Efeito da terapia complementar com probióticos sobre a composição corporal e a atividade das enzimas antioxidantes de mulheres com excesso de peso

• Autor(a) principal: Gomes, Aline Corado
• Data de Publicação: 2014
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/3967
• topic: Obesidade; Probióticos; Estresse oxidativo; Obesity; Probiotic; Oxidative stress; CIENCIAS DA SAUDE::NUTRICAO

Obesity isan inflammatory diseaserelated toexcessive and unhealthy eating that changes gut microbiota. Objectives:to evaluate the effectof a mix probioticadministrationassociated to dietery interventionon thebiochemical markers, body composition, lipopolysaccharide and antioxidant enzymes activities in overweight and obese women.Material and methods:Randomized clinicaldouble-blind, placebo-controlled with a duration of two months, consisting of 43adult overweight and obesewomenrandomized intoplacebo group(GP): maltodextrin200mg/day andsupplemented group: 2x1010 CFU probiotics/day (Lactobacilos acidophillusand casei, Lactococcus lactis; Bifidobacterium bifidum and lactis) Both groups received normocaloric dietary prescription. The body composition was assessed by the body mass index,waist circumference and Dual-energy X-ray absorptiometry. Blood samples were collected to determination of lipid profile, urea, creatinine,glycated hemoglobin,lipopolysaccharide and superoxide dismutase, catalase and glutathione peroxidaseactivities. The differencebetween groupswas determinedby Student t test or Mann Whitney, andintragroup analysis bythe paired t test or Wilcoxon, consideringp<0.05. Results:At baseline, the groups did not differ regarding to body composition. GP and GS showed a reduction in body weight, %fat, BMI, waist circumference and serum concentrations of urea, creatinine and glycated hemoglobin, furthermore both groupspresented in increase in %lean mass. However, only in GS it was observed a reduction in fat mass, serum LDL, Castelli I and IIindex, and an increase in superoxide dismutaseactivity. When compared to GP, GS showed a reduction in waist circumference and an increase in the activity of glutathione peroxidase. Conclusion:Probiotic mix supplementation associated with dietary intervention reduced abdominal adiposity and cardiovascular risk markers in a more effective way than dietary intervention alone.