Herpes zoster after autologous hematopoietic stem cell transplantation

Detalhes bibliográficos
Autor(a) principal: Santos, Kelli Borges dos
Data de Publicação: 2016
Outros Autores: Souza, Rafaela Souto e, Atalla, Angelo, Hallack Neto, Abrahão Elias
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFJF
Texto Completo: http://dx.doi.org/10.1016/j.bjhh.2016.05.015
https://repositorio.ufjf.br/jspui/handle/ufjf/7412
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spelling 2018-09-11T13:31:06Z2018-09-112018-09-11T13:31:06Z2016-10384298301http://dx.doi.org/10.1016/j.bjhh.2016.05.015https://repositorio.ufjf.br/jspui/handle/ufjf/7412-Background: The autologous hematopoietic stem cell transplantation procedure involves immunosuppression of the patient. Thus, the patient has an elevated risk for several diseases, such as infections with the varicella-zoster virus. Prevention protocols have been proposed based on the use of acyclovir from the first day of conditioning, and maintaining this drug for 30-100 days after the procedure or for as much as one year. The objective of this work was to evaluate the incidence of herpes zoster after autologous transplantations related to the early suspension of acyclovir. Methods:A retrospective study was carried out based on the collection of data from 231 medical records of transplant patients in the Bone Marrow Transplant Unit of the teaching hospital of the Universidade Federal de Juiz de Fora in the period between 2004 and 2014. Results: Fourteen (6.1%) patients had herpes zoster in the post-transplant period on average within six months of the procedure. Patients with multiple myeloma (64.3%) were the most affected. There was a statistically significant difference in the age of the patients, with older individuals having a greater chance of developing the infection (p-value = 0.002). There were no significant differences for the other variables analyzed. Conclusion: The early suspension of acyclovir can be safe in patients who receive autologous hematopoietic stem cell transplants. However some groups may benefit from extended prophylaxis with acyclovir, particularly older patients and patients with multiple myeloma.eng--BrasilRevista Brasileira de Hematologia e Hemoterapia-Transplant of hematopoietic stem cellsAutologousHerpes zosterPrevention and controlHerpes zoster after autologous hematopoietic stem cell transplantationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSantos, Kelli Borges dosSouza, Rafaela Souto eAtalla, AngeloHallack Neto, Abrahão Eliasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILHerpes zoster after autologous hematopoietic stem cell transplantation.pdf.jpgHerpes zoster after autologous hematopoietic stem cell transplantation.pdf.jpgGenerated Thumbnailimage/jpeg1782https://repositorio.ufjf.br/jspui/bitstream/ufjf/7412/4/Herpes%20zoster%20after%20autologous%20hematopoietic%20stem%20cell%20transplantation.pdf.jpg5bb459c9f1937e33908ca2df376feafcMD54ORIGINALHerpes zoster after autologous hematopoietic stem cell transplantation.pdfHerpes zoster after autologous hematopoietic stem cell transplantation.pdfapplication/pdf264687https://repositorio.ufjf.br/jspui/bitstream/ufjf/7412/1/Herpes%20zoster%20after%20autologous%20hematopoietic%20stem%20cell%20transplantation.pdf0092f09658dca1cabd260b343388ed55MD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Herpes zoster after autologous hematopoietic stem cell transplantation
title Herpes zoster after autologous hematopoietic stem cell transplantation
spellingShingle Herpes zoster after autologous hematopoietic stem cell transplantation
Santos, Kelli Borges dos
-
Transplant of hematopoietic stem cells
Autologous
Herpes zoster
Prevention and control
title_short Herpes zoster after autologous hematopoietic stem cell transplantation
title_full Herpes zoster after autologous hematopoietic stem cell transplantation
title_fullStr Herpes zoster after autologous hematopoietic stem cell transplantation
title_full_unstemmed Herpes zoster after autologous hematopoietic stem cell transplantation
title_sort Herpes zoster after autologous hematopoietic stem cell transplantation
author Santos, Kelli Borges dos
author_facet Santos, Kelli Borges dos
Souza, Rafaela Souto e
Atalla, Angelo
Hallack Neto, Abrahão Elias
author_role author
author2 Souza, Rafaela Souto e
Atalla, Angelo
Hallack Neto, Abrahão Elias
author2_role author
author
author
dc.contributor.author.fl_str_mv Santos, Kelli Borges dos
Souza, Rafaela Souto e
Atalla, Angelo
Hallack Neto, Abrahão Elias
dc.subject.cnpq.fl_str_mv -
topic -
Transplant of hematopoietic stem cells
Autologous
Herpes zoster
Prevention and control
dc.subject.por.fl_str_mv Transplant of hematopoietic stem cells
Autologous
Herpes zoster
Prevention and control
description -
publishDate 2016
dc.date.issued.fl_str_mv 2016-10
dc.date.accessioned.fl_str_mv 2018-09-11T13:31:06Z
dc.date.available.fl_str_mv 2018-09-11
2018-09-11T13:31:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufjf.br/jspui/handle/ufjf/7412
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.bjhh.2016.05.015
url http://dx.doi.org/10.1016/j.bjhh.2016.05.015
https://repositorio.ufjf.br/jspui/handle/ufjf/7412
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv -
dc.publisher.initials.fl_str_mv -
dc.publisher.country.fl_str_mv Brasil
publisher.none.fl_str_mv -
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFJF
instname:Universidade Federal de Juiz de Fora (UFJF)
instacron:UFJF
instname_str Universidade Federal de Juiz de Fora (UFJF)
instacron_str UFJF
institution UFJF
reponame_str Repositório Institucional da UFJF
collection Repositório Institucional da UFJF
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