Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFLA |
Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/50358 |
Resumo: | Human ascariasis is the most prevalent but neglected tropical disease in the world, affecting approximately 450 million people. The initial phase of Ascaris infection is marked by larval migration from the host’s organs, causing mechanical injuries followed by an intense local inflammatory response, which is characterized mainly by neutrophil and eosinophil infiltration, especially in the lungs. During the pulmonary phase, the lesions induced by larval migration and excessive immune responses contribute to tissue remodeling marked by fibrosis and lung dysfunction. In this study, we investigated the relationship between SIgA levels and eosinophils. We found that TLR2 and TLR4 signaling induces eosinophils and promotes SIgA production during Ascaris suum infection. Therefore, control of parasite burden during the pulmonary phase of ascariasis involves eosinophil influx and subsequent promotion of SIgA levels. In addition, we also demonstrate that eosinophils also participate in the process of tissue remodeling after lung injury caused by larval migration, contributing to pulmonary fibrosis and dysfunction in re-infected mice. In conclusion, we postulate that eosinophils play a central role in mediating host innate and humoral immune responses by controlling parasite burden, tissue inflammation, and remodeling during Ascaris suum infection. Furthermore, we suggest that the use of probiotics can induce eosinophilia and SIgA production and contribute to controlling parasite burden and morbidity of helminthic diseases with pulmonary cycles. |
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Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in miceEosinophilsLarvaeParasitic diseasesAscariasisInflammationImmune responseHuman ascariasis is the most prevalent but neglected tropical disease in the world, affecting approximately 450 million people. The initial phase of Ascaris infection is marked by larval migration from the host’s organs, causing mechanical injuries followed by an intense local inflammatory response, which is characterized mainly by neutrophil and eosinophil infiltration, especially in the lungs. During the pulmonary phase, the lesions induced by larval migration and excessive immune responses contribute to tissue remodeling marked by fibrosis and lung dysfunction. In this study, we investigated the relationship between SIgA levels and eosinophils. We found that TLR2 and TLR4 signaling induces eosinophils and promotes SIgA production during Ascaris suum infection. Therefore, control of parasite burden during the pulmonary phase of ascariasis involves eosinophil influx and subsequent promotion of SIgA levels. In addition, we also demonstrate that eosinophils also participate in the process of tissue remodeling after lung injury caused by larval migration, contributing to pulmonary fibrosis and dysfunction in re-infected mice. In conclusion, we postulate that eosinophils play a central role in mediating host innate and humoral immune responses by controlling parasite burden, tissue inflammation, and remodeling during Ascaris suum infection. Furthermore, we suggest that the use of probiotics can induce eosinophilia and SIgA production and contribute to controlling parasite burden and morbidity of helminthic diseases with pulmonary cycles.PLOS2022-06-27T15:56:04Z2022-06-27T15:56:04Z2021-11-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNOGUEIRA, D. S. et al. Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice. PLoS Pathogens, [S.l.], v. 17, n. 11, p. 1-33, Nov. 2021. DOI: 10.1371/journal.ppat.1010067.http://repositorio.ufla.br/jspui/handle/1/50358PLoS Pathogensreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessNogueira, Denise SilvaOliveira, Luciana Maria deAmorim, Chiara Cássia OliveiraGazzinelli-Guimarães, Ana ClaraBarbosa, Fernando SérgioOliveira, Fabrício Marcus SilvaKraemer, LucasMattos, MatheusCardoso, Mariana SantosResende, Nathália MariaClímaco, Marianna de CarvalhoNegrão-Corrêa, Deborah AparecidaFaria, Ana Maria CaetanoCaliari, Marcelo VidigalBueno, Lilian LacerdaGaze, SorayaRusso, Remo CastroGuimarães, Pedro Henrique GazzinelliFujiwara, Ricardo Toshioeng2023-05-02T10:57:57Zoai:localhost:1/50358Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2023-05-02T10:57:57Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
dc.title.none.fl_str_mv |
Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice |
title |
Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice |
spellingShingle |
Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice Nogueira, Denise Silva Eosinophils Larvae Parasitic diseases Ascariasis Inflammation Immune response |
title_short |
Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice |
title_full |
Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice |
title_fullStr |
Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice |
title_full_unstemmed |
Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice |
title_sort |
Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice |
author |
Nogueira, Denise Silva |
author_facet |
Nogueira, Denise Silva Oliveira, Luciana Maria de Amorim, Chiara Cássia Oliveira Gazzinelli-Guimarães, Ana Clara Barbosa, Fernando Sérgio Oliveira, Fabrício Marcus Silva Kraemer, Lucas Mattos, Matheus Cardoso, Mariana Santos Resende, Nathália Maria Clímaco, Marianna de Carvalho Negrão-Corrêa, Deborah Aparecida Faria, Ana Maria Caetano Caliari, Marcelo Vidigal Bueno, Lilian Lacerda Gaze, Soraya Russo, Remo Castro Guimarães, Pedro Henrique Gazzinelli Fujiwara, Ricardo Toshio |
author_role |
author |
author2 |
Oliveira, Luciana Maria de Amorim, Chiara Cássia Oliveira Gazzinelli-Guimarães, Ana Clara Barbosa, Fernando Sérgio Oliveira, Fabrício Marcus Silva Kraemer, Lucas Mattos, Matheus Cardoso, Mariana Santos Resende, Nathália Maria Clímaco, Marianna de Carvalho Negrão-Corrêa, Deborah Aparecida Faria, Ana Maria Caetano Caliari, Marcelo Vidigal Bueno, Lilian Lacerda Gaze, Soraya Russo, Remo Castro Guimarães, Pedro Henrique Gazzinelli Fujiwara, Ricardo Toshio |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nogueira, Denise Silva Oliveira, Luciana Maria de Amorim, Chiara Cássia Oliveira Gazzinelli-Guimarães, Ana Clara Barbosa, Fernando Sérgio Oliveira, Fabrício Marcus Silva Kraemer, Lucas Mattos, Matheus Cardoso, Mariana Santos Resende, Nathália Maria Clímaco, Marianna de Carvalho Negrão-Corrêa, Deborah Aparecida Faria, Ana Maria Caetano Caliari, Marcelo Vidigal Bueno, Lilian Lacerda Gaze, Soraya Russo, Remo Castro Guimarães, Pedro Henrique Gazzinelli Fujiwara, Ricardo Toshio |
dc.subject.por.fl_str_mv |
Eosinophils Larvae Parasitic diseases Ascariasis Inflammation Immune response |
topic |
Eosinophils Larvae Parasitic diseases Ascariasis Inflammation Immune response |
description |
Human ascariasis is the most prevalent but neglected tropical disease in the world, affecting approximately 450 million people. The initial phase of Ascaris infection is marked by larval migration from the host’s organs, causing mechanical injuries followed by an intense local inflammatory response, which is characterized mainly by neutrophil and eosinophil infiltration, especially in the lungs. During the pulmonary phase, the lesions induced by larval migration and excessive immune responses contribute to tissue remodeling marked by fibrosis and lung dysfunction. In this study, we investigated the relationship between SIgA levels and eosinophils. We found that TLR2 and TLR4 signaling induces eosinophils and promotes SIgA production during Ascaris suum infection. Therefore, control of parasite burden during the pulmonary phase of ascariasis involves eosinophil influx and subsequent promotion of SIgA levels. In addition, we also demonstrate that eosinophils also participate in the process of tissue remodeling after lung injury caused by larval migration, contributing to pulmonary fibrosis and dysfunction in re-infected mice. In conclusion, we postulate that eosinophils play a central role in mediating host innate and humoral immune responses by controlling parasite burden, tissue inflammation, and remodeling during Ascaris suum infection. Furthermore, we suggest that the use of probiotics can induce eosinophilia and SIgA production and contribute to controlling parasite burden and morbidity of helminthic diseases with pulmonary cycles. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-16 2022-06-27T15:56:04Z 2022-06-27T15:56:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
NOGUEIRA, D. S. et al. Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice. PLoS Pathogens, [S.l.], v. 17, n. 11, p. 1-33, Nov. 2021. DOI: 10.1371/journal.ppat.1010067. http://repositorio.ufla.br/jspui/handle/1/50358 |
identifier_str_mv |
NOGUEIRA, D. S. et al. Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice. PLoS Pathogens, [S.l.], v. 17, n. 11, p. 1-33, Nov. 2021. DOI: 10.1371/journal.ppat.1010067. |
url |
http://repositorio.ufla.br/jspui/handle/1/50358 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
PLOS |
publisher.none.fl_str_mv |
PLOS |
dc.source.none.fl_str_mv |
PLoS Pathogens reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
instname_str |
Universidade Federal de Lavras (UFLA) |
instacron_str |
UFLA |
institution |
UFLA |
reponame_str |
Repositório Institucional da UFLA |
collection |
Repositório Institucional da UFLA |
repository.name.fl_str_mv |
Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
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1784550208920616960 |