Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.1016/j.jped.2015.12.007 https://repositorio.ufjf.br/jspui/handle/ufjf/7441 |
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2018-09-12T19:25:32Z2018-09-122018-09-12T19:25:32Z2016-09925521527http://dx.doi.org/10.1016/j.jped.2015.12.007https://repositorio.ufjf.br/jspui/handle/ufjf/7441-Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance.Methods:This was a case-control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results: As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion: The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed.eng--BrasilJornal de Pediatria-Single-nucleotide polymorphismsChildhood obesityFat mass and obesity associatedGeneAKT1AKTIPLack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePereira, Patrícia de AraújoSoares Junior, António Marcos AlvimSandrim, Valéria CristinaLanna, Carla Márcia MoreiraCosta, Débora Cristine SouzaBelo, Vanessa de AlmeidaPaula, Jonas Jardim deSantos, José Eduardo TanusSilva, Marco Aurélio RomanoMiranda, Débora Marques deinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILLack of association between genetic polymorphism.pdf.jpgLack of association between genetic polymorphism.pdf.jpgGenerated Thumbnailimage/jpeg1844https://repositorio.ufjf.br/jspui/bitstream/ufjf/7441/4/Lack%20of%20association%20between%20genetic%20polymorphism.pdf.jpgfe235352cb022b99a8ac99214e530e35MD54ORIGINALLack of association between genetic polymorphism.pdfLack of association between genetic polymorphism.pdfapplication/pdf384589https://repositorio.ufjf.br/jspui/bitstream/ufjf/7441/1/Lack%20of%20association%20between%20genetic%20polymorphism.pdfa94e08222df3bb9b52d30fff87fd467dMD51LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| spellingShingle |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity Pereira, Patrícia de Araújo - Single-nucleotide polymorphisms Childhood obesity Fat mass and obesity associated Gene AKT1 AKTIP |
| title_short |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title_full |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title_fullStr |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title_full_unstemmed |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title_sort |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| author |
Pereira, Patrícia de Araújo |
| author_facet |
Pereira, Patrícia de Araújo Soares Junior, António Marcos Alvim Sandrim, Valéria Cristina Lanna, Carla Márcia Moreira Costa, Débora Cristine Souza Belo, Vanessa de Almeida Paula, Jonas Jardim de Santos, José Eduardo Tanus Silva, Marco Aurélio Romano Miranda, Débora Marques de |
| author_role |
author |
| author2 |
Soares Junior, António Marcos Alvim Sandrim, Valéria Cristina Lanna, Carla Márcia Moreira Costa, Débora Cristine Souza Belo, Vanessa de Almeida Paula, Jonas Jardim de Santos, José Eduardo Tanus Silva, Marco Aurélio Romano Miranda, Débora Marques de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pereira, Patrícia de Araújo Soares Junior, António Marcos Alvim Sandrim, Valéria Cristina Lanna, Carla Márcia Moreira Costa, Débora Cristine Souza Belo, Vanessa de Almeida Paula, Jonas Jardim de Santos, José Eduardo Tanus Silva, Marco Aurélio Romano Miranda, Débora Marques de |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- Single-nucleotide polymorphisms Childhood obesity Fat mass and obesity associated Gene AKT1 AKTIP |
| dc.subject.por.fl_str_mv |
Single-nucleotide polymorphisms Childhood obesity Fat mass and obesity associated Gene AKT1 AKTIP |
| description |
- |
| publishDate |
2016 |
| dc.date.issued.fl_str_mv |
2016-09 |
| dc.date.accessioned.fl_str_mv |
2018-09-12T19:25:32Z |
| dc.date.available.fl_str_mv |
2018-09-12 2018-09-12T19:25:32Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://repositorio.ufjf.br/jspui/handle/ufjf/7441 |
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http://dx.doi.org/10.1016/j.jped.2015.12.007 |
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http://dx.doi.org/10.1016/j.jped.2015.12.007 https://repositorio.ufjf.br/jspui/handle/ufjf/7441 |
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eng |
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eng |
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Jornal de Pediatria |
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info:eu-repo/semantics/openAccess |
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openAccess |
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- |
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- |
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Brasil |
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