_str_mv Animal Sanity
animais de experimentação
topic Animal Sanity
animais de experimentação
description Angiotensin II (ANGII) is a vasoconstrictor which action on inflammation has been studied. The objective of this study was to verify the stimulation of cyclooxigenase-2 and blood pressure on renal damage by ANGII. Wistar rats were distributed into four groups, as follows: group 1 – control; group 2 – ANGII; group 3 – ANGII + celecoxib; and group 4 – celecoxib. The ANGII was infused in the animals by subcutaneous osmotic mini-pumps during 72 hours. After that, euthanasia was performed. The blood pressure was measured before the drugs administration and before the euthanasia. Histopathological and immunohistochemical evaluations were performed in kidneys to assess the expression of COX-2. It was concluded that ANGII caused renal damage, regardless of blood pressure values. ANGII associated with celeboxib increased blood pressure. Celecoxib did not protect the kidneys against ANGII activities.KEYWORDS: Blood pressure, celecoxib, nephrotoxicity.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Research
Avaliado por pares
pesquisa científica
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistas.ufg.br/vet/article/view/4635
10.5216/cab.v11i4.4635
url https://revistas.ufg.br/vet/article/view/4635
identifier_str_mv 10.5216/cab.v11i4.4635
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistas.ufg.br/vet/article/view/4635/8361
https://revistas.ufg.br/vet/article/view/4635/8728
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Universidade Federal de Goiás
publisher.none.fl_str_mv Universidade Federal de Goiás
dc.source.none.fl_str_mv Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 11 No. 4 (2010); 867 - 873
Ciência Animal Brasileira / Brazilian Animal Science; v. 11 n. 4 (2010); 867 - 873
1809-6891
1518-2797
reponame:Ciência animal brasileira (Online)
instname:Universidade Federal de Goiás (UFG)
instacron:UFG
instname_str Universidade Federal de Goiás (UFG)
instacron_str UFG
institution UFG
reponame_str Ciência animal brasileira (Online)
collection Ciência animal brasileira (Online)
repository.name.fl_str_mv Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)
repository.mail.fl_str_mv ||revistacab@gmail.com
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