Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.5935/0100-4042.20140075 https://repositorio.ufjf.br/jspui/handle/ufjf/7731 |
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2018-10-05T18:40:58Z2018-09-182018-10-05T18:40:58Z2014-05373492496http://dx.doi.org/10.5935/0100-4042.20140075https://repositorio.ufjf.br/jspui/handle/ufjf/7731-One of the main challenges in the development of new antimalarial drugs is to achieve a viable lead candidate with good pharmacokinetic properties. Curcumin has a broad range of biological activities, including antimalarial activity. Herein, we report the antimalarial activity of six curcumin derivatives (6-12) and an initial analysis of their pharmacokinetic properties. Five compounds have demonstrated potent activity against the P. falciparum in vitro (IC50 values ranging from 1.7 to 15.2 µg mL-1), with moderate or low cytotoxicity against the HeLa cell line. The substitution of the carbonyl group in 6 by a 2,4-dinitrophenylhydrazone group (to afford 11) increases the Selective Index. These preliminary results indicate curcumin derivatives as potential antimalarial compounds.por--BrasilQuímica Nova-Curcumin derivativesAntimalarial chemotherapyPlasmodium falciparumSíntese e avaliação da atividade antimalárica de compostos derivados da curcuminaSynthesis and evaluation of antimalarial activity of curcumin derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGomes, Patrícia RamosMiguel, Fábio BalbinoOliveira, Michael Éder deFerreira, Vanessa VianaGuimarães, Daniel Silqueira MartinsLima, Aline Brito deBarbosa, Camila de SouzaOliveira, Mariana Amorim deAlmeida, Mauro Vieira deViana, Gustavo Henrique RibeiroCouri, Mara Rubia CostaVarotti, Fernando de Pillainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILSíntese e avaliação da atividade antimalárica de compostos derivados da curcumina.pdf.jpgSíntese e avaliação da atividade antimalárica de compostos derivados da curcumina.pdf.jpgGenerated Thumbnailimage/jpeg1646https://repositorio.ufjf.br/jspui/bitstream/ufjf/7731/4/S%c3%adntese%20e%20avalia%c3%a7%c3%a3o%20da%20atividade%20antimal%c3%a1rica%20de%20compostos%20derivados%20da%20curcumina.pdf.jpg227a7f97068700f19c7853e474010e45MD54ORIGINALSíntese e avaliação da atividade antimalárica de compostos derivados da curcumina.pdfSíntese e avaliação da atividade antimalárica de compostos derivados da curcumina.pdfapplication/pdf170076https://repositorio.ufjf.br/jspui/bitstream/ufjf/7731/1/S%c3%adntese%20e%20avalia%c3%a7%c3%a3o%20da%20atividade%20antimal%c3%a1rica%20de%20compostos%20derivados%20da%20curcumina.pdf1805e94425842a967b4efa632fcfddd4MD51LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina |
| dc.title.alternative.pt_BR.fl_str_mv |
Synthesis and evaluation of antimalarial activity of curcumin derivatives |
| title |
Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina |
| spellingShingle |
Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina Gomes, Patrícia Ramos - Curcumin derivatives Antimalarial chemotherapy Plasmodium falciparum |
| title_short |
Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina |
| title_full |
Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina |
| title_fullStr |
Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina |
| title_full_unstemmed |
Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina |
| title_sort |
Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina |
| author |
Gomes, Patrícia Ramos |
| author_facet |
Gomes, Patrícia Ramos Miguel, Fábio Balbino Oliveira, Michael Éder de Ferreira, Vanessa Viana Guimarães, Daniel Silqueira Martins Lima, Aline Brito de Barbosa, Camila de Souza Oliveira, Mariana Amorim de Almeida, Mauro Vieira de Viana, Gustavo Henrique Ribeiro Couri, Mara Rubia Costa Varotti, Fernando de Pilla |
| author_role |
author |
| author2 |
Miguel, Fábio Balbino Oliveira, Michael Éder de Ferreira, Vanessa Viana Guimarães, Daniel Silqueira Martins Lima, Aline Brito de Barbosa, Camila de Souza Oliveira, Mariana Amorim de Almeida, Mauro Vieira de Viana, Gustavo Henrique Ribeiro Couri, Mara Rubia Costa Varotti, Fernando de Pilla |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gomes, Patrícia Ramos Miguel, Fábio Balbino Oliveira, Michael Éder de Ferreira, Vanessa Viana Guimarães, Daniel Silqueira Martins Lima, Aline Brito de Barbosa, Camila de Souza Oliveira, Mariana Amorim de Almeida, Mauro Vieira de Viana, Gustavo Henrique Ribeiro Couri, Mara Rubia Costa Varotti, Fernando de Pilla |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- Curcumin derivatives Antimalarial chemotherapy Plasmodium falciparum |
| dc.subject.por.fl_str_mv |
Curcumin derivatives Antimalarial chemotherapy Plasmodium falciparum |
| description |
- |
| publishDate |
2014 |
| dc.date.issued.fl_str_mv |
2014-05 |
| dc.date.accessioned.fl_str_mv |
2018-10-05T18:40:58Z |
| dc.date.available.fl_str_mv |
2018-09-18 2018-10-05T18:40:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://repositorio.ufjf.br/jspui/handle/ufjf/7731 |
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http://dx.doi.org/10.5935/0100-4042.20140075 |
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http://dx.doi.org/10.5935/0100-4042.20140075 https://repositorio.ufjf.br/jspui/handle/ufjf/7731 |
| dc.language.iso.fl_str_mv |
por |
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por |
| dc.relation.ispartof.pt_BR.fl_str_mv |
Química Nova |
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info:eu-repo/semantics/openAccess |
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openAccess |
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- |
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- |
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Brasil |
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- |
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reponame:Repositório Institucional da UFJF instname:Universidade Federal de Juiz de Fora (UFJF) instacron:UFJF |
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