Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.1590/s1806-37562017000000172 https://repositorio.ufjf.br/jspui/handle/ufjf/9239 |
Resumo: | - |
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2019-02-27T15:06:35Z2019-02-262019-02-27T15:06:35Z2018-10445378382http://dx.doi.org/10.1590/s1806-37562017000000172https://repositorio.ufjf.br/jspui/handle/ufjf/9239-Objective: To evaluate whether methylene blue (MB) could minimize the effects of ischemia-reperfusion injury in the nonischemic lung on a lung transplantation rodent model. Methods: Forty female Sprague-Dawley rats were divided into 20 donors and 20 recipients. The 20 recipient rats were divided into two groups (n = 10) according to the treatment (0.9% saline vs. 1% MB solutions). All animals underwent unilateral lung transplantation. Recipients received 2 mL of saline or MB intraperitoneally prior to transplantation. After 2 h of reperfusion, the animals were euthanized and histopathological and immunohistochemical analyses were performed in the nonischemic lung. Results: There was a significant decrease in inflammation-neutrophil count and intercellular adhesion molecule-1 (ICAM-1) expression in lung parenchyma were higher in the saline group in comparison with the MB group-and in apoptosis-caspase-3 expression was higher in the saline group and Bcl-2 expression was higher in MB group. Conclusions: MB is an effective drug for the protection of nonischemic lungs against inflammation and apoptosis following unilateral lung transplantation in rats.eng--BrasilJornal Brasileiro de Pneumologia-Reperfusion injuryMethylene blueLung transplantationApoptosisInflammationDoes methylene blue attenuate inflammation in nonischemic lungs after lung transplantation?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAbreu, Marcus da MattaAlmeida, Francine Maria deSantos, Kelli Borges dosAssis, Emílio Augusto Campos Pereira deHamada, Rafael Kenji FonsecaJatene, Fabio BiscegliPêgo-Fernandes, Paulo ManuelPazetti, Rogerioinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILDoes methylene blue attenuate inflammation in nonischemic.pdf.jpgDoes methylene blue attenuate inflammation in nonischemic.pdf.jpgGenerated Thumbnailimage/jpeg1745https://repositorio.ufjf.br/jspui/bitstream/ufjf/9239/4/Does%20methylene%20blue%20attenuate%20inflammation%20in%20nonischemic.pdf.jpgef504641720022278c2eb55829250150MD54ORIGINALDoes methylene blue attenuate inflammation in nonischemic.pdfDoes methylene blue attenuate inflammation in nonischemic.pdfapplication/pdf646565https://repositorio.ufjf.br/jspui/bitstream/ufjf/9239/1/Does%20methylene%20blue%20attenuate%20inflammation%20in%20nonischemic.pdfe83a722f0ae5405f19ffdca4bf60517fMD51LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? |
| title |
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? |
| spellingShingle |
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? Abreu, Marcus da Matta - Reperfusion injury Methylene blue Lung transplantation Apoptosis Inflammation |
| title_short |
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? |
| title_full |
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? |
| title_fullStr |
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? |
| title_full_unstemmed |
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? |
| title_sort |
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? |
| author |
Abreu, Marcus da Matta |
| author_facet |
Abreu, Marcus da Matta Almeida, Francine Maria de Santos, Kelli Borges dos Assis, Emílio Augusto Campos Pereira de Hamada, Rafael Kenji Fonseca Jatene, Fabio Biscegli Pêgo-Fernandes, Paulo Manuel Pazetti, Rogerio |
| author_role |
author |
| author2 |
Almeida, Francine Maria de Santos, Kelli Borges dos Assis, Emílio Augusto Campos Pereira de Hamada, Rafael Kenji Fonseca Jatene, Fabio Biscegli Pêgo-Fernandes, Paulo Manuel Pazetti, Rogerio |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Abreu, Marcus da Matta Almeida, Francine Maria de Santos, Kelli Borges dos Assis, Emílio Augusto Campos Pereira de Hamada, Rafael Kenji Fonseca Jatene, Fabio Biscegli Pêgo-Fernandes, Paulo Manuel Pazetti, Rogerio |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- Reperfusion injury Methylene blue Lung transplantation Apoptosis Inflammation |
| dc.subject.por.fl_str_mv |
Reperfusion injury Methylene blue Lung transplantation Apoptosis Inflammation |
| description |
- |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018-10 |
| dc.date.accessioned.fl_str_mv |
2019-02-27T15:06:35Z |
| dc.date.available.fl_str_mv |
2019-02-26 2019-02-27T15:06:35Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://repositorio.ufjf.br/jspui/handle/ufjf/9239 |
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http://dx.doi.org/10.1590/s1806-37562017000000172 |
| url |
http://dx.doi.org/10.1590/s1806-37562017000000172 https://repositorio.ufjf.br/jspui/handle/ufjf/9239 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Jornal Brasileiro de Pneumologia |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
- |
| dc.publisher.initials.fl_str_mv |
- |
| dc.publisher.country.fl_str_mv |
Brasil |
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- |
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reponame:Repositório Institucional da UFJF instname:Universidade Federal de Juiz de Fora (UFJF) instacron:UFJF |
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