Histological patterns of cutaneous adverse drug reactions
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | HU Revista (Online) |
Texto Completo: | https://periodicos.ufjf.br/index.php/hurevista/article/view/657 |
Resumo: | Cutaneous adverse drug reactions (ADR) are skin conditions due to a drug, regardless of the way of administration. Knowledge about their frequency, clinical manifestations and histopathological patterns is essential for prevention and early diagnosis, avoiding complications and reducing morbidity. This work assessed the incidence of cutaneous ADR in skin biopsies from patients with dermatitis, and determined their histopathological patterns. Skin biopsies from patients with dermatitis, obtained in the years 2006-2007 at the Pathology Division of the HU/UFJF, were analyzed. The different histopathological patterns were grouped, the cases were statistically analyzed and a clinicopathological matching was attempted. Of the 1409 skin biopsies, 304 cases of dermatitis were diagnosed, 31 corresponding to cutaneous ADR. The most frequent histopathological pattern was vacuolar interface dermatitis (41.9%). The most frequently involved drug was captopril. Identification of histopathological patterns and anatomoclinical correlation are indispensable for the differential between cutaneous ADR and the other dermatitidis, allowing for an early and precise diagnosis and reducing treatment and hospitalization costs. |
id |
UFJF-8_6510e6e3cf0fbd99fa70aeba045644c9 |
---|---|
oai_identifier_str |
oai:periodicos.ufjf.br:article/657 |
network_acronym_str |
UFJF-8 |
network_name_str |
HU Revista (Online) |
repository_id_str |
|
spelling |
Histological patterns of cutaneous adverse drug reactionsDrug effectsDrug EruptionsPathologyCutaneous adverse drug reactions (ADR) are skin conditions due to a drug, regardless of the way of administration. Knowledge about their frequency, clinical manifestations and histopathological patterns is essential for prevention and early diagnosis, avoiding complications and reducing morbidity. This work assessed the incidence of cutaneous ADR in skin biopsies from patients with dermatitis, and determined their histopathological patterns. Skin biopsies from patients with dermatitis, obtained in the years 2006-2007 at the Pathology Division of the HU/UFJF, were analyzed. The different histopathological patterns were grouped, the cases were statistically analyzed and a clinicopathological matching was attempted. Of the 1409 skin biopsies, 304 cases of dermatitis were diagnosed, 31 corresponding to cutaneous ADR. The most frequent histopathological pattern was vacuolar interface dermatitis (41.9%). The most frequently involved drug was captopril. Identification of histopathological patterns and anatomoclinical correlation are indispensable for the differential between cutaneous ADR and the other dermatitidis, allowing for an early and precise diagnosis and reducing treatment and hospitalization costs.Editora UFJF2010-04-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtOrpesquisa exploratóriaapplication/pdfapplication/mswordapplication/mswordhttps://periodicos.ufjf.br/index.php/hurevista/article/view/657HU Revista; v. 35 n. 4 (2009)1982-80470103-3123reponame:HU Revista (Online)instname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFporhttps://periodicos.ufjf.br/index.php/hurevista/article/view/657/286https://periodicos.ufjf.br/index.php/hurevista/article/view/657/15039https://periodicos.ufjf.br/index.php/hurevista/article/view/657/15040Cupolilo, Sonia Maria NeumannRezende, Adymila Salim MoreiraAlmeida, Andréia MunckGomide, Bruna OliveiraCardoso, Cristiane BuchemiTavares, Natália Pinhoinfo:eu-repo/semantics/openAccess2023-05-04T03:53:20Zoai:periodicos.ufjf.br:article/657Revistahttps://periodicos.ufjf.br/index.php/hurevistaPUBhttps://periodicos.ufjf.br/index.php/hurevista/oairevista.hurevista@ufjf.edu.br1982-80470103-3123opendoar:2023-05-04T03:53:20HU Revista (Online) - Universidade Federal de Juiz de Fora (UFJF)false |
