Current approaches against Alzheimer's disease in clinical trials

Detalhes bibliográficos
Autor(a) principal: Kuca, Kamil
Data de Publicação: 2016
Outros Autores: Soukup, Ondrej, Maresova, Petra, Korabecny, Jan, Nepovimova, Eugenie, Klimova, Blanka, Honegr, Jan, Ramalho, Teodorico C., França, Tanos C. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/36716
Resumo: Alzheimer's disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Currently, this disease represents one of the uppermost human issues, both from the medical and economic point of view. Interest in the discovery of a drug for AD is enormous. However, despite the long-term and worldwide effort for a more effective therapy, the only available treatment is a symptomatic use of acetylcholinesterase inhibitors (AChEIs) and memantine. New therapeutic approaches as well as those based on cholinergic or amyloid theory have not brought the desired benefits yet. Thus, the question is whether an effective drug for this progressive disease will ever be developed or whether people will have to rely only on prevention and minimize risk factors of AD.
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spelling Current approaches against Alzheimer's disease in clinical trialsAlzheimer's disease - TreatmentAcetylcholinesterase inhibitorsDoença de Alzheimer - TratamentoInibidores da acetilcolinesteraseAlzheimer's disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Currently, this disease represents one of the uppermost human issues, both from the medical and economic point of view. Interest in the discovery of a drug for AD is enormous. However, despite the long-term and worldwide effort for a more effective therapy, the only available treatment is a symptomatic use of acetylcholinesterase inhibitors (AChEIs) and memantine. New therapeutic approaches as well as those based on cholinergic or amyloid theory have not brought the desired benefits yet. Thus, the question is whether an effective drug for this progressive disease will ever be developed or whether people will have to rely only on prevention and minimize risk factors of AD.Sociedade Brasileira de Química2019-09-06T13:07:56Z2019-09-06T13:07:56Z2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfKUCA, K. et al. Current approaches against Alzheimer's disease in clinical trials. Journal of the Brazilian Chemical Society, São Paulo, v. 27, n. 4, p. 641-649, 2016.http://repositorio.ufla.br/jspui/handle/1/36716Journal of the Brazilian Chemical Societyreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessKuca, KamilSoukup, OndrejMaresova, PetraKorabecny, JanNepovimova, EugenieKlimova, BlankaHonegr, JanRamalho, Teodorico C.França, Tanos C. C.eng2019-09-06T13:07:56Zoai:localhost:1/36716Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2019-09-06T13:07:56Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Current approaches against Alzheimer's disease in clinical trials
title Current approaches against Alzheimer's disease in clinical trials
spellingShingle Current approaches against Alzheimer's disease in clinical trials
Kuca, Kamil
Alzheimer's disease - Treatment
Acetylcholinesterase inhibitors
Doença de Alzheimer - Tratamento
Inibidores da acetilcolinesterase
title_short Current approaches against Alzheimer's disease in clinical trials
title_full Current approaches against Alzheimer's disease in clinical trials
title_fullStr Current approaches against Alzheimer's disease in clinical trials
title_full_unstemmed Current approaches against Alzheimer's disease in clinical trials
title_sort Current approaches against Alzheimer's disease in clinical trials
author Kuca, Kamil
author_facet Kuca, Kamil
Soukup, Ondrej
Maresova, Petra
Korabecny, Jan
Nepovimova, Eugenie
Klimova, Blanka
Honegr, Jan
Ramalho, Teodorico C.
França, Tanos C. C.
author_role author
author2 Soukup, Ondrej
Maresova, Petra
Korabecny, Jan
Nepovimova, Eugenie
Klimova, Blanka
Honegr, Jan
Ramalho, Teodorico C.
França, Tanos C. C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kuca, Kamil
Soukup, Ondrej
Maresova, Petra
Korabecny, Jan
Nepovimova, Eugenie
Klimova, Blanka
Honegr, Jan
Ramalho, Teodorico C.
França, Tanos C. C.
dc.subject.por.fl_str_mv Alzheimer's disease - Treatment
Acetylcholinesterase inhibitors
Doença de Alzheimer - Tratamento
Inibidores da acetilcolinesterase
topic Alzheimer's disease - Treatment
Acetylcholinesterase inhibitors
Doença de Alzheimer - Tratamento
Inibidores da acetilcolinesterase
description Alzheimer's disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Currently, this disease represents one of the uppermost human issues, both from the medical and economic point of view. Interest in the discovery of a drug for AD is enormous. However, despite the long-term and worldwide effort for a more effective therapy, the only available treatment is a symptomatic use of acetylcholinesterase inhibitors (AChEIs) and memantine. New therapeutic approaches as well as those based on cholinergic or amyloid theory have not brought the desired benefits yet. Thus, the question is whether an effective drug for this progressive disease will ever be developed or whether people will have to rely only on prevention and minimize risk factors of AD.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019-09-06T13:07:56Z
2019-09-06T13:07:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv KUCA, K. et al. Current approaches against Alzheimer's disease in clinical trials. Journal of the Brazilian Chemical Society, São Paulo, v. 27, n. 4, p. 641-649, 2016.
http://repositorio.ufla.br/jspui/handle/1/36716
identifier_str_mv KUCA, K. et al. Current approaches against Alzheimer's disease in clinical trials. Journal of the Brazilian Chemical Society, São Paulo, v. 27, n. 4, p. 641-649, 2016.
url http://repositorio.ufla.br/jspui/handle/1/36716
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0/
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society
reponame:Repositório Institucional da UFLA
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reponame_str Repositório Institucional da UFLA
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