Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis

Detalhes bibliográficos
Autor(a) principal: Chebli, Julio Maria Fonseca
Data de Publicação: 2017
Outros Autores: Chebli, Liliana Andrade, Ribeiro, Tarsila Campanha da Rocha, Gaburri, Pedro Duarte
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFJF
Texto Completo: http://dx.doi.org/10.1590/1806-9282.63.03.215
https://repositorio.ufjf.br/jspui/handle/ufjf/7328
Resumo: A doença de Ménétrier é uma condição extremamente rara, de etiologia desconhecida, caracterizada por hipertrofia da mucosa gástrica e gastropatia perdedora de proteína. Casos raros dessa patologia têm sido relatados em pacientes com doenças autoimunes. Até o momento, desconhecemos qualquer relato dessa doença associada à pancreatite autoimune (PAI). Descrevemos um caso de hipoproteinemia grave como indicador de doença de Ménétrier associada à PAI. O paciente foi tratado de forma satisfatória com octreotide e dieta hiperproteica, alcançando remissão sintomática, melhora significativa das concentrações de albumina e recuperação do estado nutricional. Portanto, em pacientes com PAI e hipoproteinemia grave e persistente, deve-se considerar a doença de Ménétrier como um diagnóstico diferencial. Nesses casos, a avaliação endoscópica com biópsia gástrica, incluindo biópsia de toda a espessura da mucosa, pode ser útil no estabelecimento do diagnóstico e do pronto início da terapêutica.
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spelling 2018-09-06T11:54:21Z2018-08-132018-09-06T11:54:21Z2017-03CHEBLI, Julio Maria Fonseca et al . Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis. Rev. Assoc. Med. Bras., São Paulo , v. 63, n. 3, p. 215-218, mar. 2017 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000300215&lng=pt&nrm=iso>. acessos em 03 set. 2018. http://dx.doi.org/10.1590/1806-9282.63.03.215.http://dx.doi.org/10.1590/1806-9282.63.03.215https://repositorio.ufjf.br/jspui/handle/ufjf/732863320152018A doença de Ménétrier é uma condição extremamente rara, de etiologia desconhecida, caracterizada por hipertrofia da mucosa gástrica e gastropatia perdedora de proteína. Casos raros dessa patologia têm sido relatados em pacientes com doenças autoimunes. Até o momento, desconhecemos qualquer relato dessa doença associada à pancreatite autoimune (PAI). Descrevemos um caso de hipoproteinemia grave como indicador de doença de Ménétrier associada à PAI. O paciente foi tratado de forma satisfatória com octreotide e dieta hiperproteica, alcançando remissão sintomática, melhora significativa das concentrações de albumina e recuperação do estado nutricional. Portanto, em pacientes com PAI e hipoproteinemia grave e persistente, deve-se considerar a doença de Ménétrier como um diagnóstico diferencial. Nesses casos, a avaliação endoscópica com biópsia gástrica, incluindo biópsia de toda a espessura da mucosa, pode ser útil no estabelecimento do diagnóstico e do pronto início da terapêutica.Ménétrier's disease is an extremely rare disease of unknown etiology causing gastric mucosal hypertrophy and protein-losing gastropathy. Rare cases of this condition have been reported in patients with autoimmune diseases. However, to the best of our knowledge, Ménétrier's disease associated with autoimmune pancreatitis (AIP) has never been reported. We described a case of severe hypoproteinemia as a harbinger of Ménétrier's disease associated with AIP. The patient was successfully treated with octreotide and high-protein diet, which led to symptomatic remission and significant improvement in serum levels of albumin and recovery of the nutritional status. Thus, in AIP patients presenting with severe and persistent hypoproteinemia without apparent cause, clinicians need to consider Ménétrier's disease in the differential diagnosis. In this setting, endoscopic evaluation with histological examination of gastric biopsy material, including a full-thickness mucosal biopsy of involved mucosa, may be helpful in promptly establishing the diagnosis and allowing appropriate and timely therapy.eng--BrasilRevista da Associação Médica Brasileira-Pancreatite autoimuneDoença de MénétrierGastropatia perdedora de proteínaAutoimmune pancreatitisMénétrier's diseaseProtein-losing gastropathySevere hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitisHipoproteinemia grave como indicador de doença de Ménétrier na pancreatite autoimuneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChebli, Julio Maria FonsecaChebli, Liliana AndradeRibeiro, Tarsila Campanha da RochaGaburri, Pedro Duarteinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILSevere