Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Detalhes bibliográficos
Autor(a) principal: Wang, Manli
Data de Publicação: 2020
Outros Autores: Cao, Ruiyuan, Zhang, Leike, Yang, Xinglou, Liu, Jia, Xu, Mingyue, Shi, Zhengli, Hu, Zhihong, Zhong, Wu, Xiao, Gengfu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/39720
Resumo: In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27, 2020, the Chinese authorities reported 2835 confirmed cases in mainland China, including 81 deaths. Additionally, 19 confirmed cases were identified in Hong Kong, Macao and Taiwan, and 39 imported cases were identified in Thailand, Japan, South Korea, United States, Vietnam, Singapore, Nepal, France, Australia and Canada. The pathogen was soon identified as a novel coronavirus (2019-nCoV), which is closely related to sever acute respiratory syndrome CoV (SARS-CoV).2 Currently, there is no specific treatment against the new virus. Therefore, identifying effective antiviral agents to combat the disease is urgently needed.
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spelling Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitroRemdesivir e cloroquina inibem efetivamente in vitro o recém-surgido coronavirus (2019-nCoV)COVID-19CoronavirusChloroquineRemdesivirCloroquinaSARS-CoVIn December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27, 2020, the Chinese authorities reported 2835 confirmed cases in mainland China, including 81 deaths. Additionally, 19 confirmed cases were identified in Hong Kong, Macao and Taiwan, and 39 imported cases were identified in Thailand, Japan, South Korea, United States, Vietnam, Singapore, Nepal, France, Australia and Canada. The pathogen was soon identified as a novel coronavirus (2019-nCoV), which is closely related to sever acute respiratory syndrome CoV (SARS-CoV).2 Currently, there is no specific treatment against the new virus. Therefore, identifying effective antiviral agents to combat the disease is urgently needed.Em dezembro de 2019, uma nova pneumonia causada por um patógeno previamente desconhecido emergiu em Wuhan, uma cidade com 11 milhões de habitantes no centro da China. Os casos iniciais foram relacionados a exposições em um mercado de frutos do mar em Wuhan. Em 27 de Janeiro de 2020, as autoridades Chinesas relataram 2835 casos confirmados na China continental, incluindo 81 mortes. Adicionalmente, 19 casos confirmados foram identificados em Hong Kong, Macau e Taiwan, e 39 casos importados foram identificados na Tailândia, Japão, Coréia do Sul, Estados Unidos, Vietnã, Singapura, Nepal, França, Austrália e Canadá. O patógeno logo foi identificado como o novo coronavírus (2019-nCoV), que está intimamente associado ao coronavírus relacionado à síndrome respiratória aguda grave CoV (SARS-CoV). Atualmente, não há tratamento específico contra o novo vírus. Portanto, a identificação de agentes antivirais efetivos para combater a doença é necessária com urgência.Springer Nature2020-04-03T12:18:15Z2020-04-03T12:18:15Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfWANG, M. et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research, [S. l.], v. 30, p. 269-271, 2020.http://repositorio.ufla.br/jspui/handle/1/39720Cell Researchreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessWang, ManliCao, RuiyuanZhang, LeikeYang, XinglouLiu, JiaXu, MingyueShi, ZhengliHu, ZhihongZhong, WuXiao, Gengfueng2020-04-03T12:18:15Zoai:localhost:1/39720Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2020-04-03T12:18:15Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Remdesivir e cloroquina inibem efetivamente in vitro o recém-surgido coronavirus (2019-nCoV)
title Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
spellingShingle Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Wang, Manli
COVID-19
Coronavirus
Chloroquine
Remdesivir
Cloroquina
SARS-CoV
title_short Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
title_full Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
title_fullStr Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
title_full_unstemmed Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
title_sort Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
author Wang, Manli
author_facet Wang, Manli
Cao, Ruiyuan
Zhang, Leike
Yang, Xinglou
Liu, Jia
Xu, Mingyue
Shi, Zhengli
Hu, Zhihong
Zhong, Wu
Xiao, Gengfu
author_role author
author2 Cao, Ruiyuan
Zhang, Leike
Yang, Xinglou
Liu, Jia
Xu, Mingyue
Shi, Zhengli
Hu, Zhihong
Zhong, Wu
Xiao, Gengfu
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Wang, Manli
Cao, Ruiyuan
Zhang, Leike
Yang, Xinglou
Liu, Jia
Xu, Mingyue
Shi, Zhengli
Hu, Zhihong
Zhong, Wu
Xiao, Gengfu
dc.subject.por.fl_str_mv COVID-19
Coronavirus
Chloroquine
Remdesivir
Cloroquina
SARS-CoV
topic COVID-19
Coronavirus
Chloroquine
Remdesivir
Cloroquina
SARS-CoV
description In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27, 2020, the Chinese authorities reported 2835 confirmed cases in mainland China, including 81 deaths. Additionally, 19 confirmed cases were identified in Hong Kong, Macao and Taiwan, and 39 imported cases were identified in Thailand, Japan, South Korea, United States, Vietnam, Singapore, Nepal, France, Australia and Canada. The pathogen was soon identified as a novel coronavirus (2019-nCoV), which is closely related to sever acute respiratory syndrome CoV (SARS-CoV).2 Currently, there is no specific treatment against the new virus. Therefore, identifying effective antiviral agents to combat the disease is urgently needed.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-03T12:18:15Z
2020-04-03T12:18:15Z
2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv WANG, M. et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research, [S. l.], v. 30, p. 269-271, 2020.
http://repositorio.ufla.br/jspui/handle/1/39720
identifier_str_mv WANG, M. et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research, [S. l.], v. 30, p. 269-271, 2020.
url http://repositorio.ufla.br/jspui/handle/1/39720
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Cell Research
reponame:Repositório Institucional da UFLA
instname:Universidade Federal de Lavras (UFLA)
instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
repository.name.fl_str_mv Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)
repository.mail.fl_str_mv nivaldo@ufla.br || repositorio.biblioteca@ufla.br
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