T-cell large granular lymphocytic leukemia: treatment experience with fludarabine

Detalhes bibliográficos
Autor(a) principal: Costa, Renata Oliveira
Data de Publicação: 2012
Outros Autores: Bellesso, Marcelo, Chamone, Dalton Alencar Fischer, Ruiz, Milton Artur, Hallack Neto, Abrahão Elias, Aldred, Vera Lucia, Pereira, Juliana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFJF
Texto Completo: http://dx.doi.org/10.6061/clinics/2012(07)07
https://repositorio.ufjf.br/jspui/handle/ufjf/8366
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spelling 2018-12-21T13:10:05Z2018-12-192018-12-21T13:10:05Z2012-07677745748http://dx.doi.org/10.6061/clinics/2012(07)07https://repositorio.ufjf.br/jspui/handle/ufjf/8366-OBJECTIVES: The aim of this retrospective study was to investigate the results of T-cell large granular lymphocytic leukemia treatment with fludarabine by assessing the complete hematologic response, the complete molecular response, progression-free survival, and overall survival. METHODS: We evaluated the records of six patients with T-cell large granular lymphocytic leukemia who were treated with fludarabine as a first-, second-, or third-line therapy, at a dose of 40 mg/m2, for three to five days per month and 6 to 8 cycles. RESULTS: Of the six patients investigated with T-cell large granular lymphocytic leukemia who were treated with fludarabine, five (83.3%) were female, and their median age was 36.5 years (range 18 to 73). The median lymphocyte level was 3.4x109/L (0.5 to 8.9). All patients exhibited a monoclonal T-cell receptor gamma gene rearrangement at diagnosis. Two (33.3%) patients received fludarabine as first-line treatment, two (33.3%) for refractory disease, one (16.6%) for relapsed disease after the suspension of methotrexate treatment dueto liver toxicity, and one (16.6%) due to dyspesia. A complete hematologic response was achieved in all cases, and a complete molecular response was achieved in five out six cases (83.3%). During a mean follow-up period of 12 months, both the progression-free survival and overall survival rates were 100%. CONCLUSION: T-cell large granular lymphocytic leukemia demonstrated a high rate of complete hematologic and molecular response to fludarabine, with excellent compliance and tolerability rates. To confirm our results in this rare disease, we believe that fludarabine should be tested in clinical trials as a first-line treatment for T-cell large granular lymphocytic leukemia.eng--BrasilClinics-FludarabineTreatmentLarge Granular Lymphocyte LeukemiaT-cell large granular lymphocytic leukemia: treatment experience with fludarabineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCosta, Renata OliveiraBellesso, MarceloChamone, Dalton Alencar FischerRuiz, Milton ArturHallack Neto, Abrahão EliasAldred, Vera LuciaPereira, Julianainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILT-cell large granular lymphocytic leukemia.pdf.jpgT-cell large granular lymphocytic leukemia.pdf.jpgGenerated Thumbnailimage/jpeg1766https://repositorio.ufjf.br/jspui/bitstream/ufjf/8366/4/T-cell%20large%20granular%20lymphocytic%20leukemia.pdf.jpgdd49f91bfc369c3a4c60128b543ff373MD54ORIGINALT-cell large granular lymphocytic leukemia.pdfT-cell large granular lymphocytic leukemia.pdfapplication/pdf149188https://repositorio.ufjf.br/jspui/bitstream/ufjf/8366/1/T-cell%20large%20granular%20lymphocytic%20leukemia.pdfe47bf3817a0e462bff2570da1abcea50MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82197https://repositorio.ufjf.br/jspui/bitstream/ufjf/8366/2/license.txt000e18a5aee6ca21bb5811ddf55fc37bMD52TEXTT-cell large granular lymphocytic leukemia.pdf.txtT-cell large granular lymphocytic leukemia.pdf.txtExtracted texttext/plain21001https://repositorio.ufjf.br/jspui/bitstream/ufjf/8366/3/T-cell%20large%20granular%20lymphocytic%20leukemia.pdf.txtafae0f39ef8d61747df5e305fcaf1319MD53ufjf/83662019-06-16 04:33:44.268oai:hermes.cpd.ufjf.br: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Repositório InstitucionalPUBhttps://repositorio.ufjf.br/oai/requestopendoar:2019-06-16T07:33:44Repositório Institucional da UFJF - Universidade Federal de Juiz de Fora (UFJF)false
dc.title.pt_BR.fl_str_mv T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
title T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
spellingShingle T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
Costa, Renata Oliveira
-
Fludarabine
Treatment
Large Granular Lymphocyte Leukemia
title_short T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
title_full T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
title_fullStr T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
title_full_unstemmed T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
title_sort T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
author Costa, Renata Oliveira
author_facet Costa, Renata Oliveira
Bellesso, Marcelo
Chamone, Dalton Alencar Fischer
Ruiz, Milton Artur
Hallack Neto, Abrahão Elias
Aldred, Vera Lucia
Pereira, Juliana
author_role author
author2 Bellesso, Marcelo
Chamone, Dalton Alencar Fischer
Ruiz, Milton Artur
Hallack Neto, Abrahão Elias
Aldred, Vera Lucia
Pereira, Juliana
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Renata Oliveira
Bellesso, Marcelo
Chamone, Dalton Alencar Fischer
Ruiz, Milton Artur
Hallack Neto, Abrahão Elias
Aldred, Vera Lucia
Pereira, Juliana
dc.subject.cnpq.fl_str_mv -
topic -
Fludarabine
Treatment
Large Granular Lymphocyte Leukemia
dc.subject.por.fl_str_mv Fludarabine
Treatment
Large Granular Lymphocyte Leukemia
description -
publishDate 2012
dc.date.issued.fl_str_mv 2012-07
dc.date.accessioned.fl_str_mv 2018-12-21T13:10:05Z
dc.date.available.fl_str_mv 2018-12-19
2018-12-21T13:10:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufjf.br/jspui/handle/ufjf/8366
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.6061/clinics/2012(07)07
url http://dx.doi.org/10.6061/clinics/2012(07)07
https://repositorio.ufjf.br/jspui/handle/ufjf/8366
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Clinics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv -
dc.publisher.initials.fl_str_mv -
dc.publisher.country.fl_str_mv Brasil
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFJF
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