Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.1016/j.bjid.2015.08.004 https://repositorio.ufjf.br/jspui/handle/ufjf/7681 |
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2018-10-05T17:14:57Z2018-09-132018-10-05T17:14:57Z2015-11196636642http://dx.doi.org/10.1016/j.bjid.2015.08.004https://repositorio.ufjf.br/jspui/handle/ufjf/7681-Mycobacterium tuberculosis is the etiologic agent of tuberculosis, one of the world's greatest cause of morbidity and mortality due to infectious disease. Many evolutionary mechanisms have contributed to its high level of adaptation as a host pathogen. Prior to become dormant, a group of about 50 genes related to metabolic changes are transcribed by the DosR regulon, one of the most complex and important systems of host-pathogen interaction. This genetic mechanism allows the mycobacteria to persist during long time periods, establishing the so-called latent infection. Even in the presence of a competent immune response, the host cannot eliminate the pathogen, only managing to keep it surrounded by an unfavorable microenvironment for its growth. However, conditions such as immunosuppression may reestablish optimal conditions for bacterial growth, culminating in the onset of active disease. The interactions between the pathogen and its host are still not completely elucidated. Nonetheless, many studies are being carried out in order to clarify this complex relationship, thus creating new possibilities for patient approach and laboratory screening.eng--BrasilBrazilian Journal of Infectious Diseases-TuberculosisLatencyDosR antigensDiagnosisChallenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potentialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChaves, Alexandre SilvaRodrigues, Michele FernandesMattos, Ana Márcia MenezesTeixeira, Henrique Coutoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILChallenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic .pdf.jpgChallenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic .pdf.jpgGenerated Thumbnailimage/jpeg1749https://repositorio.ufjf.br/jspui/bitstream/ufjf/7681/4/Challenging%20Mycobacterium%20tuberculosi%20s%20dormancy%20mechanisms%20and%20their%20immunodiagnostic%20.pdf.jpgc4557329b2310f1e45ea9021f2f0f786MD54ORIGINALChallenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic .pdfChallenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic .pdfapplication/pdf943995https://repositorio.ufjf.br/jspui/bitstream/ufjf/7681/1/Challenging%20Mycobacterium%20tuberculosi%20s%20dormancy%20mechanisms%20and%20their%20immunodiagnostic%20.pdf15aed8f284dbe2338ba5072cfc8e2b8bMD51LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential |
| title |
Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential |
| spellingShingle |
Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential Chaves, Alexandre Silva - Tuberculosis Latency DosR antigens Diagnosis |
| title_short |
Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential |
| title_full |
Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential |
| title_fullStr |
Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential |
| title_full_unstemmed |
Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential |
| title_sort |
Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential |
| author |
Chaves, Alexandre Silva |
| author_facet |
Chaves, Alexandre Silva Rodrigues, Michele Fernandes Mattos, Ana Márcia Menezes Teixeira, Henrique Couto |
| author_role |
author |
| author2 |
Rodrigues, Michele Fernandes Mattos, Ana Márcia Menezes Teixeira, Henrique Couto |
| author2_role |
author author author |
| dc.contributor.author.fl_str_mv |
Chaves, Alexandre Silva Rodrigues, Michele Fernandes Mattos, Ana Márcia Menezes Teixeira, Henrique Couto |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- Tuberculosis Latency DosR antigens Diagnosis |
| dc.subject.por.fl_str_mv |
Tuberculosis Latency DosR antigens Diagnosis |
| description |
- |
| publishDate |
2015 |
| dc.date.issued.fl_str_mv |
2015-11 |
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2018-10-05T17:14:57Z |
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2018-09-13 2018-10-05T17:14:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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https://repositorio.ufjf.br/jspui/handle/ufjf/7681 |
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http://dx.doi.org/10.1016/j.bjid.2015.08.004 |
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http://dx.doi.org/10.1016/j.bjid.2015.08.004 https://repositorio.ufjf.br/jspui/handle/ufjf/7681 |
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eng |
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Brazilian Journal of Infectious Diseases |
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openAccess |
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