Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.1016/j.htct.2017.12.003 https://repositorio.ufjf.br/jspui/handle/ufjf/7460 |
Resumo: | - |
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2018-09-13T14:43:27Z2018-09-132018-09-13T14:43:27Z2018-04402120131http://dx.doi.org/10.1016/j.htct.2017.12.003https://repositorio.ufjf.br/jspui/handle/ufjf/7460-Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods: This study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed correlations with JAK2 V617F status and clinical-hematological parameters. Results: The proinflammatory cytokine levels were increased in myeloproliferative neoplasm patients, and the presence of the JAK2 V617F mutation was associated with high IP-10 levels in primary myelofibrosis patients. Conclusions: Essential thrombocythemia, primary myelofibrosis, and polycythemia vera patients exhibited different patterns of cytokine production, as revealed by cytokine network correlations. Together, these findings suggest that augmented cytokine levels are associated with the physiopathology of myeloproliferative neoplasms.eng--BrasilHematology, Transfusion and Cell Therapy-Ph-negative myeloproliferative neoplasmsInflammationPlasma cytokinesJAK2 V617FPhiladelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCacemiro, Maira da CostaCominal, Juçara GastaldiRibeiro, Raquel TognonNunes, Natalia de SouzaSimões, Belinda PintoPontes, Lorena Lôbo de FigueiredoCatto, Luiz Fernando BazzoTraina, FabíolaSouto, Elizabeth XistoZambuzi, Fabiana AlbaniFrantz, Fabiani GaiCastro, Fabíola Attié deinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILPhiladelphia-negative myeloproliferative.pdf.jpgPhiladelphia-negative myeloproliferative.pdf.jpgGenerated Thumbnailimage/jpeg1787https://repositorio.ufjf.br/jspui/bitstream/ufjf/7460/4/Philadelphia-negative%20myeloproliferative.pdf.jpg1267bb5e54be4dbc3b999b21cda407c6MD54ORIGINALPhiladelphia-negative myeloproliferative.pdfPhiladelphia-negative myeloproliferative.pdfapplication/pdf1750609https://repositorio.ufjf.br/jspui/bitstream/ufjf/7460/1/Philadelphia-negative%20myeloproliferative.pdf9609181f7fe393a1eeecbad173d48032MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82197https://repositorio.ufjf.br/jspui/bitstream/ufjf/7460/2/license.txt000e18a5aee6ca21bb5811ddf55fc37bMD52TEXTPhiladelphia-negative myeloproliferative.pdf.txtPhiladelphia-negative myeloproliferative.pdf.txtExtracted texttext/plain39342https://repositorio.ufjf.br/jspui/bitstream/ufjf/7460/3/Philadelphia-negative%20myeloproliferative.pdf.txt0121c0b4c3dd9b8886ca19102b240960MD53ufjf/74602019-06-16 11:14:08.462oai:hermes.cpd.ufjf.br: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Repositório InstitucionalPUBhttps://repositorio.ufjf.br/oai/requestopendoar:2019-06-16T14:14:08Repositório Institucional da UFJF - Universidade Federal de Juiz de Fora (UFJF)false |
| dc.title.pt_BR.fl_str_mv |
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation |
| title |
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation |
| spellingShingle |
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation Cacemiro, Maira da Costa - Ph-negative myeloproliferative neoplasms Inflammation Plasma cytokines JAK2 V617F |
| title_short |
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation |
| title_full |
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation |
| title_fullStr |
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation |
| title_full_unstemmed |
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation |
| title_sort |
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation |
| author |
Cacemiro, Maira da Costa |
| author_facet |
Cacemiro, Maira da Costa Cominal, Juçara Gastaldi Ribeiro, Raquel Tognon Nunes, Natalia de Souza Simões, Belinda Pinto Pontes, Lorena Lôbo de Figueiredo Catto, Luiz Fernando Bazzo Traina, Fabíola Souto, Elizabeth Xisto Zambuzi, Fabiana Albani Frantz, Fabiani Gai Castro, Fabíola Attié de |
| author_role |
author |
| author2 |
Cominal, Juçara Gastaldi Ribeiro, Raquel Tognon Nunes, Natalia de Souza Simões, Belinda Pinto Pontes, Lorena Lôbo de Figueiredo Catto, Luiz Fernando Bazzo Traina, Fabíola Souto, Elizabeth Xisto Zambuzi, Fabiana Albani Frantz, Fabiani Gai Castro, Fabíola Attié de |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cacemiro, Maira da Costa Cominal, Juçara Gastaldi Ribeiro, Raquel Tognon Nunes, Natalia de Souza Simões, Belinda Pinto Pontes, Lorena Lôbo de Figueiredo Catto, Luiz Fernando Bazzo Traina, Fabíola Souto, Elizabeth Xisto Zambuzi, Fabiana Albani Frantz, Fabiani Gai Castro, Fabíola Attié de |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- Ph-negative myeloproliferative neoplasms Inflammation Plasma cytokines JAK2 V617F |
| dc.subject.por.fl_str_mv |
Ph-negative myeloproliferative neoplasms Inflammation Plasma cytokines JAK2 V617F |
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- |
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2018 |
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2018-09-13T14:43:27Z |
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2018-09-13 2018-09-13T14:43:27Z |
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2018-04 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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https://repositorio.ufjf.br/jspui/handle/ufjf/7460 |
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http://dx.doi.org/10.1016/j.htct.2017.12.003 |
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http://dx.doi.org/10.1016/j.htct.2017.12.003 https://repositorio.ufjf.br/jspui/handle/ufjf/7460 |
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eng |
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eng |
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Hematology, Transfusion and Cell Therapy |
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info:eu-repo/semantics/openAccess |
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openAccess |
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- |
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- |
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Brasil |
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