Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFLA |
Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/48992 |
Resumo: | Background: Periodontal disease is one of the most frequent comorbidities in diabetic patients and can contribute to poor blood glucose control. Objective: To evaluate the efects of ingesting diferent doses of beta-glucans (BG) isolated from Saccharomyces cer‑ evisiae on alveolar bone loss (ABL) and infammatory/metabolic parameters in normal and diabetic rats with ligatureinduced periodontal disease (PD). Design: Sixty male rats were assigned into two groups: non-diabetic or diabetic (i.p. 70 mg/kg streptozotocin) with PD. Then, groups were subdivided into fve subgroups according BG doses: 0 mg/Kg; 10 mg/Kg; 20 mg/Kg; 40 mg/Kg or 80 mg/Kg. Animals received BG for 28 days and ligatures were placed on lower frst molars during the last 14 days. Results: ABL of diabetic and non-diabetic animals receiving BG 40 mg/kg (1.33 ± 0.03 mm and 0.77 ± 0.07 mm, respectively) and 80 mg/kg (1.26 ± 0.07 mm and 0.78 ± 0.05 mm, respectively) doses was lower (p < 0.05) in com‑ parison to respective controls (1.59 ± 0.11 mm and 0.90 mm ±0.08). COX-2 (Control: 1.66 ± 0.12; 40 mg/kg: 1.13 ± 0.07; 80 mg/kg: 0.92 ± 0.18) and RANKL expressions (Control: 1.74 ± 0.34; 40 mg/kg: 1.03 ± 0.29 ;80 mg/kg: 0.75 ± 0.21), together with the RANKL/OPG ratio (Control: 1.17 ± 0.08; 40 mg/kg: 0.67 ± 0.09; 80 mg/kg: 0.63 ± 0.28) were attenuated above the same dose (p < 0.05). BG did not infuence (p > 0.05) metabolic parameters in non-diabetic rats. In diabetic animals, doses above 40 mg/kg reduced IL-1β (Control: 387 ± 66; 40 mg/kg: 309 ± 27; 80 mg/kg: 300 ± 14) and TNF-α (Control: 229 ± 19; 40 mg/kg: 128 ± 53; 80 mg/kg: 71 ± 25), blood glucose levels (Control: 402 ± 49; 40 mg/kg: 334 ± 32; 80 mg/kg: 287 ± 56), total cholesterol (Control: 124 ± 8; 40 mg/kg: 120 ± 10; 80 mg/kg: 108 ± 9), LDL-c + VLDL-c (Control: 106 ± 8; 40 mg/kg: 103 ± 10; 80 mg/kg: 87 ± 10) and triacylglycerols (Control: 508 ± 90; 40 mg/kg: 301 ± 40; 80 mg/kg: 208 ± 61), whereas increased HDL-c (Control: 18 ± 0.5; 40 mg/kg: 19 ± 1; 80 mg/kg: 21 ± 1) (p < 0.05). Optimal dose needed to reduce ABL was higher in diabetic animals with PD. |
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Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal diseasePeriodontitisDiabetes mellitusBone lossInflammatory statusβ-glucansPeriodontitePerda ósseaStatus inflamatórioβ-glucanosPrebióticosBackground: Periodontal disease is one of the most frequent comorbidities in diabetic patients and can contribute to poor blood glucose control. Objective: To evaluate the efects of ingesting diferent doses of beta-glucans (BG) isolated from Saccharomyces cer‑ evisiae on alveolar bone loss (ABL) and infammatory/metabolic parameters in normal and diabetic rats with ligatureinduced periodontal disease (PD). Design: Sixty male rats were assigned into two groups: non-diabetic or diabetic (i.p. 70 mg/kg streptozotocin) with PD. Then, groups were subdivided into fve subgroups according BG doses: 0 mg/Kg; 10 mg/Kg; 20 mg/Kg; 40 mg/Kg or 80 mg/Kg. Animals received BG for 28 days and ligatures were placed on lower frst molars during the last 14 days. Results: ABL of diabetic and non-diabetic animals receiving BG 40 mg/kg (1.33 ± 0.03 mm and 0.77 ± 0.07 mm, respectively) and 80 mg/kg (1.26 ± 0.07 mm and 0.78 ± 0.05 mm, respectively) doses was lower (p < 0.05) in com‑ parison to respective controls (1.59 ± 0.11 mm and 0.90 mm ±0.08). COX-2 (Control: 1.66 ± 0.12; 40 mg/kg: 1.13 ± 0.07; 80 mg/kg: 0.92 ± 0.18) and RANKL expressions (Control: 1.74 ± 0.34; 40 mg/kg: 1.03 ± 0.29 ;80 mg/kg: 