Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years study

Detalhes bibliográficos
Autor(a) principal: Dias, Vanessa Cordeiro
Data de Publicação: 2020
Outros Autores: Netto Bastos, Andre, Gomes Cotta, Robert, Villela Bastos, Ricardo, Quinet de Andrade Bastos, Victor, Quinet de Andrade Bastos, Lucas
Tipo de documento: Artigo
Idioma: por
Título da fonte: HU Revista (Online)
Texto Completo: https://periodicos.ufjf.br/index.php/hurevista/article/view/27338
Resumo: Introduction: Stenotrophomonas maltophilia is an emerging opportunistic pathogen, mainly associated with nosocomial infections. Therapeutic options for the treatment of S. maltophilia infections are limited because of their resistance to a wide variety of antibiotics. Objective: To investigate the prevalence and antibiotic resistance of isolates identified as S. maltophilia from hospitalized patients recovered from a clinical laboratory located in Juiz de Fora - Minas Gerais, as well as to analyze epidemiological data of these patients. Materials and Methods: Consecutive, non duplicate isolates of S. maltophilia (n=58) for the 10-year period were analyzed. All samples were identified using the automated Vitek 2® Compact system (BioMérieux/France). Antibiotic resistance standards were performed using the disk diffusion method. Patient records were evaluated and data such as age, gender, clinical specimen, and in-hospital death rate attributed to S. maltophilia infection were also analyzed. Results: From a total of 39,547 (100%) clinical specimens analyzed, 58 (0,14%) unreplicated isolates were identified as S. maltophilia. 70,6% of S. maltophilia isolates were isolated from tracheal secretion and 15,5% from blood. All samples were sensitive in vitro to the antibiotics tested. In-hospital death frequency associated with S. maltophilia infection was 44,7%. Individuals from a wide age range (0-100 years) were affected by S. maltophilia infection, with females being the most prevalent (56,9%). Conclusion: Pneumonia and Bacteremia were the most frequent clinical syndromes caused by S. maltophila. A moderate mortality rate associated with S. maltophila infections was observed, despite the high sensitivity in vitro to the antibiotics tested. New studies are necessary in order to generate data and information that may be useful in early diagnosis, management and correct treatment of infections associated with S. maltophila, especially those with a profile of antibiotic resistance.
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spelling Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years studyPrevalência e resistência a antibióticos de Stenotrophomonas maltophilia em amostras clínicas: estudo epidemiológico de 10 anosStenotrophomonas maltophiliaAnti-Bacterial AgenstStenotrophomonas maltophiliaAntibacterianosIntroduction: Stenotrophomonas maltophilia is an emerging opportunistic pathogen, mainly associated with nosocomial infections. Therapeutic options for the treatment of S. maltophilia infections are limited because of their resistance to a wide variety of antibiotics. Objective: To investigate the prevalence and antibiotic resistance of isolates identified as S. maltophilia from hospitalized patients recovered from a clinical laboratory located in Juiz de Fora - Minas Gerais, as well as to analyze epidemiological data of these patients. Materials and Methods: Consecutive, non duplicate isolates of S. maltophilia (n=58) for the 10-year period were analyzed. All samples were identified using the automated Vitek 2® Compact system (BioMérieux/France). Antibiotic resistance standards were performed using the disk diffusion method. Patient records were evaluated and data such as age, gender, clinical specimen, and in-hospital death rate attributed to S. maltophilia infection were also analyzed. Results: From a total of 39,547 (100%) clinical specimens analyzed, 58 (0,14%) unreplicated isolates were identified as S. maltophilia. 