Prevalence of positive screening for Cushing's syndrome in obese individuals who are candidates for bariatric surgery

• Autor(a) principal: Andrade, Marcella Menezes
• Data de Publicação: 2020
• Outros Autores: Mota Tiburcio, Beatriz, Alves Lima, Vinícius, Pinheiro Neiva, Silvana, Andrade Fernandes, Cláudia Maria
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: HU Revista (Online)
• Texto Completo: https://periodicos.ufjf.br/index.php/hurevista/article/view/25987
• topic: Cushing's Syndrome; Obesity, Morbid; Bariatric Surgery; Síndrome de Cushing; Obesidade Mórbida; Cirurgia Bariátrica

Introduction: Obesity affects more than a third of Americans and its prevalence is increasing in Brazilians. In severe cases, bariatric surgery is considered the most successful and long-lasting treatment. During the preoperative evaluation, secondary causes of obesity should be investigated and, specifically in Brazil, Cushing's Syndrome (CS) should be excluded in these patients, despite controversial recommendations for CS screening in current guidelines. The prevalence of endogenous SC is extremely low, but appears to be higher in specific populations, such as diabetics, patients with resistant hypertension or those with obesity. Aim: To evaluate the prevalence of positive screening for CS in obese candidates for bariatric surgery and to discuss possible risk factors or comorbidities associated with screening positivity. Material and methods: A retrospective study was conducted with 629 patients attended at the Obesity Outpatient Clinic of Santa Casa, Belo Horizonte between 2008 and 2016. CS screening was performed with a 1mg dexamethasone (1mg-DST) suppression test, dosing cortisol in the next morning (cut-off point ≥1.8μg / dL). Results: 80 of the 629 patients had positive screening for SC. Of these, 20 patients were considered negative after repeated 1mg-DST and 6 patients were negative after the Liddle 1 test. Conclusion: The prevalence of positive screening for SC was 12.7%, similar to the literature. No risk factor or co-morbidity could be directly associated with the positivity of the screening test.