0.75 ± 0.21), together with the RANKL/OPG ratio (Control: 1.17 ± 0.08; 40 mg/kg: 0.67 ± 0.09; 80 mg/kg: 0.63 ± 0.28) were attenuated above the same dose (p < 0.05). BG did not infuence (p > 0.05) metabolic parameters in non-diabetic rats. In diabetic animals, doses above 40 mg/kg reduced IL-1β (Control: 387 ± 66; 40 mg/kg: 309 ± 27; 80 mg/kg: 300 ± 14) and TNF-α (Control: 229 ± 19; 40 mg/kg: 128 ± 53; 80 mg/kg: 71 ± 25), blood glucose levels (Control: 402 ± 49; 40 mg/kg: 334 ± 32; 80 mg/kg: 287 ± 56), total cholesterol (Control: 124 ± 8; 40 mg/kg: 120 ± 10; 80 mg/kg: 108 ± 9), LDL-c + VLDL-c (Control: 106 ± 8; 40 mg/kg: 103 ± 10; 80 mg/kg: 87 ± 10) and triacylglycerols (Control: 508 ± 90; 40 mg/kg: 301 ± 40; 80 mg/kg: 208 ± 61), whereas increased HDL-c (Control: 18 ± 0.5; 40 mg/kg: 19 ± 1; 80 mg/kg: 21 ± 1) (p < 0.05). Optimal dose needed to reduce ABL was higher in diabetic animals with PD.Springer Nature2022-01-24T20:28:50Z2022-01-24T20:28:50Z2021-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAZZI, D. V. et al. Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease. Diabetology & Metabolic Syndrome, [S. I.], v. 13, 2021. DOI: https://doi.org/10.1186/s13098-021-00729-1.http://repositorio.ufla.br/jspui/handle/1/48992Diabetology & Metabolic Syndromereponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessAzzi, Diana VilelaPereira, Andressa Naira de JesusSilva, Viviam de OliveiraFoureaux, Renata de CarvalhoLima, Andressa Ribeiro VeigaBarducci, Robson SfaciottiAlbuquerque, Adriana SilvaReis, Gabriel LasmarOliveira, Raphael Ricon deAndrade, Eric FrancelinoZangeronimo, Márcio GilbertoChalfun Júnior, AntonioPereira, Luciano Joséeng2022-01-24T20:29:14Zoai:localhost:1/48992Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2022-01-24T20:29:14Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
dc.title.none.fl_str_mv |
Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease |
title |
Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease |
spellingShingle |
Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease Azzi, Diana Vilela Periodontitis Diabetes mellitus Bone loss Inflammatory status β-glucans Periodontite Perda óssea Status inflamatório β-glucanos Prebióticos |
title_short |
Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease |
title_full |
Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease |
title_fullStr |
Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease |
title_full_unstemmed |
Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease |
title_sort |
Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease |
author |
Azzi, Diana Vilela |
author_facet |
Azzi, Diana Vilela Pereira, Andressa Naira de Jesus Silva, Viviam de Oliveira Foureaux, Renata de Carvalho Lima, Andressa Ribeiro Veiga Barducci, Robson Sfaciotti Albuquerque, Adriana Silva Reis, Gabriel Lasmar Oliveira, Raphael Ricon de Andrade, Eric Francelino Zangeronimo, Márcio Gilberto Chalfun Júnior, Antonio Pereira, Luciano José |
author_role |
author |
author2 |
Pereira, Andressa Naira de Jesus Silva, Viviam de Oliveira Foureaux, Renata de Carvalho Lima, Andressa Ribeiro Veiga Barducci, Robson Sfaciotti Albuquerque, Adriana Silva Reis, Gabriel Lasmar Oliveira, Raphael Ricon de Andrade, Eric Francelino Zangeronimo, Márcio Gilberto Chalfun Júnior, Antonio Pereira, Luciano José |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Azzi, Diana Vilela Pereira, Andressa Naira de Jesus Silva, Viviam de Oliveira Foureaux, Renata de Carvalho Lima, Andressa Ribeiro Veiga Barducci, Robson Sfaciotti Albuquerque, Adriana Silva Reis, Gabriel Lasmar Oliveira, Raphael Ricon de Andrade, Eric Francelino Zangeronimo, Márcio Gilberto Chalfun Júnior, Antonio Pereira, Luciano José |
