Experimental models of obesity: critical analysis of the metabolic profile and of aplicability

Detalhes bibliográficos
Autor(a) principal: Castro, Barbara Bruna Abreu
Data de Publicação: 2019
Outros Autores: Arriel, Kaique, Renó, Petrus, Sanders-Pinheiro, Hélady
Tipo de documento: Artigo
Idioma: por
Título da fonte: HU Revista (Online)
Texto Completo: https://periodicos.ufjf.br/index.php/hurevista/article/view/14053
Resumo: Introduction: The prevalence of obesity and other related diseases is increasing worldwide worrisome. Characterized by increased body weight or excessive accumulation of body fat, obesity has been associated with increased mortality due to higher incidence of hypertension, diabetes and many types of cancer. Animal models provide key data for understanding the basic parameters that regulate the components of our energy balance. Objective: This review selected articles that used animal models (mice and mice) for obesity focusing on the main metabolic changes caused by obesity in order to present the main models used in the last 5 years. Material and Methods: Two searches were performed in the PubMed database using the expressions "obesity" AND "metabolism" AND "animal model" AND "mice" and "obesity" AND "metabolism" AND "animal model" AND "rat". We selected the papers considered more relevant from the criteria: detailed description of the experimental model and analysis of the metabolic parameters of interest: weight, lipid profile and glycemic profile. Other references were used to better elucidate the models found and also those that were not mentioned, but we considered important for the understanding of the evolution of animal models of obesity. Results: Mouse was the most used species, the predominant gender was male, the rodent age ranged from neonates up to 44 weeks and the follow-up period reached up to 53 weeks. Obesity was confirmed by a significant weight gain and most studies showed alterations in lipid and glycemic metabolism. We found five groups of induction of obesity, but the majority of studies applied hiperlipidic diets, model which better mimics metabolic chances found in humans. Conclusion: Investigating the causes and effects of induced obesity in experimental models may provide a better understanding of the pathophysiology of obesity, creating new options for prevention and treatment.
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spelling Experimental models of obesity: critical analysis of the metabolic profile and of aplicabilityModelos experimentais de obesidade: análise crítica do perfil metabólico e da aplicabilidadeAnimal modelsMetabolismObesityRodentia.MetabolismoModelos animaisObesidadeRoedoresIntroduction: The prevalence of obesity and other related diseases is increasing worldwide worrisome. Characterized by increased body weight or excessive accumulation of body fat, obesity has been associated with increased mortality due to higher incidence of hypertension, diabetes and many types of cancer. Animal models provide key data for understanding the basic parameters that regulate the components of our energy balance. Objective: This review selected articles that used animal models (mice and mice) for obesity focusing on the main metabolic changes caused by obesity in order to present the main models used in the last 5 years. Material and Methods: Two searches were performed in the PubMed database using the expressions "obesity" AND "metabolism" AND "animal model" AND "mice" and "obesity" AND "metabolism" AND "animal model" AND "rat". We selected the papers considered more relevant from the criteria: detailed description of the experimental model and analysis of the metabolic parameters of interest: weight, lipid profile and glycemic profile. Other references were used to better elucidate the models found and also those that were not mentioned, but we considered important for the understanding of the evolution of animal models of obesity. Results: Mouse was the most used species, the predominant gender was male, the rodent age ranged from neonates up to 44 weeks and the follow-up period reached up to 53 weeks. Obesity was confirmed by a significant weight gain and most studies showed alterations in lipid and glycemic metabolism. We found five groups of induction of obesity, but the majority of studies applied hiperlipidic diets, model which better mimics metabolic chances found in humans. Conclusion: Investigating the causes and effects of induced obesity in experimental models may provide a better understanding of the pathophysiology of obesity, creating new options for prevention and treatment.Introdução: a prevalência da obesidade e de outras doenças relacionadas está aumentando em todo o mundo de forma preocupante. Caracterizada pelo aumento do peso corporal ou do acúmulo excessivo de gordura corporal, a obesidade tem sido associada ao aumento da mortalidade decorrente de maior incidência de hipertensão, diabetes e vários tipos de câncer. Os modelos animais fornecem dados fundamentais para a compreensão dos parâmetros básicos que regulam os componentes do nosso balanço energético. Objetivo: esta revisão selecionou artigos que utilizaram modelos animais (ratos e camundongos) de obesidade focando nas principais alterações metabólicas causadas pela obesidade com o objetivo de apresentar os principais modelos utilizados nos últimos 5 anos. Material e Métodos: Foram realizadas duas buscas na base de dados PubMed utilizando as expressões: “obesity” AND “metabolism” AND “animal model” AND “mice” e “obesity” AND “metabolism” AND “animal model” AND “rat”, sendo selecionados os estudos considerados mais relevantes a partir dos critérios: descrição detalhada do modelo experimental e análise dos parâmetros metabólicos de interesse: peso, perfil lipídico e perfil glicêmico. Outras referências foram utilizadas para elucidar melhor os modelos encontrados e também aqueles que não foram citados, mas, que possuem importância no entendimento da evolução dos modelos animais de obesidade. Resultados: A espécie mais utilizada foi o camundongo, o sexo predominante foi o masculino, a faixa etária dos roedores variou de neonatos até 44 semanas e o período de acompanhamento chegou até 53 semanas. A obesidade