Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFLA |
Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/37623 |
Resumo: | Objective: To investigate the effect of jump training associated with fish oil (FO) supplementation (1g/Kg bodyweight/day) on biochemical parameters of cachexia and tumor growth in Walker 256 tumor-bearing rats. Methods: Eighty rats were divided into sedentary non- and tumor-bearing (S and SW), exercised (EX and EXW), FO supplemented (SO and SWO), and both supplemented and exercised (EXW and EXWO). Jump training sessions consisted of 10 series of 30 seconds each, followed by 1 minute of rest. After six weeks of jump training, ascitic cells from Walker 256 tumor bearing-rat were inoculated, and after 15 days, all the animals were sacrificed. Results: The tumor mass in the SW group was 25.32 g, p<0.05 vs the SWO, EXW and EXWO groups (~11 g). The SW group presented hypoglycemia, hyperlactacidemia and hypertriacylglycerolemia and a reduction in body weight (-7.52 ± 3.19g), characterizing a state of cachexia. Supplementation with fish oil (SWO), exercise (EXW) and both (EXWO) prevented the onset of cachexia and promoted weight gain (p<0.05 vs SW), but less than that of the supplementation alone (p<0.05 vs SWO). In vitro cell proliferation of the tumor cells was lower in the SWO group (p<0.05 vs SW) and exercise reduced still further (p<0.05 vs. SW and SWO), with no increase when both therapies were applied together. Lipoperoxidation (p<0.05) was higher in the SWO, EXW, EXWO groups vs. S. Bcl-2 expression was also lower in these groups vs. SW. Conclusions: Jump training and fish oil supplementation alone were able to effectively prevent cachexia and reduce tumor growth, tumor cell proliferation, and Bcl-2 expression, but the combination of both did not promote any additive effect. |
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Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratosExercícioCâncerCaquexiaÓleo de peixeExerciseFish oilObjective: To investigate the effect of jump training associated with fish oil (FO) supplementation (1g/Kg bodyweight/day) on biochemical parameters of cachexia and tumor growth in Walker 256 tumor-bearing rats. Methods: Eighty rats were divided into sedentary non- and tumor-bearing (S and SW), exercised (EX and EXW), FO supplemented (SO and SWO), and both supplemented and exercised (EXW and EXWO). Jump training sessions consisted of 10 series of 30 seconds each, followed by 1 minute of rest. After six weeks of jump training, ascitic cells from Walker 256 tumor bearing-rat were inoculated, and after 15 days, all the animals were sacrificed. Results: The tumor mass in the SW group was 25.32 g, p<0.05 vs the SWO, EXW and EXWO groups (~11 g). The SW group presented hypoglycemia, hyperlactacidemia and hypertriacylglycerolemia and a reduction in body weight (-7.52 ± 3.19g), characterizing a state of cachexia. Supplementation with fish oil (SWO), exercise (EXW) and both (EXWO) prevented the onset of cachexia and promoted weight gain (p<0.05 vs SW), but less than that of the supplementation alone (p<0.05 vs SWO). In vitro cell proliferation of the tumor cells was lower in the SWO group (p<0.05 vs SW) and exercise reduced still further (p<0.05 vs. SW and SWO), with no increase when both therapies were applied together. Lipoperoxidation (p<0.05) was higher in the SWO, EXW, EXWO groups vs. S. Bcl-2 expression was also lower in these groups vs. SW. Conclusions: Jump training and fish oil supplementation alone were able to effectively prevent cachexia and reduce tumor growth, tumor cell proliferation, and Bcl-2 expression, but the combination of both did not promote any additive effect.Objetivo: Investigar o efeito do treinamento de salto associado à suplementação com óleo de peixe (1g/kg peso corporal/dia) em ratos portadores do tumor de Walker 256, sobre parâmetros bioquímicos de caquexia e crescimento tumoral. Métodos: Oitenta Ratos foram divididos em sedentário sem ou com tumor (S ou SW), exercitado (EX ou EXW), suplementado com óleo de peixe (SO ou SWO) e suplementado e exercitado (EXO ou EXWO). Sessões de treinamento de salto consistiram de 10 séries com duração de 30 segundos e intervalo de 1 minuto entre cada série. Após seis semanas de treinamento, células do tumor de Walker 256 foram inoculadas e após 15 dias os animais foram mortos. Resultados: O peso médio do tumor no grupo SW foi de 25,32 g, p<0,05 vs. ao dos SWO, EXW e EXWO (~11 g). O grupo SW apresentou hipoglicemia, hiperlactatemia, hipertriacilglicerolemia e perda de peso (-7,52±3,19g), caracterizando estado caquético. Suplementação com óleo de peixe (SWO), exercício (EXW) e associação de ambos (EXWO) impediram a instalação da caquexia (p<0,05 vs. SW). No grupo SWO, EXW e suas associações (EXWO) promoveram ganho de peso (p<0,05 vs. SW), mas inferior ao da suplementação isolada (p<0,05 vs. SWO). A proliferação celular in vitro das células tumorais foi menor no grupo SWO (p<0,05 vs. SW) e o exercício reduziu ainda mais (p<0,05 vs. SW e SWO), não havendo incremento quando se associaram ambas as terapias. Lipoperoxidação (p<0,05) foi maior nos SWO, EXW, EXWO vs. S. A expressão de Bcl-2 foi menor também nestes grupos vs. SW. Conclusões: O treinamento de força e a suplementação com óleo de peixe foram eficazes em evitar a caquexia e induzir a redução do crescimento tumoral, da proliferação tumoral e expressão de Bcl-2, mas a associação de ambos não promoveu efeito aditivoSociedade Brasileira de Medicina do Exercício e do Esporte2019-11-13T13:20:14Z2019-11-13T13:20:14Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGOMES, R. T. M. et al. Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos. Revista Brasileira de Medicina do Esporte, São Paulo, v. 20, n. 3, p. 204-209, 2014.http://repositorio.ufla.br/jspui/handle/1/37623Revista Brasileira de Medicina do Esportereponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessGomes, Renata Teixeira MamusKryczyk, MarceloMinuzzi, LucieleBorghetti, GinaAikawa, JuliaPequito, Danielle Cristina TonelloCoelho, IsabelaFernandes, Luiz Cláudiopor2023-04-24T18:14:59Zoai:localhost:1/37623Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2023-04-24T18:14:59Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
dc.title.none.fl_str_mv |
Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos |
title |
Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos |
spellingShingle |
Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos Gomes, Renata Teixeira Mamus Exercício Câncer Caquexia Óleo de peixe Exercise Fish oil |
title_short |
Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos |
title_full |
Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos |
title_fullStr |
Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos |
title_full_unstemmed |
Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos |
title_sort |
Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos |
author |
Gomes, Renata Teixeira Mamus |
author_facet |
Gomes, Renata Teixeira Mamus Kryczyk, Marcelo Minuzzi, Luciele Borghetti, Gina Aikawa, Julia Pequito, Danielle Cristina Tonello Coelho, Isabela Fernandes, Luiz Cláudio |
author_role |
author |
author2 |
Kryczyk, Marcelo Minuzzi, Luciele Borghetti, Gina Aikawa, Julia Pequito, Danielle Cristina Tonello Coelho, Isabela Fernandes, Luiz Cláudio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Renata Teixeira Mamus Kryczyk, Marcelo Minuzzi, Luciele Borghetti, Gina Aikawa, Julia Pequito, Danielle Cristina Tonello Coelho, Isabela Fernandes, Luiz Cláudio |
dc.subject.por.fl_str_mv |
Exercício Câncer Caquexia Óleo de peixe Exercise Fish oil |
topic |
Exercício Câncer Caquexia Óleo de peixe Exercise Fish oil |
description |
Objective: To investigate the effect of jump training associated with fish oil (FO) supplementation (1g/Kg bodyweight/day) on biochemical parameters of cachexia and tumor growth in Walker 256 tumor-bearing rats. Methods: Eighty rats were divided into sedentary non- and tumor-bearing (S and SW), exercised (EX and EXW), FO supplemented (SO and SWO), and both supplemented and exercised (EXW and EXWO). Jump training sessions consisted of 10 series of 30 seconds each, followed by 1 minute of rest. After six weeks of jump training, ascitic cells from Walker 256 tumor bearing-rat were inoculated, and after 15 days, all the animals were sacrificed. Results: The tumor mass in the SW group was 25.32 g, p<0.05 vs the SWO, EXW and EXWO groups (~11 g). The SW group presented hypoglycemia, hyperlactacidemia and hypertriacylglycerolemia and a reduction in body weight (-7.52 ± 3.19g), characterizing a state of cachexia. Supplementation with fish oil (SWO), exercise (EXW) and both (EXWO) prevented the onset of cachexia and promoted weight gain (p<0.05 vs SW), but less than that of the supplementation alone (p<0.05 vs SWO). In vitro cell proliferation of the tumor cells was lower in the SWO group (p<0.05 vs SW) and exercise reduced still further (p<0.05 vs. SW and SWO), with no increase when both therapies were applied together. Lipoperoxidation (p<0.05) was higher in the SWO, EXW, EXWO groups vs. S. Bcl-2 expression was also lower in these groups vs. SW. Conclusions: Jump training and fish oil supplementation alone were able to effectively prevent cachexia and reduce tumor growth, tumor cell proliferation, and Bcl-2 expression, but the combination of both did not promote any additive effect. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2019-11-13T13:20:14Z 2019-11-13T13:20:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
GOMES, R. T. M. et al. Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos. Revista Brasileira de Medicina do Esporte, São Paulo, v. 20, n. 3, p. 204-209, 2014. http://repositorio.ufla.br/jspui/handle/1/37623 |
identifier_str_mv |
GOMES, R. T. M. et al. Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos. Revista Brasileira de Medicina do Esporte, São Paulo, v. 20, n. 3, p. 204-209, 2014. |
url |
http://repositorio.ufla.br/jspui/handle/1/37623 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina do Exercício e do Esporte |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina do Exercício e do Esporte |
dc.source.none.fl_str_mv |
Revista Brasileira de Medicina do Esporte reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
instname_str |
Universidade Federal de Lavras (UFLA) |
instacron_str |
UFLA |
institution |
UFLA |
reponame_str |
Repositório Institucional da UFLA |
collection |
Repositório Institucional da UFLA |
repository.name.fl_str_mv |
Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
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1815439157370028032 |