Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFLA |
Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/50866 |
Resumo: | Bone quality is an important issue in dentistry. Low bone density may be associated with more severe periodontitis, and may influence implant therapy success. Recent evidence suggests that physical activity can improve alveolar bone quality. Irisin is an exercise-mediated peptide that might be involved in this process. We assessed the effect of exercise and that of intra-peritoneal irisin administration on bone quality in healthy and osteoporosis-induced rodents. This study was registered at PROSPERO (CRD42020184140), and followed PRISMA guidelines. A search by two independent examiners was conducted in five databases and gray literature up to July 2021, without restrictions regarding language or date of publication. Initially, they analyzed retrieved titles and abstracts (n=3,844) based on eligibility criteria. Of this total, 19 studies remained for full-text reading, and 16 proceeded to the data extraction and quality assessment phases. Meta-analyses were conducted (n= 6 studies) to establish the effects of irisin administration on cancellous bone mineral density (BMD). Exercise or irisin administration enhanced bone quality, but the meta-analysis showed that BMD increased only slightly in osteoporotic rodents (BMD: mean difference 0.03 mg/cm3 - 95% CI 0.01-0.05). This indicates that they had no significant benefits on the bones of healthy animals. Implications of key findings evidence the potential of irisin as an agent able to mitigate bone loss caused by osteoporosis, an outcome that could favor dental rehabilitation. More studies investigating the effect of irisin on alveolar bone are needed to elucidate its therapeutic viability and implications. |
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Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral healthBone and BonesChronic DiseaseExerciseDentistryPhysiologySaúde bucalDoença crônicaOsso alveolarOdontologiaAtividade físicaIrisinaBone quality is an important issue in dentistry. Low bone density may be associated with more severe periodontitis, and may influence implant therapy success. Recent evidence suggests that physical activity can improve alveolar bone quality. Irisin is an exercise-mediated peptide that might be involved in this process. We assessed the effect of exercise and that of intra-peritoneal irisin administration on bone quality in healthy and osteoporosis-induced rodents. This study was registered at PROSPERO (CRD42020184140), and followed PRISMA guidelines. A search by two independent examiners was conducted in five databases and gray literature up to July 2021, without restrictions regarding language or date of publication. Initially, they analyzed retrieved titles and abstracts (n=3,844) based on eligibility criteria. Of this total, 19 studies remained for full-text reading, and 16 proceeded to the data extraction and quality assessment phases. Meta-analyses were conducted (n= 6 studies) to establish the effects of irisin administration on cancellous bone mineral density (BMD). Exercise or irisin administration enhanced bone quality, but the meta-analysis showed that BMD increased only slightly in osteoporotic rodents (BMD: mean difference 0.03 mg/cm3 - 95% CI 0.01-0.05). This indicates that they had no significant benefits on the bones of healthy animals. Implications of key findings evidence the potential of irisin as an agent able to mitigate bone loss caused by osteoporosis, an outcome that could favor dental rehabilitation. More studies investigating the effect of irisin on alveolar bone are needed to elucidate its therapeutic viability and implications.Sociedade Brasileira de Pesquisa Odontológica (SBPqO)2022-08-05T22:23:21Z2022-08-05T22:23:21Z2022-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPEREIRA, L. J. et al. Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health. Brazilian Oral Research, São Paulo, v. 36, e055, 2022. DOI: https://doi.org/10.1590/1807-3107bor-2022.vol36.0055.http://repositorio.ufla.br/jspui/handle/1/50866Brazilian Oral Researchreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessPereira, Luciano JoséAndrade, Eric FrancelinoBarroso, Lívia CorrêaLima, Renato Ribeiro deMacari, SoraiaPaiva, Saul MartinsSilva, Tarcília Aparecidaeng2023-05-02T10:55:21Zoai:localhost:1/50866Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2023-05-02T10:55:21Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
dc.title.none.fl_str_mv |
Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health |
title |
Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health |
spellingShingle |
Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health Pereira, Luciano José Bone and Bones Chronic Disease Exercise Dentistry Physiology Saúde bucal Doença crônica Osso alveolar Odontologia Atividade física Irisina |
title_short |
Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health |
title_full |
Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health |
title_fullStr |
Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health |
title_full_unstemmed |
Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health |
title_sort |
Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health |
author |
Pereira, Luciano José |
author_facet |
Pereira, Luciano José Andrade, Eric Francelino Barroso, Lívia Corrêa Lima, Renato Ribeiro de Macari, Soraia Paiva, Saul Martins Silva, Tarcília Aparecida |
author_role |
author |
author2 |
Andrade, Eric Francelino Barroso, Lívia Corrêa Lima, Renato Ribeiro de Macari, Soraia Paiva, Saul Martins Silva, Tarcília Aparecida |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, Luciano José Andrade, Eric Francelino Barroso, Lívia Corrêa Lima, Renato Ribeiro de Macari, Soraia Paiva, Saul Martins Silva, Tarcília Aparecida |
dc.subject.por.fl_str_mv |
Bone and Bones Chronic Disease Exercise Dentistry Physiology Saúde bucal Doença crônica Osso alveolar Odontologia Atividade física Irisina |
topic |
Bone and Bones Chronic Disease Exercise Dentistry Physiology Saúde bucal Doença crônica Osso alveolar Odontologia Atividade física Irisina |
description |
Bone quality is an important issue in dentistry. Low bone density may be associated with more severe periodontitis, and may influence implant therapy success. Recent evidence suggests that physical activity can improve alveolar bone quality. Irisin is an exercise-mediated peptide that might be involved in this process. We assessed the effect of exercise and that of intra-peritoneal irisin administration on bone quality in healthy and osteoporosis-induced rodents. This study was registered at PROSPERO (CRD42020184140), and followed PRISMA guidelines. A search by two independent examiners was conducted in five databases and gray literature up to July 2021, without restrictions regarding language or date of publication. Initially, they analyzed retrieved titles and abstracts (n=3,844) based on eligibility criteria. Of this total, 19 studies remained for full-text reading, and 16 proceeded to the data extraction and quality assessment phases. Meta-analyses were conducted (n= 6 studies) to establish the effects of irisin administration on cancellous bone mineral density (BMD). Exercise or irisin administration enhanced bone quality, but the meta-analysis showed that BMD increased only slightly in osteoporotic rodents (BMD: mean difference 0.03 mg/cm3 - 95% CI 0.01-0.05). This indicates that they had no significant benefits on the bones of healthy animals. Implications of key findings evidence the potential of irisin as an agent able to mitigate bone loss caused by osteoporosis, an outcome that could favor dental rehabilitation. More studies investigating the effect of irisin on alveolar bone are needed to elucidate its therapeutic viability and implications. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-05T22:23:21Z 2022-08-05T22:23:21Z 2022-04 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
PEREIRA, L. J. et al. Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health. Brazilian Oral Research, São Paulo, v. 36, e055, 2022. DOI: https://doi.org/10.1590/1807-3107bor-2022.vol36.0055. http://repositorio.ufla.br/jspui/handle/1/50866 |
identifier_str_mv |
PEREIRA, L. J. et al. Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health. Brazilian Oral Research, São Paulo, v. 36, e055, 2022. DOI: https://doi.org/10.1590/1807-3107bor-2022.vol36.0055. |
url |
http://repositorio.ufla.br/jspui/handle/1/50866 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
dc.source.none.fl_str_mv |
Brazilian Oral Research reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
instname_str |
Universidade Federal de Lavras (UFLA) |
instacron_str |
UFLA |
institution |
UFLA |
reponame_str |
Repositório Institucional da UFLA |
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Repositório Institucional da UFLA |
repository.name.fl_str_mv |
Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
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1815439324380921856 |