Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health

Detalhes bibliográficos
Autor(a) principal: Pereira, Luciano José
Data de Publicação: 2022
Outros Autores: Andrade, Eric Francelino, Barroso, Lívia Corrêa, Lima, Renato Ribeiro de, Macari, Soraia, Paiva, Saul Martins, Silva, Tarcília Aparecida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/50866
Resumo: Bone quality is an important issue in dentistry. Low bone density may be associated with more severe periodontitis, and may influence implant therapy success. Recent evidence suggests that physical activity can improve alveolar bone quality. Irisin is an exercise-mediated peptide that might be involved in this process. We assessed the effect of exercise and that of intra-peritoneal irisin administration on bone quality in healthy and osteoporosis-induced rodents. This study was registered at PROSPERO (CRD42020184140), and followed PRISMA guidelines. A search by two independent examiners was conducted in five databases and gray literature up to July 2021, without restrictions regarding language or date of publication. Initially, they analyzed retrieved titles and abstracts (n=3,844) based on eligibility criteria. Of this total, 19 studies remained for full-text reading, and 16 proceeded to the data extraction and quality assessment phases. Meta-analyses were conducted (n= 6 studies) to establish the effects of irisin administration on cancellous bone mineral density (BMD). Exercise or irisin administration enhanced bone quality, but the meta-analysis showed that BMD increased only slightly in osteoporotic rodents (BMD: mean difference 0.03 mg/cm3 - 95% CI 0.01-0.05). This indicates that they had no significant benefits on the bones of healthy animals. Implications of key findings evidence the potential of irisin as an agent able to mitigate bone loss caused by osteoporosis, an outcome that could favor dental rehabilitation. More studies investigating the effect of irisin on alveolar bone are needed to elucidate its therapeutic viability and implications.
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spelling Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral healthBone and BonesChronic DiseaseExerciseDentistryPhysiologySaúde bucalDoença crônicaOsso alveolarOdontologiaAtividade físicaIrisinaBone quality is an important issue in dentistry. Low bone density may be associated with more severe periodontitis, and may influence implant therapy success. Recent evidence suggests that physical activity can improve alveolar bone quality. Irisin is an exercise-mediated peptide that might be involved in this process. We assessed the effect of exercise and that of intra-peritoneal irisin administration on bone quality in healthy and osteoporosis-induced rodents. This study was registered at PROSPERO (CRD42020184140), and followed PRISMA guidelines. A search by two independent examiners was conducted in five databases and gray literature up to July 2021, without restrictions regarding language or date of publication. Initially, they analyzed retrieved titles and abstracts (n=3,844) based on eligibility criteria. Of this total, 19 studies remained for full-text reading, and 16 proceeded to the data extraction and quality assessment phases. Meta-analyses were conducted (n= 6 studies) to establish the effects of irisin administration on cancellous bone mineral density (BMD). Exercise or irisin administration enhanced bone quality, but the meta-analysis showed that BMD increased only slightly in osteoporotic rodents (BMD: mean difference 0.03 mg/cm3 - 95% CI 0.01-0.05). This indicates that they had no significant benefits on the bones of healthy animals. Implications of key findings evidence the potential of irisin as an agent able to mitigate bone loss caused by osteoporosis, an outcome that could favor dental rehabilitation. More studies investigating the effect of irisin on alveolar bone are needed to elucidate its therapeutic viability and implications.Sociedade Brasileira de Pesquisa Odontológica (SBPqO)2022-08-05T22:23:21Z2022-08-05T22:23:21Z2022-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPEREIRA, L. J. et al. Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health. Brazilian Oral Research, São Paulo, v. 36, e055, 2022. DOI: https://doi.org/10.1590/1807-3107bor-2022.vol36.0055.http://repositorio.ufla.br/jspui/handle/1/50866Brazilian Oral Researchreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessPereira, Luciano JoséAndrade, Eric FrancelinoBarroso, Lívia CorrêaLima, Renato Ribeiro deMacari, SoraiaPaiva, Saul MartinsSilva, Tarcília Aparecidaeng2023-05-02T10:55:21Zoai:localhost:1/50866Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2023-05-02T10:55:21Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
title Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
spellingShingle Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
Pereira, Luciano José
Bone and Bones
Chronic Disease
Exercise
Dentistry
Physiology
Saúde bucal
Doença crônica
Osso alveolar
Odontologia
Atividade física
Irisina
title_short Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
title_full Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
title_fullStr Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
title_full_unstemmed Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
title_sort Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
author Pereira, Luciano José
author_facet Pereira, Luciano José
Andrade, Eric Francelino
Barroso, Lívia Corrêa
Lima, Renato Ribeiro de
Macari, Soraia
Paiva, Saul Martins
Silva, Tarcília Aparecida
author_role author
author2 Andrade, Eric Francelino
Barroso, Lívia Corrêa
Lima, Renato Ribeiro de
Macari, Soraia
Paiva, Saul Martins
Silva, Tarcília Aparecida
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Luciano José
Andrade, Eric Francelino
Barroso, Lívia Corrêa
Lima, Renato Ribeiro de
Macari, Soraia
Paiva, Saul Martins
Silva, Tarcília Aparecida
dc.subject.por.fl_str_mv Bone and Bones
Chronic Disease
Exercise
Dentistry
Physiology
Saúde bucal
Doença crônica
Osso alveolar
Odontologia
Atividade física
Irisina
topic Bone and Bones
Chronic Disease
Exercise
Dentistry
Physiology
Saúde bucal
Doença crônica
Osso alveolar
Odontologia
Atividade física
Irisina
description Bone quality is an important issue in dentistry. Low bone density may be associated with more severe periodontitis, and may influence implant therapy success. Recent evidence suggests that physical activity can improve alveolar bone quality. Irisin is an exercise-mediated peptide that might be involved in this process. We assessed the effect of exercise and that of intra-peritoneal irisin administration on bone quality in healthy and osteoporosis-induced rodents. This study was registered at PROSPERO (CRD42020184140), and followed PRISMA guidelines. A search by two independent examiners was conducted in five databases and gray literature up to July 2021, without restrictions regarding language or date of publication. Initially, they analyzed retrieved titles and abstracts (n=3,844) based on eligibility criteria. Of this total, 19 studies remained for full-text reading, and 16 proceeded to the data extraction and quality assessment phases. Meta-analyses were conducted (n= 6 studies) to establish the effects of irisin administration on cancellous bone mineral density (BMD). Exercise or irisin administration enhanced bone quality, but the meta-analysis showed that BMD increased only slightly in osteoporotic rodents (BMD: mean difference 0.03 mg/cm3 - 95% CI 0.01-0.05). This indicates that they had no significant benefits on the bones of healthy animals. Implications of key findings evidence the potential of irisin as an agent able to mitigate bone loss caused by osteoporosis, an outcome that could favor dental rehabilitation. More studies investigating the effect of irisin on alveolar bone are needed to elucidate its therapeutic viability and implications.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-05T22:23:21Z
2022-08-05T22:23:21Z
2022-04
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv PEREIRA, L. J. et al. Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health. Brazilian Oral Research, São Paulo, v. 36, e055, 2022. DOI: https://doi.org/10.1590/1807-3107bor-2022.vol36.0055.
http://repositorio.ufla.br/jspui/handle/1/50866
identifier_str_mv PEREIRA, L. J. et al. Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health. Brazilian Oral Research, São Paulo, v. 36, e055, 2022. DOI: https://doi.org/10.1590/1807-3107bor-2022.vol36.0055.
url http://repositorio.ufla.br/jspui/handle/1/50866
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
dc.source.none.fl_str_mv Brazilian Oral Research
reponame:Repositório Institucional da UFLA
instname:Universidade Federal de Lavras (UFLA)
instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
repository.name.fl_str_mv Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)
repository.mail.fl_str_mv nivaldo@ufla.br || repositorio.biblioteca@ufla.br
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