Perinatal Group B streptococcal disease: clinical-microbiological aspects and prevention
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | HU Revista (Online) |
Texto Completo: | https://periodicos.ufjf.br/index.php/hurevista/article/view/104 |
Resumo: | Lancefield group B streptococci (GBS, or Streptococcus agalactiae) are Gram-positive bacterial components of the resident microbiota of human mucous membranes, chiefly colonizing the gut and the urogenital tract. Vertical perinatal transmission, from colonized women, is known to occur both as intrauterine infection or through contamination during labor. The worldwide prevalence of GBS-colonized pregnant women ranges from 3% to 41%. Neonatal infection may lead chiefly to sepsis and pneumonia, with less frequent occurrences of meningitis, celullitis, osteomyelitis and septic arthritis. The first guidelines for prevention of the vertical transmission of perinatal streptococcal disease were issued in 1996. Routine investigation of the S. agalactiae colonization status, through selective-medium culture of vaginal and rectal secretions at the term of pregnancy, and intrapartum antimicrobial prophylaxis were established in 2002. A significant decrease in the incidence of perinatal infection was seen in the countries that adopted the prophylactic measures. Although neonatal mortality in Brazil is a serious public health issue, no preventive or treatment strategies targeting GBS-neonatal infection have been adopted. Because of the high cost and serious consequences of perinatal streptococcal disease, health policies aiming at reducing vertical transmission are clearly called for. |
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Perinatal Group B streptococcal disease: clinical-microbiological aspects and preventionDoença Perinatal associada aos estreptococos do Grupo B: aspectos clínico-microbiológicos e prevenção.Streptococcus agalactiaeEstreptococo do Grupo BSepse NeonatalDoença Estreptocócica PerinatalLancefield group B streptococci (GBS, or Streptococcus agalactiae) are Gram-positive bacterial components of the resident microbiota of human mucous membranes, chiefly colonizing the gut and the urogenital tract. Vertical perinatal transmission, from colonized women, is known to occur both as intrauterine infection or through contamination during labor. The worldwide prevalence of GBS-colonized pregnant women ranges from 3% to 41%. Neonatal infection may lead chiefly to sepsis and pneumonia, with less frequent occurrences of meningitis, celullitis, osteomyelitis and septic arthritis. The first guidelines for prevention of the vertical transmission of perinatal streptococcal disease were issued in 1996. Routine investigation of the S. agalactiae colonization status, through selective-medium culture of vaginal and rectal secretions at the term of pregnancy, and intrapartum antimicrobial prophylaxis were established in 2002. A significant decrease in the incidence of perinatal infection was seen in the countries that adopted the prophylactic measures. Although neonatal mortality in Brazil is a serious public health issue, no preventive or treatment strategies targeting GBS-neonatal infection have been adopted. Because of the high cost and serious consequences of perinatal streptococcal disease, health policies aiming at reducing vertical transmission are clearly called for.Os cocos Gram positivo Streptococcus agalactiae ou estreptococos do Grupo B de Lancefield (EGB) são bactérias que fazem parte da microbiota residente das membranas mucosas de seres humanos, colonizando principalmente os tratos gastrintestinal e geniturinário. Sua importância é relacionada à contaminação vertical dos neonatos de parturientes colonizadas, que pode acontecer de forma ascendente ainda no útero ou durante o parto. Mundialmente, a prevalência da colonização pelos EGB nas gestantes, varia de 3% a 41%. Entre as infecções neonatais associadas a estes microrganismos destacam-se, principalmente, a septicemia e a pneumonia e, em menor incidência, meningite, celulite, osteomielite e artrite séptica. Em 1996, foi publicado o primeiro guia preventivo da doença estreptocócica perinatal estabelecendo as diretrizes e critérios para a prevenção da transmissão vertical destes agentes. Em 2002, foi estabelecido o uso da profilaxia antimicrobiana intraparto e a investigação rotineira da colonização pelo S. agalactiae no final da gestação, através de cultura de material vaginal e retal em meio seletivo. Nos países que adotaram estas medidas profiláticas, registrou-se um decréscimo significativo na incidência da doença. No Brasil, a mortalidade neonatal é grave problema de saúde pública e ainda não foram adotadas estratégias de prevenção e tratamento para reduzir a prevalência de infecção neonatal pelo EGB. Considerando o custo elevado e as graves conseqüências da doença estreptocócica perinatal, percebe-se a necessidade de elaboração de políticas de saúde visando reduzir a transmissão vertical.Editora UFJF2008-10-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtRevLitPesquisa bibliografica