Drogas anti-VIH: passado, presente e perspectivas futuras
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.1590/S0100-40422003000300014 https://repositorio.ufjf.br/jspui/handle/ufjf/9117 |
Resumo: | - |
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2019-02-22T12:19:49Z2019-02-192019-02-22T12:19:49Z2003-06263366372http://dx.doi.org/10.1590/S0100-40422003000300014https://repositorio.ufjf.br/jspui/handle/ufjf/9117-Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). In addition to the reverse transcriptase (RT) and protease reaction, various other events in the HIV replicative cycle can be considered as potential targets for chemotherapeutic intervention: (1) viral adsorption, through binding to the viral envelope glycoprotein gp120; (2) viral entry, through blockage of the viral coreceptors CXCR4 and CCR5; (3) virus-cell fusion, through binding to the viral envelope glycoprotein gp 41; (4) viral assembly and disassembly through NCp7 zinc finger-targeted agents; (5) proviral DNA integration, through integrase inhibitors and (6) viral mRNA transcription, through inhibitors of the transcription (transactivation) process. Also, various new NRTIs, NNRTIs and PIs have been developed, possessing different improved characteristics.por--BrasilQuímica Nova-AIDSNew Anti-HIV drugsReplicative cycleDrogas anti-VIH: passado, presente e perspectivas futurasDrugs anti-HIV: past, present and future perspectivesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSouza, Marcus Vinícius Nora deAlmeida, Mauro Vieira deinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILDrogas anti-VIH.pdf.jpgDrogas anti-VIH.pdf.jpgGenerated Thumbnailimage/jpeg1550https://repositorio.ufjf.br/jspui/bitstream/ufjf/9117/4/Drogas%20anti-VIH.pdf.jpg5db5b5849370dd3fc1d6847cbf7a1f72MD54ORIGINALDrogas anti-VIH.pdfDrogas anti-VIH.pdfapplication/pdf1109561https://repositorio.ufjf.br/jspui/bitstream/ufjf/9117/1/Drogas%20anti-VIH.pdfda0f8440106c2e7558b79db1bb8d35c3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82197https://repositorio.ufjf.br/jspui/bitstream/ufjf/9117/2/license.txt000e18a5aee6ca21bb5811ddf55fc37bMD52TEXTDrogas anti-VIH.pdf.txtDrogas anti-VIH.pdf.txtExtracted texttext/plain27348https://repositorio.ufjf.br/jspui/bitstream/ufjf/9117/3/Drogas%20anti-VIH.pdf.txt01b2b6d7c0c74621c3db282c9a40511eMD53ufjf/91172019-06-16 12:15:38.425oai:hermes.cpd.ufjf.br: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Repositório InstitucionalPUBhttps://repositorio.ufjf.br/oai/requestopendoar:2019-06-16T15:15:38Repositório Institucional da UFJF - Universidade Federal de Juiz de Fora (UFJF)false |
| dc.title.pt_BR.fl_str_mv |
Drogas anti-VIH: passado, presente e perspectivas futuras |
| dc.title.alternative.pt_BR.fl_str_mv |
Drugs anti-HIV: past, present and future perspectives |
| title |
Drogas anti-VIH: passado, presente e perspectivas futuras |
| spellingShingle |
Drogas anti-VIH: passado, presente e perspectivas futuras Souza, Marcus Vinícius Nora de - AIDS New Anti-HIV drugs Replicative cycle |
| title_short |
Drogas anti-VIH: passado, presente e perspectivas futuras |
| title_full |
Drogas anti-VIH: passado, presente e perspectivas futuras |
| title_fullStr |
Drogas anti-VIH: passado, presente e perspectivas futuras |
| title_full_unstemmed |
Drogas anti-VIH: passado, presente e perspectivas futuras |
| title_sort |
Drogas anti-VIH: passado, presente e perspectivas futuras |
| author |
Souza, Marcus Vinícius Nora de |
| author_facet |
Souza, Marcus Vinícius Nora de Almeida, Mauro Vieira de |
| author_role |
author |
| author2 |
Almeida, Mauro Vieira de |
| author2_role |
author |
| dc.contributor.author.fl_str_mv |
Souza, Marcus Vinícius Nora de Almeida, Mauro Vieira de |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- AIDS New Anti-HIV drugs Replicative cycle |
| dc.subject.por.fl_str_mv |
AIDS New Anti-HIV drugs Replicative cycle |
| description |
- |
| publishDate |
2003 |
| dc.date.issued.fl_str_mv |
2003-06 |
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2019-02-22T12:19:49Z |
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2019-02-19 2019-02-22T12:19:49Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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https://repositorio.ufjf.br/jspui/handle/ufjf/9117 |
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http://dx.doi.org/10.1590/S0100-40422003000300014 |
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por |
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Química Nova |
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Brasil |
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