Obesity: an inflammatory and microbial approach

• Autor(a) principal: Lutkemeyer, Diego da Silva
• Data de Publicação: 2019
• Outros Autores: do Amaral, Mariana Abrantes, Ishida Assunção, Nathalia Hiromi, Marques Tejada, Nathália Franchon, Saraiva Camara, Niels Olsen
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: HU Revista (Online)
• Texto Completo: https://periodicos.ufjf.br/index.php/hurevista/article/view/13963
• topic: Immunology; Obesity; Inflammation; Microbiota; Imunologia; Obesidade; Inflamação; Microbiota

Obesity is closely linked to an inflammatory state, being considered a complex metabolic pathology. Hypercaloric diets alter the composition of intestinal microbiota, and the change in the proportion of bacteria from the Bacteroidetes and Firmicutes phyla is one of the most known consequences. This change causes the production of specific immune system metabolites, inducing an inflammatory state which is responsible for aggravating some diseases. The hypercaloric diet represents a risk factor for obesity and diabetes mellitus, diseases linked by the concept of lipotoxicity, and the inflammatory state also contributes to the onset and to the progression of cardiovascular diseases. In this article, we aim to study obesity from the immunological and microbiological perspective, addressing the consequences of hypercaloric diets on the inflammatory state and microbiota. In addition, to analyze the role of microbiome change in prevalent diseases like diabetes mellitus and cardiovascular diseases, pointing out potential therapeutic approaches.