dc.subject.por.fl_str_mv |
Periodontitis Diabetes mellitus Bone loss Inflammatory status β-glucans Periodontite Perda óssea Status inflamatório β-glucanos Prebióticos |
topic |
Periodontitis Diabetes mellitus Bone loss Inflammatory status β-glucans Periodontite Perda óssea Status inflamatório β-glucanos Prebióticos |
description |
Background: Periodontal disease is one of the most frequent comorbidities in diabetic patients and can contribute to poor blood glucose control. Objective: To evaluate the efects of ingesting diferent doses of beta-glucans (BG) isolated from Saccharomyces cer‑ evisiae on alveolar bone loss (ABL) and infammatory/metabolic parameters in normal and diabetic rats with ligatureinduced periodontal disease (PD). Design: Sixty male rats were assigned into two groups: non-diabetic or diabetic (i.p. 70 mg/kg streptozotocin) with PD. Then, groups were subdivided into fve subgroups according BG doses: 0 mg/Kg; 10 mg/Kg; 20 mg/Kg; 40 mg/Kg or 80 mg/Kg. Animals received BG for 28 days and ligatures were placed on lower frst molars during the last 14 days. Results: ABL of diabetic and non-diabetic animals receiving BG 40 mg/kg (1.33 ± 0.03 mm and 0.77 ± 0.07 mm, respectively) and 80 mg/kg (1.26 ± 0.07 mm and 0.78 ± 0.05 mm, respectively) doses was lower (p < 0.05) in com‑ parison to respective controls (1.59 ± 0.11 mm and 0.90 mm ±0.08). COX-2 (Control: 1.66 ± 0.12; 40 mg/kg: 1.13 ± 0.07; 80 mg/kg: 0.92 ± 0.18) and RANKL expressions (Control: 1.74 ± 0.34; 40 mg/kg: 1.03 ± 0.29 ;80 mg/kg: 0.75 ± 0.21), together with the RANKL/OPG ratio (Control: 1.17 ± 0.08; 40 mg/kg: 0.67 ± 0.09; 80 mg/kg: 0.63 ± 0.28) were attenuated above the same dose (p < 0.05). BG did not infuence (p > 0.05) metabolic parameters in non-diabetic rats. In diabetic animals, doses above 40 mg/kg reduced IL-1β (Control: 387 ± 66; 40 mg/kg: 309 ± 27; 80 mg/kg: 300 ± 14) and TNF-α (Control: 229 ± 19; 40 mg/kg: 128 ± 53; 80 mg/kg: 71 ± 25), blood glucose levels (Control: 402 ± 49; 40 mg/kg: 334 ± 32; 80 mg/kg: 287 ± 56), total cholesterol (Control: 124 ± 8; 40 mg/kg: 120 ± 10; 80 mg/kg: 108 ± 9), LDL-c + VLDL-c (Control: 106 ± 8; 40 mg/kg: 103 ± 10; 80 mg/kg: 87 ± 10) and triacylglycerols (Control: 508 ± 90; 40 mg/kg: 301 ± 40; 80 mg/kg: 208 ± 61), whereas increased HDL-c (Control: 18 ± 0.5; 40 mg/kg: 19 ± 1; 80 mg/kg: 21 ± 1) (p < 0.05). Optimal dose needed to reduce ABL was higher in diabetic animals with PD. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10 2022-01-24T20:28:50Z 2022-01-24T20:28:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
AZZI, D. V. et al. Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease. Diabetology & Metabolic Syndrome, [S. I.], v. 13, 2021. DOI: https://doi.org/10.1186/s13098-021-00729-1. http://repositorio.ufla.br/jspui/handle/1/48992 |
identifier_str_mv |
AZZI, D. V. et al. Dose-response effect of prebiotic ingestion (β-glucans isolated from Saccharomyces cerevisiae) in diabetic rats with periodontal disease. Diabetology & Metabolic Syndrome, [S. I.], v. 13, 2021. DOI: https://doi.org/10.1186/s13098-021-00729-1. |
url |
http://repositorio.ufla.br/jspui/handle/1/48992 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
Diabetology & Metabolic Syndrome reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
instname_str |
Universidade Federal de Lavras (UFLA) |
instacron_str |
UFLA |
institution |
UFLA |
reponame_str |
Repositório Institucional da UFLA |
collection |
Repositório Institucional da UFLA |
repository.name.fl_str_mv |
Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
_version_ |
1807835192762564608 |