Exercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.5935/abc.20180053 https://repositorio.ufjf.br/jspui/handle/ufjf/9231 |
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2019-02-27T15:00:59Z2019-02-262019-02-27T15:00:59Z2018-031103263269http://dx.doi.org/10.5935/abc.20180053https://repositorio.ufjf.br/jspui/handle/ufjf/9231-Background: Alterations in the structure of resistance vessels contribute to elevated systemic vascular resistance in hypertension and are linked to sympathetic hyperactivity and related lesions in target organs. Objective: To assess the effects of exercise training on hemodynamic and autonomic parameters, as well as splenic arteriolar damages in male Wistar Kyoto (WKY) and Spontaneously Hypertensive Rats (SHR). Methods: Normotensive sedentary (WKYS) and trained (WKYT) rats, and hypertensive sedentary (SHRS) and trained (SHRT) rats were included in this study. After 9 weeks of experimental protocol (swimming training or sedentary control), arterial pressure (AP) and heart rate (HR) were recorded in freely moving rats. We assessed the autonomic control of the heart by sympathetic and vagal autonomic blockade. Morphometric analyses of arterioles were performed in spleen tissues. The statistical significance level was set at p < 0.05. Results: Resting bradycardia was observed in both trained groups (WKYT: 328.0 ± 7.3 bpm; SHRT: 337.0 ± 5.2 bpm) compared with their respective sedentary groups (WKYS: 353.2 ± 8.5 bpm; SHRS: 412.1 ± 10.4 bpm; p < 0.001). Exercise training attenuated mean AP only in SHRT (125.9 ± 6.2 mmHg) vs. SHRS (182.5 ± 4.2 mmHg, p < 0.001). The WKYT showed a higher vagal effect (∆HR: 79.0 ± 2.3 bpm) compared with WKYS (∆HR: 67.4 ± 1.7 bpm; p < 0.05). Chronic exercise decreased sympathetic effects on SHRT (∆HR: -62.8 ± 2.8 bpm) in comparison with SHRS (∆HR: -99.8 ± 9.2 bpm; p = 0.005). The wall thickness of splenic arterioles in SHR was reduced by training (332.1 ± 16.0 µm2 in SHRT vs. 502.7 ± 36.3 µm2 in SHRS; p < 0.05). Conclusions: Exercise training attenuates sympathetic activity and AP in SHR, which may be contributing to the morphological improvement of the splenic arterioles.eng--BrasilArquivos Brasileiros de Cardiologia-ExercisePhysical exertionHypertensionVascular resistanceArteriolesRatsExercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLemos, Marina de PaivaMota, Gustavo Ribeiro daMarocolo, MoacirSordi, Carla Cristina deChriguer, Rosângela SoaresBarbosa Neto, Octávioinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILExercise training attenuates sympathetic activity and improves morphometry.pdf.jpgExercise training attenuates sympathetic activity and improves morphometry.pdf.jpgGenerated Thumbnailimage/jpeg1687https://repositorio.ufjf.br/jspui/bitstream/ufjf/9231/4/Exercise%20training%20attenuates%20sympathetic%20activity%20and%20improves%20morphometry.pdf.jpgaceca5a5b83670170d2027cc418a1ab0MD54ORIGINALExercise training attenuates sympathetic activity and improves morphometry.pdfExercise training attenuates sympathetic activity and improves morphometry.pdfapplication/pdf296177https://repositorio.ufjf.br/jspui/bitstream/ufjf/9231/1/Exercise%20training%20attenuates%20sympathetic%20activity%20and%20improves%20morphometry.pdf5f1d5b1ee7d3510baf39be3522a2d523MD51LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Exercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive rats |
| title |
Exercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive rats |
| spellingShingle |
Exercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive rats Lemos, Marina de Paiva - Exercise Physical exertion Hypertension Vascular resistance Arterioles Rats |
| title_short |
Exercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive rats |
| title_full |
Exercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive rats |
| title_fullStr |
Exercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive rats |
| title_full_unstemmed |
Exercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive rats |
| title_sort |
Exercise training attenuates sympathetic activity and improves morphometry of splenic arterioles in spontaneously hipertensive rats |
| author |
Lemos, Marina de Paiva |
| author_facet |
Lemos, Marina de Paiva Mota, Gustavo Ribeiro da Marocolo, Moacir Sordi, Carla Cristina de Chriguer, Rosângela Soares Barbosa Neto, Octávio |
| author_role |
author |
| author2 |
Mota, Gustavo Ribeiro da Marocolo, Moacir Sordi, Carla Cristina de Chriguer, Rosângela Soares Barbosa Neto, Octávio |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Lemos, Marina de Paiva Mota, Gustavo Ribeiro da Marocolo, Moacir Sordi, Carla Cristina de Chriguer, Rosângela Soares Barbosa Neto, Octávio |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- Exercise Physical exertion Hypertension Vascular resistance Arterioles Rats |
| dc.subject.por.fl_str_mv |
Exercise Physical exertion Hypertension Vascular resistance Arterioles Rats |
| description |
- |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018-03 |
| dc.date.accessioned.fl_str_mv |
2019-02-27T15:00:59Z |
| dc.date.available.fl_str_mv |
2019-02-26 2019-02-27T15:00:59Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://repositorio.ufjf.br/jspui/handle/ufjf/9231 |
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http://dx.doi.org/10.5935/abc.20180053 |
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http://dx.doi.org/10.5935/abc.20180053 https://repositorio.ufjf.br/jspui/handle/ufjf/9231 |
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eng |
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eng |
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Arquivos Brasileiros de Cardiologia |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Brasil |
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reponame:Repositório Institucional da UFJF instname:Universidade Federal de Juiz de Fora (UFJF) instacron:UFJF |
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Universidade Federal de Juiz de Fora (UFJF) |
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UFJF |
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