70,6% of S. maltophilia isolates were isolated from tracheal secretion and 15,5% from blood. All samples were sensitive in vitro to the antibiotics tested. In-hospital death frequency associated with S. maltophilia infection was 44,7%. Individuals from a wide age range (0-100 years) were affected by S. maltophilia infection, with females being the most prevalent (56,9%). Conclusion: Pneumonia and Bacteremia were the most frequent clinical syndromes caused by S. maltophila. A moderate mortality rate associated with S. maltophila infections was observed, despite the high sensitivity in vitro to the antibiotics tested. New studies are necessary in order to generate data and information that may be useful in early diagnosis, management and correct treatment of infections associated with S. maltophila, especially those with a profile of antibiotic resistance.Introdução: Stenotrophomonas maltophilia é um patógeno oportunista emergente, associado, principalmente, a infecções nosocomiais. As opções terapêuticas para o tratamento de infecções por S. maltophilia são limitadas, devido a sua resistência a uma grande variedade de antibióticos.Objetivo: investigar a prevalência e a resistência aos antibióticos de isolados identificados como S. maltophilia, a partir de pacientes hospitalizados, recuperados em um laboratório clínico, localizado em Juiz de Fora – Minas Gerais, bem como analisar dados epidemiológicos destes pacientes.Materiais e Métodos: Isolados consecutivos, não duplicados de S. maltophilia (n=58),referentes ao período de 10 anos foram analisados. Todas as amostras foram identificadas utilizando o sistema automatizado Vitek 2® Compact (BioMérieux/França). Os padrões de resistência aos antibióticos foram realizados utilizando o método de disco difusão. Os prontuários dos pacientes foram avaliados e dados como idade, sexo, espécime clínico, bem como índice de óbito intra-hospitalar atribuído à infecção por S. maltophilia foi igualmente analisado. Resultados: De um total de 39.547 (100%) espécimes clínicos analisados, 58 (0,14%) isolados não replicados foram identificados como S. maltophilia. 70,6% dos isolados de S. maltophilia foram isolados de secreção traqueal e 15,5% de sangue.Todas as amostras foram sensíveis, in vitro, aos antibióticos testados.Frequência de óbito intra-hospitalar associado à infecção por S. maltophilia foi de 44,7%. Indivíduos de ampla faixa etária (0-100 anos) foram acometidos por infecção por S. maltophilia, sendo o sexo feminino o mais prevalente (56,9%). Conclusão: Pneumonia e bacteremia foram as síndromes clínicas mais frequentes causadas por S. maltophila. Constatou-se moderada taxa de mortalidade associada a infecções por S. maltophilia, apesar da alta sensibilidade in vitro aos antibióticos testados. Novos trabalhos se fazem necessários, a fim de gerar dados e informações que possam ser úteis no diagnóstico precoce, manejo e tratamento correto de infecções associadas a S. maltophilia, em especial aquelas com perfil de resistência aos antibóticos.Editora UFJF2020-02-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtOrapplication/pdfhttps://periodicos.ufjf.br/index.php/hurevista/article/view/2733810.34019/1982-8047.2019.v45.27338HU Revista; v. 45 n. 4 (2019); 402-4071982-80470103-3123reponame:HU Revista (Online)instname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFporhttps://periodicos.ufjf.br/index.php/hurevista/article/view/27338/20084Copyright (c) 2020 Vanessa Cordeiro Dias, Andre Netto Bastos, Robert Gomes Cotta, Ricardo Villela Bastos, Victor Quinet de Andrade Bastos, Lucas Quinet de Andrade Bastosinfo:eu-repo/semantics/openAccessDias, Vanessa Cordeiro Netto Bastos, Andre Gomes Cotta, RobertVillela Bastos, Ricardo Quinet de Andrade Bastos, Victor Quinet de Andrade Bastos, Lucas2020-06-16T12:58:48Zoai:periodicos.ufjf.br:article/27338Revistahttps://periodicos.ufjf.br/index.php/hurevistaPUBhttps://periodicos.ufjf.br/index.php/hurevista/oairevista.hurevista@ufjf.edu.br1982-80470103-3123opendoar:2020-06-16T12:58:48HU Revista (Online) - Universidade Federal de Juiz de Fora (UFJF)false
dc.title.none.fl_str_mv Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years study
Prevalência e resistência a antibióticos de Stenotrophomonas maltophilia em amostras clínicas: estudo epidemiológico de 10 anos
title Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years study
spellingShingle Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years study
Dias, Vanessa Cordeiro
Stenotrophomonas maltophilia
Anti-Bacterial Agenst
Stenotrophomonas maltophilia
Antibacterianos
title_short Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years study
title_full Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years study
title_fullStr Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years study
title_full_unstemmed Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years study
title_sort Epidemiological and physiological characteristics of clinical isolates of Stenotrophomonas maltophilia: 10 years study
author Dias, Vanessa Cordeiro
author_facet Dias, Vanessa Cordeiro
Netto Bastos, Andre
Gomes Cotta, Robert
Villela Bastos, Ricardo
Quinet de Andrade Bastos, Victor
Quinet de Andrade Bastos, Lucas
author_role author
author2 Netto Bastos, Andre
Gomes Cotta, Robert
Villela Bastos, Ricardo
Quinet de Andrade Bastos, Victor
Quinet de Andrade Bastos, Lucas
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Dias, Vanessa Cordeiro
Netto Bastos, Andre
Gomes Cotta, Robert
Villela Bastos, Ricardo
Quinet de Andrade Bastos, Victor
Quinet de Andrade Bastos, Lucas
dc.subject.por.fl_str_mv Stenotrophomonas maltophilia
Anti-Bacterial Agenst
Stenotrophomonas maltophilia
Antibacterianos
topic Stenotrophomonas maltophilia
Anti-Bacterial Agenst
Stenotrophomonas maltophilia
Antibacterianos
description Introduction: Stenotrophomonas maltophilia is an emerging opportunistic pathogen, mainly associated with nosocomial infections. Therapeutic options for the treatment of S. maltophilia infections are limited because of their resistance to a wide variety of antibiotics. Objective: To investigate the prevalence and antibiotic resistance of isolates identified as S. maltophilia from hospitalized patients recovered from a clinical laboratory located in Juiz de Fora - Minas Gerais, as well as to analyze epidemiological data of these patients. Materials and Methods: Consecutive, non duplicate isolates of S. maltophilia (n=58) for the 10-year period were analyzed. All samples were identified using the automated Vitek 2® Compact system (BioMérieux/France). Antibiotic resistance standards were performed using the disk diffusion method. Patient records were evaluated and data such as age, gender, clinical specimen, and in-hospital death rate attributed to S. maltophilia infection were also analyzed. Results: From a total of 39,547 (100%) clinical specimens analyzed, 58 (0,14%) unreplicated isolates were identified as S. maltophilia. 70,6% of S. maltophilia isolates were isolated from tracheal secretion and 15,5% from blood. All samples were sensitive in vitro to the antibiotics tested. In-hospital death frequency associated with S. maltophilia infection was 44,7%. Individuals from a wide age range (0-100 years) were affected by S. maltophilia infection, with females being the most prevalent (56,9%). Conclusion: Pneumonia and Bacteremia were the most frequent clinical syndromes caused by S. maltophila. A moderate mortality rate associated with S. maltophila infections was observed, despite the high sensitivity in vitro to the antibiotics tested. New studies are necessary in order to generate data and information that may be useful in early diagnosis, management and correct treatment of infections associated with S. maltophila, especially those with a profile of antibiotic resistance.
publishDate 2020
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url https://periodicos.ufjf.br/index.php/hurevista/article/view/27338
identifier_str_mv 10.34019/1982-8047.2019.v45.27338
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://periodicos.ufjf.br/index.php/hurevista/article/view/27338/20084
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publisher.none.fl_str_mv Editora UFJF
dc.source.none.fl_str_mv HU Revista; v. 45 n. 4 (2019); 402-407
1982-8047
0103-3123
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instname:Universidade Federal de Juiz de Fora (UFJF)
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