dc.title.none.fl_str_mv |
Histological patterns of cutaneous adverse drug reactions |
title |
Histological patterns of cutaneous adverse drug reactions |
spellingShingle |
Histological patterns of cutaneous adverse drug reactions Cupolilo, Sonia Maria Neumann Drug effects Drug Eruptions Pathology |
title_short |
Histological patterns of cutaneous adverse drug reactions |
title_full |
Histological patterns of cutaneous adverse drug reactions |
title_fullStr |
Histological patterns of cutaneous adverse drug reactions |
title_full_unstemmed |
Histological patterns of cutaneous adverse drug reactions |
title_sort |
Histological patterns of cutaneous adverse drug reactions |
author |
Cupolilo, Sonia Maria Neumann |
author_facet |
Cupolilo, Sonia Maria Neumann Rezende, Adymila Salim Moreira Almeida, Andréia Munck Gomide, Bruna Oliveira Cardoso, Cristiane Buchemi Tavares, Natália Pinho |
author_role |
author |
author2 |
Rezende, Adymila Salim Moreira Almeida, Andréia Munck Gomide, Bruna Oliveira Cardoso, Cristiane Buchemi Tavares, Natália Pinho |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Cupolilo, Sonia Maria Neumann Rezende, Adymila Salim Moreira Almeida, Andréia Munck Gomide, Bruna Oliveira Cardoso, Cristiane Buchemi Tavares, Natália Pinho |
dc.subject.por.fl_str_mv |
Drug effects Drug Eruptions Pathology |
topic |
Drug effects Drug Eruptions Pathology |
description |
Cutaneous adverse drug reactions (ADR) are skin conditions due to a drug, regardless of the way of administration. Knowledge about their frequency, clinical manifestations and histopathological patterns is essential for prevention and early diagnosis, avoiding complications and reducing morbidity. This work assessed the incidence of cutaneous ADR in skin biopsies from patients with dermatitis, and determined their histopathological patterns. Skin biopsies from patients with dermatitis, obtained in the years 2006-2007 at the Pathology Division of the HU/UFJF, were analyzed. The different histopathological patterns were grouped, the cases were statistically analyzed and a clinicopathological matching was attempted. Of the 1409 skin biopsies, 304 cases of dermatitis were diagnosed, 31 corresponding to cutaneous ADR. The most frequent histopathological pattern was vacuolar interface dermatitis (41.9%). The most frequently involved drug was captopril. Identification of histopathological patterns and anatomoclinical correlation are indispensable for the differential between cutaneous ADR and the other dermatitidis, allowing for an early and precise diagnosis and reducing treatment and hospitalization costs. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-04-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ArtOr pesquisa exploratória |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufjf.br/index.php/hurevista/article/view/657 |
url |
https://periodicos.ufjf.br/index.php/hurevista/article/view/657 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.ufjf.br/index.php/hurevista/article/view/657/286 https://periodicos.ufjf.br/index.php/hurevista/article/view/657/15039 https://periodicos.ufjf.br/index.php/hurevista/article/view/657/15040 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/msword application/msword |
dc.publisher.none.fl_str_mv |
Editora UFJF |
publisher.none.fl_str_mv |
Editora UFJF |
dc.source.none.fl_str_mv |
HU Revista; v. 35 n. 4 (2009) 1982-8047 0103-3123 reponame:HU Revista (Online) instname:Universidade Federal de Juiz de Fora (UFJF) instacron:UFJF |
instname_str |
Universidade Federal de Juiz de Fora (UFJF) |
instacron_str |
UFJF |
institution |
UFJF |
reponame_str |
HU Revista (Online) |
collection |
HU Revista (Online) |
repository.name.fl_str_mv |
HU Revista (Online) - Universidade Federal de Juiz de Fora (UFJF) |
repository.mail.fl_str_mv |
revista.hurevista@ufjf.edu.br |
_version_ |
1796798240101761024 |