New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review

Detalhes bibliográficos
Autor(a) principal: Sathler, Ana de Araújo
Data de Publicação: 2018
Tipo de documento: Trabalho de conclusão de curso
Idioma: eng
Título da fonte: Repositório Institucional da UFJF
Texto Completo: https://repositorio.ufjf.br/jspui/handle/ufjf/14428
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spelling Lang, Karen Luisehttp://lattes.cnpq.br/0384253894180436Ferreira, Gabriella Freitashttp://lattes.cnpq.br/7970414057350848Medeiros, Vanessa Gonçalveshttp://lattes.cnpq.br/6917966979631986http://lattes.cnpq.br/9120688268358031Sathler, Ana de Araújo2022-09-08T12:34:42Z2022-09-022022-09-08T12:34:42Z2018-12-06https://repositorio.ufjf.br/jspui/handle/ufjf/14428---Systemic fungal infections caused by fungal species of the genus Candida sp. and Cryptococcus sp. have important epidemiological significance, because they affect immunocompromised patients and present high mortality rates. The available drugs used for the treatment of the diseases caused by these fungi species are restricted of three classes of antifungals. Besides the limited number of therapeutic alternatives, these drugs are associated with several factors that limiting its use, such as the incidence of serious adverse effects, drug interactions, development of resistance and high cost, justifying the search for new chemical entities. Natural products are historically relevant sources of compounds for the development of new drugs, and studies with these organisms has resulted in the discovery of new molecules with anti-cryptococcus and anti-candida activity. In this review, 125 molecules with minimal inhibitory concentration (MICs) in the range of 0.63 to 50 μg mL -1 were compiled. 88% of these molecules were active against the different species of Candida sp. and 35.2% were active against fungi of the genus Cryptococcus sp.. 77.6% were molecules isolated from plants, 8% isolated from microorganisms and 13.6% isolated from algae and marine sponges.engUniversidade Federal de Juiz de Fora - Campus Avançado de Governador ValadaresUFJF/GVBrasilICV - Instituto de Ciências da Vidahttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessCNPQ::CIENCIAS DA SAUDE::FARMACIACryptococcusAndida,natural productsAntifungalsNew promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFORIGINALanadearaujosathler.pdfanadearaujosathler.pdfapplication/pdf1069919https://repositorio.ufjf.br/jspui/bitstream/ufjf/14428/1/anadearaujosathler.pdf4123d63507b8172582710fd17d4ecc20MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufjf.br/jspui/bitstream/ufjf/14428/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufjf.br/jspui/bitstream/ufjf/14428/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53TEXTanadearaujosathler.pdf.txtanadearaujosathler.pdf.txtExtracted texttext/plain121948https://repositorio.ufjf.br/jspui/bitstream/ufjf/14428/4/anadearaujosathler.pdf.txt215ae47bd26f7cfe0921309aea76fc20MD54THUMBNAILanadearaujosathler.pdf.jpganadearaujosathler.pdf.jpgGenerated Thumbnailimage/jpeg1189https://repositorio.ufjf.br/jspui/bitstream/ufjf/14428/5/anadearaujosathler.pdf.jpgc4cdc9b575b01498fa3f5e27ea5d16c2MD55ufjf/144282022-09-09 03:10:34.401oai:hermes.cpd.ufjf.br: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Repositório InstitucionalPUBhttps://repositorio.ufjf.br/oai/requestopendoar:2022-09-09T06:10:34Repositório Institucional da UFJF - Universidade Federal de Juiz de Fora (UFJF)false
dc.title.pt_BR.fl_str_mv New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review
title New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review
spellingShingle New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review
Sathler, Ana de Araújo
CNPQ::CIENCIAS DA SAUDE::FARMACIA
Cryptococcus
Andida,
natural products
Antifungals
title_short New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review
title_full New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review
title_fullStr New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review
title_full_unstemmed New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review
title_sort New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review
author Sathler, Ana de Araújo
author_facet Sathler, Ana de Araújo
author_role author
dc.contributor.advisor1.fl_str_mv Lang, Karen Luise
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/0384253894180436
dc.contributor.referee1.fl_str_mv Ferreira, Gabriella Freitas
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/7970414057350848
dc.contributor.referee2.fl_str_mv Medeiros, Vanessa Gonçalves
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/6917966979631986
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/9120688268358031
dc.contributor.author.fl_str_mv Sathler, Ana de Araújo
contributor_str_mv Lang, Karen Luise
Ferreira, Gabriella Freitas
Medeiros, Vanessa Gonçalves
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE::FARMACIA
topic CNPQ::CIENCIAS DA SAUDE::FARMACIA
Cryptococcus
Andida,
natural products
Antifungals
dc.subject.por.fl_str_mv Cryptococcus
Andida,
natural products
Antifungals
description ---
publishDate 2018
dc.date.issued.fl_str_mv 2018-12-06
dc.date.accessioned.fl_str_mv 2022-09-08T12:34:42Z
dc.date.available.fl_str_mv 2022-09-02
2022-09-08T12:34:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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url https://repositorio.ufjf.br/jspui/handle/ufjf/14428
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/br/
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dc.publisher.none.fl_str_mv Universidade Federal de Juiz de Fora - Campus Avançado de Governador Valadares
dc.publisher.initials.fl_str_mv UFJF/GV
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv ICV - Instituto de Ciências da Vida
publisher.none.fl_str_mv Universidade Federal de Juiz de Fora - Campus Avançado de Governador Valadares
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFJF
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