Enzymes modulation by dried grape pomace from the manufacture of wines and juices

Detalhes bibliográficos
Autor(a) principal: Freire, Juliana Mesquita
Data de Publicação: 2020
Outros Autores: Barroso, Amanda Ribeiro, Assis, Amanda Araújo de, Texeira, Bruna Helena, Braga, Jonatas Henrique Guimarães, Oliveira, Daniela Aparecida, Braga, Mariana Aparecida, Marcussi, Silvana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/48006
Resumo: The processing of grapes for the manufacture of juices and wines, generates large quantities of by-products rich in metabolites with antioxidant, antimicrobial, anti-inflammatory and cicatrizing activities. The high homology between human enzymes and snake venoms makes the latter valuable laboratory tools for the study of pathophysiological processes. Proteases and phospholipases A2 act in processes related to hemostasis and inflammatory response. Thus, in this work, dried pomace obtained from grape (Isabel, Niagara, Bordô, BRS Violeta and Blend cultivars) processing were evaluated on phospholipase, proteolytic, hemolytic and thrombolytic activities induced by snakes venoms and the content of phenolic compounds and minerals was evaluated. The dried pomace exerted inhibitory and potentiating actions in all analyzed activities. The enzymatic modulators present in the evaluated dried pomace have potential for therapeutic use, although their broad characterization is still necessary, in order to define adequate amounts and formulations to obtain efficacy and safety in their use.
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spelling Enzymes modulation by dried grape pomace from the manufacture of wines and juicesGrape extractsIndustrial wastesPhenolic compoundsProtease modulatorsPhospholipase A2 modulatorsExtratos de uvaResíduos IndustriaisCompostos fenólicosModuladores de proteaseModuladores de fosfolipase A2The processing of grapes for the manufacture of juices and wines, generates large quantities of by-products rich in metabolites with antioxidant, antimicrobial, anti-inflammatory and cicatrizing activities. The high homology between human enzymes and snake venoms makes the latter valuable laboratory tools for the study of pathophysiological processes. Proteases and phospholipases A2 act in processes related to hemostasis and inflammatory response. Thus, in this work, dried pomace obtained from grape (Isabel, Niagara, Bordô, BRS Violeta and Blend cultivars) processing were evaluated on phospholipase, proteolytic, hemolytic and thrombolytic activities induced by snakes venoms and the content of phenolic compounds and minerals was evaluated. The dried pomace exerted inhibitory and potentiating actions in all analyzed activities. The enzymatic modulators present in the evaluated dried pomace have potential for therapeutic use, although their broad characterization is still necessary, in order to define adequate amounts and formulations to obtain efficacy and safety in their use.Universidade de São Paulo, Faculdade de Ciências Farmacêuticas2021-08-31T17:55:37Z2021-08-31T17:55:37Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfFREIRE, J. M. et al. Enzymes modulation by dried grape pomace from the manufacture of wines and juices. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 56, e18467, 2020. DOI: 10.1590/s2175-97902020000118467.http://repositorio.ufla.br/jspui/handle/1/48006Brazilian Journal of Pharmaceutical Sciencesreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessFreire, Juliana MesquitaBarroso, Amanda RibeiroAssis, Amanda Araújo deTexeira, Bruna HelenaBraga, Jonatas Henrique GuimarãesOliveira, Daniela AparecidaBraga, Mariana AparecidaMarcussi, Silvanaeng2021-08-31T17:55:37Zoai:localhost:1/48006Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2021-08-31T17:55:37Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Enzymes modulation by dried grape pomace from the manufacture of wines and juices
title Enzymes modulation by dried grape pomace from the manufacture of wines and juices
spellingShingle Enzymes modulation by dried grape pomace from the manufacture of wines and juices
Freire, Juliana Mesquita
Grape extracts
Industrial wastes
Phenolic compounds
Protease modulators
Phospholipase A2 modulators
Extratos de uva
Resíduos Industriais
Compostos fenólicos
Moduladores de protease
Moduladores de fosfolipase A2
title_short Enzymes modulation by dried grape pomace from the manufacture of wines and juices
title_full Enzymes modulation by dried grape pomace from the manufacture of wines and juices
title_fullStr Enzymes modulation by dried grape pomace from the manufacture of wines and juices
title_full_unstemmed Enzymes modulation by dried grape pomace from the manufacture of wines and juices
title_sort Enzymes modulation by dried grape pomace from the manufacture of wines and juices
author Freire, Juliana Mesquita
author_facet Freire, Juliana Mesquita
Barroso, Amanda Ribeiro
Assis, Amanda Araújo de
Texeira, Bruna Helena
Braga, Jonatas Henrique Guimarães
Oliveira, Daniela Aparecida
Braga, Mariana Aparecida
Marcussi, Silvana
author_role author
author2 Barroso, Amanda Ribeiro
Assis, Amanda Araújo de
Texeira, Bruna Helena
Braga, Jonatas Henrique Guimarães
Oliveira, Daniela Aparecida
Braga, Mariana Aparecida
Marcussi, Silvana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freire, Juliana Mesquita
Barroso, Amanda Ribeiro
Assis, Amanda Araújo de
Texeira, Bruna Helena
Braga, Jonatas Henrique Guimarães
Oliveira, Daniela Aparecida
Braga, Mariana Aparecida
Marcussi, Silvana
dc.subject.por.fl_str_mv Grape extracts
Industrial wastes
Phenolic compounds
Protease modulators
Phospholipase A2 modulators
Extratos de uva
Resíduos Industriais
Compostos fenólicos
Moduladores de protease
Moduladores de fosfolipase A2
topic Grape extracts
Industrial wastes
Phenolic compounds
Protease modulators
Phospholipase A2 modulators
Extratos de uva
Resíduos Industriais
Compostos fenólicos
Moduladores de protease
Moduladores de fosfolipase A2
description The processing of grapes for the manufacture of juices and wines, generates large quantities of by-products rich in metabolites with antioxidant, antimicrobial, anti-inflammatory and cicatrizing activities. The high homology between human enzymes and snake venoms makes the latter valuable laboratory tools for the study of pathophysiological processes. Proteases and phospholipases A2 act in processes related to hemostasis and inflammatory response. Thus, in this work, dried pomace obtained from grape (Isabel, Niagara, Bordô, BRS Violeta and Blend cultivars) processing were evaluated on phospholipase, proteolytic, hemolytic and thrombolytic activities induced by snakes venoms and the content of phenolic compounds and minerals was evaluated. The dried pomace exerted inhibitory and potentiating actions in all analyzed activities. The enzymatic modulators present in the evaluated dried pomace have potential for therapeutic use, although their broad characterization is still necessary, in order to define adequate amounts and formulations to obtain efficacy and safety in their use.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021-08-31T17:55:37Z
2021-08-31T17:55:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv FREIRE, J. M. et al. Enzymes modulation by dried grape pomace from the manufacture of wines and juices. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 56, e18467, 2020. DOI: 10.1590/s2175-97902020000118467.
http://repositorio.ufla.br/jspui/handle/1/48006
identifier_str_mv FREIRE, J. M. et al. Enzymes modulation by dried grape pomace from the manufacture of wines and juices. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 56, e18467, 2020. DOI: 10.1590/s2175-97902020000118467.
url http://repositorio.ufla.br/jspui/handle/1/48006
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences
reponame:Repositório Institucional da UFLA
instname:Universidade Federal de Lavras (UFLA)
instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
repository.name.fl_str_mv Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)
repository.mail.fl_str_mv nivaldo@ufla.br || repositorio.biblioteca@ufla.br
_version_ 1815439201219379200

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