foi confirmada pelo aumento significativo do peso e na maioria dos estudos foram encontradas alterações no metabolismo lipídico e glicêmico. Encontramos cinco grupos de mecanismos de indução da obesidade porém a maioria dos estudos utilizou dietas hiperlipídicas, modelo que mais se assemelha às alterações metabólicas encontradas em humanos. Conclusão: Investigar as causas e efeitos da obesidade induzida em modelos experimentais pode fornecer uma melhor compreensão da fisiopatologia da obesidade, e proporcionar novas opções de prevenção e tratamento.Editora UFJF2019-04-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtRevLitPesquisa bibliografica descritivaapplication/pdfimage/tiffapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttps://periodicos.ufjf.br/index.php/hurevista/article/view/1405310.34019/1982-8047.2018.v44.14053HU Revista; v. 44 n. 2 (2018): Obesidade: da fisiopatologia ao tratamento; 199 - 2101982-80470103-3123reponame:HU Revista (Online)instname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFporhttps://periodicos.ufjf.br/index.php/hurevista/article/view/14053/pdfhttps://periodicos.ufjf.br/index.php/hurevista/article/view/14053/17142https://periodicos.ufjf.br/index.php/hurevista/article/view/14053/17143https://periodicos.ufjf.br/index.php/hurevista/article/view/14053/17144Castro, Barbara Bruna AbreuArriel, KaiqueRenó, PetrusSanders-Pinheiro, Héladyinfo:eu-repo/semantics/openAccess2019-07-19T03:01:04Zoai:periodicos.ufjf.br:article/14053Revistahttps://periodicos.ufjf.br/index.php/hurevistaPUBhttps://periodicos.ufjf.br/index.php/hurevista/oairevista.hurevista@ufjf.edu.br1982-80470103-3123opendoar:2019-07-19T03:01:04HU Revista (Online) - Universidade Federal de Juiz de Fora (UFJF)false
dc.title.none.fl_str_mv Experimental models of obesity: critical analysis of the metabolic profile and of aplicability
Modelos experimentais de obesidade: análise crítica do perfil metabólico e da aplicabilidade
title Experimental models of obesity: critical analysis of the metabolic profile and of aplicability
spellingShingle Experimental models of obesity: critical analysis of the metabolic profile and of aplicability
Castro, Barbara Bruna Abreu
Animal models
Metabolism
Obesity
Rodentia.
Metabolismo
Modelos animais
Obesidade
Roedores
title_short Experimental models of obesity: critical analysis of the metabolic profile and of aplicability
title_full Experimental models of obesity: critical analysis of the metabolic profile and of aplicability
title_fullStr Experimental models of obesity: critical analysis of the metabolic profile and of aplicability
title_full_unstemmed Experimental models of obesity: critical analysis of the metabolic profile and of aplicability
title_sort Experimental models of obesity: critical analysis of the metabolic profile and of aplicability
author Castro, Barbara Bruna Abreu
author_facet Castro, Barbara Bruna Abreu
Arriel, Kaique
Renó, Petrus
Sanders-Pinheiro, Hélady
author_role author
author2 Arriel, Kaique
Renó, Petrus
Sanders-Pinheiro, Hélady
author2_role author
author
author
dc.contributor.author.fl_str_mv Castro, Barbara Bruna Abreu
Arriel, Kaique
Renó, Petrus
Sanders-Pinheiro, Hélady
dc.subject.por.fl_str_mv Animal models
Metabolism
Obesity
Rodentia.
Metabolismo
Modelos animais
Obesidade
Roedores
topic Animal models
Metabolism
Obesity
Rodentia.
Metabolismo
Modelos animais
Obesidade
Roedores
description Introduction: The prevalence of obesity and other related diseases is increasing worldwide worrisome. Characterized by increased body weight or excessive accumulation of body fat, obesity has been associated with increased mortality due to higher incidence of hypertension, diabetes and many types of cancer. Animal models provide key data for understanding the basic parameters that regulate the components of our energy balance. Objective: This review selected articles that used animal models (mice and mice) for obesity focusing on the main metabolic changes caused by obesity in order to present the main models used in the last 5 years. Material and Methods: Two searches were performed in the PubMed database using the expressions "obesity" AND "metabolism" AND "animal model" AND "mice" and "obesity" AND "metabolism" AND "animal model" AND "rat". We selected the papers considered more relevant from the criteria: detailed description of the experimental model and analysis of the metabolic parameters of interest: weight, lipid profile and glycemic profile. Other references were used to better elucidate the models found and also those that were not mentioned, but we considered important for the understanding of the evolution of animal models of obesity. Results: Mouse was the most used species, the predominant gender was male, the rodent age ranged from neonates up to 44 weeks and the follow-up period reached up to 53 weeks. Obesity was confirmed by a significant weight gain and most studies showed alterations in lipid and glycemic metabolism. We found five groups of induction of obesity, but the majority of studies applied hiperlipidic diets, model which better mimics metabolic chances found in humans. Conclusion: Investigating the causes and effects of induced obesity in experimental models may provide a better understanding of the pathophysiology of obesity, creating new options for prevention and treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-04
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https://periodicos.ufjf.br/index.php/hurevista/article/view/14053/17142
https://periodicos.ufjf.br/index.php/hurevista/article/view/14053/17143
https://periodicos.ufjf.br/index.php/hurevista/article/view/14053/17144
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dc.publisher.none.fl_str_mv Editora UFJF
publisher.none.fl_str_mv Editora UFJF
dc.source.none.fl_str_mv HU Revista; v. 44 n. 2 (2018): Obesidade: da fisiopatologia ao tratamento; 199 - 210
1982-8047
0103-3123
reponame:HU Revista (Online)
instname:Universidade Federal de Juiz de Fora (UFJF)
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reponame_str HU Revista (Online)
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repository.mail.fl_str_mv revista.hurevista@ufjf.edu.br
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