hypoproteinemia as a harbinger of Ménétrier’s disease in autoimmune pancreatitis.pdf.jpgSevere hypoproteinemia as a harbinger of Ménétrier’s disease in autoimmune pancreatitis.pdf.jpgGenerated Thumbnailimage/jpeg1650https://repositorio.ufjf.br/jspui/bitstream/ufjf/7328/6/Severe%20hypoproteinemia%20as%20a%20harbinger%20of%20M%c3%a9n%c3%a9trier%e2%80%99s%20disease%20in%20autoimmune%20pancreatitis.pdf.jpgad40429dc6000866ee60c6b99c24dd5dMD56ORIGINALSevere hypoproteinemia as a harbinger of Ménétrier’s disease in autoimmune pancreatitis.pdfSevere hypoproteinemia as a harbinger of Ménétrier’s disease in autoimmune pancreatitis.pdfapplication/pdf316125https://repositorio.ufjf.br/jspui/bitstream/ufjf/7328/3/Severe%20hypoproteinemia%20as%20a%20harbinger%20of%20M%c3%a9n%c3%a9trier%e2%80%99s%20disease%20in%20autoimmune%20pancreatitis.pdf1dc3c3d657a216cf82a51866c32dc603MD53LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis
dc.title.alternative.pt_BR.fl_str_mv Hipoproteinemia grave como indicador de doença de Ménétrier na pancreatite autoimune
title Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis
spellingShingle Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis
Chebli, Julio Maria Fonseca
-
Pancreatite autoimune
Doença de Ménétrier
Gastropatia perdedora de proteína
Autoimmune pancreatitis
Ménétrier's disease
Protein-losing gastropathy
title_short Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis
title_full Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis
title_fullStr Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis
title_full_unstemmed Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis
title_sort Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis
author Chebli, Julio Maria Fonseca
author_facet Chebli, Julio Maria Fonseca
Chebli, Liliana Andrade
Ribeiro, Tarsila Campanha da Rocha
Gaburri, Pedro Duarte
author_role author
author2 Chebli, Liliana Andrade
Ribeiro, Tarsila Campanha da Rocha
Gaburri, Pedro Duarte
author2_role author
author
author
dc.contributor.author.fl_str_mv Chebli, Julio Maria Fonseca
Chebli, Liliana Andrade
Ribeiro, Tarsila Campanha da Rocha
Gaburri, Pedro Duarte
dc.subject.cnpq.fl_str_mv -
topic -
Pancreatite autoimune
Doença de Ménétrier
Gastropatia perdedora de proteína
Autoimmune pancreatitis
Ménétrier's disease
Protein-losing gastropathy
dc.subject.por.fl_str_mv Pancreatite autoimune
Doença de Ménétrier
Gastropatia perdedora de proteína
Autoimmune pancreatitis
Ménétrier's disease
Protein-losing gastropathy
description A doença de Ménétrier é uma condição extremamente rara, de etiologia desconhecida, caracterizada por hipertrofia da mucosa gástrica e gastropatia perdedora de proteína. Casos raros dessa patologia têm sido relatados em pacientes com doenças autoimunes. Até o momento, desconhecemos qualquer relato dessa doença associada à pancreatite autoimune (PAI). Descrevemos um caso de hipoproteinemia grave como indicador de doença de Ménétrier associada à PAI. O paciente foi tratado de forma satisfatória com octreotide e dieta hiperproteica, alcançando remissão sintomática, melhora significativa das concentrações de albumina e recuperação do estado nutricional. Portanto, em pacientes com PAI e hipoproteinemia grave e persistente, deve-se considerar a doença de Ménétrier como um diagnóstico diferencial. Nesses casos, a avaliação endoscópica com biópsia gástrica, incluindo biópsia de toda a espessura da mucosa, pode ser útil no estabelecimento do diagnóstico e do pronto início da terapêutica.
publishDate 2017
dc.date.issued.fl_str_mv 2017-03
dc.date.accessioned.fl_str_mv 2018-09-06T11:54:21Z
dc.date.available.fl_str_mv 2018-08-13
2018-09-06T11:54:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv CHEBLI, Julio Maria Fonseca et al . Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis. Rev. Assoc. Med. Bras., São Paulo , v. 63, n. 3, p. 215-218, mar. 2017 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000300215&lng=pt&nrm=iso>. acessos em 03 set. 2018. http://dx.doi.org/10.1590/1806-9282.63.03.215.
dc.identifier.uri.fl_str_mv https://repositorio.ufjf.br/jspui/handle/ufjf/7328
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.1590/1806-9282.63.03.215
identifier_str_mv CHEBLI, Julio Maria Fonseca et al . Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis. Rev. Assoc. Med. Bras., São Paulo , v. 63, n. 3, p. 215-218, mar. 2017 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000300215&lng=pt&nrm=iso>. acessos em 03 set. 2018. http://dx.doi.org/10.1590/1806-9282.63.03.215.
url http://dx.doi.org/10.1590/1806-9282.63.03.215
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