Twisting development, the birth of a potential new gene

• Autor(a) principal: Marsch-Martínez, Nayelli
• Data de Publicação: 2022
• Outros Autores: Reyes-Olalde, J. Irepan, Chalfun-Junior, Antonio, Bemer, Marian, Durán-Medina, Yolanda, Ochoa-Sánchez, Juan Carlos, Guerrero-Largo, Herenia, Herrera-Ubaldo, Humberto, Mes, Jurriaan, Chacón, Alejandra, Escobar-Guzmán, Rocio, Pereira, Andy, Herrera-Estrella, Luis, Angenent, Gerco C., Delaye, Luis, Folter, Stefan de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFLA
• Texto Completo: http://repositorio.ufla.br/jspui/handle/1/56490
• topic: Molecular biology; Evolutionary biology; Plant development; Biologia molecular; Biologia evolutiva; Desenvolvimento vegetal

Evolution has long been considered to be a conservative process in which new genes arise from pre-existing genes through gene duplication, domain shuffling, horizontal transfer, overprinting, retrotransposition, etc. However, this view is changing as new genes originating from non-genic sequences are discovered in different organisms. Still, rather limited functional information is available. Here, we have identified TWISTED1 (TWT1), a possible de novo-originated protein-coding gene that modifies microtubule arrangement and causes helicoidal growth in Arabidopsis thaliana when its expression is increased. Interestingly, even though TWT1 is a likely recent gene, the lack of TWT1 function affects A. thaliana development. TWT1 seems to have originated from a non-genic sequence. If so, it would be one of the few examples to date of how during evolution de novo genes are integrated into developmental cellular and organismal processes.