descritivaapplication/pdfapplication/mswordhttps://periodicos.ufjf.br/index.php/hurevista/article/view/104HU Revista; v. 34 n. 2 (2008)1982-80470103-3123reponame:HU Revista (Online)instname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFporhttps://periodicos.ufjf.br/index.php/hurevista/article/view/104/113https://periodicos.ufjf.br/index.php/hurevista/article/view/104/14893Castellano Filho, Didier SilveiraTibiriçá, Sandra Helena CerratoDiniz, Cláudio Galuppoinfo:eu-repo/semantics/openAccess2023-05-04T03:53:16Zoai:periodicos.ufjf.br:article/104Revistahttps://periodicos.ufjf.br/index.php/hurevistaPUBhttps://periodicos.ufjf.br/index.php/hurevista/oairevista.hurevista@ufjf.edu.br1982-80470103-3123opendoar:2023-05-04T03:53:16HU Revista (Online) - Universidade Federal de Juiz de Fora (UFJF)false |
dc.title.none.fl_str_mv |
Perinatal Group B streptococcal disease: clinical-microbiological aspects and prevention Doença Perinatal associada aos estreptococos do Grupo B: aspectos clínico-microbiológicos e prevenção. |
title |
Perinatal Group B streptococcal disease: clinical-microbiological aspects and prevention |
spellingShingle |
Perinatal Group B streptococcal disease: clinical-microbiological aspects and prevention Castellano Filho, Didier Silveira Streptococcus agalactiae Estreptococo do Grupo B Sepse Neonatal Doença Estreptocócica Perinatal |
title_short |
Perinatal Group B streptococcal disease: clinical-microbiological aspects and prevention |
title_full |
Perinatal Group B streptococcal disease: clinical-microbiological aspects and prevention |
title_fullStr |
Perinatal Group B streptococcal disease: clinical-microbiological aspects and prevention |
title_full_unstemmed |
Perinatal Group B streptococcal disease: clinical-microbiological aspects and prevention |
title_sort |
Perinatal Group B streptococcal disease: clinical-microbiological aspects and prevention |
author |
Castellano Filho, Didier Silveira |
author_facet |
Castellano Filho, Didier Silveira Tibiriçá, Sandra Helena Cerrato Diniz, Cláudio Galuppo |
author_role |
author |
author2 |
Tibiriçá, Sandra Helena Cerrato Diniz, Cláudio Galuppo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Castellano Filho, Didier Silveira Tibiriçá, Sandra Helena Cerrato Diniz, Cláudio Galuppo |
dc.subject.por.fl_str_mv |
Streptococcus agalactiae Estreptococo do Grupo B Sepse Neonatal Doença Estreptocócica Perinatal |
topic |
Streptococcus agalactiae Estreptococo do Grupo B Sepse Neonatal Doença Estreptocócica Perinatal |
description |
Lancefield group B streptococci (GBS, or Streptococcus agalactiae) are Gram-positive bacterial components of the resident microbiota of human mucous membranes, chiefly colonizing the gut and the urogenital tract. Vertical perinatal transmission, from colonized women, is known to occur both as intrauterine infection or through contamination during labor. The worldwide prevalence of GBS-colonized pregnant women ranges from 3% to 41%. Neonatal infection may lead chiefly to sepsis and pneumonia, with less frequent occurrences of meningitis, celullitis, osteomyelitis and septic arthritis. The first guidelines for prevention of the vertical transmission of perinatal streptococcal disease were issued in 1996. Routine investigation of the S. agalactiae colonization status, through selective-medium culture of vaginal and rectal secretions at the term of pregnancy, and intrapartum antimicrobial prophylaxis were established in 2002. A significant decrease in the incidence of perinatal infection was seen in the countries that adopted the prophylactic measures. Although neonatal mortality in Brazil is a serious public health issue, no preventive or treatment strategies targeting GBS-neonatal infection have been adopted. Because of the high cost and serious consequences of perinatal streptococcal disease, health policies aiming at reducing vertical transmission are clearly called for. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-10-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ArtRevLit Pesquisa bibliografica descritiva |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufjf.br/index.php/hurevista/article/view/104 |
url |
https://periodicos.ufjf.br/index.php/hurevista/article/view/104 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.ufjf.br/index.php/hurevista/article/view/104/113 https://periodicos.ufjf.br/index.php/hurevista/article/view/104/14893 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/msword |
dc.publisher.none.fl_str_mv |
Editora UFJF |
publisher.none.fl_str_mv |
Editora UFJF |
dc.source.none.fl_str_mv |
HU Revista; v. 34 n. 2 (2008) 1982-8047 0103-3123 reponame:HU Revista (Online) instname:Universidade Federal de Juiz de Fora (UFJF) instacron:UFJF |
instname_str |
Universidade Federal de Juiz de Fora (UFJF) |
instacron_str |
UFJF |
institution |
UFJF |
reponame_str |
HU Revista (Online) |
collection |
HU Revista (Online) |
repository.name.fl_str_mv |
HU Revista (Online) - Universidade Federal de Juiz de Fora (UFJF) |
repository.mail.fl_str_mv |
revista.hurevista@ufjf.edu.br |
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