Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFLA |
Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/50756 |
Resumo: | Oral thrush or candidiasis is a fairly common infectious fungal disease that is mainly caused by species of the genus Candida spp. In this work, we evaluated the antifungal activity of the essential oil of Cymbopogon citratus (DC) Stapf (lemongrass) and its combination with nystatin against oral cavity yeasts. The oil was extracted by the steam distillation method, and its constituents were quantified. The yeasts were identified using MALDI-TOF MS. The sensitivity to the essential oil and its association with nystatin was verified by the minimum inhibitory concentration (MIC) and checkerboard methods. In the essential oil samples, there were 84.53% of citral. A total of 64.77% of strains were identified as Candida albicans. On susceptibility tests, 83.55% of the yeast isolates were inhibited in concentrations of ≥16 µg/mL of nystatin. C. citratus’s oil was capable of inhibiting and killing all the isolates tested with concentrations that varied from 0.137 to 2.2 mg/mL. The association of oil and nystatin had an additive effect on more than 78% of the strains. The association of this herbal drug with nystatin potentialized the antifungal effect on yeast samples isolated from the oral cavity of oncologic patients. |
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Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeastsInfectious diseasesMedicinal plantsNystatinOral CandidiasisPharmacological synergismCapim-limãoDoenças infecciosasPlantas medicinaisNistatinaCandidíase oralInterações medicamentosasOral thrush or candidiasis is a fairly common infectious fungal disease that is mainly caused by species of the genus Candida spp. In this work, we evaluated the antifungal activity of the essential oil of Cymbopogon citratus (DC) Stapf (lemongrass) and its combination with nystatin against oral cavity yeasts. The oil was extracted by the steam distillation method, and its constituents were quantified. The yeasts were identified using MALDI-TOF MS. The sensitivity to the essential oil and its association with nystatin was verified by the minimum inhibitory concentration (MIC) and checkerboard methods. In the essential oil samples, there were 84.53% of citral. A total of 64.77% of strains were identified as Candida albicans. On susceptibility tests, 83.55% of the yeast isolates were inhibited in concentrations of ≥16 µg/mL of nystatin. C. citratus’s oil was capable of inhibiting and killing all the isolates tested with concentrations that varied from 0.137 to 2.2 mg/mL. The association of oil and nystatin had an additive effect on more than 78% of the strains. The association of this herbal drug with nystatin potentialized the antifungal effect on yeast samples isolated from the oral cavity of oncologic patients.Academia Brasileira de Ciências2022-07-28T20:48:03Z2022-07-28T20:48:03Z2022-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPAIVA, L. F. de et al. Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 94, n. 1, e20200681, 2022. DOI: 10.1590/0001-3765202220200681.http://repositorio.ufla.br/jspui/handle/1/50756Anais da Academia Brasileira de Ciênciasreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessPaiva, Luiz Francisley deTeixeira-Loyola, Ana Beatriz A.Schnaider, Taylor B.Souza, Angélica Cristina deLima, Lidiany M. ZacaroniDias, Disney R.eng2022-07-28T20:48:56Zoai:localhost:1/50756Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2022-07-28T20:48:56Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
dc.title.none.fl_str_mv |
Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts |
title |
Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts |
spellingShingle |
Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts Paiva, Luiz Francisley de Infectious diseases Medicinal plants Nystatin Oral Candidiasis Pharmacological synergism Capim-limão Doenças infecciosas Plantas medicinais Nistatina Candidíase oral Interações medicamentosas |
title_short |
Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts |
title_full |
Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts |
title_fullStr |
Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts |
title_full_unstemmed |
Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts |
title_sort |
Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts |
author |
Paiva, Luiz Francisley de |
author_facet |
Paiva, Luiz Francisley de Teixeira-Loyola, Ana Beatriz A. Schnaider, Taylor B. Souza, Angélica Cristina de Lima, Lidiany M. Zacaroni Dias, Disney R. |
author_role |
author |
author2 |
Teixeira-Loyola, Ana Beatriz A. Schnaider, Taylor B. Souza, Angélica Cristina de Lima, Lidiany M. Zacaroni Dias, Disney R. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Paiva, Luiz Francisley de Teixeira-Loyola, Ana Beatriz A. Schnaider, Taylor B. Souza, Angélica Cristina de Lima, Lidiany M. Zacaroni Dias, Disney R. |
dc.subject.por.fl_str_mv |
Infectious diseases Medicinal plants Nystatin Oral Candidiasis Pharmacological synergism Capim-limão Doenças infecciosas Plantas medicinais Nistatina Candidíase oral Interações medicamentosas |
topic |
Infectious diseases Medicinal plants Nystatin Oral Candidiasis Pharmacological synergism Capim-limão Doenças infecciosas Plantas medicinais Nistatina Candidíase oral Interações medicamentosas |
description |
Oral thrush or candidiasis is a fairly common infectious fungal disease that is mainly caused by species of the genus Candida spp. In this work, we evaluated the antifungal activity of the essential oil of Cymbopogon citratus (DC) Stapf (lemongrass) and its combination with nystatin against oral cavity yeasts. The oil was extracted by the steam distillation method, and its constituents were quantified. The yeasts were identified using MALDI-TOF MS. The sensitivity to the essential oil and its association with nystatin was verified by the minimum inhibitory concentration (MIC) and checkerboard methods. In the essential oil samples, there were 84.53% of citral. A total of 64.77% of strains were identified as Candida albicans. On susceptibility tests, 83.55% of the yeast isolates were inhibited in concentrations of ≥16 µg/mL of nystatin. C. citratus’s oil was capable of inhibiting and killing all the isolates tested with concentrations that varied from 0.137 to 2.2 mg/mL. The association of oil and nystatin had an additive effect on more than 78% of the strains. The association of this herbal drug with nystatin potentialized the antifungal effect on yeast samples isolated from the oral cavity of oncologic patients. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-28T20:48:03Z 2022-07-28T20:48:03Z 2022-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
PAIVA, L. F. de et al. Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 94, n. 1, e20200681, 2022. DOI: 10.1590/0001-3765202220200681. http://repositorio.ufla.br/jspui/handle/1/50756 |
identifier_str_mv |
PAIVA, L. F. de et al. Association of the essential oil of Cymbopogon citratus (DC) Stapf with nystatin against oral cavity yeasts. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 94, n. 1, e20200681, 2022. DOI: 10.1590/0001-3765202220200681. |
url |
http://repositorio.ufla.br/jspui/handle/1/50756 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
instname_str |
Universidade Federal de Lavras (UFLA) |
instacron_str |
UFLA |
institution |
UFLA |
reponame_str |
Repositório Institucional da UFLA |
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Repositório Institucional da UFLA |
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Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
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1807835059870236672 |