Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos

Detalhes bibliográficos
Autor(a) principal: Gomes, Renata Teixeira Mamus
Data de Publicação: 2014
Outros Autores: Kryczyk, Marcelo, Minuzzi, Luciele, Borghetti, Gina, Aikawa, Julia, Pequito, Danielle Cristina Tonello, Coelho, Isabela, Fernandes, Luiz Cláudio
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/37623
Resumo: Objective: To investigate the effect of jump training associated with fish oil (FO) supplementation (1g/Kg bodyweight/day) on biochemical parameters of cachexia and tumor growth in Walker 256 tumor-bearing rats. Methods: Eighty rats were divided into sedentary non- and tumor-bearing (S and SW), exercised (EX and EXW), FO supplemented (SO and SWO), and both supplemented and exercised (EXW and EXWO). Jump training sessions consisted of 10 series of 30 seconds each, followed by 1 minute of rest. After six weeks of jump training, ascitic cells from Walker 256 tumor bearing-rat were inoculated, and after 15 days, all the animals were sacrificed. Results: The tumor mass in the SW group was 25.32 g, p<0.05 vs the SWO, EXW and EXWO groups (~11 g). The SW group presented hypoglycemia, hyperlactacidemia and hypertriacylglycerolemia and a reduction in body weight (-7.52 ± 3.19g), characterizing a state of cachexia. Supplementation with fish oil (SWO), exercise (EXW) and both (EXWO) prevented the onset of cachexia and promoted weight gain (p<0.05 vs SW), but less than that of the supplementation alone (p<0.05 vs SWO). In vitro cell proliferation of the tumor cells was lower in the SWO group (p<0.05 vs SW) and exercise reduced still further (p<0.05 vs. SW and SWO), with no increase when both therapies were applied together. Lipoperoxidation (p<0.05) was higher in the SWO, EXW, EXWO groups vs. S. Bcl-2 expression was also lower in these groups vs. SW. Conclusions: Jump training and fish oil supplementation alone were able to effectively prevent cachexia and reduce tumor growth, tumor cell proliferation, and Bcl-2 expression, but the combination of both did not promote any additive effect.
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spelling Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratosExercícioCâncerCaquexiaÓleo de peixeExerciseFish oilObjective: To investigate the effect of jump training associated with fish oil (FO) supplementation (1g/Kg bodyweight/day) on biochemical parameters of cachexia and tumor growth in Walker 256 tumor-bearing rats. Methods: Eighty rats were divided into sedentary non- and tumor-bearing (S and SW), exercised (EX and EXW), FO supplemented (SO and SWO), and both supplemented and exercised (EXW and EXWO). Jump training sessions consisted of 10 series of 30 seconds each, followed by 1 minute of rest. After six weeks of jump training, ascitic cells from Walker 256 tumor bearing-rat were inoculated, and after 15 days, all the animals were sacrificed. Results: The tumor mass in the SW group was 25.32 g, p<0.05 vs the SWO, EXW and EXWO groups (~11 g). The SW group presented hypoglycemia, hyperlactacidemia and hypertriacylglycerolemia and a reduction in body weight (-7.52 ± 3.19g), characterizing a state of cachexia. Supplementation with fish oil (SWO), exercise (EXW) and both (EXWO) prevented the onset of cachexia and promoted weight gain (p<0.05 vs SW), but less than that of the supplementation alone (p<0.05 vs SWO). In vitro cell proliferation of the tumor cells was lower in the SWO group (p<0.05 vs SW) and exercise reduced still further (p<0.05 vs. SW and SWO), with no increase when both therapies were applied together. Lipoperoxidation (p<0.05) was higher in the SWO, EXW, EXWO groups vs. S. Bcl-2 expression was also lower in these groups vs. SW. Conclusions: Jump training and fish oil supplementation alone were able to effectively prevent cachexia and reduce tumor growth, tumor cell proliferation, and Bcl-2 expression, but the combination of both did not promote any additive effect.Objetivo: Investigar o efeito do treinamento de salto associado à suplementação com óleo de peixe (1g/kg peso corporal/dia) em ratos portadores do tumor de Walker 256, sobre parâmetros bioquímicos de caquexia e crescimento tumoral. Métodos: Oitenta Ratos foram divididos em sedentário sem ou com tumor (S ou SW), exercitado (EX ou EXW), suplementado com óleo de peixe (SO ou SWO) e suplementado e exercitado (EXO ou EXWO). Sessões de treinamento de salto consistiram de 10 séries com duração de 30 segundos e intervalo de 1 minuto entre cada série. Após seis semanas de treinamento, células do tumor de Walker 256 foram inoculadas e após 15 dias os animais foram mortos. Resultados: O peso médio do tumor no grupo SW foi de 25,32 g, p<0,05 vs. ao dos SWO, EXW e EXWO (~11 g). O grupo SW apresentou hipoglicemia, hiperlactatemia, hipertriacilglicerolemia e perda de peso (-7,52±3,19g), caracterizando estado caquético. Suplementação com óleo de peixe (SWO), exercício (EXW) e associação de ambos (EXWO) impediram a instalação da caquexia (p<0,05 vs. SW). No grupo SWO, EXW e suas associações (EXWO) promoveram ganho de peso (p<0,05 vs. SW), mas inferior ao da suplementação isolada (p<0,05 vs. SWO). A proliferação celular in vitro das células tumorais foi menor no grupo SWO (p<0,05 vs. SW) e o exercício reduziu ainda mais (p<0,05 vs. SW e SWO), não havendo incremento quando se associaram ambas as terapias. Lipoperoxidação (p<0,05) foi maior nos SWO, EXW, EXWO vs. S. A expressão de Bcl-2 foi menor também nestes grupos vs. SW. Conclusões: O treinamento de força e a suplementação com óleo de peixe foram eficazes em evitar a caquexia e induzir a redução do crescimento tumoral, da proliferação tumoral e expressão de Bcl-2, mas a associação de ambos não promoveu efeito aditivoSociedade Brasileira de Medicina do Exercício e do Esporte2019-11-13T13:20:14Z2019-11-13T13:20:14Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGOMES, R. T. M. et al. Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos. Revista Brasileira de Medicina do Esporte, São Paulo, v. 20, n. 3, p. 204-209, 2014.http://repositorio.ufla.br/jspui/handle/1/37623Revista Brasileira de Medicina do Esportereponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessGomes, Renata Teixeira MamusKryczyk, MarceloMinuzzi, LucieleBorghetti, GinaAikawa, JuliaPequito, Danielle Cristina TonelloCoelho, IsabelaFernandes, Luiz Cláudiopor2023-04-24T18:14:59Zoai:localhost:1/37623Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2023-04-24T18:14:59Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos
title Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos
spellingShingle Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos
Gomes, Renata Teixeira Mamus
Exercício
Câncer
Caquexia
Óleo de peixe
Exercise
Fish oil
title_short Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos
title_full Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos
title_fullStr Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos
title_full_unstemmed Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos
title_sort Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos
author Gomes, Renata Teixeira Mamus
author_facet Gomes, Renata Teixeira Mamus
Kryczyk, Marcelo
Minuzzi, Luciele
Borghetti, Gina
Aikawa, Julia
Pequito, Danielle Cristina Tonello
Coelho, Isabela
Fernandes, Luiz Cláudio
author_role author
author2 Kryczyk, Marcelo
Minuzzi, Luciele
Borghetti, Gina
Aikawa, Julia
Pequito, Danielle Cristina Tonello
Coelho, Isabela
Fernandes, Luiz Cláudio
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Renata Teixeira Mamus
Kryczyk, Marcelo
Minuzzi, Luciele
Borghetti, Gina
Aikawa, Julia
Pequito, Danielle Cristina Tonello
Coelho, Isabela
Fernandes, Luiz Cláudio
dc.subject.por.fl_str_mv Exercício
Câncer
Caquexia
Óleo de peixe
Exercise
Fish oil
topic Exercício
Câncer
Caquexia
Óleo de peixe
Exercise
Fish oil
description Objective: To investigate the effect of jump training associated with fish oil (FO) supplementation (1g/Kg bodyweight/day) on biochemical parameters of cachexia and tumor growth in Walker 256 tumor-bearing rats. Methods: Eighty rats were divided into sedentary non- and tumor-bearing (S and SW), exercised (EX and EXW), FO supplemented (SO and SWO), and both supplemented and exercised (EXW and EXWO). Jump training sessions consisted of 10 series of 30 seconds each, followed by 1 minute of rest. After six weeks of jump training, ascitic cells from Walker 256 tumor bearing-rat were inoculated, and after 15 days, all the animals were sacrificed. Results: The tumor mass in the SW group was 25.32 g, p<0.05 vs the SWO, EXW and EXWO groups (~11 g). The SW group presented hypoglycemia, hyperlactacidemia and hypertriacylglycerolemia and a reduction in body weight (-7.52 ± 3.19g), characterizing a state of cachexia. Supplementation with fish oil (SWO), exercise (EXW) and both (EXWO) prevented the onset of cachexia and promoted weight gain (p<0.05 vs SW), but less than that of the supplementation alone (p<0.05 vs SWO). In vitro cell proliferation of the tumor cells was lower in the SWO group (p<0.05 vs SW) and exercise reduced still further (p<0.05 vs. SW and SWO), with no increase when both therapies were applied together. Lipoperoxidation (p<0.05) was higher in the SWO, EXW, EXWO groups vs. S. Bcl-2 expression was also lower in these groups vs. SW. Conclusions: Jump training and fish oil supplementation alone were able to effectively prevent cachexia and reduce tumor growth, tumor cell proliferation, and Bcl-2 expression, but the combination of both did not promote any additive effect.
publishDate 2014
dc.date.none.fl_str_mv 2014
2019-11-13T13:20:14Z
2019-11-13T13:20:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv GOMES, R. T. M. et al. Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos. Revista Brasileira de Medicina do Esporte, São Paulo, v. 20, n. 3, p. 204-209, 2014.
http://repositorio.ufla.br/jspui/handle/1/37623
identifier_str_mv GOMES, R. T. M. et al. Exercício de forca associado a óleo de peixe reduzem massa tumoral e caquexia em ratos. Revista Brasileira de Medicina do Esporte, São Paulo, v. 20, n. 3, p. 204-209, 2014.
url http://repositorio.ufla.br/jspui/handle/1/37623
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina do Exercício e do Esporte
publisher.none.fl_str_mv Sociedade Brasileira de Medicina do Exercício e do Esporte
dc.source.none.fl_str_mv Revista Brasileira de Medicina do Esporte
reponame:Repositório Institucional da UFLA
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reponame_str Repositório Institucional da UFLA
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